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Cihad Anamur et al.
International journal of pharmaceutics, 483(1-2), 131-141 (2015-02-11)
A clear limitation of many liquid vaccines is the obligatory cold-chain distribution system. Therefore, distribution of a dried vaccine formulation may be beneficial in terms of vaccine stability, handling and transport. Collapse freeze-drying is a process which utilizes fairly aggressive
Inas Helwa et al.
The Journal of pharmacology and experimental therapeutics, 352(1), 90-97 (2014-10-22)
Monomethylfumarate (MMF) is thought to be the bioactive ingredient of the drug Fumaderm (Biogen Idec, Cambridge, MA), licensed in Germany since 1994 for the treatment of moderate-to-severe psoriasis. Psoriasis is a common inflammatory hyperproliferative skin disorder that involves cross-talk between
Daniele G Castilho et al.
Journal of proteome research, 13(10), 4259-4271 (2014-08-26)
Few virulence factors have been identified for Paracoccidioides brasiliensis, the agent of paracoccidioidomycosis. In this study, we quantitatively evaluated the protein composition of P. brasiliensis in the yeast phase using minimal and rich media to obtain a better understanding of
Dandan Ge et al.
Talanta, 132, 132-136 (2014-12-06)
An ultra-hydrophobic ionic liquid, 1-hexyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate ([HMIM][FAP]) was immobilized in the pores of a polypropylene hollow fiber for liquid-liquid-liquid microextraction (HF-LLLME) of chlorophenols (CPs) (4-chloro-3-methylphenol, 2,4-dichlorophenol and 2,4,6-trichlorophenol). The analytes were first extracted from 10 ml of water sample into
Tania Mitra et al.
Journal of hazardous materials, 273, 94-103 (2014-04-15)
Hyacinth root was used as a biosorbent for generating adsorption data in fixed-bed glass column. The influence of different operating parameters like inlet Pb(II) ion concentration, liquid flow rate and bed height on the breakthrough curves and the performance of
Hui Zhang et al.
Environmental science and pollution research international, 21(16), 9939-9947 (2014-05-16)
An efficient pretreatment and analytical method was developed to investigate the occurrence and fate of four free estrogens (estrone (E1), 17β-estradiol (17β-E2), estriol (E3), and 17α-ethinylestradiol (EE2)), four conjugated estrogens (estrone-3-sulfate sodium salt (E1-3S), 17β-estradiol-3-sulfate sodium salt (E2-3S), estrone-3-glucuronide sodium
Thomas Berg et al.
Journal of chromatography. A, 1344, 83-90 (2014-05-02)
Stable isotope-labeled internal standards (SIL-ISs) are often used when applying liquid chromatography-tandem mass spectrometry (LC-MS/MS) to analyze for legal and illegal drugs. ISs labeled with (13)C, (15)N, and (18)O are expected to behave more closely to their corresponding unlabeled analytes
Partha Ray et al.
PloS one, 9(11), e112343-e112343 (2014-11-07)
Cephapirin, a cephalosporin antibiotic, is used by the majority of dairy farms in the US. Fecal and urinary excretion of cephapirin could introduce this compound into the environment when manure is land applied as fertilizer, and may cause development of
Inés Racamonde et al.
Analytica chimica acta, 865, 22-30 (2015-03-04)
Fabric phase sorptive extraction (FPSE) is a new, yet very promising member of the sorbent-based sorptive microextraction family. It has simultaneously improved both the extraction sensitivity and the speed of the extraction by incorporating high volume of sol-gel hybrid inorganic-organic
Kh Ghanbari et al.
Analytical biochemistry, 473, 53-62 (2015-01-13)
Novel zinc oxide (ZnO) nanosheets and copper oxide (CuxO, CuO, and Cu2O) decorated polypyrrole (PPy) nanofibers (ZnO-CuxO-PPy) have been successfully fabricated for the simultaneous determination of ascorbic acid (AA), dopamine (DA), and uric acid (UA). The morphology and structure of
Arianne C Richard et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3567-3582 (2015-03-20)
The TNF family cytokine TL1A (Tnfsf15) costimulates T cells and type 2 innate lymphocytes (ILC2) through its receptor DR3 (Tnfrsf25). DR3-deficient mice have reduced T cell accumulation at the site of inflammation and reduced ILC2-dependent immune responses in a number
Yaonan Zhang et al.
Biochemical and biophysical research communications, 454(2), 301-307 (2014-12-03)
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in patients with injuries and inflammation of tendon and ligament, and as post-surgical analgesics. The aim of this study is to investigate the effect of indomethacin, a classic NSAID and its combinational effect
Lars Eklund et al.
Dalton transactions (Cambridge, England : 2003), 43(33), 12711-12720 (2014-07-11)
Theoretical ab initio quantum mechanical charge field molecular dynamics (QMCF MD) has been applied in conjunction with experimental large angle X-ray scattering (LAXS) to study the structure and dynamics of the hydrated thiosulfate ion, S2O3(2-), in aqueous solution. The S-O
Petr Tůma
Journal of chromatography. A, 1345, 207-211 (2014-05-06)
Two CE methods with contactless conductivity detection have been developed for determining the oral antidiabetic drug metformin in human urine and blood. The determination of metformin is performed on a separation capillary with an effective length of 14 cm, using
Myunghee Lim et al.
Ultrasonics sonochemistry, 21(6), 1976-1981 (2014-04-22)
This report describes the effects of H2O2 concentration (0.01, 0.1, 1, and 10mM) on the sonochemical degradation of phenol and bisphenol A (BPA) using an ultrasonic source of 35kHz and 0.08W/mL. The concentration of the target pollutants (phenol or BPA)
Rakan Matsui et al.
Biological & pharmaceutical bulletin, 37(10), 1661-1667 (2014-10-03)
A transdermal oil-in-water type emulsified formulation containing propiverine hydrochloride, used for treatment of an overactive bladder (OAB), was evaluated for in vitro skin permeation under finite conditions and in vivo transdermal absorption. Propiverine hydrochloride solubility was determined using 1,3-butyleneglycol, polyoxyethylene
Miranda G M Kok et al.
Talanta, 132, 1-7 (2014-12-06)
In order to assess the utility of a recently developed capillary electrophoresis-mass spectrometry (CE-MS) method for the study of anionic metabolites in urine, a comparison was made with hydrophilic interaction chromatography-MS (HILIC-MS) using negative electrospray ionization. After optimization of the
Gregory Stockdale et al.
Journal of pharmaceutical sciences, 104(1), 25-33 (2014-11-11)
Comparing higher order structure (HOS) in therapeutic proteins is a significant challenge. Previously, we showed that changes in solution conditions produced detectable changes in the second-derivative amide I Fourier transform infrared (FTIR) spectra for a variety of model proteins. Those
Emma Lawless et al.
Pharmaceutical research, 32(5), 1817-1829 (2014-11-28)
Intestinal lymphatic transport of specific lipophilic drugs offers therapeutic advantages and maximises oral bioavailability. The aims of this study were; to compare intestinal lymphatic transport of a range of drugs and to investigate the influence of cyclosporine A on the
Anna Sankiewicz et al.
Analytical biochemistry, 469, 4-11 (2014-10-15)
We have developed a new method for highly selective determination of the ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) concentration using a surface plasmon resonance imaging (SPRI) technique and two different biosensors. UCH-L1 was captured from a solution by immobilized specific rabbit
Leila Bagheri et al.
Journal of microencapsulation, 31(7), 636-643 (2014-04-29)
Whey proteins were inter-connected either by the enzyme transglutaminase or citric acid and then desolvated with ethanol to generate particles. Both samples comprised of sub-micron (>300 nm) and nano-scaled (~100 nm) particles based on the hydrodynamic size measurements. Enzyme-induced cross-linking
Philipp Malsch et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(30), 9845-9856 (2014-07-25)
Glycoprotein 130 (gp130) is the signal transducing receptor subunit for cytokines of the interleukin-6 (IL-6) family, and it is expressed in a multitude of cell types of the immune and nervous system. IL-6-like cytokines are not only key regulators of
Andrea Hetzel et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(9), 2114-2130 (2014-03-13)
Severe and repeated stress has damaging effects on health, including initiation of depression and anxiety. Stress that occurs during development has long-lasting and particularly damaging effects on emotion. The basolateral amygdala (BLA) plays a key role in many affective behaviors
Lucy C Stott et al.
Aquatic toxicology (Amsterdam, Netherlands), 159, 127-137 (2014-12-30)
The gill is the principle site of xenobiotic transfer to and from the aqueous environment. To replace, refine or reduce (3Rs) the large numbers of fish used in in vivo uptake studies an effective in vitro screen is required that
Dmitri Gordienko et al.
Cardiovascular research, 105(2), 131-142 (2014-12-18)
P2X receptors (P2XRs) mediate sympathetic control and autoregulation of renal circulation triggering preglomerular vasoconstriction, which protects glomeruli from elevated pressures. Although previous studies established a casual link between glomerular susceptibility to hypertensive injury and decreased preglomerular vascular reactivity to P2XR
Cuilian Tao et al.
Dalton transactions (Cambridge, England : 2003), 43(41), 15482-15490 (2014-09-06)
Magnetic mesoporous silica (MMS) nanoparticles with controllable magnetization have been synthesized by encapsulating Fe3O4 nanoparticles in a mesoporous silica matrix. The structure, magnetic heating capacity and drug delivery ability of MMS nanoparticles were evaluated. The results showed that MMS nanoparticles
Pamela Maher et al.
Neurochemical research, 40(3), 609-620 (2015-01-07)
There is growing evidence for alterations in iron homeostasis during aging that are exacerbated in neurodegenerative diseases such as Alzheimer's disease. However, since essentially all neurodegenerative diseases are multi-factorial in the sense that there are a large number of mechanisms
Ali Es-Haghi et al.
Talanta, 128, 231-236 (2014-07-26)
Sol-gel based solid-phase microextraction fibers supported by a stainless steel wire were fabricated and employed for GC-MS determination of oxadiargyl in real samples. The fibers were based on four compounds with different polarity: polar and non-polar (end-capped) poly(dimethylsiloxane) (PDMS), polyethylene
Marie W Pettit et al.
International journal of pharmaceutics, 468(1-2), 264-271 (2014-04-01)
An increasing human population requires a secure food supply and a cost effective, oral vaccine delivery system for livestock would help facilitate this end. Recombinant antigen adsorbed onto silica beads and coated with myristic acid, was released (∼15% (w/v)) over
M Alyassin et al.
Food chemistry, 315, 126221-126221 (2020-01-31)
Xylo- and arabinoxylo-oligosaccharides (XOS and AXOS) are of interest for their prebiotic activity. The production of these oligomers might be accompanied with monosaccharides. The measurement of both oligosaccharides and monosaccharides usually requires two methods. The current work presents an HPAEC-PAD
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