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Showing 1-30 of 520 results for "75-16-1" within Papers
Sriram Venneti et al.
The American journal of surgical pathology, 35(10), 1463-1472 (2011-09-17)
Malignant rhabdoid tumors (MRTs) are highly aggressive pediatric tumors associated with loss of expression of SMARCB1, commonly occurring in the central nervous system [referred to as atypical teratoid/rhabdoid tumors (AT/RTs)] and in the kidney and soft tissues. Histologically, MRTs are
D L Manning et al.
Molecular and cellular endocrinology, 59(3), 205-212 (1988-10-01)
A cDNA library has been constructed from the poly(A)+ mRNA of oestrogen-stimulated ZR-75-1 human breast cancer cells. Screening by differential hybridization has identified eight clones which are stimulated between 4- and 16-fold by oestrogen. Two clones (pLIV-1) that are stimulated
Y-M Nie et al.
Transfusion medicine (Oxford, England), 20(6), 376-382 (2010-07-30)
Typing of human platelet antigens (HPA) has proven to be useful in some clinical situations related to platelet alloimmunization. The objective of this study was to investigate HPA 1-16 and to determine genotype and allele frequencies by polymerase chain reaction-sequence
K Gertow et al.
European journal of clinical nutrition, 60(12), 1406-1413 (2006-06-22)
Proteins involved in cellular fatty acid (FA) uptake and metabolism may be of relevance in the context of disturbed FA metabolism associated with insulin resistance. Therefore this study investigated relationships between FA handling protein mRNA expression in adipose tissue, FA
J D Pelletier et al.
Bioorganic & medicinal chemistry, 4(10), 1617-1628 (1996-10-01)
To develop inhibitors of 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) without residual estrogenic activity, the synthesis of 16 alpha-(bromoalkylamide) derivatives of estradiol was performed starting from a key intermediate aldehyde obtained from commercially available estrone. In addition, series of 16 alpha-(bromoalkyl)
Bo Yu et al.
Molecular medicine reports, 19(5), 4027-4034 (2019-04-04)
MicroRNAs (miRNAs) are non‑coding RNAs of ~22 nucleotides in length, which serve an important role in numerous diseases. Asthma is a chronic airway inflammatory disease, which is the most common chronic disease among children. The role of miRNA (miR)‑16 in
Heiner Adams et al.
Expert opinion on therapeutic targets, 14(6), 577-584 (2010-04-27)
HDAC inhibitors (HDI) are anti-neoplastic drugs with preliminary successful clinical applications in Hodgkin's lymphoma (HL). Systematic investigations of HDAC expression in HL, based on histology and immunohistochemistry are yet rare. We investigated the expression of HDAC1, 2 and 3 in
Erin M Carney et al.
The American journal of surgical pathology, 35(2), 262-267 (2011-01-26)
Hemangioblastomas account for up to 2.5% of all intracranial tumors. They may occur sporadically or as a part of the multisystem genetic syndrome of Von Hippel-Lindau syndrome (VHL). Patients with VHL are also at an increased risk of developing clear
S M Hasan et al.
European journal of medicinal chemistry, 44(12), 4896-4903 (2009-08-29)
A series of 6-aminomethyl-2-aryl-1-benzopyran-4-one derivatives (10-24) were synthesized. The compounds were tested for anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. Among the tested compounds, six compounds 11, 13, 16, 18, 21 and 23 showed higher degree of anti-inflammatory activity (>75%
Hiroshi Miyamoto et al.
The American journal of surgical pathology, 34(3), 418-422 (2010-02-16)
Studies predominantly performed on cystectomy specimens have shown that antibodies against smoothelin can distinguish between muscularis mucosae (MM) (negative or weak stain) and muscularis propria (MP) (strong stain). However, studies on diagnostically difficult (transurethral resection) specimens have not been performed.
Andrew Blauvelt et al.
Lancet (London, England), 389(10086), 2287-2303 (2017-05-10)
Dupilumab (an anti-interleukin-4-receptor-α monoclonal antibody) blocks signalling of interleukin 4 and interleukin 13, type 2/Th2 cytokines implicated in numerous allergic diseases ranging from asthma to atopic dermatitis. Previous 16-week monotherapy studies showed that dupilumab substantially improved signs and symptoms of
Shahar Lavi et al.
Mayo Clinic proceedings, 83(2), 158-164 (2008-02-05)
To test the hypothesis that allelic variants of the paraoxonase-1 gene are associated with endothelial dysfunction, an early stage of atherosclerosis. We assessed 192Q>R and 55L>M allelic variants of the paraoxonase gene and coronary endothelial function in response to intracoronary
K A Sharif et al.
Biochemical pharmacology, 55(10), 1683-1689 (1998-06-20)
Human RFC1 (hRFC1) transfected in transport-deficient methotrexate MTXR(R)ZR-75-1 human breast carcinoma cells (MTX(R)ZR-75/RFC) were used to investigate the impact of hRFC1 overexpression on influx and concentrative transport of methotrexate (MTX). Eight-fold overexpression of hRFC1, as determined by northern analysis, resulted
David E Lee et al.
Journal of cellular biochemistry, 117(8), 1775-1787 (2015-12-20)
Insulin resistant diabetes, currently at epidemic levels in developed countries, begins in the skeletal muscle and is linked to altered protein turnover. microRNAs downregulate targeted mRNA translation decreasing the amount of translated protein, thereby regulating many cellular processes. Regulation of
Meeghan A Hart et al.
Pediatric pulmonology, 39(6), 544-550 (2005-04-05)
There has been a recent emphasis on identifying modifier genes that influence the severity of cystic fibrosis (CF) lung disease. The beta-2-adrenergic receptor is expressed on airway smooth muscle, is the target for inhaled beta agonists, and has several common
John F Seymour et al.
British journal of haematology, 165(1), 49-56 (2014-01-29)
The efficacy and tolerance of azacitidine in higher-risk myelodysplasia with hypocellular bone marrow (BM) are unknown. This post hoc AZA-001 trial analysis assessed whether baseline BM cellularity affected the overall survival (OS) advantage demonstrated with azacitidine versus conventional care regimens
Kalpana Bhandari et al.
Bioorganic & medicinal chemistry, 14(8), 2535-2544 (2005-12-13)
Several 1-aryloxy-2-substituted aminomethyltetrahydronaphthalenes (7-21) as conformationally rigid analogues of fluoxetine were synthesized and evaluated for their anorexigenic and antidepressant activities. For SAR studies the related acyclic analogues (22-27) were also prepared. Out of the 21 synthesized compounds, 10 compounds (9
J Marín et al.
British journal of pharmacology, 124(3), 473-478 (1998-07-01)
1. The aim of the present study was to explore the contribution of adrenergic, sensory and nitrergic innervations to the inhibitory effects of the beta2-adrenoceptor agonist clenbuterol on responses to electrical field stimulation (EFS, 200 mA, 0.3 ms, 1-16 Hz
Chengcheng Han et al.
Extremophiles : life under extreme conditions, 24(6), 909-922 (2020-10-08)
Elucidation of the acetic acid resistance (AAR) mechanisms of Acetobacter pasteurianus is significant for vinegar production. In this study, cell membrane lipid profile of A. pasteurianus Ab3 was investigated by gas chromatography-mass spectrometer (GC-MS) and high performance liquid chromatography-electrospray ionization
Claire Faulkner et al.
Journal of neuropathology and experimental neurology, 74(9), 867-872 (2015-07-30)
Pilocytic astrocytomas (PAs) are increasingly tested for KIAA1549-BRAF fusions. We used reverse transcription polymerase chain reaction for the 3 most common KIAA1549-BRAF fusions, together with BRAF V600E and histone H3.3 K27M analyses to identify relationships of these molecular characteristics with
Mona Ghazi et al.
Journal of pediatric hematology/oncology, 34(2), 128-130 (2011-12-03)
Morbidity and mortality due to infections remain serious problems in pediatric oncology patients receiving chemotherapy. Association of mannose-binding lectin (MBL) levels with an increased risk for infection in previous studies was contradictory. The aim of this study was to determine
J E Sigel et al.
Journal of cutaneous pathology, 28(10), 520-524 (2001-12-12)
Cutaneous spindle cell squamous cell carcinoma (SSCC) is a challenging diagnosis since it may be difficult to distinguish from spindle cell melanoma, leiomyosarcoma and atypical fibroxanthoma. Furthermore, it may be difficult to demonstrate epithelial differentiation by a traditional immunohistochemical panel.
Inas A Ahmed et al.
Cancer genetics and cytogenetics, 199(2), 96-100 (2010-05-18)
Novel strategies for early detection of breast cancer, the most common and second most lethal cancer in women, are urgently needed. Silencing tumor suppressor genes via DNA methylation has established hypermethylation as one of the most frequent molecular alterations that
Vishwas D Joshi et al.
Journal of immunology (Baltimore, Md. : 1950), 169(5), 2536-2544 (2002-08-24)
LPS enhanced antibacterial host defenses (ABHD) when given at low (75 micro g) doses (16 of 19 mice survived 3x LD(50) Escherichia coli vs 3 of 19 LPS-naive mice; p = 0.0001), but induced lethal inflammation at high (500 micro
H Vierhapper et al.
Thyroid : official journal of the American Thyroid Association, 14(8), 580-583 (2004-08-24)
The possibility of germline mutations of the RET proto-oncogene (exons 10, 11, 13, 14, and 16) was investigated in 75 patients (57 men, 18 women) with a negative family history for medullary thyroid carcinoma (MTC), elevated (> 10 pg/mL) basal
M H Vermeer et al.
The American journal of pathology, 154(4), 1203-1210 (1999-05-11)
Granzyme B (GrB) and T-cell-restricted intracellular antigen (TIA-1) are cytotoxic proteins that are specifically expressed by cytotoxic CD4 or CD8 positive T cells and natural killer cells. Recent studies demonstrated frequent expression of GrB and TIA-1 by neoplastic cells in
Virgínia Carla A Falcão et al.
Mycopathologia, 171(1), 77-84 (2010-06-29)
The objectives of this study were to evaluate the fumonisin production by 16 F. verticillioides strains on corn cultures and the effect of quintozene and fludioxonil + metalaxyl-M fungicides on "in vitro" mycelial growth on agar. In addition, the effect
Franklin Y Quarcoo et al.
Insects, 10(2) (2019-02-02)
Behavioral symptoms and mortality associated with intoxication with insecticides fipronil and indoxacarb were determined in field-collected eastern subterranean termites, Reticulitermes flavipes (Kollar), and Formosan subterranean termites, Coptotermes formosanus Shiraki. Behaviors and mortality were evaluated at three temperatures (16, 22, and
Zhanyong Bing et al.
Applied immunohistochemistry & molecular morphology : AIMM, 16(4), 316-321 (2008-06-06)
The Wilms tumor 1 (WT-1) is a zinc finger transcription factor essential for the development of the kidneys and gonads. Alterations in the WT-1 gene were observed in several tumor types. Depending on the tumor types, WT-1 might function as
Mariana Figueiroa Careta et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 39(5), 734-738 (2013-02-06)
Earlobe keloids are benign, fibrous proliferations that occur in predisposed persons at sites of cutaneous injury. No single best therapeutic modality is indicated. To describe a 1-year follow-up of 12 patients with earlobe keloids treated by shaving followed by cryosurgery
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