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Corinne Loutelier-Bourhis et al.
Rapid communications in mass spectrometry : RCM, 26(11), 1265-1276 (2012-05-05)
The grafting of maleic anhydride onto fatty C=C double bonds is a well-known and used method to functionalize triglyceride molecules. Nevertheless, grafted products are not actually structurally well defined. In this work, the thermal grafting of maleic anhydride onto (un)saturated...
Michael D Hardy et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8187-8192 (2015-06-24)
Cell membranes are dynamic structures found in all living organisms. There have been numerous constructs that model phospholipid membranes. However, unlike natural membranes, these biomimetic systems cannot sustain growth owing to an inability to replenish phospholipid-synthesizing catalysts. Here we report...
Franco Cataldo
Chemistry and physics of lipids, 163(6), 524-529 (2010-03-27)
Unsaturated lipids when exposed to air at room temperature undergo a slow autoxidation. When fullerene C(60) was dissolved in selected lipids (ethyl oleate, ethyl linoleate, linseed oil and castor oil) the spectrophotometric analysis shows that the oxidation is concentrated to...
Yizhen Chen et al.
International journal of pharmaceutics, 487(1-2), 17-24 (2015-04-07)
The toxicity and irritation associated with high amounts of surfactants restrict the extensive utilization of microemulsions. To address these shortcomings, employing mixed oils to enlarge microemulsion areas therefore reducing surfactant contents is a promising strategy. However, what kinds of mixed...
Velio Bocci et al.
Virulence, 1(3), 215-217 (2010-12-24)
A vaccine against HIV able to generate properly neutralizing antibodies and an efficacious cytotoxic T lymphocyte response is of paramount importance. We are proposing a novel approach based on the collection of thousand small HIV-infected human plasma samples for preparing...
Juan Jin et al.
New biotechnology, 28(2), 190-195 (2010-10-19)
The ability of free and immobilized lipase on the production of diacylglycerols (DAG) by transesterification of glycerol monooleate (GMO) and ethyl oleate was investigated. Among three free lipases such as lipase G (Penicillium cyclopium), lipase AK (Pseudomonas fluorescens) and lipase...
Dehua Liao et al.
Drug delivery, 22(4), 516-521 (2014-01-29)
The aim of this research was to increase the oral bioavailability of puerarin by N-trimethyl chitosan-modified microemulsions (TMC-MEs) loaded with puerarin. Different concentrations of TMC-modified microemulsions were prepared in our study, and then evaluated for particle size, zeta potential, morphological...
Shujauddin Changi et al.
ChemSusChem, 5(9), 1743-1757 (2012-08-29)
We examined the behavior of phenylalanine in high-temperature water (HTW) at 220, 250, 280, and 350 °C. Under these conditions, the major product is phenylethylamine. The minor products include styrene and phenylethanol (1-phenylethanol and 2-phenylethanol), which appear at higher temperatures and...
Y Ingrid Goh et al.
Alcohol (Fayetteville, N.Y.), 44(7-8), 629-634 (2010-06-30)
Meconium fatty acid ethyl esters (FAEEs) are sensitive and specific biomarkers for prenatal alcohol exposure (PAE) in pregnancy. We recently reported a 2.5% rate of FAEE positive meconium in a general population sample of infants born in the region of...
Qi Shen et al.
AAPS PharmSciTech, 12(4), 1044-1049 (2011-08-16)
In the present study, the effect of a borneol/menthol eutectic mixture (25:75) and microemulsion on the absorption of daidzein in rat intestinal membrane was evaluated. The microemulsion formulation was composed of ethyl oleate (oil), Cremophor RH40 (surfactant), PEG400 (co-surfactant), and...
Claudia Dussaubat et al.
Journal of chemical ecology, 36(5), 522-525 (2010-04-20)
Pheromones in social insects play a key role in the regulation of group homoeostasis. It is well-established that parasites can modify hormone signaling of their host, but less is known about the effect of parasites on pheromone signaling in insect...
Gurpreet Kaur et al.
Langmuir : the ACS journal of surfaces and colloids, 28(29), 10640-10652 (2012-06-23)
Microemulsions are important formulations in cosmetics and pharmaceutics and one peculiarity lies in the so-called "phase inversion" that takes place at a given water-to-oil concentration ratio and where the average curvature of the surfactant film is zero. In that context...
Ping Li et al.
Acta pharmacologica Sinica, 31(7), 881-888 (2010-06-22)
To improve the oral absorption of adefovir dipivoxil (ADV) by employing MCT and the esterase inhibitor ethyl oleate (EO) as a complex oil phase in emulsion. EO was used as the esterase inhibitor, and its inhibitory effect on esterase activity...
Subhankar Dolai et al.
Gastroenterology, 143(3), 832-843 (2012-06-20)
During development of alcoholic pancreatitis, oxidative (acetaldehyde) and nonoxidative metabolites (ethyl palmitate, ethyl oleate), rather than ethanol itself, mediate toxic injury. Exposure of pancreatic acini to ethanol blocks cholecystokinin (CCK)-8-stimulated apical exocytosis and redirects exocytosis to the basolateral plasma membrane...
Neil Loftus et al.
Journal of proteome research, 10(2), 705-713 (2010-10-30)
Alcoholism is a complex disorder that, in man, appears to be genetically influenced, although the underlying genes and molecular pathways are not completely known. Here, the intragastric alcohol feeding model in rodents was used together with high mass accuracy LC-MS(n)...
K J Dussan et al.
Bioresource technology, 101(24), 9542-9549 (2010-08-19)
Magnetic nanoparticles were prepared by coprecipitating Fe(2+) and Fe(3+) ions in a sodium hydroxide solution and used as support for lipase. The lipase-coated particles were applied in a reactive extraction process that allowed separation of the products formed during transesterification....
Sowmya S Mohan et al.
Alcoholism, clinical and experimental research, 39(3), 434-444 (2015-02-24)
Chronic alcohol exposure alters the function of alveolar macrophages (AM), impairing immune defenses in both adult and neonatal lungs. Fatty acid ethyl esters (FAEEs) are biological markers of prenatal alcohol exposure in newborns. FAEEs contribute to alcohol-induced mitochondrial (MT) damage...
Aihua Yu et al.
Journal of pharmaceutical sciences, 100(3), 933-941 (2010-09-24)
The main objective of the study was to investigate the efficacy of microemulsion (ME) to facilitate bioavailability of puerarin (PUE) after oral and nasal administration. The pseudo-ternary phase diagrams were constructed to screen the ME components and optimize the ME...
Chemical and thermochemical aspects of the ozonolysis of ethyl oleate: Decomposition enthalpy of ethyl oleate ozonide.
Cataldo F.
Chemistry and Physics of Lipids, 175, 41-49 (2013)
Brian T Bennett et al.
Oxidative medicine and cellular longevity, 2020, 3938672-3938672 (2020-08-11)
Beta-hydroxy-beta-methylbutyrate (HMB), a naturally occurring leucine metabolite, has been shown to attenuate plantar flexor muscle loss and increase myogenic stem cell activation during reloading after a period of significant muscle wasting by disuse in old rodents. However, it was less...
Shantanu Bandyopadhyay et al.
Current drug delivery, 12(5), 544-563 (2015-03-04)
The objectives of the present studies were to develop the systematically optimized selfnanoemulsifying drug delivery systems (SNEDDS) of valsartan employing the holistic QbD approach. The quality profile target product (QTPP) was defined and critical quality attributes (CQAs) earmarked. Preformulation studies...
Jianbin Zhang et al.
AAPS PharmSciTech, 15(3), 731-740 (2014-02-21)
The objective of this study is to investigate the effect of lipolysis on the release of poorly water-soluble drug from SMEDDS in the perspective of drug core/shell location. For this purpose, four SMEDDS formulations with various core/shell properties were developed...
Vipaporn Panapisal et al.
AAPS PharmSciTech, 13(2), 389-399 (2012-02-22)
Silymarin is a standardized extract from Silybum marianum seeds, known for its many skin benefits such as antioxidant, anti-inflammatory, and immunomodulatory properties. In this study, the potential of several microemulsion formulations for dermal delivery of silymarin was evaluated. The pseudo-ternary...
Simona Pichini et al.
Clinical chemistry and laboratory medicine, 52(8), 1179-1185 (2014-03-13)
Ethyl glucuronide (EtG) measurement in neonatal meconium has emerged as a reliable marker to objectively assess prenatal exposure to maternal ethanol complementary to fatty acid ethyl ester (FAEEs) measurement. The detection of EtG in meconium is currently a lengthy, difficult...
Obie Farobie et al.
Bioresource technology, 191, 306-311 (2015-05-26)
In this study, biodiesel production under supercritical conditions among methanol, ethanol, and tert-butyl methyl ether (MTBE) was compared in order to elucidate the differences in their reaction behavior. A continuous reactor was employed, and experiments were conducted at various reaction...
Carlos Castillo et al.
Insect biochemistry and molecular biology, 42(6), 404-416 (2012-03-13)
Honey bees undergo a physiological transition from nursing to foraging approximately 21 days after adult emergence. This transition is delayed by ethyl oleate (EO), a primer pheromone produced by foragers when exposed to ethanol from fermented nectar. We demonstrate here...
Jerry Nesamony et al.
Drug development and industrial pharmacy, 39(2), 240-251 (2012-04-07)
Water-in-oil microemulsions (w/o ME) are ideal for parenteral drug delivery. However, no such formulations have been tested for biocompatibility in in vitro cell cultures. Furthermore, sterilization of w/o MEs is a challenging process that has not been previously developed and...
Khushwinder Kaur
Journal of the science of food and agriculture, 95(13), 2718-2728 (2014-11-25)
Inclusion complex formation between β-cyclodextrin (β-CD) and suitable guest molecules such as cholesterol (Ch) has regularly been exploited to design self-assembled structures. In the present study an effective nanoemulsion medium (lecithin/Tween 80/ethyl oleate/water) was selected for solubilizing and stabilizing Ch...
Wei-Na Li et al.
Applied biochemistry and biotechnology, 163(1), 102-111 (2010-07-28)
In this study, the immobilized lipase was prepared by fabric membrane adsorption in fermentation broth. The lipase immobilization method in fermentation broth was optimized on broth activity units and pH adjustments. The viscose fermentation broth can be used with a...
Hongda Ma et al.
Drug development and industrial pharmacy, 38(10), 1200-1206 (2012-04-20)
To improve the dissolution and oral absorption of Rhizoma corydalis decumbentis extracts (RCDE), a famous traditional Chinese herbal medicine which contains poorly water-soluble active components, self-emulsifying drug-delivery systems (SEDDS) were designed and evaluated in vitro and in vivo for the...
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