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71950

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Arti Shukla et al.
The American journal of pathology, 175(5), 2197-2206 (2009-10-10)
Little is known about the cellular mechanisms contributing to the development and chemoresistance of malignant mesothelioma (MM), an aggressive asbestos-associated tumor. A human mesothelial cell line (LP9/TERT-1) and isolated human pleural mesothelial cells showed rapid and protracted asbestos-induced cAMP response
Hui Liu et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt B, 483-491 (2014-09-24)
Leydig cells are the primary source of testosterone in the testes, and their steroidogenic function is strictly controlled by the hypothalamus-pituitary-gonad axis. Emerging evidence has indicated that fibroblast growth factors play a role in regulating stem Leydig cell development and
H Luo et al.
Cell death & disease, 4, e481-e481 (2013-02-09)
Mounting evidence shows that selenium possesses chemotherapeutic potential against tumor cells, including leukemia, prostate cancer and colorectal cancer (CRC) cells. However, the detailed mechanism by which sodium selenite specifically kills tumor cells remains unclear. Herein, we demonstrated that supranutritional doses
Justin L Luebke et al.
Metallomics : integrated biometal science, 5(4), 335-342 (2013-02-07)
Staphylococcus aureus CstR (CsoR-like sulfur transferase repressor) is a member of the CsoR family of transition metal sensing metalloregulatory proteins. Unlike CsoR, CstR does not form a stable complex with transition metals but instead reacts with sulfite to form a
J I Eze et al.
Experimental parasitology, 135(2), 331-336 (2013-08-07)
Trypanosomosis has been associated with immunosuppression, anemia and oxidative damage while selenium possesses both immunostimulatory and antioxidative effects. This study was designed to assess the effect of dietary selenium supplementation on parasitemia, anemia, survival pattern and serum protein profiles of
Urška Kristan et al.
Biological trace element research, 151(2), 240-246 (2012-12-18)
The distribution and speciation of selenium (Se) in freshwater fish (muscle and liver tissue) from lakes in Argentina was investigated. Three introduced species, brown trout (Salmo trutta), rainbow trout (Oncorhynchus mykiss) and brook trout (Salvelinus fontinalis), and one native species
Alper Yazici et al.
Cutaneous and ocular toxicology, 33(4), 327-332 (2014-03-20)
The aim of this study is to evaluate the retinal toxicity of cisplatin and neuroprotective effect of selenium in cisplatin-related retinal toxicity. Eighteen adult Wistar-Albino rats were divided into three groups. Group 1 (n = 6) received intraperitoneal (i.p.) injection
E Pulido et al.
Journal of dairy science, 102(4), 3097-3109 (2019-02-18)
The aim of this research was to study the effect of milking frequency [once-daily milking (ODM) vs. twice-daily milking (TDM)] and antioxidant (AOX) supplementation on fatty acid (FA) profile and oxidative stability in sheep milk. Sixteen Assaf ewes were used;
Hitoshi Ueno et al.
Biological & pharmaceutical bulletin, 37(8), 1352-1358 (2014-08-05)
Although supplementation with the selenocompound, sodium selenite has been shown to stimulate the concanavalin A-induced T-cell mitogenic response, the mechanisms responsible remain unclear. This study was conducted to evaluate the relationships between the induction of apoptosis, formation of tumor necrosis
Takeshi Imai et al.
Bioscience, biotechnology, and biochemistry, 78(8), 1376-1380 (2014-08-19)
Selenite is a selenium source for selenoprotein biosynthesis in mammalian cells. Although previous studies have suggested the involvement of glutathione (GSH) and/or thioredoxin reductase in selenite metabolism, intracellular selenite metabolism remains largely unknown. Here, we report that GSH depletion did
Lei Rao et al.
International journal of nanomedicine, 9, 4819-4828 (2014-11-08)
As a potential protein therapeutic for type 2 diabetes mellitus (T2DM), BAY 55-9837 is limited by poor stability and a very short half-life in vivo. The purpose of this study was to construct a novel nanostructured biomaterial by conjugating BAY
Vivek Narayan et al.
The Journal of nutritional biochemistry, 26(2), 138-145 (2014-12-03)
Acetylation of histone and non-histone proteins by histone acetyltransferases plays a pivotal role in the expression of proinflammatory genes. Given the importance of dietary selenium in mitigating inflammation, we hypothesized that selenium supplementation may regulate inflammatory gene expression at the
Jia Liu et al.
Molecular and cellular biochemistry, 398(1-2), 207-215 (2014-09-23)
It is well accepted that β1 integrin plays a key role in maintaining normal podocytes form and functions; however, its mechanism of the potential protective effect remains unclear. Furthermore, the investigation and understanding of the non-lipid-dependent renal protection of Statins
Multifunctional bismuth selenide nanocomposites for antitumor thermo-chemotherapy and imaging.
Li Z, et al.
ACS Nano, 10(1), 984-997 (2015)
Fabiola Rusolo et al.
Molecules (Basel, Switzerland), 18(3), 2549-2562 (2013-02-28)
The need to explore new alternative therapeutic strategies and chemoprevention methods for hepatocellular carcinoma is growing significantly. Selenium is a trace element that plays a critical role in physiological processes, and is used in cancer chemoprevention. The aim of this
Meiling Li et al.
Cellular signalling, 26(7), 1539-1548 (2014-04-08)
Progranulin (PGRN) was reported to be a stress-response factor in response to hypoxia and acidosis. Here we present evidences demonstrating that PGRN is also an endoplasmic reticulum (ER) stress responsive factor: PGRN expression was induced and its activation of Erk1/2
C I O'Connor-Robison et al.
Journal of animal science, 92(10), 4607-4615 (2014-09-04)
Dietary long-chain PFO including arachidonic acid (ARA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) are precursors for several inflammatory mediators. The objective of this study was to characterize the effects of dietary PFO supplementation on bone, cartilage, and synovial fluid
Hongjie Chen et al.
Toxicology letters, 216(2-3), 181-188 (2012-12-01)
Selenite cataract, as an experimental animal model of nuclear cataract to mimic human senile cataract, is produced only when overdose selenite is injected to neonatal rats before eyelid opening. To clarify the cause of age differences on selenite cataract formation
Lei Zeng et al.
Journal of biomedical materials research. Part A, 103(5), 1693-1702 (2014-08-12)
Although chondrocytes exist in native cartilage all over the body, it is still a challenge to use them as therapeutic cells for cartilage tissue engineering (TE) because of their easy dedifferentiation in in vitro culture. An improved culture system to
Barbara Dolińska et al.
Biological trace element research, 150(1-3), 509-512 (2012-10-27)
Together with vitamin C, zinc, selenium, manganese, and magnesium play a vital role in the preservation of organs scheduled for transplantation. In the present study, it is shown that addition of 1 mg/l of these elements influences the stability of 0.3 mM
Prashant S Daundkar et al.
Environmental toxicology and pharmacology, 38(3), 711-719 (2014-10-10)
In the present investigation, ameliorative effect of selenium on carbendazim induced oral sub chronic toxicity in bucks was assessed by studying various indices of antioxidant defense system. Bucks were randomly divided into four groups of four animals each. Group I
Alper Yazici et al.
International journal of ophthalmology, 8(2), 263-268 (2015-05-06)
To investigate the effects of selenium in rat retinal ischemia reperfusion (IR) model and compare pre-treatment and post-treatment use. Selenium pre-treatment group (n=8) was treated with intraperitoneal (i.p.) selenium 0.5 mg/kg for 7d and terminated 24h after the IR injury.
Emil Rudolf et al.
Toxicology letters, 231(1), 29-37 (2014-09-11)
Effects of chronic exposure to supranutritional sodium selenite (Se) were investigated in colonic fibroblasts. Initially, Se did not produce any gross changes in exposed cells; however, basal levels of autophagy were transiently increased and p38 activity was stimulated. From the
DE-Geng Zhang et al.
Oncology letters, 9(1), 47-54 (2014-12-02)
Recently, an increasing number of studies have demonstrated that lung cancer is a stem cell disease. However, ideal cell surface markers for isolating stem cells in lung cancer are yet to be identified. In the present study, a cell population
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Fuiyee Lee et al.
PloS one, 9(7), e103254-e103254 (2014-07-23)
Graft versus host disease (GvHD) is one of the main complications after hematological stem cell transplantation (HSCT). CAMPATH-1H is used in the pre-transplant conditioning regimen to effectively reduce GvHD by targeting CD52 antigens on T cells resulting in their depletion.
Bimetallic nickel cobalt selenides: a new kind of electroactive material for high-power energy storage.
Chen H, et al.
Journal of Material Chemistry A, 3(47), 23653-23659 (2015)
Ying Li et al.
Electromagnetic biology and medicine, 33(4), 264-275 (2013-08-07)
Biological effects of extra-low-frequency (ELF) magnetic fields (MFs) have lacked a credible mechanism of interaction between MFs and living material. To examine the effect of ELF-MFs on cancer cells. Five cancer cell lines were exposed to ELF-MFs within the range
New method for bis (methylmercuric) selenide synthesis from methylmercuric chloride, sodium selenite and reduced glutathione
Naganuma A and Imura N
Chemosphere, 10(4), 441-443 (1981)
Noriaki Hashimoto et al.
BMC cancer, 14, 722-722 (2014-09-28)
Cancer stem cells (CSCs) are thought to play important roles in therapy-resistance. In this study, we induced cancer stem-like cells from hepatocellular carcinoma (HCC) cell lines using a unique medium, and examined their potential for resistance to anti-cancer drugs. The
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