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Teai, T.; Claude-Lafontaine, A. et al.
J. Essent. Oil Res., 13, 314-314 (2001)
C A Mielnik et al.
Genes, brain, and behavior, 13(7), 592-602 (2014-07-22)
NR1 knockdown (NR1KD) mice are genetically modified to express low levels of the NR1 subunit of N-methyl-D-aspartate (NMDA) receptors, and show deficits in affiliative social behaviour. In this study, we determined which brain regions were selectively activated in response to...
M Ferrer et al.
Biotechnology and bioengineering, 65(1), 10-16 (1999-08-10)
The enzymatic synthesis of 6-O-lauroylsucrose and 6-O-palmitoylsucrose was performed by transesterification of sucrose with the corresponding vinyl esters in a medium constituted by two solvents. More specifically, the acylation was carried out in 2-methyl-2-butanol (tert-amyl alcohol) containing a low percentage...
Supriya Swarnkar et al.
Neurobiology of disease, 82, 66-77 (2015-06-07)
Huntington's disease (HD) is caused by an expansion of glutamine repeats in the huntingtin protein (mHtt) that invokes early and prominent damage of the striatum, a region that controls motor behaviors. Despite its ubiquitous expression, why certain brain regions, such...
Drew L Sellers et al.
Biomaterials, 35(31), 8895-8902 (2014-07-30)
Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural progenitor proliferation in the intact murine spinal cord. A local...
Harry Karmouty-Quintana et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(1), 50-60 (2014-10-17)
Idiopathic pulmonary fibrosis (IPF) is a lethal, fibroproliferative disease. Pulmonary hypertension (PH) can develop secondary to IPF and increase mortality. Alternatively, activated macrophages (AAMs) contribute to the pathogenesis of both IPF and PH. Here we hypothesized that adenosine signaling through...
Shaojing Ye et al.
The Journal of clinical investigation, 124(10), 4517-4528 (2014-09-23)
Genome-wide association studies (GWAS) have linked genes encoding several soluble NSF attachment protein receptor (SNARE) regulators to cardiovascular disease risk factors. Because these regulatory proteins may directly affect platelet secretion, we used SNARE-containing complexes to affinity purify potential regulators from...
Funk, R.L.; Daily, W.J.; Parvez, D.M.
The Journal of Organic Chemistry, 53, 4143-4143 (1998)
Maria Victoria Flores et al.
Biotechnology and bioengineering, 78(7), 815-821 (2002-05-10)
The lipase catalyzed acylation of glucose by dodecanoic acid in 2-methyl 2-butanol was studied. The initial reaction rate was strongly dependent on the dissolved glucose concentration in the medium. Several methods were shown to increase dissolved glucose concentrations and initial...
H R Lee et al.
Oral diseases, 20(8), 803-808 (2014-01-01)
The aim of this study was to evaluate the effects of Tannerella forsythia and its major surface virulence factor, BspA, on the progression of atherosclerosis in ApoE(-/-) mice and the expression of lipid metabolism-related genes. PMA-differentiated THP-1 cells were treated...
Joshua Strom et al.
Cardiovascular drugs and therapy, 28(6), 541-547 (2014-10-17)
Dodecafluoropentane emulsion (DDFPe) is a perfluorocarbon with high oxygen dissolving, transport, and delivery capacity that may offer the potential to limit ischemic injury prior to clinical reperfusion. Here we investigated the cardiac protective potential of DDFPe in a mouse model...
Toshifumi Tezuka et al.
PloS one, 10(3), e0121615-e0121615 (2015-03-19)
Plasminogen activator inhibitor (PAI)-1 is the principal inhibitor of plasminogen activators, and is responsible for the degradation of fibrin and extracellular matrix. IMD-4690 is a newly synthesized inhibitor for PAI-1, whereas the effect on allergic airway inflammation and remodeling is...
Helen Larson et al.
The Journal of organic chemistry, 84(20), 13092-13103 (2019-09-25)
This manuscript details the development of the nickel-catalyzed arylation of oxazoles and benzoxazoles with aryl halides. A series of aryl, heteroaryl, and druglike electrophiles relevant to pharmaceutical applications were surveyed. The desired arylated products were obtained in synthetically useful yields...
Judith Schuster et al.
Journal of bacteriology, 194(5), 972-981 (2011-12-24)
Tertiary alcohols, such as tert-butyl alcohol (TBA) and tert-amyl alcohol (TAA) and higher homologues, are only slowly degraded microbially. The conversion of TBA seems to proceed via hydroxylation to 2-methylpropan-1,2-diol, which is further oxidized to 2-hydroxyisobutyric acid. By analogy, a...
Alfonso Pérez-Garrido et al.
Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the molecular structure of the compounds under investigation...
Wouter F Slotema et al.
Biotechnology and bioengineering, 82(6), 664-669 (2003-04-04)
An economically pertinent process for the lipase-catalyzed synthesis of amides was developed. A continuous plug flow reactor was used. The model reaction was the production of oleamide, a lubricant and anti-slip agent, via direct Candida antarctica lipase B-catalyzed amidation of...
Alejandra Bosco et al.
Disease models & mechanisms, 8(5), 443-455 (2015-03-11)
Microglia serve key homeostatic roles, and respond to neuronal perturbation and decline with a high spatiotemporal resolution. The course of all chronic CNS pathologies is thus paralleled by local microgliosis and microglia activation, which begin at early stages of the...
Lucy Coughlin et al.
Investigative ophthalmology & visual science, 56(3), 1437-1446 (2015-02-07)
Decreased ATP correlates with intraocular pressure exposure in the optic nerves of mice with glaucoma. To understand what underlies this energy deficit, we examined mitochondria in the myelinated optic nerve axons of the DBA/2J mouse, a model of glaucoma secondary...
Edwin S Olson et al.
Applied biochemistry and biotechnology, 113-116, 913-932 (2004-04-01)
The concept of a biorefinery for higher-alcohol production is to integrate ethanol and methanol formation via fermentation and biomass gasification, respectively, with conversion of these simple alcohol intermediates into higher alcohols via the Guerbet reaction. 1-Butanol results from the self-condensation...
Sinikka Vainiotalo et al.
Journal of occupational and environmental hygiene, 4(10), 739-750 (2007-08-02)
Healthy male volunteers were exposed via inhalation to gasoline oxygenates methyl tert-butyl ether (MTBE) or tert-amyl methyl ether (TAME). The 4-hr exposures were carried out in a dynamic chamber at 25 and 75 ppm for MTBE and at 15 and...
Fabien Létisse et al.
Biochimica et biophysica acta, 1652(1), 27-34 (2003-10-29)
The influence of the addition of an extra component in a gaseous reaction medium, on the kinetics of alcoholysis of methyl propionate and n-propanol catalyzed by immobilized lipase B from Candida antarctica was studied in a continuous solid/gas reactor. In...
Clemencia Chaves-López et al.
International journal of food microbiology, 150(1), 50-58 (2011-08-19)
Strains of Saccharomyces cerevisiae isolated from Italian salami were screened for proteolytic activity in a model system containing sarcoplasmic (SMS) or myofibrillar (MMS) proteins, at 20°C for 14days, to evaluate the possible influence on the proteolysis of fermented sausages. SDS-PAGE...
Marianthi Karali et al.
PloS one, 6(7), e22166-e22166 (2011-08-06)
Gene transfer using adeno-associated viral (AAV) vectors has been successfully applied in the retina for the treatment of inherited retinal dystrophies. Recently, microRNAs have been exploited to fine-tune transgene expression improving therapeutic outcomes. Here we evaluated the ability of retinal-expressed...
A Nicole Desch et al.
Nature communications, 5, 4674-4674 (2014-08-20)
Dendritic cells (DCs) are required for the induction of cytotoxic T cells (CTL). In most tissues, including the lung, the resident DCs fall into two types expressing the integrin markers CD103 and CD11b. The current supposition is that DC function...
Joseph V Martin et al.
Toxicology letters, 129(3), 219-226 (2002-03-13)
As a foundation for evaluating potential mechanisms of the neurological effects (e.g. headache, nausea, dizziness) of some octane boosters, we studied the gamma-aminobutyric acid(A) (GABA(A)) receptor in a series of binding assays in membranes from rat brain. The GABA(A) receptor...
Latifa Chebil et al.
The journal of physical chemistry. B, 114(38), 12308-12313 (2010-08-19)
A strategy to infer solubilities from the combination of experiment and all-atom simulations is presented. From a single experimental estimate, the solubility of a substrate can be predicted in various environments from the related free energies of solvation. In the...
Juliet Morrison et al.
Journal of virology, 88(18), 10556-10568 (2014-07-06)
Modulating the host response is a promising approach to treating influenza, caused by a virus whose pathogenesis is determined in part by the reaction it elicits within the host. Though the pathogenicity of emerging H7N9 influenza virus in several animal...
G W Xing et al.
The journal of peptide research : official journal of the American Peptide Society, 52(4), 300-304 (1998-12-01)
The activity of enzymes to form a peptide bond in organic solvent was greatly influenced by observed pH and water content. The precursors of two sweeteners, P-Asp-Xaa-OR (P=Z or For, Xaa-OR=Phe-OMe or Ala-OcHex), were synthesized by enzyme, and the reaction...
Maria Victoria Flores et al.
Biotechnology and bioengineering, 78(7), 795-801 (2002-05-10)
A kinetic model derived from the ping-pong bi-bi reversible mechanism is proposed to described the acylation of glucose by lauric acid in 2-methyl 2-butanol mediated by Candida antarctica lipase at 60 degrees C. The model accounts for the effect of...
Richard Cheng-An Chang et al.
Investigative ophthalmology & visual science, 56(4), 2367-2380 (2015-03-20)
The purpose of this study was to investigate the impact of obesity-induced prediabetes/early diabetes on the retina to provide new evidence on the pathogenesis of type 2 diabetes-associated diabetic retinopathy (DR). A high-fat diet (HFD)-induced obesity mouse model (male C57BL/6J)...
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