Showing 1-18 of 18 results for "

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Arega Tsegaye et al.
Malaria journal, 13, 438-438 (2014-11-20)
Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is widespread across malaria endemic regions. G6PD-deficient individuals are at risk of haemolysis when exposed, among other agents, to primaquine and tafenoquine, which are capable of blocking malaria transmission by killing Plasmodium falciparum gametocytes and preventing...
Yoshinori Aso et al.
eLife, 3, e04580-e04580 (2014-12-24)
Animals discriminate stimuli, learn their predictive value and use this knowledge to modify their behavior. In Drosophila, the mushroom body (MB) plays a key role in these processes. Sensory stimuli are sparsely represented by ∼2000 Kenyon cells, which converge onto...
John Apergis-Schoute et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(14), 5435-5441 (2015-04-10)
The lateral hypothalamus (LH) is a key regulator of multiple vital behaviors. The firing of brain-wide-projecting LH neurons releases neuropeptides promoting wakefulness (orexin/hypocretin; OH), or sleep (melanin-concentrating hormone; MCH). OH neurons, which coexpress glutamate and dynorphin, have been proposed to...
Anupama Tyagi et al.
Prostaglandins, leukotrienes, and essential fatty acids, 91(6), 289-297 (2014-12-03)
Imbalances in the dietary n-6 and n-3 polyunsaturated fatty acids have been implicated in the increased prevalence of inflammatory bowel disease. This study investigated the effects of substitution of linoleic acid with long chain n-3 polyunsaturated fatty acids and hence...
S M Jeong et al.
Oncogene, 34(16), 2115-2124 (2014-06-10)
Iron metabolism is essential for many cellular processes, including oxygen transport, respiration and DNA synthesis, and many cancer cells exhibit dysregulation in iron metabolism. Maintenance of cellular iron homeostasis is regulated by iron regulatory proteins (IRPs), which control the expression...
Yingning Zheng et al.
Analytica chimica acta, 834, 45-50 (2014-06-15)
Our present work aimed at developing a pseudo triple-enzyme cascade electrocatalytic electrochemical aptasensor for determination of thrombin with the amplification of alcohol dehydrogenase (ADH)-Pt-Pd nanowires bionanocomposite and hemin/G-quadruplex structure that simultaneously acted as NADH oxidase and HRP-mimicking DNAzyme. With the...
Laura Mateo-Vivaracho et al.
Journal of chromatography. A, 1146(2), 242-250 (2007-02-24)
A fast method for the determination of aroma-powerful polyfunctional thiols at nanogram per liter level has been developed and applied to wine. A small volume of wine (6 mL) was extracted with 1.5 mL of benzene containing four internal standards....
Bridget S Penman et al.
British journal of haematology, 169(1), 117-128 (2014-12-19)
Genetic disorders of haemoglobin, particularly the sickle cell diseases and the alpha and beta thalassaemias, are the commonest inherited disorders worldwide. The majority of affected births occur in low-income and lower-middle income countries. Screening programmes are a vital tool to...
Akie Hamamoto et al.
Cellular signalling, 27(4), 818-827 (2015-01-27)
Many G-protein-coupled receptors (GPCRs) are known to functionally couple to multiple G-protein subfamily members. Although promiscuous G-protein coupling enables GPCRs to mediate diverse signals, only a few GPCRs have been identified with differential determinants for coupling to distinct Gα proteins....
Analysis of volatile thiols in alcoholic beverages by simultaneous derivatization/extraction and liquid chromatography-high resolution mass spectrometry
Vichi S, et al.
Food Chemistry, 175(2), 401-408 (2015)
Collins Odhiambo et al.
PloS one, 10(4), e0123140-e0123140 (2015-04-16)
Important differences have been demonstrated in laboratory parameters from healthy persons in different geographical regions and populations, mostly driven by a combination of genetic, demographic, nutritional, and environmental factors. Despite this, European and North American derived laboratory reference intervals are...
S Chometton et al.
Journal of chemical neuroanatomy, 61-62, 72-82 (2014-08-16)
Neurons producing melanin-concentrating hormone (MCH) or hypocretin/orexin (Hcrt) have been implicated in the sleep/wake cycle and feeding behavior. Sleep and feeding habits vary greatly among mammalian species, depending in part of the prey/predatory status of animals. However, the distribution of...
Hao Chen et al.
PloS one, 10(2), e0115482-e0115482 (2015-02-07)
Giant cell arteritis (GCA) and Takayasu's disease are inflammatory vasculitic syndromes (IVS) causing sudden blindness and widespread arterial obstruction and aneurysm formation. Glucocorticoids and aspirin are mainstays of treatment, predominantly targeting T cells. Serp-1, a Myxomavirus-derived serpin, blocks macrophage and...
Karsten Geletneky et al.
Comparative medicine, 65(1), 23-35 (2015-03-03)
Parvovirus H1 (H1PV) is an autonomous parvovirus that is transmitted in rodent populations. Its natural host is rats. H1PV infection is nonpathogenic except in rat and hamster fetuses and newborns. H1PV infection of human cancer cells caused strong oncolytic effects...
Chang Liu et al.
The Analyst, 139(21), 5460-5465 (2014-08-30)
Due to its low growth rate and its fastidious nature, Mycobacterium tuberculosis is difficult to identify. Its rapid and sensitive detection is, however, critical for the control of tuberculosis. Molecular biology, and more recently electrochemical technology, have been exploited for...
Siana Nkya Mtatiro et al.
American journal of hematology, 90(1), E1-E4 (2014-09-30)
Fetal hemoglobin (HbF) is a recognized modulator of sickle cell disease (SCD) severity. HbF levels are strongly influenced by genetic variants at three major genetic loci, Xmn1-HBG2, HMIP-2, and BCL11A, but the effect of these loci on the hematological phenotype...
Amparo Vayá et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 21(3), 241-245 (2014-08-27)
There is no information about a possible association of red blood cell distribution width (RDW) with cryptogenic stroke (CS). We aimed to analyze the association of RDW with CS. One hundred and sixty-three patients with CS were included along with...
Laura Mateo-Vivaracho et al.
Journal of chromatography. A, 1185(1), 9-18 (2008-02-09)
A fast method for the determination of aroma-powerful polyfunctional thiols at ng L(-1) level has been developed. Mercaptans are selectively retained in a 50mg solid-phase extraction cartridge and derivatization takes place in the same cartridge at room temperature (25 degrees...