Showing 1-30 of 2439 results for "

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Tarun Singhal et al.
Journal of neuroimaging : official journal of the American Society of Neuroimaging, 27(1), 33-36 (2016-07-29)
Spinal cord atrophy occurs early in the multiple sclerosis (MS) disease course, is closely related to physical disability, and is a putative neuroprotective therapeutic outcome measure. This pilot study explored glatiramer acetate (GA)'s effect on spinal cord volume in patients...
Zhaohua Ding et al.
Magnetic resonance imaging, 34(1), 8-17 (2015-10-20)
Functional magnetic resonance imaging usually detects changes in blood oxygenation level dependent (BOLD) signals from T2*-sensitive acquisitions, and is most effective in detecting activity in brain cortex which is irrigated by rich vasculature to meet high metabolic demands. We recently...
Prateek Katiyar et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 19(3), 391-397 (2016-10-14)
We aimed to precisely estimate intra-tumoral heterogeneity using spatially regularized spectral clustering (SRSC) on multiparametric MRI data and compare the efficacy of SRSC with the previously reported segmentation techniques in MRI studies. Six NMRI nu/nu mice bearing subcutaneous human glioblastoma...
Lisa Warren et al.
Experimental biology and medicine (Maywood, N.J.), 240(5), 576-584 (2014-11-30)
This study was conducted to determine if correlations exist between the numbers of microscopic follicles comprising ovarian follicular reserve (OFR) and antral follicle counts (AFCs), and to assess the usefulness of computerized analyses of ovarian ultrasonograms and magnetic resonance (MR)...
Wenyu Liu et al.
Epilepsy research, 133, 33-40 (2017-04-16)
The purpose of this study was to better delineate the clinical spectrum of periventricular nodular heterotopia (PNH) in a large patient population after long term follow up. Specifically, this study aimed to relate PNH subtypes to clinical or epileptic outcomes...
Jessica De Wit et al.
Amyotrophic lateral sclerosis & frontotemporal degeneration, 21(5-6), 344-354 (2020-05-05)
Objective: To evaluate whether a blended (face-to-face and online) psychosocial support program for caregivers of patients with Amyotrophic Lateral Sclerosis (ALS) and Progressive Muscular Atrophy (PMA), aimed at enhancing feeling of control over caregiving, reduces psychological distress. Methods: A randomized...
Santhosh Jayachandran et al.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 150(6), 979-988 (2016-11-30)
Our objectives were to compare the skeletal, dentoalveolar, and soft tissue effects of the AdvanSync appliance (Ormco, Glendora, Calif) with intermaxillary elastics in the correction of Class II malocclusions in growing patients. A retrospective study was conducted using lateral cephalograms...
Kevin Moulin et al.
Radiology, 295(3), 542-549 (2020-03-26)
Background After acute myocardial infarction (AMI), reperfusion injury is associated with microvascular lesions and myocardial edema. Purpose To evaluate the performance of apparent diffusion coefficient (ADC) quantification compared with T1 and T2 values in the detection of acute myocardial injury....
Kun Chen et al.
Cancer immunology research, 8(1), 81-93 (2019-11-02)
Cancer vaccines can amplify existing antitumor responses or prime naïve T cells to elicit effector T-cell functions in patients through immunization. Antigen-specific CD8+ T cells are crucial for the rejection of established tumors. We constructed XCL1-GPC3 fusion molecules as a...
Yoo Jin Choi et al.
PloS one, 13(1), e0190638-e0190638 (2018-01-04)
Cancer stem-like cells (CSCs) may play a key role in tumor initiation, self-renewal, differentiation, and resistance to current treatments. Dendritic cells (DCs) play a vital role in host immune reactions as well as antigen presentation. In this study, we explored...
N-T Ha et al.
Journal of dairy science, 100(11), 9311-9323 (2017-09-04)
During early lactation, dairy cows experience a severe metabolic load often resulting in the development of various diseases. The inevitable deficiency in nutrients and energy at the onset of lactation requires an optimal adaptation of the hepatic metabolism to overcome...
Maria-Filothei Lazaridou et al.
Journal of clinical medicine, 9(9) (2020-08-23)
The underlying molecular mechanisms of the aberrant expression of components of the HLA class I antigen processing and presentation machinery (APM) in tumors leading to evasion from T cell-mediated immune surveillance could be due to posttranscriptional regulation mediated by microRNAs...
Silke Kreitz et al.
Frontiers in neuroscience, 12, 334-334 (2018-06-08)
Resting state (RS) connectivity has been increasingly studied in healthy and diseased brains in humans and animals. This paper presents a new method to analyze RS data from fMRI that combines multiple seed correlation analysis with graph-theory (MSRA). We characterize...
Xiaodi Zhang et al.
Magnetic resonance imaging, 41, 53-62 (2017-04-24)
Magnetic resonance fingerprinting (MR fingerprinting or MRF) is a newly introduced quantitative magnetic resonance imaging technique, which enables simultaneous multi-parameter mapping in a single acquisition with improved time efficiency. The current MRF reconstruction method is based on dictionary matching, which...
M Trajkovic-Arsic et al.
Scientific reports, 7(1), 17038-17038 (2017-12-08)
Recent advances in molecular subtyping of Pancreatic Ductal Adenocarcinoma (PDAC) support individualization of therapeutic strategies in this most aggressive disease. With the emergence of various novel therapeutic strategies and neoadjuvant approaches in this quickly deteriorating disease, robust approaches for fast...
Joseph M Keca et al.
Advanced healthcare materials, 8(6), e1800857-e1800857 (2018-09-14)
The discovery and synthesis of multifunctional organic building blocks for nanoparticles have remained challenging. Texaphyrin macrocycles are multifunctional, all-organic compounds that possess versatile metal-chelation capabilities and unique theranostics properties for biomedical applications. Unfortunately, there are significant difficulties associated with the...
Samantha L Bowerbank et al.
Analytical and bioanalytical chemistry, 411(13), 2839-2853 (2019-05-13)
A new and improved method was developed for the determination and quantification of four "free" thyroid hormones (i.e. 3,5-diiodothyronine (T2), 3,3',5-triiodothyronine (T3), 3,3',5'-triiodothyrone (rT3) and 3,5,3',5'-tetraiodothyronine (T4)) in human serum by low- and high-resolution liquid chromatography-mass spectrometry (LC-MS). Several sample...
K Sam et al.
AJNR. American journal of neuroradiology, 37(12), 2258-2264 (2016-08-06)
The pathogenesis of leukoaraiosis has long been debated. This work addresses a less well-studied mechanism, cerebrovascular reactivity, which could play a leading role in the pathogenesis of this disease. Our aim was to evaluate blood flow dysregulation and its relation...
Glen Pridham et al.
Magnetic resonance imaging, 72, 150-158 (2020-07-21)
The Stockwell Transform has the potential to perform multi-resolution texture analysis in magnetic resonance imaging (MRI). However, it is computationally intensive and memory demanding. The polar Stockwell Transform (PST) is rotation-invariant and relatively memory efficient, but still computationally demanding. The...
Suzanne C van Es et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 62(2), 177-183 (2020-08-21)
It is unknown whether assessment of potential bone lesions in metastatic breast cancer (MBC) by 18F-FDG PET instead of 99mTc bone scintigraphy (BS) supports clinically relevant changes in MBC management. Therefore, we retrospectively compared management recommendations based on bone lesion...
Tuba Celik et al.
Current eye research, 40(3), 346-353 (2014-05-30)
To evaluate the fibrovascular in-growth of coralline and synthetic hydroxyapatite orbital implants by reporting the enhancement patterns on Gadolinium-Dietilen triamin penta acetic acid (Gad-DTPA) enhanced magnetic resonance imaging (MRI). The medical records of 26 patients who had undergone primary or...
Kristopher D Knott et al.
Circulation. Cardiovascular imaging, 12(7), e008872-e008872 (2019-07-05)
Fabry disease (FD) is an X-linked lysosomal storage disease resulting in tissue accumulation of sphingolipids. Key myocardial processes that lead to adverse outcomes in FD include storage, hypertrophy, inflammation, and fibrosis. These are quantifiable by multiparametric cardiovascular magnetic resonance. Recent...
B Shaun Bushman et al.
Plant disease, 103(2), 324-330 (2018-12-14)
Orchardgrass, or cocksfoot (Dactylis glomerata L.), is a cool-season forage grass susceptible to the choke disease caused by Epichloë typhina. Choke has been reported in orchardgrass seed production fields across the temperate regions of the world, but fungicides have not...
Jemma Bhoday et al.
Diseases of the colon and rectum, 59(10), 925-933 (2016-09-08)
Pathological complete response after chemoradiotherapy for rectal cancer occurs in 10% to 30% of patients. The best method to identify such patients remains unclear. Clinical assessment of residual mucosal abnormality is considered the most accurate method. In our institution, magnetic...
Xi Chen et al.
Developmental psychology, 56(3), 503-515 (2020-02-23)
Guided by Eisenberg, Cumberland, and Spinrad's (1998) conceptual framework, we examined multiple components of maternal emotion socialization (i.e., reactions to children's negative emotion, emotion talk, emotional expressiveness) at 33 months of age as predictors of adolescents' amygdala-vmPFC connectivity and amygdala...
Marina Gazdic et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 24(5), 687-702 (2018-03-04)
One of the therapeutic options for the treatment of fulminant hepatitis is repopulation of intrahepatic regulatory cells because their pool is significantly reduced during acute liver failure. Although it is known that mesenchymal stem cells (MSCs), which have beneficent effects...
Maria von Salisch et al.
Journal of abnormal child psychology, 45(1), 45-56 (2016-04-30)
Attention problems are likely to hinder children in acquiring knowledge of their own and others' emotions. Children with little knowledge of emotions tend to have difficulties with representing emotions, interpreting them, and sharing them, so that they are likely to...
Tessa D Kooiman et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 76(2), 408-415 (2017-08-23)
Micrognathia is the initiating feature of Robin sequence (RS) and leads to airway obstruction. Prenatal identification of micrognathia is currently qualitative and has not correlated with postnatal findings in previous studies. Oropharyngeal airway space has not been evaluated prenatally. The...
Tiangang Yang et al.
Biomaterials science, 7(7), 2951-2960 (2019-05-18)
Recently, block copolymer micelles have attracted widespread attention due to their controlled biodegradability and excellent loading capability. Unfortunately, the poor in vivo stability and low delivery efficiency of drug-loaded micelles greatly hampered their biomedical applications. Herein, we develop a new...
Taina Vuorio et al.
Scientific reports, 8(1), 16709-16709 (2018-11-14)
Heart has a wide lymphatic network but the importance of cardiac lymphatic system in heart diseases has remained unclear. Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) is a key molecule in the development and maintenance of cardiac lymphatic vessels. Here...