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Showing 1-8 of 8 results for "74667" within Papers

Senataxin Ortholog Sen1 Limits DNA:RNA Hybrid Accumulation at DNA Double-Strand Breaks to Control End Resection and Repair Fidelity.

Chetan C Rawal et al.

Cell reports, 31(5), 107603-107603 (2020-05-07)

An important but still enigmatic function of DNA:RNA hybrids is their role in DNA double-strand break (DSB) repair. Here, we show that Sen1, the budding yeast ortholog of the human helicase Senataxin, is recruited at an HO endonuclease-induced DSB and

Systematic genetics and single-cell imaging reveal widespread morphological pleiotropy and cell-to-cell variability.

Mojca Mattiazzi Usaj et al.

Molecular systems biology, 16(2), e9243-e9243 (2020-02-18)

Our ability to understand the genotype-to-phenotype relationship is hindered by the lack of detailed understanding of phenotypes at a single-cell level. To systematically assess cell-to-cell phenotypic variability, we combined automated yeast genetics, high-content screening and neural network-based image analysis of

Taxonomically Restricted Genes with Essential Functions Frequently Play Roles in Chromosome Segregation in

Adrian J Verster et al.

G3 (Bethesda, Md.), 7(10), 3337-3347 (2017-08-26)

Genes encoding essential components of core cellular processes are typically highly conserved across eukaryotes. However, a small proportion of essential genes are highly taxonomically restricted; there appear to be no similar genes outside the genomes of highly related species. What

A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy.

Tomokazu Murakawa et al.

Cell reports, 26(2), 338-345 (2019-01-10)

Degradation of mitochondria by selective autophagy, termed mitophagy, contributes to the control of mitochondrial quality. Bcl2-L-13 is a mammalian homolog of Atg32, which is an essential mitophagy receptor in yeast. However, the molecular machinery involved in Bcl2-L-13-mediated mitophagy remains to

Translational Regulation of Pmt1 and Pmt2 by Bfr1 Affects Unfolded Protein O-Mannosylation.

Joan Castells-Ballester et al.

International journal of molecular sciences, 20(24) (2019-12-15)

O-mannosylation is implicated in protein quality control in Saccharomyces cerevisiae due to the attachment of mannose to serine and threonine residues of un- or misfolded proteins in the endoplasmic reticulum (ER). This process also designated as unfolded protein O-mannosylation (UPOM)

Systematic Nanoscale Analysis of Endocytosis Links Efficient Vesicle Formation to Patterned Actin Nucleation.

Markus Mund et al.

Cell, 174(4), 884-896 (2018-07-31)

Clathrin-mediated endocytosis is an essential cellular function in all eukaryotes that is driven by a self-assembled macromolecular machine of over 50 different proteins in tens to hundreds of copies. How these proteins are organized to produce endocytic vesicles with high precision

Extending the Schizosaccharomyces pombe molecular genetic toolbox.

Dorota Fennessy et al.

PloS one, 9(5), e97683-e97683 (2014-05-23)

Targeted alteration of the genome lies at the heart of the exploitation of S. pombe as a model system. The rate of analysis is often determined by the efficiency with which a target locus can be manipulated. For most loci

Quantitative Yeast Genetic Interaction Profiling of Bacterial Effector Proteins Uncovers a Role for the Human Retromer in Salmonella Infection.

Kristin L Patrick et al.

Cell systems, 7(3), 323-338 (2018-08-06)

Intracellular bacterial pathogens secrete a repertoire of effector proteins into host cells that are required to hijack cellular pathways and cause disease. Despite decades of research, the molecular functions of most bacterial effectors remain unclear. To address this gap, we

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