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Yonghua Taylor Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 65-71 (2014-07-08)
Deamidation is one of the most common degradation pathways for proteins and frequently occurs at "hot spots" with Asn-Gly, Asn-Ser or Asn-Thr sequences. Occasionally, deamidation may occur at other motifs if the local protein structure can participate or assist in
Mohammad Taher Tahoori et al.
International immunopharmacology, 24(2), 474-480 (2014-12-03)
Plasmacytoid dendritic cell (pDC), plays central role in antiviral immunity. The aim of this study was to assess the effect of Flt3 ligand (FL) alone or with L929 fibroblast feeder or L929 conditioned media on differentiation of mouse bone marrow
W G Brydon et al.
European journal of gastroenterology & hepatology, 8(2), 117-123 (1996-02-01)
To assess the reliability of serum 7 alpha-hydroxy-4-cholesten-3-one (7 alpha-3ox-C) in the differential diagnosis of bile acid induced diarrhoea by comparison with 75selenohomocholyltaurine whole body retention (SeHCAT WBR). One hundred and sixty-four patients with chronic diarrhoea were investigated prospectively in
Kun Yao et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(8), 8023-8031 (2014-05-20)
RLIP76 is known to play a role in cell growth, division, apoptosis, and chemosensitivity in various malignant cancer cells. However, few studies have been done on the role of RLIP76 in leukemia. In this study, human leukemia cell line U937
Abdulrhman A Al-Majed et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 989, 104-111 (2015-03-31)
A highly selective, sensitive, and rapid microemulsion liquid chromatography (MELC) method was developed and validated for the simultaneous determination of a novel type of dopamine receptor antagonist LE300 and its N-methyl metabolite in mouse sera. LE300, its N-methyl metabolite, and
Lili Wu et al.
Acta biomaterialia, 27, 294-304 (2015-09-01)
Coculture of osteoblasts and osteoclasts is a subject of interest in the understanding of how magnesium (Mg)-based implants influence the bone metabolism and remodeling upon degradation. Human telomerase reverse transcriptase (hTERT) transduced mesenchymal stem cells (SCP-1) were first differentiated into
Xiao-Bing Cui et al.
The Journal of endocrinology, 224(2), 127-137 (2014-11-12)
Obesity is an important independent risk factor for type 2 diabetes, cardiovascular diseases and many other chronic diseases. Adipose tissue inflammation is a critical link between obesity and insulin resistance and type 2 diabetes and a contributor to disease susceptibility
Nataša Djordjević Filijović et al.
Drug development and industrial pharmacy, 41(3), 502-514 (2014-03-13)
Stress stability testing represents an important part of the drug development process. It is used as an important tool for the identification of degradation products and degradation pathways, as well as for the assessment of changes in physical form of
Yaarit Simchon-Tenenbaum et al.
Behavioural brain research, 282, 125-132 (2015-01-13)
Attention deficit hyperactivity disorder (ADHD) overdiagnosis and a pharmacological attempt to increase cognitive performance, are the major causes for the frequent (ab)use of psychostimulants in non-ADHD individuals. Methylphenidate is a non-addictive psychostimulant, although its mode of action resembles that of
Maria Schindler et al.
Endocrinology, 155(4), 1498-1509 (2014-01-17)
According to the "developmental origin of health and disease" hypothesis, the metabolic set points of glucose and lipid metabolism are determined prenatally. In the case of a diabetic pregnancy, the embryo is exposed to higher glucose and lipid concentrations as
Jiří Danihlík et al.
Journal of chromatography. A, 1374, 134-144 (2014-12-02)
Apidaecins represent an important group of antimicrobial peptides occurring in honey bee hemolymph, where they play an important role as key components of humoral immunity. The present study demonstrates the development of a highly sensitive assay for apidaecin 1 isoforms
Marjan Gharagozloo et al.
Journal of neuroinflammation, 12, 198-198 (2015-11-02)
Multiple sclerosis (MS) is an organ-specific autoimmune disease resulting in demyelinating plaques throughout the central nervous system. In MS, the exact role of microglia remains unknown. On one hand, they can present antigens, skew T cell responses, and upregulate the
A W Jones et al.
Forensic science international, 37(4), 277-285 (1988-06-01)
Headspace gas chromatography was used to determine the concentration of ethanol and methanol in blood samples from 519 individuals suspected of drinking and driving in Sweden where the legal alcohol limit is 0.50 mg/g in whole blood (11 mmol/l). The
László Pál et al.
Immunopharmacology and immunotoxicology, 37(2), 193-201 (2015-02-19)
A large volume of alcoholic beverages containing aliphatic alcohols is consumed worldwide. Previous studies have confirmed the presence of ethanol-induced immunosuppression in heavy drinkers, thereby increasing susceptibility to infectious diseases. However, the aliphatic alcohols contained in alcoholic beverages might also
H A Ramirez Ramirez et al.
Journal of dairy science, 98(3), 1903-1914 (2014-12-31)
Two experiments were conducted to evaluate the additive effects of starch and fat as risk factors associated with milk fat depression in dairy diets containing corn dried distillers grains with solubles. In experiment 1, 4 multiparous ruminally cannulated Holstein cows
Thomas O Krag et al.
Journal of neuropathology and experimental neurology, 74(12), 1137-1146 (2015-11-18)
Limb-girdle muscular dystrophy type 2I (LGMD2I) is caused by mutations in the Fukutin-related protein (FKRP) gene, leading to inadequate glycosylation of α-dystroglycan, an important protein linking the extracellular matrix to the cytoskeleton. We created a mouse model of the common
Urs Duthaler et al.
Journal of pharmaceutical and biomedical analysis, 105, 163-173 (2015-01-02)
Tribendimidine has emerged as potential alternative to praziquantel in the treatment of Opisthorchis viverrini infections. To support its clinical development program, a quantitative high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay was developed for tribendimidine's degradation product deacylated amidantel (dADT)
Eun Young Kim et al.
PloS one, 9(5), e97747-e97747 (2014-05-23)
Adipose tissue, mainly composed of adipocytes, plays an important role in metabolism by regulating energy homeostasis. Obesity is primarily caused by an abundance of adipose tissue. Therefore, specific targeting of adipose tissue is critical during the treatment of obesity, and
Bridget K Mutuma et al.
Journal of colloid and interface science, 442, 1-7 (2014-12-17)
TiO2 photocatalysts with a mixture of different TiO2 crystal polymorphs have customarily been synthesized hydrothermally at high temperatures using complicated and expensive equipment. In this study TiO2 nanoparticles with a mixture of TiO2 crystals were synthesized using a modified sol-gel
George S Weeden et al.
Journal of chromatography. A, 1422, 99-116 (2015-10-21)
Over 500,000t of flame retardants in electronic wastes are consigned to landfills each year. A room-temperature, size-exclusion simulated moving bed (SEC-SMB) was developed to recover high purity (>99%) flame retardants with high yield (>99%). The SSWD method for ternary mixtures
Anne-Charlotte Dubbelman et al.
Investigational new drugs, 33(1), 233-240 (2014-11-08)
Lenvatinib is an orally available multi-targeted tyrosine kinase inhibitor with anti-angiogenic and antitumor activity. To get more insight into the disposition of lenvatinib, a mass balance study was performed in patients with advanced solid tumors. A single oral 24 mg
R Zena et al.
Ecotoxicology and environmental safety, 122, 116-125 (2015-08-02)
Polycyclic aromatic hydrocarbons (PAHs) can accumulate in the food chain, due to their lipophilic properties. Fish can accumulate contaminants including PAHs and frequent consumption of such contaminated fish can pose risk to human health. The aim of this study was
K P Goetz et al.
Nature communications, 5, 5642-5642 (2014-12-04)
The crystalline structure of organic materials dictates their physical properties, but while significant research effort is geared towards understanding structure-property relationships in such materials, the details remain unclear. Many organic crystals exhibit transitions in their electrical properties as a function
David R Barnidge et al.
Journal of proteome research, 13(11), 5198-5205 (2014-08-20)
We previously described a microLC-ESI-Q-TOF MS method for identifying monoclonal immunoglobulins in serum and then tracking them over time using their accurate molecular mass. Here we demonstrate how the same methodology can be used to identify and characterize polyclonal immunoglobulins
Georg Reiter et al.
Toxicology letters, 232(2), 438-448 (2014-12-03)
In vitro inhibition data of cholinesterases (ChEs) and reactivation with HI 6 are presented for separated VX and VR enantiomers with high purity (enantiomer excess >99.999%). Inhibition rate constants for (-)-VR were fourfold higher than for (-)-VX. Marked higher stereoselectivity
Karolien Gellynck et al.
Experimental biology and medicine (Maywood, N.J.), 240(4), 446-457 (2014-10-12)
Continuous glucose monitoring (CGM) is crucial in diabetic care. Long-term CGM systems however require an accurate sensor as well as a suitable measuring environment. Since large intravenous sensors are not feasible, measuring inside the interstitial fluid is considered the best
Zhen Chen et al.
PloS one, 10(1), e0116553-e0116553 (2015-01-15)
Currently, it is still a tough task for dentists to remineralize dentine in deep caries. The aim of this study was to remineralize demineralized dentine in a tooth model of deep caries using nanocomplexes of carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP)
Veronika Ruzsanyi et al.
Journal of breath research, 8(4), 046005-046005 (2014-11-02)
Breath tests allow a non-invasive and fast diagnostic of different specific enzymes' phenotypic functionality. Over the last decade several 13C-breath tests were successfully tested, with the (13)C-urea breath test being approved by the US Food and Drug Administration (FDA) and
Marcos Tascon et al.
Analytica chimica acta, 863, 78-85 (2015-03-04)
A novel high performance system to control the temperature of the microcartridge in on-line solid phase extraction capillary electrophoresis (SPE-CE) is introduced. The mini-device consists in a thermostatic bath that fits inside of the cassette of any commercial CE instrument
John P Sundberg et al.
PloS one, 9(12), e113582-e113582 (2014-12-05)
Papillomaviruses (PVs) induce papillomas, premalignant lesions, and carcinomas in a wide variety of species. PVs are classified first based on their host and tissue tropism and then their genomic diversities. A laboratory mouse papillomavirus, MmuPV1 (formerly MusPV), was horizontally transmitted
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