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Carolien Grammen et al.
Journal of pharmaceutical sciences, 103(11), 3696-3703 (2014-09-19)
In this study, we investigated the potential of supersaturation for the formulation of the poorly water-soluble microbicide dapivirine (DPV) in an aqueous vaginal gel in order to enhance its vaginal tissue uptake. Different excipients such as hydroxypropylmethylcellulose, polyethylene glycol 1000
Amish Shah et al.
The American journal of emergency medicine, 32(7), 752-755 (2014-05-13)
Gastrointestinal hemorrhage (GIH) is a common complaint seen in the emergency department (ED) and carries a small but significant mortality rate. The principal purpose of this investigation was to determine whether an ED venous lactate as part of initial laboratory
X Lin et al.
Oral diseases, 21(1), e128-e134 (2014-05-09)
To compare the effects of five probiotic lactobacilli strains on the growth and biofilm formation of Streptococcus mutans (MS). Five probiotic lactobacilli bacteria (LB), Lactobacillus casei Shirota, Lactobacillus casei LC01, Lactobacillus plantarum ST-III, Lactobacillus paracasei Lpc-37, and Lactobacillus rhamnosus HN001
Mengying Yao et al.
American journal of physiology. Lung cellular and molecular physiology, 307(11), L829-L837 (2014-08-31)
Lung alveolar epithelial cells are exposed to hypoxia under a variety of physiological and pathological conditions. It has been shown recently that miR-143, which can directly target the key glycolytic enzyme hexokinase II (HK2), may be regulated by miR-155. We
Wen Jen Lin et al.
Expert opinion on drug delivery, 11(10), 1537-1550 (2014-06-21)
The aim of this study was to develop the hexapeptide-conjugated active targeting micelles for delivery of doxorubicin (DOX) and paclitaxel (PTX) to EGFR high-expressed cancer cells. A hexapeptide, which mimicked the EGFR, was applied as a targeting ligand. The active
Zhonghua Wei et al.
FEBS letters, 588(9), 1773-1779 (2014-04-02)
Cancer cell metabolism is often characterized by a shift from an oxidative to a glycolytic bioenergetics pathway, a phenomenon known as the warburg effect. Whether the deregulation of miRNAs contributes to the warburg effect remains largely unknown. Here we show
Min Liang et al.
Nitric oxide : biology and chemistry, 46, 114-122 (2014-12-20)
Hydrogen sulfide (H2S) has been reported to inhibit myocardial hypertrophy in a cell model of cardiomyocyte hypertrophy. Our previous study also shows an H2S-induced increase in glucose metabolism in insulin-targeting cells. The present study aims to examine the hypothesis that
Mar Collado-González et al.
Marine drugs, 18(1) (2020-01-19)
Polyelectrolyte nanocomposites rarely reach a stable state and aggregation often occurs. Here, we report the synthesis of nanocomposites for the oral delivery of insulin composed of alginate, dextran sulfate, poly-(ethylene glycol) 4000, poloxamer 188, chitosan, and bovine serum albumin. The
B Bhattacharya et al.
British journal of pharmacology, 171(13), 3255-3267 (2014-03-07)
The testing of anticancer compounds in vitro is usually performed in hyperglycaemic cell cultures, although many tumours and their in vivo microenvironments are hypoglycaemic. Here, we have assessed, in cultures of tumour cells, the effects of reduced glucose levels on
Jinfang Zhao et al.
Wei sheng wu xue bao = Acta microbiologica Sinica, 53(4), 328-337 (2013-07-19)
In this study, we constructed a recombinant Escherichia coli strain for the production of high-purity L-lactic acid, using a homoethanol fermenting mutant E. coli SZ470 (deltafrdBC deltaldhA deltaackA deltafocA-pflB deltapdhR: :pflBp6-pflBrbs-aceEF-lpd) as the starting strain. By using homologous recombination, we
Dan Bi Lee et al.
The Journal of dermatological treatment, 25(6), 523-528 (2013-12-03)
Although low-fluence 1064-nm Q-switched Nd:YAG laser (QSNYL) is widely used for the treatment of melasma, multiple treatments are necessary for clinical improvement. Superficial chemical peeling using Jessner's solution has been used for treatment of melasma conventionally. To evaluate the additional
Laurence L Miller et al.
Pain, 156(1), 175-184 (2015-01-20)
Pain-related depression of behavior and mood is a key therapeutic target in the treatment of pain. Clinical evidence suggests a role for decreased dopamine (DA) signaling in pain-related depression of behavior and mood. Similarly, in rats, intraperitoneal injection of dilute
K T Shalumon et al.
Journal of biomedical nanotechnology, 9(12), 2117-2122 (2013-11-26)
This work explains the fabrication and potential applicability of high thick three dimensional (3-D) electrospun multiscale fibrous scaffolds in tissue engineering by focusing on the possible fabrication techniques. Multiscale fibrous scaffold of poly(lactic acid) (PLA) was fabricated by combining nano
Case records of the Massachusetts General Hospital. Case 23-2013. A 54-year-old woman with abdominal pain, vomiting, and confusion.
Kamyar Kalantar-Zadeh et al.
The New England journal of medicine, 369(4), 374-382 (2013-07-12)
B H Laster et al.
Journal of cancer research and clinical oncology, 141(1), 23-34 (2014-07-31)
Telomerase activation and an alternative lengthening of telomeres (ALT) mechanism are two telomere-lengthening cancer cell survival mechanisms elicited by both chemo- and/or radiotherapy. Telomere lengthening interferes with cell lethality and results in the immortalization of cancer cells. To counteract these
Jens Wiebe et al.
Journal of the American College of Cardiology, 64(23), 2541-2551 (2014-12-17)
State-of-the-art drug-eluting metal stents are the gold standard for interventional treatment of coronary artery disease. Although they overcome some disadvantages and limitations of plain balloon angioplasty and bare-metal stents, some limitations apply, most notably a chronic local inflammatory reaction due
Franklin García-Godoy et al.
American journal of dentistry, 26(1), 56-60 (2013-06-04)
To evaluate the effects of experimental xylitol dentifrices with and without fluoride on in vitro root caries formation. Root surfaces from caries-free human permanent teeth (n = 10) underwent debridement and a fluoride-free prophylaxis. The tooth roots were sectioned into
Junlong Tian et al.
Scientific reports, 5, 8025-8025 (2015-01-27)
A carbon-matrix nickel composite magnetoplasmonic film with a 3D sub-micron periodic triangular roof-type antireflection structure (SPTAS) was fabricated via a simple and promising method that combines chemosynthesis with biomimetic techniques. The Troides helena (Linnaeus) forewing (T_FW) was chosen as the
Sungyong Mun
Journal of chromatography. A, 1350, 72-82 (2014-06-03)
The performance of a three-zone simulated moving bed (SMB) chromatographic process for separation of succinic acid and lactic acid has been improved to a certain extent in previous researches by applying either a partial-feeding (PF) or a port-location rearrangement (PR)
Xiaomin He et al.
Journal of nanoscience and nanotechnology, 13(6), 3818-3825 (2013-07-19)
Electrospinning has recently received much attention, showing great potential as a novel scaffold fabrication method for cartilage tissue engineering. In this study, we developed a biodegradable hybrid nanofibrous membrane of collagen and poly(L-lactic acid-co-epsilon-caprolactone) (PLCL, 75:25) by electrospinning for cartilage
Nina Bjerre Østergaard et al.
International journal of food microbiology, 188, 15-25 (2014-08-03)
Four mathematical models were developed and validated for simultaneous growth of mesophilic lactic acid bacteria from added cultures and Listeria monocytogenes, during chilled storage of cottage cheese with fresh- or cultured cream dressing. The mathematical models include the effect of
Esther Jiménez et al.
MicrobiologyOpen, 3(6), 937-949 (2014-10-23)
Bile is a biological fluid synthesized in the liver, stored and concentrated in the gall bladder (interdigestive), and released into the duodenum after food intake. The microbial populations of different parts of mammal's gastrointestinal tract (stomach, small and large intestine)
Zhang Bo et al.
Environmental technology, 35(9-12), 1277-1285 (2014-04-08)
This study is aimed at investigating the performance of the two-phase anaerobic digestion of kitchen wastes in a lab-scale setup. The semi-continuous experiment showed that the two-phase anaerobic digestion of kitchen wastes had a bioconversion rate of 83%, biogas yield
Pei Gao et al.
Food chemistry, 331, 127353-127353 (2020-06-25)
Aroma defects limit the application of fish protein hydrolysates as flavourings. This study aimed to develop a flavour concentrate from fermented tilapia fish head hydrolysate bymaximising the Maillard reaction production of meaty and roasted aroma associated compounds. We studied the
Ryosuke Hashide et al.
Journal of nanoscience and nanotechnology, 14(4), 3100-3105 (2014-04-17)
Poly(lactic acid) (PLA) microparticles were coated with layer-by-layer (LbL) films containing insulin and the pH-dependent release of insulin was studied. The LbL films were prepared on the surface of PLA microparticles by the alternate deposition of insulin and poly(allylamine hydrochloride)
Z Paul Lorenc
Aesthetic plastic surgery, 36(5), 1222-1229 (2012-08-29)
With the recognition of the key role of volume loss in the facial aging process, injectable dermal fillers and volumizers have become increasingly important treatment options for recontouring and rejuvenating the aging face. While replacement fillers effectively correct individual lines
Beatriz Ferreira de Carvalho Patricio et al.
Journal of biomedical nanotechnology, 10(7), 1242-1248 (2014-05-09)
Bone metastasis is responsible for up to 99% of bone tumors. As no cure has yet to be discovered, available treatments simply strive to improve quality of life. One of such treatments is the use of EDTMP (ethylenediamine-tetramethylenephosphonic acid) labeled
Rachel M Stenger et al.
Clinical and vaccine immunology : CVI, 21(5), 641-650 (2014-03-07)
Knowledge of naturally processed Bordetella pertussis-specific T cell epitopes may help to increase our understanding of the basis of cell-mediated immune mechanisms to control this reemerging pathogen. Here, we elucidate for the first time the dominant major histocompatibility complex (MHC)
Arianna De Mori et al.
International journal of molecular sciences, 21(7) (2020-04-01)
In this work, we prepared silver nanowires (AgNWs) via the polyol method in the presence or absence of single wall carbon nanotubes (CNTs) and tested their physicochemical, antibacterial and cytotoxic properties. Results showed that the introduction of CNTs lead to
In-Yong Eom et al.
Bioresource technology, 185, 143-149 (2015-03-15)
A simple and cost-effective biochemical conversion process consisting of hydrothermal treatment, enzymatic hydrolysis and fermentation of pretreated whole slurry (PWS) was developed for producing l-lactic acid (L-LA) from oil palm trunk (OPT). When OPT was hydrothermally treated at optimal condition
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