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Ying Tong et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 173-178 (2015-01-01)
To study the systemic exposure of tazarotene formulation after topical administration, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of tazarotene and tazarotenic acid in minipig plasma. Similar extraction recoveries for both analytes
John E Immoos
Journal of labelled compounds & radiopharmaceuticals, 58(11-12), 419-424 (2015-08-27)
A novel method for the preparation of isoeugenol, [ring-(U)-(14)C] is presented. Phenols and phenyl esters substituted in the para position with 1-hydroxyethyl or 1-hydroxypropyl acetate esters when treated with 1,8-diazabicyclo[5.4.0]undec-7-ene in dimethylformamide (DMF) eliminate the alkyl carboxylate function to give
Jennifer H Ahn-Jarvis et al.
Cancer prevention research (Philadelphia, Pa.), 8(11), 1045-1054 (2015-08-16)
Epidemiologic associations suggest that populations consuming substantial amounts of dietary soy exhibit a lower risk of prostate cancer. A 20-week randomized, phase II, crossover trial was conducted in 32 men with asymptomatic prostate cancer. The crossover involved 8 weeks each
Shivaram Selvam et al.
Colloids and surfaces. B, Biointerfaces, 126, 35-43 (2014-12-30)
Injectable in situ crosslinking hydrogels offer unique advantages over conventional prefabricated hydrogel methodologies. Herein, we synthesize poly(xylitol-co-maleate-co-PEG) (pXMP) macromers and evaluate their performance as injectable cell carriers for tissue engineering applications. The designed pXMP elastomers were non-toxic and water-soluble with
Verena M Ahrens et al.
ChemMedChem, 10(1), 164-172 (2014-10-24)
Peptidic ligands selectively targeting distinct G protein-coupled receptors that are highly expressed in tumor tissue represent a promising approach in drug delivery. Receptor-preferring analogues of neuropeptide Y (NPY) bind and activate the human Y1 receptor subtype (hY1 receptor), which is
Lucia Grumetto et al.
Environmental monitoring and assessment, 187(3), 88-88 (2015-02-11)
The "Triangle of Death" is an area of southern Italy highly polluted due to the presence of numerous illegal waste sites. To assess whether environmental contamination could produce an increased intake of harmful chemicals, we determined the serum levels of
Tiziana Rubino et al.
Neurobiology of disease, 73, 60-69 (2014-10-05)
Current concepts suggest that exposure to THC during adolescence may act as a risk factor for the development of psychiatric disorders later in life. However, the molecular underpinnings of this vulnerability are still poorly understood. To analyze this, we investigated
Yoshimasa Taniguchi et al.
Journal of agricultural and food chemistry, 63(46), 10181-10191 (2015-10-29)
The bitter taste of beer originates from resins in hops (Humulus lupulus L.), which are classified into two subtypes (soft and hard). Whereas the nature and reactivity of soft-resin-derived compounds, such as α-, β-, and iso-α-acids, are well studied, there
K M Sharif et al.
Biomedical chromatography : BMC, 29(12), 1826-1833 (2015-06-03)
Multivariate analysis of thin-layer chromatography (TLC) images was modeled to predict antioxidant activity of Pereskia bleo leaves and to identify the contributing compounds of the activity. TLC was developed in optimized mobile phase using the 'PRISMA' optimization method and the
Adam J McShane et al.
Journal of the American Society for Mass Spectrometry, 25(10), 1694-1704 (2014-08-06)
Direct reductive methylation of peptides is a common method for quantitative proteomics. It is an active derivatization technique; with participation of the dimethylamino group, the derivatized peptides preferentially release intense a1 ions. The advantageous generation of a1 ions for quantitative
Justin A Bogart et al.
Inorganic chemistry, 54(6), 2830-2837 (2015-02-25)
Understanding of the sensitivity of the reduction potential of cerium(IV) cations to ligand field strength has yet to benefit from systematic variation of the ligand environment. Detailed analyses for a series of seven cerium(IV) tetrakis(pyridyl-nitroxide) compounds and their cerium(III) analogues
Ai-Bao Xia et al.
The Journal of organic chemistry, 78(3), 1254-1259 (2013-01-05)
The organocatalytic Michael reaction of ketones with γ-monohalonitrodienes catalyzed by chiral prolinethiol ether under solvent-free conditions was developed. The described method represents a novel approach for accessing highly functionalized monohaloalkenes with α, β-stereocenters of up to >99% ee.
Claire Chen et al.
Endocrinology, 155(8), 2976-2985 (2014-06-01)
The ability of the central nervous system to synthesize steroid hormones has wide-ranging implications for physiology and pathology. Among the proposed roles of neurosteroids is the regulation of the LH surge. This involvement in the estrogen-positive feedback demonstrates the integration
Jiaji Zhao et al.
Organic letters, 14(20), 5362-5365 (2012-10-03)
An efficient synthesis of 2- or 4-iododibenzofurans through CuI-mediated sequential iodination/cycloetherification of two aromatic C-H bonds in o-arylphenols has been developed. Both the preexisting electron-withdrawing groups (NO(2), CN, and CHO) and the newly introduced iodide are readily modified for a
Franziska Janusch et al.
Environmental toxicology and pharmacology, 38(3), 792-799 (2014-10-13)
The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necessary to determine the
"Charles Thomas Jackson"--compliments of J. B. Woodworth.
Anesthesiology, 121(4), 893-893 (2014-09-24)
Farewell! flammable agents - ether and cyclopropane.
T C K Brown
Paediatric anaesthesia, 23(2), 195-196 (2012-10-16)
Tatsuya Yoshino et al.
Organic letters, 14(16), 4290-4292 (2012-08-09)
A highly efficient total synthesis of the 11-membered cyclic aspercyclides A (1) and B (2) has been achieved by chemo- and regioselective intramolecular oxidative C-O bond formation from differently substituted diphenols.
Alan K Brisdon et al.
Dalton transactions (Cambridge, England : 2003), 44(45), 19717-19731 (2015-07-28)
A series of new perfluoropropenyl-containing phosphines of the type R3-nP(E-CF[double bond, length as m-dash]CFCF3)n (R = Ph, iPr, n = 1, 2; R = tBu, n = 2) have been prepared from the reaction of the hydrofluoroolefin Z-CF3CF[double bond, length
Julia J Griese et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(43), 17189-17194 (2013-10-09)
Although metallocofactors are ubiquitous in enzyme catalysis, how metal binding specificity arises remains poorly understood, especially in the case of metals with similar primary ligand preferences such as manganese and iron. The biochemical selection of manganese over iron presents a
Maria Grazia Sarpietro et al.
International journal of pharmaceutics, 471(1-2), 69-74 (2014-05-23)
In this study we prepared solid lipid nanoparticles (SLN), by the phase inversion temperature (PIT) method, using cetyl palmitate as solid lipid and three different non-ionic emulsifiers of the polyoxyethylene ethers family (ceteth-20, isoceteth-20, oleth-20). These SLN were loaded with
Jiansheng Liu et al.
Biomaterials, 74, 64-76 (2015-10-09)
Despite optimal therapeutic regimen with currently available antiepileptic drugs (AEDs), approximately a third of epilepsy patients remain drug refractory. Region-specific overexpression of multidrug efflux transporters at the blood-brain barrier, such as P-glycoprotein (P-gp), might contribute to multidrug resistance (MDR) by
Chao Zhao et al.
Nature communications, 5, 5079-5079 (2014-10-07)
The remarkable stability of peptide nucleic acids (PNAs) towards enzymatic degradation makes this class of molecules ideal to develop as part of a diagnostic device. Here we report the development of chemically engineered PNAs for the quantitative detection of HIV
Liang Hu et al.
Materials science & engineering. C, Materials for biological applications, 47, 313-324 (2014-12-11)
We used a combination of mesoporous silica nanospheres (MSN) and layer-by-layer (LBL) self-assembly technology to establish a new oral sustained drug delivery system for the poorly water-soluble drug felodipine. Firstly, the model drug was loaded into MSN, and then the
Ana-Maria Rosu et al.
Carbohydrate polymers, 93(1), 184-190 (2013-03-08)
For the development of renewable bioproducts able to solubilize organic persistent pollutant such as benzo[a]pyrene (BaP), modified potato starch was synthesized by alkylation. The addition of alkyl chains was performed with three different alkylation agents: epoxyalkane, alkenyl succinic anhydride and
Natasha Arksey et al.
Bioorganic & medicinal chemistry, 22(15), 3931-3937 (2014-07-16)
The 2-[(18)F]fluoro-3-pent-4-yn-1-yloxypyridine ([(18)F]FPyKYNE) analog of the potent non-peptide angiotensin II type 1 receptor (AT1R) blocker losartan was produced via click chemistry linking [(18)F]FPyKYNE to azide-modified tetrazole-protected losartan followed by TFA deprotection. Preliminary small animal imaging with positron emission tomography (PET)
Fumbling at your soul: from celestial to chemical ether, the hypothesis of anesthesia in Emily Dickinson's poem 315 ("He fumbles at your soul").
Claire Poinsot et al.
Anesthesiology, 117(6), 1381-1384 (2012-10-24)
Chang Yoon Moon et al.
Biomaterials, 41, 53-68 (2014-12-20)
Oncolytic adenoviruses (Ads) have shown great promise in cancer gene therapy but their efficacy has been compromised by potent immunological, biochemical, and specific tumor-targeting limitations. To take full advantage of the innate cancer-specific killing potency of oncolytic Ads but also
Rohit Mishra et al.
Nanotechnology, 25(22), 225501-225501 (2014-05-09)
We investigate here the nanomechanical response of microcantilever sensors in real-time for detecting a range of ultra-low concentrations of oligonucleotides in a complex background of total cellular RNA extracts from cell lines without labeling or amplification. Cantilever sensor arrays were
Nicolas Chevalier et al.
Human reproduction (Oxford, England), 30(2), 447-453 (2014-12-21)
Does a relationship exist between insulin-like peptide 3 (INSL3) and selected environmental endocrine disruptors (EEDs) in human cord blood (cb)? In the whole population (cryptorchid and control boys) cbINSL3 correlated negatively with cb free bisphenol A (BPA) providing indirect evidence
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