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Raj Kumar Verma et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(8), 2061-2070 (2015-07-23)
Anthothecol, a limonoid isolated from plant Khaya anthotheca (Meliaceae), is an antimalarial compound. The objectives of this study were to examine the molecular mechanisms by which anthothecol-encapsulated PLGA-nanoparticles (Antho-NPs) regulate the behavior of pancreatic cancer stem cells (CSCs). Antho-NPs inhibited
Andrew W Owen et al.
Analytica chimica acta, 849, 12-18 (2014-10-11)
A specially designed thermal vaporiser was used with a process mass spectrometer designed for gas analysis to monitor the esterification of butan-1-ol and acetic anhydride. The reaction was conducted at two scales: in a 150 mL flask and a 1L
Stephen W Stein et al.
Molecular pharmaceutics, 12(9), 3455-3467 (2015-08-11)
A simulation model has been established to predict the residual aerodynamic particle size distribution (APSD) of dual-component pressurized metered dose inhalers (pMDIs). More specifically, this model estimates the APSD of pMDI formulations containing dissolved and suspended compounds for various formulations
Stacie M Gutowski et al.
Biomaterials, 44, 55-70 (2015-01-27)
Neural electrodes are an important part of brain-machine interface devices that can restore functionality to patients with sensory and movement disorders. Chronically implanted neural electrodes induce an unfavorable tissue response which includes inflammation, scar formation, and neuronal cell death, eventually
Carina Bäcktorp et al.
Journal of pharmaceutical sciences, 104(4), 1409-1420 (2015-02-26)
We have developed a predictive method, based on quantum chemical calculations, that qualitatively predicts N-oxidation by hydrogen peroxides in drug structures. The method uses linear correlations of two complementary approaches to estimate the activation barrier without calculating it explicitly. This
Yu-Chieh Tu et al.
Journal of colloid and interface science, 448, 315-319 (2015-03-10)
Here we demonstrated an approach to increase performance of P3HT:TiO2 solar cell either by electron deficient boron or electron rich bismuth doping into TiO2 nanorods. The B doping increases the absorption, crystallinity and electron mobility of TiO2 nanorods. The Bi-doped
Voin Petrović et al.
Journal of inorganic biochemistry, 140, 228-235 (2014-09-01)
Na(+)/K(+)-ATPase is in charge of maintaining the ionic and osmotic intracellular balance by using ATP as an energy source to drive excess Na(+) ions out of the cell in exchange for K(+) ions. We explored whether three representative cytotoxic gold(III)
Yu-Shin Nai et al.
Journal of invertebrate pathology, 120, 4-8 (2014-05-08)
We briefly described the morphology and transmission pathway of a Spiroplasma sp. isolated from the field cricket, Gryllus bimaculatus in Taiwan, followed by the phylogenetic analysis based on the 16S rRNA gene sequence. The cricket spiroplasma infected the hemolymph, gut
Catherine M Lockhart et al.
Investigative ophthalmology & visual science, 55(9), 5572-5581 (2014-08-15)
Bietti crystalline dystrophy (BCD) is a rare, autosomal recessive, progressive, degenerative eye disease caused by mutations in the CYP4V2 gene, for which no treatments are currently available. Cyp4v3 is the murine ortholog to CYP4V2, and to better understand the molecular
Pradipbhai D Kalariya et al.
Journal of mass spectrometry : JMS, 50(11), 1222-1233 (2015-10-28)
Tinoridine is a nonsteroidal anti-inflammatory drug and also has potent radical scavenger and antiperoxidative activity. However, metabolism of tinoridine has not been thoroughly investigated. To identify in vivo metabolites, the drug was administered to Sprague-Dawley rats (n = 5) at a dose
Ashish Soman et al.
Journal of chromatographic science, 52(5), 413-417 (2013-05-17)
Soluplus, a graft copolymer of polyethylene glycol, vinyl caprolactam and vinyl acetate, is designed to solubilize poorly soluble active pharmaceutical ingredients. A straightforward aqueous gel permeation chromatography method that exploits both size exclusion and adsorption modes of separation was used
Andrea Anesi et al.
BMC plant biology, 15, 191-191 (2015-08-08)
The definition of the terroir concept is one of the most debated issues in oenology and viticulture. The dynamic interaction among diverse factors including the environment, the grapevine plant and the imposed viticultural techniques means that the wine produced in
Haiyin Li et al.
Macromolecular bioscience, 14(10), 1361-1367 (2014-06-14)
Phospholipid monomer and aggregation-induced emission (AIE) dye-based dimers are incorporated via reversible addition-fragmentation transfer polymerization to afford cross-linked zwitterionic fluorescent copolymers. Such copolymers are prone to self-assembly into fluorescent polymeric nanoparticles (FPNs) in physiological solution due to their amphiphilic nature.
Yuzhen Xu et al.
International journal of nanomedicine, 10, 4225-4237 (2015-07-15)
The use of vincristine (VCR) to treat cancer has been limited by its dose-dependent toxicity and development of drug resistance after repeated administrations. In this study, we investigated the mechanism by which quinine hydrochloride (QN) acts as a sensitizer for
Li Chu et al.
DNA and cell biology, 34(3), 178-188 (2015-01-22)
The traditional Chinese medicinal formula BDL301 has been used to inhibit inflammation for hundreds of years. The development of colorectal cancer and chronic inflammation are closely related. In this study, we investigated whether BDL301 could inhibit tumor growth. We found
Cristina Díez et al.
Analytica chimica acta, 882, 127-139 (2015-06-05)
In this study, fourteen highly polar aminoglycoside (AGs) antibiotics were selected. Various stationary phases were tested, including Obelisc R, ZIC-HILIC, BEH amide and aminopropyl. The nature of the stationary phase, mobile phase (water or buffer solutions and acetonitrile), pH (percentage
Roman Generalov et al.
Colloids and surfaces. B, Biointerfaces, 129, 79-86 (2015-04-02)
Nanoparticulates responsive to X-rays offer increased efficacy of radiation therapy. However, successful demonstrations of such nanoparticle use are limited so far due to lack of significant radiosensitizing effects or poor nanoparticle stability in a biological system. Zinc oxide (ZnO) is
Lennart Leßmeier et al.
Applied microbiology and biotechnology, 99(23), 10163-10176 (2015-08-16)
Methanol, a one-carbon compound, can be utilized by a variety of bacteria and other organisms as carbon and energy source and is regarded as a promising substrate for biotechnological production. In this study, a strain of non-methylotrophic Corynebacterium glutamicum, which
Anna C C Aguiar et al.
Memorias do Instituto Oswaldo Cruz, 110(7), 906-913 (2015-11-13)
Several species of Aspidosperma plants are used to treat diseases in the tropics, including Aspidosperma ramiflorum, which acts against leishmaniasis, an activity that is experimentally confirmed. The species, known as guatambu-yellow, yellow peroba, coffee-peroba and matiambu, grows in the Atlantic
Ting-Wen Yang et al.
Journal of pharmaceutical and biomedical analysis, 114, 280-287 (2015-06-21)
Single standard to determine multi-components (SSDMC) is a practical pattern for quality evaluation of herbal medicines (HMs). However, it remains challenging because of potential inconsistency of relative response factors (RRF) on different instruments. In this work, the effects of two
Sung Pil Hyun et al.
Environmental science and pollution research international, 22(21), 16463-16474 (2015-08-19)
Cis-1,2,-dichloroethylene (cis-DCE) is a toxic, persistent contaminant occurring mainly as a daughter product of incomplete degradation of perchloroethylene (PCE) and trichloroethylene (TCE). This paper reports on abiotic reductive dechlorination of cis-DCE by mackinawite (FeS1-x), a ferrous monosulfide, under variable geochemical
Francesca Giuffrida et al.
Lipids, 49(10), 997-1004 (2014-09-05)
It has been reported that dietary gangliosides may have an important role in preventing infections and in brain development during early infancy. However, data related to the evolution of their concentration over the different stages of lactation are scarce. Liquid
Sohail Mohammad et al.
Therapie, 70(4), 329-335 (2015-02-14)
A two way, randomized cross-over bioequivalence study was conducted to analyse the rate and extent of absorption of atorvastatin after a single dose of 80 mg atorvastatin as atorvastatin calcium tablets. The study was carried out using healthy male volunteers
Panfeng Yu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 959, 55-61 (2014-04-29)
This paper described a novel application of PEGylated magnetic carbon nanotubes as solid-phase extraction nanosorbents for the determination of puerarin in rat plasma by high performance liquid chromatography (HPLC). A solvothermal method was employed for the synthesis of monodisperse magnetites
Amanda S Mota et al.
Molecules (Basel, Switzerland), 20(5), 7925-7939 (2015-05-06)
Seed oil (Pp-oil) of Plukenetia polyadenia is used by native people of the Brazilian Amazon against arthritis and rheumatism, spreading it on the arms and legs to reduce the pain and inflammation. Pp-oil was obtained by pressing dried seeds at
Lien Taevernier et al.
International journal of pharmaceutics, 491(1-2), 144-151 (2015-06-28)
Fusafungine, a mixture of the cyclic hexadepsipeptides enniatins, is currently on the market for the treatment of upper respiratory tract diseases because of its bacteriostatic and anti-inflammatory effects. In this study, a quality-by-design risk assessment was performed with two objectives:
Colloidal lipid nanodispersion enriched hydrogel of antifungal agent for management of fungal infections: Comparative in-vitro, ex-vivo and in-vivo evaluation for oral and topical application.
Dudhipala, et al.
Chemistry and Physics of Lipids, 233, 104981-104981 (2020)
Esther See et al.
International journal of pharmaceutics, 473(1-2), 528-535 (2014-08-01)
To facilitate the development of a liposomal formulation for cancer therapy, the physicochemical properties of asulacrine (ASL), an anticancer drug candidate, were characterized. Nano-liposomes were prepared by thin-film hydration in conjugation with active drug loading using ammonium sulphate and post-insertion
Isabelle A Kagan et al.
Natural product communications, 10(7), 1263-1267 (2015-09-29)
Red clover (Trifolium pratense) contains soluble phenolic compounds with roles in inhibiting proteolysis and ammonia production. Alfalfa (Medicago sativa) has been found to have a low phenolic content, but few alfalfa and red clover cultivars have been compared for phenolic
Tue Kruse Rasmussen et al.
Arthritis research & therapy, 17, 154-154 (2015-06-10)
Interleukin (IL)-21 is a key cytokine in autoimmune diseases such as systemic lupus erythematosus (SLE) by its regulation of autoantibody production and inflammatory responses. The objective of this study is to investigate the signaling capacity of IL-21 in T and
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