Showing 1-30 of 30 results for "71718"
Elena Zagato et al.
Nature microbiology, 5(3), 511-524 (2020-01-29)
The microbiota has been shown to promote intestinal tumourigenesis, but a possible anti-tumourigenic effect has also been postulated. Here, we demonstrate that changes in the microbiota and mucus composition are concomitant with tumourigenesis. We identified two anti-tumourigenic strains of the...
Rupali Vohra et al.
Molecular neurobiology, 55(12), 9108-9121 (2018-04-13)
Müller cells are pivotal in sustaining retinal ganglion cells, and an intact energy metabolism is essential for upholding Müller cell functions. The present study aimed to investigate the impact of lactate on Müller cell survival and function. Primary mice Müller...
Lucy Liu et al.
Cell metabolism, 26(5), 719-737 (2017-10-03)
Elevated reactive oxygen species (ROS) induce the formation of lipids in neurons that are transferred to glia, where they form lipid droplets (LDs). We show that glial and neuronal monocarboxylate transporters (MCTs), fatty acid transport proteins (FATPs), and apolipoproteins are...
Thomas McNerney et al.
mAbs, 7(2), 413-428 (2015-02-24)
High titer (>10 g/L) monoclonal antibody (mAb) cell culture processes are typically achieved by maintaining high viable cell densities over longer culture durations. A corresponding increase in the solids and sub-micron cellular debris particle levels are also observed. This higher burden...
Petya Berger et al.
BMC genomics, 20(1), 504-504 (2019-06-19)
Enterohemorrhagic Escherichia coli (E. coli) are intestinal pathogenic bacteria that cause life-threatening disease in humans. Their cardinal virulence factor is Shiga toxin (Stx), which is encoded on lambdoid phages integrated in the chromosome. Stx phages can infect and lysogenize susceptible...
Ya-Nan Yin et al.
Neuroscience bulletin, 37(1), 1-14 (2020-08-14)
Every organism inevitably experiences stress. In the face of acute, intense stress, for example, periods of passivity occur when an organism's actions fail to overcome the challenge. The occurrence of inactive behavior may indicate that struggling would most likely be...
Alexandra M Kozlov et al.
Scientific reports, 10(1), 8388-8388 (2020-05-21)
Recent evidence has emerged that cancer cells can use various metabolites as fuel sources. Restricting cultured cancer cells to sole metabolite fuel sources can promote metabolic changes leading to enhanced glycolysis or mitochondrial OXPHOS. However, the effect of metabolite-restriction on non-transformed...
Maarten van der Velden et al.
Malaria journal, 14, 76-76 (2015-04-18)
Membrane-associated ATP binding cassette (ABC) transport proteins hydrolyze ATP in order to translocate a broad spectrum of substrates, from single ions to macromolecules across membranes. In humans, members from this transport family have been linked to drug resistance phenotypes, e.g....
Wanda van der Stel et al.
Archives of toxicology, 94(8), 2707-2729 (2020-07-02)
Evidence is mounting for the central role of mitochondrial dysfunction in several pathologies including metabolic diseases, accelerated ageing, neurodegenerative diseases and in certain xenobiotic-induced organ toxicity. Assessing mitochondrial perturbations is not trivial and the outcomes of such investigations are dependent...
Takeshi Hara et al.
PloS one, 9(11), e111833-e111833 (2014-11-13)
Diacetyl (2,3-butanedione) is a key contributor to unpleasant odors emanating from the axillae, feet, and head regions. To investigate the mechanism of diacetyl generation on human skin, resident skin bacteria were tested for the ability to produce diacetyl via metabolism...
Clinical evaluation of sodium bicarbonate, sodium L-lactate, and sodium acetate for the treatment of acidosis in diarrheic calves.
Kasari TR
Journal of the American Veterinary Medical Association, 187(4), 392-397 (1985)
Jun Wang et al.
Cell stem cell, 25(6), 754-767 (2019-11-26)
Increased understanding of the functions of lactate has suggested a close relationship between lactate homeostasis and normal brain activity because of its importance as an energy source and signaling molecule. Here we show that lactate levels affect adult hippocampal neurogenesis....
Helena Lind et al.
International journal of microbiology, 2010, 430873-430873 (2011-02-19)
Dairy propionibacteria are widely used in starter cultures for Swiss type cheese. These bacteria can ferment glucose, lactic acid, and glycerol into propionic acid, acetic acid, and carbon dioxide. This research examined the antifungal effect of dairy propionibacteria when glycerol...
Sofía Arriarán et al.
PloS one, 10(3), e0119572-e0119572 (2015-03-06)
Female and male adult Wistar rats were fed standard chow or a simplified cafeteria diet for one month. Then, the rats were killed and the white adipose tissue (WAT) in four sites: perigonadal, retroperitoneal, mesenteric and subcutaneous (inguinal) were sampled...
Ru-Juan Zuo et al.
The Journal of biological chemistry, 290(35), 21280-21291 (2015-07-17)
Decidualization is an essential process of maternal endometrial stromal cells to support pregnancy. Although it is known that enhanced glucose influx is critical for decidualization, the underlying mechanism in regulating glucose metabolism in decidua remains insufficiently understood. Here, we demonstrate...
Chen Huang et al.
Oncology reports, 33(2), 875-884 (2014-12-09)
Solid tumors grow faster and need more glucose than normal tissue; however, due to poor angiogenesis and excessive growth, tumors remote from blood vessels are always under glucose starvation. Even so, cancer cells remain alive in vivo. Thus, making cancer...
Agnes R Banreti et al.
Nature communications, 11(1), 2228-2228 (2020-05-08)
Cell competition is an emerging principle that eliminates suboptimal or potentially dangerous cells. For 'unfit' cells to be detected, their competitive status needs to be compared to the collective fitness of cells within a tissue. Here we report that the...
Matteo Gabba et al.
Biophysical journal, 118(2), 422-434 (2019-12-18)
We present a fluorescence-based approach for determination of the permeability of small molecules across the membranes of lipid vesicles and living cells. With properly designed experiments, the method allows us to assess the membrane physical properties both in vitro and in vivo....
Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System.
Li, et al.
Cell Metabolism, 32, 767-785 (2021)
Asifiqbal Kadari et al.
Stem cell reviews, 11(4), 560-569 (2014-11-14)
Various strategies have been published enabling cardiomyocyte differentiation of human induced pluripotent stem (iPS) cells. However the complex nature of signaling pathways involved as well as line-to-line variability compromises the application of a particular protocol to robustly obtain cardiomyocytes from...
Salma H Azam et al.
Oncogene, 38(26), 5191-5210 (2019-03-29)
Angiogenesis is critical to cancer development and metastasis. However, anti-angiogenic agents have only had modest therapeutic success, partly due to an incomplete understanding of tumor endothelial cell (EC) biology. We previously reported that the microRNA (miR)-200 family inhibits metastasis through...
Jian-Hua Mao et al.
Microbiome, 8(1), 53-53 (2020-04-18)
Recent evidence has linked the gut microbiome to host behavior via the gut-brain axis [1-3]; however, the underlying mechanisms remain unexplored. Here, we determined the links between host genetics, the gut microbiome and memory using the genetically defined Collaborative Cross...
Mark Watson et al.
Molecular and cellular biology, 29(21), 5872-5888 (2009-08-26)
GMX1777 is a prodrug of the small molecule GMX1778, currently in phase I clinical trials for the treatment of cancer. We describe findings indicating that GMX1778 is a potent and specific inhibitor of the NAD(+) biosynthesis enzyme nicotinamide phosphoribosyltransferase (NAMPT)....
Michael G Tordoff et al.
Chemical senses, 39(6), 515-528 (2014-05-23)
Genetic ablation of calcium homeostasis modulator 1 (CALHM1), which releases adenosine triphosphate from Type 2 taste cells, severely compromises the behavioral and electrophysiological responses to tastes detected by G protein-coupled receptors, such as sweet and bitter. However, the contribution of...
Wesley L McKeithan et al.
Cell stem cell, 27(5), 813-821 (2020-09-16)
Modeling cardiac disorders with human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes is a new paradigm for preclinical testing of candidate therapeutics. However, disease-relevant physiological assays can be complex, and the use of hiPSC-cardiomyocyte models of congenital disease phenotypes for guiding...
Yuval Gavriel et al.
Journal of Alzheimer's disease : JAD, 78(2), 653-671 (2020-10-06)
Alzheimer's disease (AD), the prevalent dementia in the elderly, involves many related and interdependent pathologies that manifest simultaneously, leading to cognitive impairment and death. Amyloid-β (Aβ) accumulation in the brain triggers the onset of AD, accompanied by neuroinflammatory response and...
Li-Ting Liao et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 72-77 (2014-05-13)
Uric acid measurement has become increasingly important, and electrochemically modified detection method based portable devices hold a dominant position in the market for point of care and self-monitoring of uric acid blood levels. However, there has been a lack of...
Alessio Innocenti et al.
Bioorganic & medicinal chemistry, 17(7), 2654-2657 (2009-03-20)
The inhibition of the beta-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic fungi Cryptococcus neoformans (Can2) and Candida albicans (Nce103) with carboxylates such as the C1-C5 aliphatic carboxylates, oxalate, malonate, maleate, malate, pyruvate, lactate, citrate and some benzoates has been...
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Jennifer R McKenzie et al.
Analytical chemistry, 87(15), 7857-7864 (2015-07-01)
Real-time monitoring of changes to cellular bioenergetics can provide new insights into mechanisms of action for disease and toxicity. This work describes the development of a multianalyte screen-printed electrode for the detection of analytes central to cellular bioenergetics: glucose, lactate...

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