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Seok Mo Lee et al.
Clinical nuclear medicine, 40(12), 950-958 (2015-09-12)
Data in the literature regarding the use of F-FDG avidity of non-small cell lung cancer (NSCLC) as an imaging biomarker to predict the status of epidermal growth factor receptor (EGFR) mutation are conflicting. Association between KRAS mutation and FDG avidity
Ying Tian et al.
Nuclear medicine communications, 36(9), 892-897 (2015-05-02)
Extramammary Paget's disease (EMPD) is rare, and limited data have been reported on the utilization of fluorine-18 fluorodeoxyglucose PET/computed tomography ((18)F-FDG PET/CT) in this disease. The aim of this study is to evaluate the role of (18)F-FDG PET/CT in the
Zhiguo Zhang et al.
Nature communications, 5, 5493-5493 (2014-11-26)
Obesity develops when energy intake exceeds energy expenditure. Promoting brown adipose tissue formation and function increases energy expenditure and hence may counteract obesity. Berberine (BBR) is a compound derived from the Chinese medicinal plant Coptis chinensis. Here we show that
Nathalie L Jansen et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(1), 9-15 (2014-12-30)
Despite advances in diagnosis and the use of different therapeutic regimens in astrocytic high-grade glioma (HGG), the prognosis for patients remains grim. Additional pretherapeutic information is needed to tailor management. To gain additional prognostic information at primary diagnosis, we investigated
P P Shah et al.
Oncogene, 34(13), 1709-1717 (2014-04-22)
Ubiquilin1 (UBQLN1) is a ubiquitin-like domain and a ubiquitin-associated domain containing protein that has been reported to be involved in shuttling proteins to the proteasome, especially during endoplasmic reticulum-associated protein degradation. Thus, UBQLN1 function has been shown to be critical
Cornelia Brendle et al.
Investigative radiology, 50(5), 339-346 (2015-01-15)
The objective of this study was to evaluate the frequency and characteristics of artifacts in segmentation-based attenuation correction maps (μ-maps) of positron emission tomography/magnetic resonance (PET/MR) and their impact on PET interpretation and the standardized uptake value (SUV) quantification in
Joke Parthoens et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(6), 856-864 (2015-04-29)
We evaluated the glucose metabolism after microinjections of a GABAA antagonist, bicuculline, and a GABAA agonist, muscimol, in the rat prelimbic cortex (PL) by small animal positron emission tomography (μPET). Following a microinjection of either 0.5 μl bicuculline (0.1 mg/ml), muscimol (1 mg/ml)
Hyun Jung Koo et al.
Medicine, 94(27), e1095-e1095 (2015-07-15)
The aim of this study was to analyze the clinical, computed tomography (CT), and positron emission tomography (PET) findings of sarcoidosis, sarcoid reaction, and malignant lymph nodes (LNs) to the results of transbronchial LN aspiration and biopsy (TBNA).The TBNA results
Yoshifumi Noda et al.
European radiology, 25(10), 3009-3016 (2015-04-10)
To evaluate the usefulness of Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18-F FDG-PET/CT) in the prediction of Fuhrman pathological grades of renal clear cell carcinoma (cRCC). This retrospective study was approved by our institutional review board, and written informed consent
Ya-Yao Huang et al.
EJNMMI research, 4(1), 71-71 (2015-06-28)
[(18) F]AFM is a potent and promising PET imaging agent for the serotonin transporter. We carried out an acute toxicity study in rats and radiation dosimetry in monkeys before the translation of the tracer to humans. Single- and multiple-dose toxicity studies
Simon Puttick et al.
Molecular imaging, 14, 385-399 (2015-07-29)
Noninvasive imaging is a critical technology for diagnosis, classification, and subsequent treatment planning for patients with glioblastoma. It has been shown that the EphA2 receptor tyrosine kinase (RTK) is overexpressed in a number of tumors, including glioblastoma. Expression levels of
Azadeh Firouzian et al.
EJNMMI research, 4, 69-69 (2015-01-17)
Defining tumour volume for treatment response and radiotherapy planning is challenging and prone to inter- and intra-observer variability. Various automated tumour delineation methods have been proposed in the literature, each having abilities and limitations. Therefore, there is a need to
Valeria Ferretti et al.
Molecular pharmaceutics, 12(5), 1501-1511 (2015-03-21)
Co-crystals are crystalline complexes of two or more molecules bound together in crystal lattices through noncovalent interactions. The solubility and dissolution properties of co-crystals can allow to increase the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). It is currently
Karolina Skagen et al.
International journal of stroke : official journal of the International Stroke Society, 10(5), 730-736 (2015-01-16)
Carotid artery plaque inflammation is thought to be an important marker of plaque vulnerability and increased stroke risk. The main aim of this study was to assess the level of agreement between 2-deoxy-2-[(18)F] fluoro-D-glucose (18F-FDG) uptake on PET (positron emission
Seong-Jang Kim et al.
Clinical nuclear medicine, 40(12), 930-935 (2015-07-24)
: The goal of the present study was to determine whether volumetric parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured by sequential F-FDG PET/CT imaging could be used as prognostic factors in patients with locally
Eun Young Kim et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 10(12), 1795-1799 (2015-10-21)
The primary objective of this study was to determine the prognostic significance of computed tomography (CT)-determined sarcopenia in small-cell lung cancer (SCLC) patients. This retrospective study consisted of a total of 149 consecutive SCLC patients. The cross-sectional area of muscle
Marc C Mabray et al.
Clinical imaging, 39(6), 1073-1079 (2015-09-02)
The purpose was to test whether patient's primary malignancy type and presence of F-18-fluorodeoxyglucose (FDG)-avid cervical lymph node(s) are predictors of pathologic outcome of incidental focal FDG-avid parotid lesions. A retrospective cohort study of pathologically proven incidental cases was performed.
Jeffrey M Miller et al.
Synapse (New York, N.Y.), 70(1), 24-32 (2015-10-02)
Bipolar disorder (BD) is associated with abnormalities in the serotonin transporter (5-HTT), but specific in vivo findings have been discrepant. Using positron emission tomography (PET) and [(11)C]DASB, we compared 5-HTT binding between unmedicated depressed BD subjects and healthy volunteers (HVs).
Angela S Koh et al.
European journal of nuclear medicine and molecular imaging, 42(10), 1551-1561 (2015-05-28)
Longstanding uncontrolled atherogenic risk factors may contribute to left atrial (LA) hypertension, LA enlargement (LAE) and coronary vascular dysfunction. Together they may better identify risk of major adverse cardiac events (MACE). The aim of this study was to test the
Ken Herrmann et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(6), 855-861 (2015-04-18)
Prostate-specific membrane antigen (PSMA) is a promising target for diagnosis and treatment of prostate cancer. EuK-Subkff-(68)Ga-DOTAGA ((68)Ga-PSMA Imaging & Therapy [PSMA I&T]) is a recently introduced PET tracer for imaging PSMA expression in vivo. Whole-body distribution and radiation dosimetry of
Azusa Tokue et al.
Annals of nuclear medicine, 29(6), 499-505 (2015-04-17)
The aim of the current study was to evaluate the utility of F-18-fluoro-2-deoxy-D-glucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) in assessing patients diagnosed with immunoglobulin G4 (IgG4)-related disease (IgG4-RD) with inflammation of the head and neck glands. We reviewed
Dongwoo Kim et al.
Thyroid : official journal of the American Thyroid Association, 25(11), 1249-1254 (2015-09-04)
The Hounsfield unit (HU) ratio of thyroid nodules was assessed compared to the contralateral thyroid lobe on noncontrast computed tomography (CT) to stratify further the risk of malignancy in thyroid incidentalomas found on 18F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/CT (PET/CT). This
Catharina M L Zegers et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(24), 6389-6397 (2014-10-16)
Increased tumor metabolism and hypoxia are related to poor prognosis in solid tumors, including non-small cell lung cancer (NSCLC). PET imaging is a noninvasive technique that is frequently used to visualize and quantify tumor metabolism and hypoxia. The aim of
Bugra Kaya et al.
Clinical imaging, 39(4), 632-635 (2015-02-25)
We aimed to investigate the impact of chemotherapy on (18)F-FDG uptake in the liver and mediastinal blood pool (MBP) among patients with non-Hodgkin's lymphoma. Twenty-three patients with NHL underwent baseline, interim, and postchemotherapy (18)F-FDG PET/CT. SUVmax and SUVmean values of
Y Noh et al.
AJNR. American journal of neuroradiology, 36(11), 2010-2016 (2015-08-22)
In the early stages of idiopathic Parkinson disease, motor symptoms are usually asymmetric. We aimed to assess the feasibility of nigrosome 1 detection at 3T MR imaging to analyze the agreement of its asymmetry and clinical laterality. High-resolution 3D multiecho
I Suridjan et al.
Molecular psychiatry, 20(12), 1579-1587 (2015-02-25)
Our primary aim was to compare neuroinflammation in cognitively intact control subjects and patients with Alzheimer's disease (AD) by using positron emission tomography (PET) with translocator protein 18 kDa (TSPO)-specific radioligand [(18)F]-FEPPA. [(18)F]-FEPPA PET scans were acquired on a high-resolution
C Kobe et al.
Nuklearmedizin. Nuclear medicine, 54(6), 241-246 (2015-09-22)
The aim was to analyze the degree of agreement between the central review panel and the local PET interpretation within the HD15 trial and its impact on subsequent treatment and progression free survival. The analysis set consisted of 739 patients
Shang-Wen Chen et al.
The Laryngoscope, 124(12), 2732-2738 (2014-07-22)
The study aimed to investigate the prognostic effects of interim (18) fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (PET/CT) during definitive radiotherapy (RT) or chemoradiotherapy (CRT) in patients with head and neck cancer. This is a prospectively treatment study. The pretreatment and
Martin W Huellner et al.
EJNMMI research, 4(1), 6-6 (2014-01-24)
The purpose of this study was to assess the relationship of CT-perfusion (CTP), 18F-FDG-PET/CT and histological parameters, and the possible added value of CTP to FDG-PET/CT in the initial staging of lung cancer. Fifty-four consecutive patients (median age 65 years
Ting Shen et al.
PloS one, 10(4), e0122756-e0122756 (2015-04-09)
To evaluate and compare the prognostic value of Epstein-Barr virus (EBV) DNA and maximal standard uptake values (SUVmax ) of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG-PET) in subgroups of nasopharyngeal carcinoma (NPC) patients with locoregional or distant recurrence. A total of
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