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Wei Rao et al.
Journal of the American Society for Mass Spectrometry, 26(6), 986-993 (2015-03-26)
Ambient mass spectrometry imaging (MSI) is an emerging field with great potential for the detailed spatial analysis of biological samples with minimal pretreatment. We have developed a miniaturized sampling and ionization device, the Single-probe, which uses in-situ surface micro-extraction to
Wenwen Gong et al.
Molecules (Basel, Switzerland), 20(4), 6901-6912 (2015-04-29)
In order to investigate the pharmacokinetics of a combination of diazepam and dexamethasone under hypoxic conditions, a novel, sensitive and specific liquid chromatography with tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of diazepam and dexamethasone in rat plasma
Megan J Kelman et al.
Rapid communications in mass spectrometry : RCM, 29(19), 1805-1810 (2015-09-04)
Many species of Alternaria damage important agricultural crops, including small grains and tomatoes. These fungi can produce a variety of secondary metabolites, some of which are toxic to humans and animals. Interest in screening for conjugated or 'modified' mycotoxins has
Shen Wang et al.
ACS applied materials & interfaces, 7(44), 24791-24798 (2015-10-22)
We propose a spectrum-dependent mechanism for the oxidation of 2,2',7,7'-tetrakis(N,N-di-p-methoxyphenylamine)-9,9'-spirobifluorene (Spiro-OMeTAD) with bis(trifluoromethane)sulfonimide lithium salt (LiTFSI), which is commonly used in perovskite solar cells as the hole transport layer. The perovskite layer plays different roles in the Spiro-OMeTAD oxidization for
Yu-Xi He et al.
Molecular medicine reports, 12(2), 2291-2300 (2015-05-06)
Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is a technique widely used for the quantification of mRNA transcription, It is well recognized that the reference genes used in RT-qPCR require appropriate validation to ensure that gene expression is unaffected by experimental
Christopher A Behr et al.
The Journal of surgical research, 198(2), 424-433 (2015-05-03)
Ewing sarcoma (ES) is an aggressive childhood solid tumor in which 30% of cases are metastatic at presentation, and subsequently carry a poor prognosis. We have previously shown that treatment with celecoxib significantly reduces invasion and metastasis of ES cells
Emdad Hossain et al.
Acta poloniae pharmaceutica, 70(2), 255-260 (2013-04-26)
In different parts of India, Bombax malabaricum DC. (Family: Bombacaceae), a lofty deciduous tree with large leaves, is traditionally used in inflammation. The aim of the present study was to confirm its antiinflammatory activity and to search for the possible
Ettore Varricchio et al.
Microscopy research and technique, 78(8), 707-714 (2015-06-23)
In this study, we report the distribution of orexin A (OXA), orexin B (OXB), and orexin receptor (OX2R) immunoreactive (ir) cells in the hypothalamus and gastrointestinal tract of Oncorhynchus mykiss fed diets with different dietary fatty acid compositions. Trout were
Changtao Jiang et al.
The Journal of clinical investigation, 125(1), 386-402 (2014-12-17)
Nonalcoholic fatty liver disease (NAFLD) is a major worldwide health problem. Recent studies suggest that the gut microbiota influences NAFLD pathogenesis. Here, a murine model of high-fat diet-induced (HFD-induced) NAFLD was used, and the effects of alterations in the gut
Fatai Adigun Aborode et al.
Metallomics : integrated biometal science, 7(7), 1056-1066 (2015-03-10)
Three month old Thunbergia alata were exposed for 13 days to 10 μM selenite to determine the biotransformation of selenite in their roots. Selenium in formic acid extracts (80 ± 3%) was present as selenopeptides with Se-S bonds and selenium-PC
Naoyuki Nakada et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(9), 757-765 (2015-04-15)
1. Here, we elucidated the structure of metabolites of novel oral Janus kinase inhibitor ASP015K in rats and humans and evaluated the predictability of human metabolites using chimeric mice with humanized liver (PXB mice). 2. Rat biological samples collected after oral dosing
Yong Wang et al.
Chemical biology & drug design, 84(6), 685-696 (2014-06-04)
Peptidoglycan glycosyltransferase (PGT) has been shown to be an important pharmacological target for the inhibition of bacterial cell wall biosynthesis. Structure-based virtual screening of about 3,000,000 commercially available compounds against the crystal structure of the glycosyltransferase (GT) domain of the
Maria G Carranza et al.
Annals of clinical microbiology and antimicrobials, 14, 29-29 (2015-05-24)
Antimicrobial resistance (AMR) is a major threat to global public health. Medicinal plants have long been used as remedies for infectious diseases by native cultures around the world and have the potential for providing effective treatments for antibiotic-resistant infections. Rhamnus
Habib Bagheri et al.
Analytica chimica acta, 886, 56-65 (2015-09-01)
A nanocomposite of silica-polydiphenylamine doped with silver nanoparticles (Ag-SiO2-PDPA) was successfully synthesized by the sol-gel process. For its preparation, PDPA was mixed with butanethiol capped Ag nanoparticles (NPs) and added to the silica sol solution. The Ag NPs were stabilized
Gabriella Klausz et al.
Biomedical chromatography : BMC, 29(12), 1859-1865 (2015-06-25)
A liquid chromatography-electrospray-mass spectrometry method (LC/MS) has been developed and validated for determination of praziquantel (PZQ), pyrantel (PYR), febantel (FBT), and the active metabolites fenbendazole (FEN) and oxfendazole (OXF), in dog plasma, using mebendazole as internal standard (IS). The method
G Groeneveld et al.
Scientific reports, 5, 11716-11716 (2015-06-30)
Despite the proven capabilities of Matrix Assisted Laser Desorption Ionisation Mass Spectrometry (MALDI MS) in laboratory settings, research is still needed to integrate this technique into current forensic fingerprinting practice. Optimised protocols enabling the compatible application of MALDI to developed
Kenji Tsukigawa et al.
Cancer science, 106(3), 270-278 (2014-12-23)
Previously, we prepared a pirarubicin (THP)-encapsulated micellar drug using styrene-maleic acid copolymer (SMA) as the drug carrier, in which active THP was non-covalently encapsulated. We have now developed covalently conjugated SMA-THP (SMA-THP conjugate) for further investigation toward clinical development, because
Jessica Quijada et al.
Journal of agricultural and food chemistry, 63(28), 6346-6354 (2015-06-13)
Plants containing condensed tannins (CTs) may hold promise as alternatives to synthetic anthelmintic (AH) drugs for controlling gastrointestinal nematodes (GINs). However, the structural features that contribute to the AH activities of CTs remain elusive. This study probed the relationships between
Suvi-Katriina Ruokonen et al.
Journal of chromatography. A, 1405, 178-187 (2015-06-15)
The effect of three phosphonium and imidazolium ionic liquids (ILs) on the interaction between liposomes and common pharmaceuticals found in wastewaters was studied. The liposomes comprised zwitterionic phosphatidyl choline and negatively charged phosphatidyl glycerol. A set of common cationic, anionic
Juan C Domínguez-Romero et al.
Journal of chromatography. A, 1361, 34-42 (2014-08-21)
Sample preparation is a critical step in large-scale multiclass analysis such as sport drug testing. Due to the wide heterogeneity of the analytes and the complexity of the matrix, the selection of a correct sample preparation method is essential, looking
Andrew R S Ross et al.
Analytica chimica acta, 889, 147-155 (2015-09-08)
Polyethoxylated tallow amine (POEA) surfactants have been used in many glyphosate-based herbicide formulations for agricultural, industrial and residential weed control. The potential for release of these compounds into the environment is of increasing concern due to their toxicity towards aquatic
Volker Strenger et al.
The Journal of antimicrobial chemotherapy, 69(9), 2522-2526 (2014-06-04)
Although amphotericin B (AmB) and its lipid formulations are used for the treatment of fungal infections of the CNS, the kinetics of AmB in the CSF after intravenous administration of liposomal amphotericin B (LAmB) are not well characterized. From 14
Yuanyan Liu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 963, 90-98 (2014-06-20)
Frankincense resins are extensively used as natural remedies in regions ranging from North Africa to China. Triterpenoid metabolites from frankincense exhibit notable anti-inflammatory and anti-tumor properties. In the present paper, without the use of an isolation process, the fragmentation rules
Fei Yang et al.
Journal of chromatographic science, 52(8), 788-792 (2013-07-28)
A liquid chromatography-tandem quadrupole mass spectrometry (LC-MS-MS) multi-residue method for the simultaneous target analysis of a wide range of pesticides in tobacco has been developed. Gradient elution has been used in conjunction with positive mode electrospray ionization tandem mass spectrometry
Zari Hooshyar et al.
Luminescence : the journal of biological and chemical luminescence, 30(5), 538-548 (2014-10-15)
Diamine-sarcophagine (DiAmsar) binding to human serum albumin (HSA) and bovine serum albumin (BSA) was investigated under simulative physiological conditions. Fluorescence spectra in combination with Fourier transform infrared (FT-IR), UV-visible (UV-vis) spectroscopy, cyclic voltammetry (CV), and molecular docking method were used
Wen-Ming Chen et al.
Digestive diseases and sciences, 60(6), 1655-1662 (2015-02-18)
Long noncoding RNAs (lncRNAs) have been recently shown to play important regulatory roles in fundamental biological processes, and many of them are deregulated in several human cancers. LncRNA hypoxia-inducible factor 1alpha antisense RNA-2 (HIF1A-AS2) is overexpressed in nonpapillary clear-cell renal
Emmanouil-Nikolaos Papadakis et al.
The Science of the total environment, 536, 793-802 (2015-08-09)
A study was undertaken for the evaluation of the pesticide pollution caused by the agricultural activities in the basin of Lake Vistonis, Greece during the years 2010-2012. Water samples were collected from Lake Vistonis, four major rivers and various small
Khanh-Van Ho et al.
Metabolites, 8(4) (2018-10-03)
Black walnut (Juglans nigra L.) is one of the most economically valuable hardwood species and a high value tree for edible nut production in the United States. Although consumption of black walnut has been linked to multiple health-promoting effects (e.g.
James Daubney et al.
Basic & clinical pharmacology & toxicology, 116(2), 96-109 (2014-09-10)
Whilst mitotic rat embryonic cardiomyoblast-derived H9c2 cells have been widely used as a model system to study the protective mechanisms associated with flavonoids, they are not fully differentiated cardiac cells. Hence, the aim of this study was to investigate the
Cristian Vilos et al.
PloS one, 10(4), e0123335-e0123335 (2015-04-29)
Drug delivery systems based on polymeric microparticles represent an interesting field of development for the treatment of several infectious diseases for humans and animals. In this work, we developed PLGA microparticles loaded with ceftiofur (PLGA-cef), a third- generation cephalosporin that
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