Showing 1-30 of 100 results for "65-31-6"
Yasushi Kawaguchi et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(39), 14501-14506 (2006-09-15)
The aberrant production of precursor IL-1alpha (pre-IL-1alpha) in skin fibroblasts that are derived from systemic sclerosis (SSc) is associated with the induction of IL-6 and procollagen, which contributes to the fibrosis of SSc. However, little is understood about how intracellular...
H Nitta et al.
Oral microbiology and immunology, 8(3), 141-145 (1993-06-01)
Genetic regulation of the immune response may be involved in the onset and progression of an early-onset type of periodontitis. We analyzed the genetic control of the primary antibody response to Actinobacillus actinomycetemcomitans in inbred strains of mice using an...
N Bahary et al.
Genomics, 11(1), 33-47 (1991-09-01)
We have generated a moderate resolution genetic map of mouse chromosomes 4 and 6 utilizing a (C57BL/6J x Mus spretus) F1 x Mus spretus backcross with RFLPs for 31 probes. The map for chromosome 4 covers 77 cM and details...
Karim Stamboul et al.
PloS one, 12(7), e0179929-e0179929 (2017-07-14)
To better understand the role of myeloperoxidases (MPO) in microvascular obstruction (MO) phenomenon and infarct size (IS) using cardiac magnetic resonance (CMR) data in patients with acute myocardial infarction (AMI). 40 consecutive patients classified according to the median level of...
Richard Conway et al.
Clinical rheumatology, 31(12), 1707-1711 (2012-09-06)
The aim of this study was to evaluate adherence to recommended serum uric acid levels in the rheumatology outpatients department of a university teaching hospital. We performed a retrospective study of all patients with a definitive diagnosis of gout attending...
Fredrik Bredin et al.
Interactive cardiovascular and thoracic surgery, 8(2), 191-194 (2008-11-15)
To evaluate the influence on circulating plasma levels of natriuretic peptides following passive containment surgery in heart failure patients with dilated cardiomyopathy, thirteen patients with dilated cardiomyopathy subjected to cardiac surgery received the Acorn Cardiac Support Device. Patients with ischemic...
Vishal Sondhi et al.
Journal of pediatric hematology/oncology, 35(7), 493-499 (2013-08-10)
Propranolol has emerged as front-line therapy for infantile hemangiomas (IHs). However, a well-defined protocol for administering and predicting response to propranolol is unavailable. In this open-label trial, 31 children with IH (median age=5 mo; range,1 mo to 9 y) were...
J Li et al.
Science (New York, N.Y.), 275(5308), 1943-1947 (1997-03-28)
Mapping of homozygous deletions on human chromosome 10q23 has led to the isolation of a candidate tumor suppressor gene, PTEN, that appears to be mutated at considerable frequency in human cancers. In preliminary screens, mutations of PTEN were detected in...
G J Fennington et al.
Microbiology (Reading, England), 142 ( Pt 2), 321-330 (1996-02-01)
The Rhizobium leguminosarum bv. trifolii BAL fructokinase (frk) gene was isolated on a 2 center dot 4 kb BamHI fragment from the cosmid pLA72 by complementation analysis of the Tn5-induced frk mutant BAL79, and confirmed by hybridization analysis. The nucleotide...
Jan R Ortlepp et al.
International journal of cardiology, 105(1), 90-95 (2005-10-07)
Cardiovascular risk factors (CRF) have been associated with myocardial infarction (MI), while the role of genetic risk factors (GRF) remains undetermined. Cineventriculograms of 3436 were analyzed for presence of regional function impairment as sign of MI. Genotyping for genetic polymorphism...
Giovanni Zuliani et al.
Atherosclerosis, 213(1), 319-324 (2010-09-28)
Increased interleukin-6 plasma levels have been reported in metabolic syndrome (MS); nevertheless, it is unclear whether interleukin-6 activity is exerted through direct signalling only or also through the "trans-signalling". This issue is important to clarify since signalling and "trans-signalling" affect...
Nayana Jayatilaka et al.
The journal of physical chemistry. B, 111(27), 7887-7896 (2007-06-19)
An EPR (electron paramagnetic resonance) and ENDOR (electron-nuclear double resonance) study of 9-ethylguanine crystals X-irradiated at 10 K detected evidence for three radical forms. Radical R1, characterized by three proton and two nitrogen hyperfine interactions, was identified as the product...
Thomas Maischberger et al.
Biotechnology journal, 5(8), 838-847 (2010-07-30)
A novel heterodimeric beta-galactosidase with a molecular mass of 105 kDa was purified from crude cell extracts of the soil isolate Lactobacillus pentosus KUB-ST10-1 using ammonium sulphate fractionation followed by hydrophobic interaction and affinity chromatography. The electrophoretically homogenous enzyme has...
Michelle Furtado et al.
British journal of haematology, 168(1), 55-62 (2014-08-26)
The proteasome inhibitor, bortezomib, potentially increases cell sensitivity to chemotherapy. This study was performed to determine the overall response rate (ORR), overall survival (OS), progression-free survival (PFS) and toxicity of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) compared to CHOP +...
Maha Saber-Ayad et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 11(2), 111-118 (2010-04-27)
The presence of the deletion (D) allele in the angiotensin-converting enzyme (ACE) gene has been reported as a probable genetic risk factor for idiopathic nephrotic syndrome (INS), but its role in determining resistance to steroid therapy remains to be evaluated....
Yi-Long Wu et al.
The Lancet. Oncology, 14(8), 777-786 (2013-06-21)
The results of FASTACT, a randomised, placebo-controlled, phase 2 study, showed that intercalated chemotherapy and erlotinib significantly prolonged progression-free survival (PFS) in patients with advanced non-small-cell lung cancer. We undertook FASTACT-2, a phase 3 study in a similar patient population....
Akosua B Domfeh et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(10), 1217-1223 (2008-05-13)
Current literature suggests that strong WT1 expression in a carcinoma of unknown origin virtually excludes a breast primary. Our previous pilot study on WT1 expression in breast carcinomas has shown WT1 expression in approximately 10% of carcinomas that show mixed...
Jacob A Doll et al.
JAMA cardiology, 1(7), 787-794 (2016-10-21)
Patients with dual Medicare-Medicaid eligibility have a higher burden of chronic disease conditions and increased health care utilization compared with patients with Medicare coverage alone, but the treatment patterns and outcomes of dual-eligible patients with myocardial infarction (MI) are unknown....
Fei Zhao et al.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 14(12), 1726-1733 (2012-05-02)
The aim of this study was to determine whether altered expression and distribution of calcium- and integrin-binding protein-1 (CIB1) is involved in the pathogenesis of different types of patients with atrial fibrillation (AF) associated with valvular heart disease (VHD). Right...
Skander Mulder et al.
Translational research : the journal of laboratory and clinical medicine, 222, 17-27 (2020-05-22)
The mineralocorticoid receptor antagonist spironolactone significantly reduces albuminuria in subjects with diabetic kidney disease, albeit with a large variability between individuals. Identifying novel biomarkers that predict response to therapy may help to tailor spironolactone therapy. We aimed to identify a...
Heinrike Schmeling et al.
The Journal of rheumatology, 32(9), 1832-1836 (2005-09-06)
To study the relationship of C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene to toxicity and efficacy of methotrexate (MTX) in patients with juvenile idiopathic arthritis (JIA). Single nucleotide polymorphisms of the MTHFR gene were investigated by polymerase...
Joshua M Barnett et al.
Investigative ophthalmology & visual science, 48(2), 907-915 (2007-01-26)
The efficacy of three matrix metalloproteinase (MMP) inhibitors with various selectivities (Ro-31-9790, AG3340, and DPC-A37668) was investigated in a rat model of retinopathy of prematurity, to examine the roles of MMP-2 and -9 in retinal neovascularization. The susceptibilities of MMP-2(-/-)...
Vundli Ramokolo et al.
The Journal of nutrition, 144(1), 42-48 (2013-11-08)
Data from a prospective multisite cohort study were used to examine the effect of HIV exposure, untreated HIV infection, and single-dose nevirapine on infant growth velocity. The 2009 WHO growth velocity standards constitute a new tool for this type of...
Ling Huang et al.
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 30(2), 116-120 (2007-04-21)
To investigate the effect of rosiglitazone on the expression of T-bet/GATA-3 in peripheral blood T lymphocytes and cytokine derived from Th1/Th2 in patients with acute asthma and to compare its mechanism with that of dexamethasone (DXM). Peripheral blood T lymphocytes...
Liang Shan et al.
Breast cancer research and treatment, 88(3), 263-272 (2004-12-21)
Signal transducer and activator of transcription (Stat) 5a is a transcription factor mediating the action of specific cytokines, growth factors and hormones on gene expression. In the mammary gland, Stat5a is well recognized for its function in prolactin signaling, lobuloalveolar...
Kathryn Patton et al.
Clinical and vaccine immunology : CVI, 21(5), 628-635 (2014-02-28)
Respiratory syncytial virus (RSV) causes significant disease in elderly adults, and we have previously reported that individuals 65 years of age and older have reduced RSV F protein-specific gamma interferon (IFN-γ)-producing T cells compared to healthy younger adults. To measure...
Paulina M Wojnarowicz et al.
International journal of oncology, 40(6), 1865-1880 (2012-02-22)
It has been proposed that the frequent loss of heterozygosity (LOH) of an entire chromosome 17 contig in epithelial ovarian cancers (EOC) is the consequence of the inactivation of multiple tumour suppressor genes on this chromosome. We report the characterization...
Tamao Hisano et al.
The Journal of biological chemistry, 278(1), 617-624 (2002-11-01)
The (R)-specific enoyl coenzyme A hydratase ((R)-hydratase) from Aeromonas caviae catalyzes the addition of a water molecule to trans-2-enoyl coenzyme A (CoA), with a chain-length of 4-6 carbons, to produce the corresponding (R)-3-hydroxyacyl-CoA. It forms a dimer of identical subunits...
Javariah Siddiqui et al.
Journal of the American College of Cardiology, 62(22), 2134-2140 (2013-08-21)
This study sought to compare outcomes after surgical valvuloplasty and balloon dilation of the aortic valve in neonates and infants. Surgical techniques of aortic valve repair have improved and there is today controversy on the best approach to treat neonatal...
Ellen Warner et al.
JAMA, 292(11), 1317-1325 (2004-09-16)
Current recommendations for women who have a BRCA1 or BRCA2 mutation are to undergo breast surveillance from age 25 years onward with mammography annually and clinical breast examination (CBE) every 6 months; however, many tumors are detected at a relatively...

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon


Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.