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673439

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Xing Zhou et al.
Journal of pharmacological sciences, 125(1), 51-58 (2014-05-23)
In the present study, we investigated the protective effect of methyl 3,4-dihydroxybenzoate (MDHB) against H2O2-induced apoptosis in RGC-5 cells. The RGC-5 cells were cultured in plates for 24 h, which were then pretreated with dimethyl sulfoxide, different concentrations of MDHB
Roxane Darbousset et al.
Blood, 124(16), 2575-2585 (2014-08-26)
Adenosine triphosphate (ATP) and its metabolite, adenosine, are key regulators of polymorphonuclear neutrophil (PMN) functions. PMNs have recently been implicated in the initiation of thrombosis. We investigated the role of ATP and adenosine in PMN activation and recruitment at the
Tatiana Shioji Tiuman et al.
BMC microbiology, 14, 152-152 (2014-06-11)
Leishmania amazonensis infection results in diverse clinical manifestations: cutaneous, mucocutaneous or visceral leishmaniasis. The arsenal of drugs available for treating Leishmania infections is limited. Therefore, new, effective, and less toxic leishmaniasis treatments are still needed. We verified cell death in
P C J Schmeits et al.
Archives of toxicology, 89(12), 2325-2337 (2014-09-17)
Transcriptomics in combination with in vitro cell systems is a powerful approach to unravel modes of action of toxicants. An important question is to which extent the modes of action as revealed by transcriptomics depend on cell type, species and
Haiyuan Zhang et al.
PloS one, 9(5), e96418-e96418 (2014-05-09)
Gambogic acid (GA), the main active component of gamboge resin, has potent antitumor activity both in vivo and in vitro. However, the underlying molecular mechanisms remain unclear. In this study, we found that GA could initiate autophagy in colorectal cancer
Leanna Cheung et al.
Biochemical pharmacology, 93(3), 380-388 (2014-12-03)
Multidrug resistance protein 4 (MRP4) effluxes a wide variety of drugs and endogenous signaling molecules from cells and has been proposed as an attractive therapeutic target in several solid tumors, including neuroblastoma and colorectal cancer. MRP4 also regulates the pharmacokinetics
Pengfei Liu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(2), 740-754 (2015-01-24)
This study investigated the clinical relevance and biological function of paired box gene 2 (PAX2) in esophageal squamous cell carcinoma (ESCC). Results showed that PAX2 expression was significantly increased in tumor tissues and that its expression correlated with the ESCC
Severiano Risco et al.
Pharmacology, biochemistry, and behavior, 126, 7-12 (2014-09-17)
Previous studies demonstrated that the intracerebroventricular administration of SB-334867-A, a selective antagonist of orexin OX1R receptors, blocks the acquisition of saccharin-induced conditioned flavor preference (CFP) but not LiCl-induced taste aversion learning (TAL). Orexinergic fibers from the lateral hypothalamus end in
Chun-Yan Wu et al.
Phytochemistry, 106, 171-177 (2014-08-02)
Forty-six abietane type diterpenoids possessing nine different fused ring systems were characterized from the roots of Salvia yunnanensis, six of which (salyunnanins A-F, 1-6) had different nor-abietane, homo-abietane, seco-abietane, and normal abietane architectures. Their structures were elucidated by comprehensive NMR
Shogo Endo et al.
Ultrasound in medicine & biology, 41(9), 2458-2465 (2015-06-15)
Because it is highly infiltrative, malignant glioma is a cancer with a poor prognosis despite multidisciplinary treatment strategies, such as aggressive surgery and chemoradiotherapy, necessitating new therapeutic approaches to control migration of tumor cells. In our study, we investigated the
Yi-Chun Liao et al.
Archives of toxicology, 89(11), 1971-1979 (2014-09-10)
Inorganic arsenite (iAs) is a human carcinogen. Numerous studies have shown that mutation-activated H-Ras is frequently observed in human urothelial carcinomas. The interaction between iAs, an environmental factor, and H-Ras, an oncogene, is not clear. In this study, we explored
Subburayan Karthikeyan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 274-282 (2015-03-18)
Previously, we reported that the prepared resveratrol (RSV) loaded gelatin nanoparticles (GNPs) possessed enhanced anticancer effect than free RSV in non-small cell lung carcinoma cells and Swiss albino mice. The present study aims to explore the relevant mechanism of cell
Yi-Fei Chen et al.
International journal of molecular medicine, 34(6), 1591-1598 (2014-10-17)
The difficulties faced in the effective treatment of ovarian cancer are multifactorial, but are mainly associated with relapse and drug resistance. Cancer stem-like cells have been reported to be an important contributor to these hindering factors. In this study, we
Hiromi Yamamoto et al.
Life sciences, 126, 37-41 (2015-02-25)
To assess the acute effects of intravenous azelnidipine, a third-generation L-type calcium channel blocker, on sympathetic outflow from the central nervous system and to compare the effects of intravenous azelnidipine with those of intravenous nifedipine. In anesthetized Wistar Kyoto rats
Zhixiong Long et al.
International journal of molecular medicine, 34(5), 1388-1394 (2014-09-19)
Nasopharyngeal carcinoma (NPC) is a relatively radiosensitive disease. However, the therapeutic effects of radiotherapy are not always satisfactory due to radioresistance. The hypofractionated schema is currently widely used in clinical practice. In the present study, we investigated the effects of
Melissa Rosso et al.
Oncotarget, 6(33), 34573-34591 (2015-09-30)
A single nucleotide polymorphism (T to G) in the mdm2 P2 promoter, mdm2 SNP309, leads to MDM2 overexpression promoting chemotherapy resistant cancers. Two mdm2 G/G SNP309 cancer cell lines, MANCA and A875, have compromised wild-type p53 that co-localizes with MDM2
Fengge Shen et al.
Applied microbiology and biotechnology, 99(1), 359-373 (2014-09-27)
Staphylococcus aureus is one of the most important pathogens in humans and animals. The formation of biofilm by S. aureus is considered an important mechanism of antimicrobial resistance. Therefore, finding effective drugs against the biofilm produced by S. aureus has
Nilufer Cinkilic et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 770, 72-79 (2014-10-26)
The present study was designed to determine the protective activity of cinnamic acid against induction by X-rays of genomic instability in normal human blood lymphocytes. This radio-protective activity was assessed by use of the cytokinesis-block micronucleus test and the alkaline
Hongsheng Li et al.
Oncology reports, 33(3), 1307-1313 (2015-01-13)
Hepatocellular carcinoma (HCC) is a common malignant carcinoma worldwide and the third leading cause of cancer mortality. However, current treatment strategies are not potent enough to combat this disease. Therefore, identification of novel and more effective treatments is crucial. Of
Li Wang et al.
Biochimica et biophysica acta, 1838(12), 3162-3170 (2014-09-15)
The organic solvent dimethylsulphoxide (DMSO) and 1,1,1,3,3,3-hexafluoro-2-isopropanol (HFIP) have been widely used as a pre-treating agent of amyloid peptides and as a vehicle for water-insoluble inhibitors. These solvents are left in many cases as a trace quantity in bulk and
Joëlle Nader et al.
Neuropharmacology, 87, 214-221 (2014-04-09)
Methamphetamine toxicity is associated with cell death and loss of dopamine neuron terminals in the striatum similar to what is found in some neurodegenerative diseases. Conversely, the endocannabinoid system (ECS) has been suggested to be neuroprotective in the brain, and
Rafael M Bitencourt et al.
Neurochemistry international, 90, 72-84 (2015-07-22)
Corticosteroid and endocannabinoid actions converge on prefrontocortical circuits associated with neuropsychiatric illnesses. Corticosteroids can also modulate forebrain synapses by using endocannabinoid effector systems. Here, we determined whether corticosteroids can modulate transmitter release directly in the frontal cortex and, in doing
Bin Fang et al.
Biochemical and biophysical research communications, 448(4), 443-447 (2014-05-07)
Cisplatin-induced ototoxicity affects a high percentage of new cancer patients worldwide. The detailed mechanism of cisplatin-induced ototoxicity is not completely understood. We investigated whether rapamycin could protect rats from cisplatin-induced ototoxicity. Forty-eight male Wistar rats were randomly divided into six
Chubiao Zhao et al.
Cellular signalling, 26(10), 2223-2233 (2014-07-16)
Our recent studies have demonstrated the key roles of reactive oxygen species (ROS)-mediated caspase-8- and Bax-dependent apoptotic pathways in dihydroartemisinin (DHA)-induced apoptosis of A549 cells. This report is designed to investigate the proapoptotic mechanisms of DHA in gemcitabine (Gem)-resistant A549
Andrew J Washkowitz et al.
Development (Cambridge, England), 142(1), 31-40 (2014-12-18)
The maintenance and control of pluripotency is of great interest in stem cell biology. The dual specificity T-box/basic-helix-loop-helix-zipper transcription factor Mga is expressed in the pluripotent cells of the inner cell mass (ICM) and epiblast of the peri-implantation mouse embryo
Nicholas J Lodge et al.
Nuclear medicine and biology, 41(6), 524-535 (2014-05-06)
A radioligand for measuring the density of corticotropin-releasing factor subtype-1 receptors (CRF1 receptors) in living animal and human brain with positron emission tomography (PET) would be a useful tool for neuropsychiatric investigations and the development of drugs intended to interact
Andressa Ardiani et al.
Oncotarget, 5(19), 9335-9348 (2014-10-27)
Despite recent advances in diagnosis and management, prostrate cancer remains the second most common cause of death from cancer in American men, after lung cancer. Failure of chemotherapies and hormone-deprivation therapies is the major cause of death in patients with
Qiang Yu et al.
Journal of medicinal food, 17(9), 1036-1042 (2014-07-22)
Polyphyllin D (PD), an active component from a traditional medicinal herb Paris polyphylla, which has long been used for the treatment of cancer in Asian countries, has been found to hold significant antitumor activity in vivo or in vitro. However
Yasuo Ido et al.
PloS one, 10(2), e0115341-e0115341 (2015-02-04)
The aging process is perceived as resulting from a combination of intrinsic factors such as changes in intracellular signaling and extrinsic factors, most notably environmental stressors. In skin, the relationship between intrinsic changes and keratinocyte function is not clearly understood.
Hyun-Woo Kim et al.
Oncology reports, 35(1), 235-242 (2015-11-05)
The histone deacetylases (HDACs), Sirtuin 1 (Sirt1) and Sirt2, play crucial roles in many biological processes, including cell proliferation, differentiation and apoptosis. HDAC inhibitors have been considered as a potential therapeutic approach for various types of cancers. Here, we demonstrated
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