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Zhe Li et al.
Nucleic acids research, 42(6), 4068-4079 (2013-12-29)
G-quadruplex-forming oligonucleotides containing modified nucleotide chemistries have demonstrated promising pharmaceutical potential. In this work, we systematically investigate the effects of sugar-modified guanosines on the structure and stability of a (4+0) parallel and a (3+1) hybrid G-quadruplex using over 60 modified...
Sebastian Daum et al.
Biological chemistry, 395(7-8), 801-812 (2014-07-09)
As shape transformations of membranes are vital for intracellular trafficking, it is crucial to understand both the mechanics and the biochemistry of these processes. The interplay of these two factors constitutes an experimental challenge, however, because biochemical experiments are not...
Carrie H Croy et al.
Molecular pharmacology, 86(1), 106-115 (2014-05-09)
The M(4) receptor is a compelling therapeutic target, as this receptor modulates neural circuits dysregulated in schizophrenia, and there is clinical evidence that muscarinic agonists possess both antipsychotic and procognitive efficacy. Recent efforts have shifted toward allosteric ligands to maximize...
Rui Weng et al.
Scientific reports, 5, 11864-11864 (2015-07-15)
Serotonin is an important neurotransmitter that broadly participates in various biological processes. While serotonin deficiency has been associated with multiple pathological conditions such as depression, schizophrenia, Alzheimer's disease and Parkinson's disease, the serotonin-dependent mechanisms remain poorly understood. This study therefore...
Sylwia Studzińska et al.
Journal of separation science, 38(12), 2076-2084 (2015-04-14)
Quantitative structure-retention relationships studies were performed for cholesterol and alkylamide stationary phases, which were previously applied in the analysis of nucleotides and oligonucleotides. An octadecyl column was also tested. Twenty-four oligonucleotides of various sequences and length were chosen; next, their...
Nitin K Singh et al.
Interdisciplinary sciences, computational life sciences, 4(3), 183-189 (2013-01-08)
Dormant endospores of Bacillus anthracis are the causative agent of anthrax, which is an acute disease for both human and animals. Anthrax has been practised as biological weapon because of two attributes: i) short duration of spore germination, and ii)...
Beate Pesch et al.
Archives of toxicology, 89(8), 1257-1269 (2014-08-12)
The International Agency for Research on Cancer considers the carcinogenicity of welding fume of priority for re-evaluation. Genotoxic effects in experimental animals are still inconclusive. Here, we investigated the association of personal exposure to metals in respirable welding fumes during...
Fan Shen et al.
The Journal of clinical endocrinology and metabolism, 100(1), E148-E154 (2014-10-11)
N(6)-methyladenosine (m(6)A) modification plays a fundamental role in the epigenetic regulation of the mammalian transcriptome. m(6)A can be demethylated by fat mass- and obesity-associated (FTO) protein and α-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5) protein. However, the importance of m(6)A alteration...
Eva Tyteca et al.
Journal of chromatography. A, 1368, 125-131 (2014-12-03)
In this study, the separation of twelve nucleobases and nucleosides was optimized via chromatogram simulation (i.e., prediction of individual retention times and estimation of the peak widths) with the use of an empirical (reversed-phase) non-linear model proposed by Neue and...
Yanjie Sun et al.
Antimicrobial agents and chemotherapy, 51(1), 84-88 (2006-10-25)
Ribavirin (RBV) is a broad-spectrum antiviral agent that inhibits the production of infectious Hantaan virus (HTNV). Although the mechanism of action of RBV against HTNV is not understood, RBV is metabolized in human cells to both RBV-5'-monophosphate, which inhibits IMP...
Zhiwei Huang et al.
Leukemia & lymphoma, 55(8), 1876-1883 (2013-11-12)
It has been recently shown that the type I insulin-like growth factor receptor (IGF-IR) contributes significantly to the survival of T lymphoblastic leukemia/lymphoma (T-LBL) cells, and it was therefore suggested that IGF-IR could represent a legitimate therapeutic target in this...
Maria Z Alfaradhi et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(1), R26-R34 (2014-05-03)
Changes in the maternal nutritional environment during fetal development can influence offspring's metabolic risk in later life. Animal models have demonstrated that offspring of diet-induced obese dams develop metabolic complications, including nonalcoholic fatty liver disease. In this study we investigated...
Yingying Dong et al.
Electrophoresis, 32(10), 1209-1216 (2011-05-06)
Sieving gels are used in capillary gel electrophoresis to resolve DNA strands of different lengths. For complex samples, however, such as those encountered in metagenomic analysis of microbial communities or biofilms, length-based separation may mask the true genetic diversity of...
Down-regulation of mitochondrial thymidine kinase 2 and deoxyguanosine kinase by didanosine: implication for mitochondrial toxicities of anti-HIV nucleoside analogs.
Sun R, Eriksson S, and Wang L
Biochemical and Biophysical Research Communications, 450(2), 1021-1026 (2014)
Qing Wang et al.
The Analyst, 140(22), 7657-7662 (2015-10-07)
A novel unmodified gold nanoparticle (AuNP)-based colorimetric assay was demonstrated using split aptamers and the hybridization chain reaction (HCR) amplification strategy. Here, the aptamer was divided into a structure-switching hairpin probe (DNA probe H1 (or H1')) and a single-stranded probe...
Huiying Song et al.
Journal of chromatography. A, 1369, 83-91 (2014-12-03)
An intrinsic performance comparison is made of the reduction in analysis time that can be obtained when switching from HPLC to UHPLC column formats in HILIC and reversed-phase conditions. A detailed overview of the packing characteristics of both stationary phase...
Szu-Ying Hung et al.
Analytica chimica acta, 857, 64-70 (2015-01-22)
This study describes the development of a simple, enzyme-free, label-free, sensitive, and selective system for detecting adenosine based on the use of Tween 20-stabilized gold nanoparticles (Tween 20-AuNPs) as an efficient fluorescence quencher for boron dipyrromethene-conjugated adenosine 5'-triphosphate (BODIPY-ATP) and...
Annelise Soulier et al.
Blood, 122(19), 3288-3297 (2013-10-02)
Although the inhibitory effects of therapeutic glucocorticoids (GCs) on dendritic cells (DCs) are well established, the roles of endogenous GCs in DC homeostasis are less clear. A critical element regulating endogenous GC concentrations involves local conversion of inactive substrates to...
Mingyi Xie et al.
Cell, 155(7), 1568-1580 (2013-12-24)
MicroRNAs (miRNAs) are short RNA gene regulators typically produced from primary transcripts that are cleaved by the nuclear microprocessor complex, with the resulting precursor miRNA hairpins exported by exportin 5 and processed by cytoplasmic Dicer to yield two (5p and 3p) miRNAs....
Jeremy Bastid et al.
Cancer immunology research, 3(3), 254-265 (2014-11-19)
The ectonucleotidases CD39 and CD73 hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to generate adenosine, which binds to adenosine receptors and inhibits T-cell and natural killer (NK)-cell responses, thereby suppressing the immune system. The generation of adenosine via...
Dueling nucleosides: cross-regulation of extracellular adenosine by guanosine. Focus on "Extracellular guanosine regulates extracellular adenosine levels".
George R Dubyak
American journal of physiology. Cell physiology, 304(5), C403-C405 (2013-01-18)
Emilia Daghir-Wojtkowiak et al.
Journal of chromatography. A, 1403, 54-62 (2015-06-04)
The objective of this study was to model the retention of nucleosides and pterins in hydrophilic interaction liquid chromatography (HILIC) via QSRR-based approach. Two home-made (Amino-P-C18, Amino-P-C10) and one commercial (IAM.PC.DD2) HILIC stationary phases were considered. Logarithm of retention factor...
Giovanni Gottarelli et al.
Chemical record (New York, N.Y.), 4(1), 39-49 (2004-04-02)
Several supramolecular architectures generated by guanosine derivatives are described. The research started from the fortuitous observation of a lyotropic behavior exhibited by a guanylic nucleotide in water. This observation stimulated extensive research on several natural and lipophilic guanosine derivatives which...
Basel A Abdel-Wahab et al.
Pharmacology, biochemistry, and behavior, 135, 105-113 (2015-06-06)
Levetiracetam (LEV) is a unique, effective, relatively safe antiepileptic drug that preferentially interacts with synaptic vesicle protein 2A (SV2A). This study aimed to explore the effect of combined treatment of LEV with omega 3 (OM3) on cognitive impairment and hippocampal...
Jia Zhou et al.
The Journal of biological chemistry, 288(38), 27263-27272 (2013-08-09)
The telomeric DNA of vertebrates consists of d(TTAGGG)n tandem repeats, which can form quadruplex DNA structures in vitro and likely in vivo. Despite the fact that the G-rich telomeric DNA is susceptible to oxidation, few biochemical studies of base excision...
Lokesh et al.
Chemical communications (Cambridge, England), 49(20), 2049-2051 (2013-03-28)
A novel weakly ordered chiral lyotropic alignment medium, derived by the self-assembly of guanosine 5'-monophosphate (5'-GMP):guanosine for scaling RDCs to desired strengths and for the discrimination of enantiomers, is reported. The preparation of this inexpensive mesophase is straightforward, requires less...
Zofia Iskierko et al.
Biosensors & bioelectronics, 74, 526-533 (2015-07-18)
A novel recognition unit of chemical sensor for selective determination of the inosine, renal disfunction biomarker, was devised and prepared. For that purpose, inosine-templated molecularly imprinted polymer (MIP) film was deposited on an extended-gate field-effect transistor (EG-FET) signal transducing unit....
Rossella Sartorius et al.
EMBO molecular medicine, 7(7), 973-988 (2015-04-19)
Filamentous bacteriophage fd particles delivering antigenic determinants via DEC-205 (fdsc-αDEC) represent a powerful delivery system that induces CD8(+) T-cell responses even when administered in the absence of adjuvants or maturation stimuli for dendritic cells. In order to investigate the mechanisms...
Jia-Xuan Qiu et al.
Drug design, development and therapy, 9, 349-417 (2015-01-23)
Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells using the approach...
Katharina Röttger et al.
The journal of physical chemistry. A, 117(12), 2469-2478 (2013-03-21)
Guanosine (G) derivatives in nonpolar aprotic solvents self-assemble to intricate hydrogen-bonded supramolecular architectures, including dimers, ribbons, and cyclic quartets. Considerable interest exists in the nature of the excited electronic states, their lifetimes and the radiationless deactivation mechanisms of the molecules...
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