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Showing 1-30 of 230 results for "67-48-1" within Papers
Shinji Yamamoto et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 10(8), 2846-2850 (2004-04-23)
Akt is a serine/threonine kinase that plays a central role in tumorigenesis. Among the members of Akt family, Akt2 is associated with the development of human cancers. The present study was designed to clarify the prognostic significance of Akt2 and
Qingxian Cai et al.
PloS one, 10(10), e0140853-e0140853 (2015-10-29)
The optimal treatment of hepatitis C virus (HCV) genotype 6 is unclear owing to its limited geographic distribution. Because of a high predictive value of rapid virological response (RVR) for sustained virological response (SVR), we conducted an open-label randomized controlled
Rile Li et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 10(12 Pt 1), 4118-4124 (2004-06-26)
Proliferative activity defined by Ki-67 staining index (SI) has been correlated with progression and prognosis in a number of malignant tumors including prostate cancer. However, few studies have examined Ki-67 SI in pretreatment diagnostic material from patients treated with definitive
L Mastronardi et al.
BMC cancer, 1, 12-12 (2001-09-26)
The Ki-67 is a nuclear antigen detected by the monoclonal antibody MIB-1 and its Labeling Index (LI) is considered a marker of normal and abnormal cell proliferation. Pituitary adenomas are generally well differentiated neoplasms, even if in about one third
E Dong et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(11), 4676-4681 (2007-03-16)
Reelin and glutamic acid decarboxylase 67 (GAD(67)) expression down-regulation in GABAergic interneurons of mice exposed to protracted treatment with l-methionine (MET) is attributed to RELN and GAD(67) promoter cytosine-5-hypermethylation. This process recruits various transcription repressor proteins [methyl-CpG binding protein (MeCP2)
E Dong et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(11), 4676-4681 (2007-03-16)
Reelin and glutamic acid decarboxylase 67 (GAD(67)) expression down-regulation in GABAergic interneurons of mice exposed to protracted treatment with l-methionine (MET) is attributed to RELN and GAD(67) promoter cytosine-5-hypermethylation. This process recruits various transcription repressor proteins [methyl-CpG binding protein (MeCP2)
Wenni Tong et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(8), R613-R620 (2013-02-22)
Maternal hypoxia inhibits cardiomyocyte proliferation in the heart of fetal and neonatal rats. The present study tested the hypothesis that hypoxia has a direct effect inhibiting cardiomyocyte proliferation via upregulating tissue inhibitors of metalloproteinases (TIMP) in fetal rat hearts. Isolated
K K Ray et al.
Journal of thrombosis and haemostasis : JTH, 3(2), 287-291 (2005-01-27)
Our aim was to determine a pharmacogenomic approach to heparin use in non-ST elevation acute coronary syndromes, specifically the impact of interleukin (IL)-1 receptor antagonist polymorphisms upon von Willebrand factor (vWF) responses to unfractionated heparin (UFH) and low molecular weight
Histological expression of angiogenic factors: VEGF, PDGFRalpha, and HIF-1alpha in Hodgkin lymphoma.
Freda H Passam et al.
Pathology, research and practice, 205(1), 11-20 (2008-10-28)
Angiogenesis is a prerequisite for solid tumor growth, but there is relatively limited data regarding Hodgkin lymphoma. The purpose of this study was to examine the immunohistochemical expression of angiogenic and proliferation markers in Hodgkin biopsies in relation to clinical
Raed Salim et al.
Obstetrics and gynecology, 120(6), 1323-1331 (2012-11-22)
To compare the tocolytic efficacy and tolerability of nifedipine with that of atosiban among pregnant women with preterm labor. Pregnant women admitted with preterm labor and intact membranes between 24 and 33 weeks 6 days of gestation, between January 2008
T A Judge et al.
International immunology, 7(2), 171-178 (1995-02-01)
T cell activation involves the delivery of two independent signals to the naive T cell. The first signal occurs with engagement of the TCR. One of the best characterized second signals is ligation of CD28 on the surface of T
C Popa et al.
Journal of analytical toxicology, 22(2), 142-147 (1998-04-21)
In drugs-of-abuse testing, opiates constitute a delicate and controversial task because morphine may occur in urine for several reasons. Ethylmorphine (EtM), which is used as an antitussive drug in many countries, is metabolically converted to morphine. The present study was
Manoj Mathew et al.
Cardiovascular diabetology, 9, 9-9 (2010-02-18)
CVD in obesity and T2DM are associated with endothelial activation, elevated plasma vascular inflammation markers and a prothrombotic state. We examined the contribution of FFA to these abnormalities following a 48-hour physiological increase in plasma FFA to levels of obesity
T K Kim et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 122(4), 240-245 (2014-03-14)
3,5,3'-Triiodothyronine (T3) has a stimulatory effect on cellular growth via thyroid hormone receptors (TRs) in several cell lines. TR expression in the pancreas suggests that pancreatic beta cell proliferation might be induced by T3. The purpose of this study was
Keigo Murakami et al.
Human pathology, 45(3), 589-597 (2014-01-22)
Vasohibin 1, an endothelium-derived negative feedback regulator of angiogenesis, is induced by fibroblast growth factor 2 (FGF-2) and vascular endothelial growth factor A (VEGF-A). In this study, we retrospectively evaluated immunoreactivity of FGF-2 and VEGF-A as well as microvessel density
D E Richards et al.
Archives of toxicology, 67(8), 531-537 (1993-01-01)
The metabolism of the reproductive and developmental toxicant bis(2-methoxyethyl)ether (diglyme) was studied in isolated rat hepatocytes and in the intact rat. Male Sprague-Dawley rats (190-220 g) were used in both studies. Hepatocytes, isolated by a two-step in situ collagenase perfusion
Rogelio Barreto et al.
Hepatology (Baltimore, Md.), 59(4), 1505-1513 (2013-09-17)
Type-1 hepatorenal syndrome (HRS) is a common complication of bacterial infections in cirrhosis, but its natural history remains undefined. To assess the outcome of kidney function and survival of patients with type-1 HRS associated with infections, 70 patients diagnosed during
Yohei Yukizawa et al.
Acta orthopaedica, 83(1), 14-21 (2012-01-18)
Markers of coagulation and fibrinolysis, such as soluble fibrin (SF), D-dimer, and plasminogen activator inhibitor 1 (PAI-1), have been developed in order to determine thrombotic tendency. We investigated whether these markers could be used to diagnose venous thromboembolism (VTE) in
M E Hershberger et al.
Developmental biology, 199(1), 80-92 (1998-07-24)
During gestation, transport by placental trophoblasts is solely responsible for nutrient supply to the developing fetus. The calcium (Ca) transport machinery of the placenta thus represents the primary tissue site for regulating fetal Ca homeostasis. The exact mechanism of trophoblast
F W Bär et al.
European heart journal, 14(8), 1118-1126 (1993-08-01)
Taprostene is a prostacyclin analogue that inhibits platelet aggregation and thus might be a useful adjuvant to thrombolytic agents in acute myocardial infarction. In a placebo-controlled dose rising study, taprostene or placebo was intravenously infused in 80 patients treated with
Amy C Degnim et al.
Annals of surgery, 258(2), 240-247 (2013-03-23)
To determine whether bacterial colonization of drains can be reduced by local antiseptic interventions. Drains are a potential source of bacterial entry into surgical wounds and may contribute to surgical site infection after breast surgery. After institutional review board approval
Xue Zhou et al.
Zhonghua fu chan ke za zhi, 45(5), 353-357 (2010-07-22)
To explore the effect of hydrogen peroxide (H2O2) on the expression of human leukocyte antigen-G (HLA-G) in placental trophoblasts in pregnant women with pre-eclampsia. Forty pregnant women, delivered through cesarean section in the Department of Obstetrics of and Gynecology, the
Andre Wieringa et al.
British journal of haematology, 165(4), 489-496 (2014-04-24)
An observational population-based cohort study was performed to investigate the role of comorbidity on outcome and treatment-related toxicity in patients with newly diagnosed advanced-stage diffuse large B-cell lymphoma (DLBCL) treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone). Data for the
K H Kilburn et al.
Teratology, 26(2), 155-162 (1982-10-01)
N, N1-bis (dichloroacetyl) diamine 1, 8-octomethylenediamine (WIN 18,446) is an experimental drug which was first investigated as a male contraceptive. It is soluble in lipid solvents but not in water. The administration of 1,200 to 1,600 mg/kg to pregnant rats
Valerianna K Amorosa et al.
HIV clinical trials, 14(6), 274-283 (2013-12-18)
We hypothesized that nitazoxanide (NTZ) added to pegylated interferon alfa-2a (PEG-IFN) and weight-based ribavirin (WBR) would improve hepatitis C virus (HCV) virologic responses in HCV treatment-naïve HIV-1/HCV genotype 1 coinfected persons. Prospective, single-arm study in which subjects received 4-week lead-in
Ming Shao et al.
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 32(3), 182-186 (2011-05-04)
To investigate the effect of proteasome inhibitor bortezomib on proliferation, apoptosis of K562 cells and the expression of XIAP. K562 cells were treated with bortezomib at different concentration. Cell proliferation was analyzed by WST-1 assay, cell apoptosis by flow cytometry
Hong-Juan Li et al.
Wei sheng yan jiu = Journal of hygiene research, 34(1), 76-78 (2005-05-03)
To explore the effect of insulin-like growth factor-1 (IGF-1) on female pubertal development and estimate heritability of the serum free IGF-1. The study population consisted of 427 girls aged 6 to 18 years: 132 pairs monozygotic twins, 48 pairs same-sex
Victor Llorenç et al.
Ocular immunology and inflammation, 26(5), 786-792 (2016-12-25)
To investigate bacillus Calmette-Guérin (BCG) infective capability and cytotoxicity in ARPE-19 cells. BCG inoculum was dispensed at a MOI 100:1 for 3 h in 90% confluent ARPE-19 cells. Infection rates at different time points were determined by colony forming units
Didem Cosan et al.
Genetic testing and molecular biomarkers, 13(4), 543-546 (2009-07-17)
This study has been performed on asthmatic patients in the Turkish population to determine the frequency of 4G/5G polymorphism genotypes of plasminogen activator inhibitor type-1 gene, and with the aim of examining the role of this polymorphism in asthma development.
Kyoichi Kaira et al.
Annals of surgical oncology, 16(12), 3473-3481 (2009-09-25)
The purpose of this study was to evaluate the prognostic value of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in resectable non-small-cell lung cancer (NSCLC) patients with N1 and N2 nodal involvement. A total of
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