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Lorenz Deserno et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(5), 1595-1600 (2015-01-22)
Dual system theories suggest that behavioral control is parsed between a deliberative "model-based" and a more reflexive "model-free" system. A balance of control exerted by these systems is thought to be related to dopamine neurotransmission. However, in the absence of
Eun Young Kim et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 10(12), 1795-1799 (2015-10-21)
The primary objective of this study was to determine the prognostic significance of computed tomography (CT)-determined sarcopenia in small-cell lung cancer (SCLC) patients. This retrospective study consisted of a total of 149 consecutive SCLC patients. The cross-sectional area of muscle
Seok Mo Lee et al.
Clinical nuclear medicine, 40(12), 950-958 (2015-09-12)
Data in the literature regarding the use of F-FDG avidity of non-small cell lung cancer (NSCLC) as an imaging biomarker to predict the status of epidermal growth factor receptor (EGFR) mutation are conflicting. Association between KRAS mutation and FDG avidity
Armin Kolb et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(6), 951-954 (2015-03-15)
Simultaneous PET/MR imaging is an emerging hybrid modality for clinical and preclinical imaging. The static magnetic field of the MR imaging device affects the trajectory of the positrons emitted by the PET radioisotopes. This effect translates into an improvement of
Abolfazl Mehranian et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(4), 635-641 (2015-03-07)
Time-of-flight (TOF) PET/MR imaging is an emerging imaging technology with great capabilities offered by TOF to improve image quality and lesion detectability. We assessed, for the first time, the impact of TOF image reconstruction on PET quantification errors induced by
Christos Sachpekidis et al.
Clinical nuclear medicine, 40(6), e300-e307 (2015-03-19)
The value of F-FDG PET in the diagnostic approach of multiple myeloma (MM) remains incompletely elicited. Little is known about the kinetics of F-FDG in the bone marrow and extramedullary sites in MM. This study aimed to evaluate quantitative data
Y Noh et al.
AJNR. American journal of neuroradiology, 36(11), 2010-2016 (2015-08-22)
In the early stages of idiopathic Parkinson disease, motor symptoms are usually asymmetric. We aimed to assess the feasibility of nigrosome 1 detection at 3T MR imaging to analyze the agreement of its asymmetry and clinical laterality. High-resolution 3D multiecho
Ya-Yao Huang et al.
EJNMMI research, 4(1), 71-71 (2015-06-28)
[(18) F]AFM is a potent and promising PET imaging agent for the serotonin transporter. We carried out an acute toxicity study in rats and radiation dosimetry in monkeys before the translation of the tracer to humans. Single- and multiple-dose toxicity studies
Cornelia Brendle et al.
Investigative radiology, 50(5), 339-346 (2015-01-15)
The objective of this study was to evaluate the frequency and characteristics of artifacts in segmentation-based attenuation correction maps (μ-maps) of positron emission tomography/magnetic resonance (PET/MR) and their impact on PET interpretation and the standardized uptake value (SUV) quantification in
Joke Parthoens et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(6), 856-864 (2015-04-29)
We evaluated the glucose metabolism after microinjections of a GABAA antagonist, bicuculline, and a GABAA agonist, muscimol, in the rat prelimbic cortex (PL) by small animal positron emission tomography (μPET). Following a microinjection of either 0.5 μl bicuculline (0.1 mg/ml), muscimol (1 mg/ml)
Zhitao Liang et al.
Journal of pharmaceutical and biomedical analysis, 105, 121-133 (2014-12-30)
The root and rhizome of Panax ginseng C.A. Mey, known as ginseng, is a commonly used medicinal plant. Ginsenosides are the major active components responsible for the tonic effects of this herb. Here, the combination of laser microdissection and ultra-high
Nathalie Van Den Berge et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(3), 373-383 (2014-11-02)
The effects of deep brain stimulation (DBS) have been studied primarily by cellular studies, which lack the ability to elucidate DBS-related responses on a whole-brain scale. 2-Deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography ([(18)F]FDG-PET) reflects changes in neural activity throughout the entire brain
Tanja Seifen et al.
European journal of nuclear medicine and molecular imaging, 42(2), 272-277 (2014-09-17)
We evaluated (18)F-fluoride PET/CT for the diagnosis of screw loosening after intervertebral fusion stabilization and compared the results with those from functional radiography. A group of 59 patients with pain in the region of previous intervertebral fusion stabilization and suspicion
D Di Gioia et al.
British journal of cancer, 112(5), 809-818 (2015-02-04)
Follow-up care in breast cancer is still an issue of debate. Diagnostic methods are more sensitive, and more effective therapeutic options are now available. The risk of recurrence is not only influenced by tumour stage but also by the different
C Kobe et al.
Nuklearmedizin. Nuclear medicine, 54(6), 241-246 (2015-09-22)
The aim was to analyze the degree of agreement between the central review panel and the local PET interpretation within the HD15 trial and its impact on subsequent treatment and progression free survival. The analysis set consisted of 739 patients
Claudio Scafoglio et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(30), E4111-E4119 (2015-07-15)
Glucose is a major metabolic substrate required for cancer cell survival and growth. It is mainly imported into cells by facilitated glucose transporters (GLUTs). Here we demonstrate the importance of another glucose import system, the sodium-dependent glucose transporters (SGLTs), in
Markus Kajo Schuler et al.
Clinical imaging, 39(5), 866-870 (2015-06-29)
(18)F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) has proven to be of substantial benefit in imaging of sarcoma patients. We therefore investigated the feasibility and benefit of combined PET/magnetic resonance imaging (MRI). Twelve patients with sarcoma who underwent FDG PET/MRI for
Ronnarit Cheirsilp et al.
Computers in biology and medicine, 62, 222-238 (2015-05-11)
X-ray computed tomography (CT) and positron emission tomography (PET) serve as the standard imaging modalities for lung-cancer management. CT gives anatomical details on diagnostic regions of interest (ROIs), while PET gives highly specific functional information. During the lung-cancer management process
Kim A Muñoz-Álvarez et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(4), 728-736 (2015-01-23)
Hepatocellular carcinoma (HCC) is the most predominant form of liver cancer and the third leading cause of cancer-related death worldwide. Due to the relative ineffectiveness of conventional HCC therapies, oncolytic viruses have emerged as novel alternative treatment agents. Our previous
Maki Okada et al.
Nuclear medicine communications, 36(12), 1239-1248 (2015-09-24)
The blood-brain barrier (BBB) limits the entry of some therapeutics into the brain, resulting in reduced efficacy. BBB-opening techniques have been developed to enhance the entry into the brain. However, a noninvasive, highly sensitive and quantitative method for evaluating the
Hye Jin Yoo et al.
The American journal of cardiology, 115(4), 523-528 (2014-12-23)
Recent studies have suggested that body size phenotype may contribute to atherosclerosis and cardiovascular disease. (18)F-fluorodeoxyglucose (FDG) positron emission tomography is a useful imaging technique for detecting vascular inflammation that may reflect plaque vulnerability. Therefore, we analyzed which body size
Natale Quartuccio et al.
AJR. American journal of roentgenology, 204(1), 153-160 (2014-12-30)
The purpose of this study was to compare the diagnostic performance of (18)F-FDG PET/CT and conventional imaging for staging and follow-up of pediatric osteosarcoma and skeletal Ewing sarcoma. We calculated sensitivity, specificity, and accuracy of PET/CT and conventional imaging (CT
Andreas Pfeifer et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(6), 847-854 (2015-05-09)
Neuroendocrine tumors (NETs) can be visualized using radiolabeled somatostatin analogs. We have previously shown the clinical potential of (64)Cu-DOTATATE in a small first-in-human feasibility study. The aim of the present study was, in a larger prospective design, to compare on
Dario Camellino et al.
Arthritis research & therapy, 16(6), 492-492 (2014-12-02)
Polymyalgia rheumatica (PMR) is a common inflammatory disease in older people characterized by shoulder and/or pelvic girdle, and cervical and, occasionally, lumbar pain. Interspinous bursitis has been suggested as a potential cause of spinal symptoms. We evaluated, by 18 F-fluorodeoxyglucose (FDG)
Kazuhiro Kitajima et al.
European journal of nuclear medicine and molecular imaging, 42(8), 1268-1275 (2015-04-03)
To evaluate the usefulness of metabolic parameters obtained by (18)F-FDG PET/CT for preoperative stratification of high-risk and low-risk endometrial carcinomas. Preoperative (18)F-FDG PET/CT was performed in 56 women with endometrial cancer. Maximum standardized uptake values (SUVmax), metabolic tumour volume (MTV)
Marin Talbot Brewer et al.
Phytopathology, 105(6), 815-824 (2015-02-25)
Combining population genetics with epidemiology provides insight into the population biology of pathogens, which could lead to improved management of plant diseases. Gummy stem blight, caused by three closely related species of Stagonosporopsis-Stagonosporopsis cucurbitacearum (syn. Didymella bryoniae), S. citrulli, and
Kazuhiro Ueda et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 47(5), 905-911 (2014-08-16)
The aim of the present study was to clarify the differences between lung cancer arising in emphysematous lungs and that arising in nonemphysematous lungs with regard to radiopathological features and the postoperative recurrence rate. We retrospectively reviewed a prospective database
Tilman Läppchen et al.
European journal of medicinal chemistry, 89, 279-295 (2014-12-03)
Calixarene 0118 is a potent anti-angiogenic agent that effectively inhibited tumor growth in preclinical studies, and is currently being evaluated in a phase I clinical trial. We have designed two close mimetics of calixarene 0118 containing a terminal alkynyl-functional group
Francesco Collamati et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(1), 3-8 (2014-12-17)
A novel radioguided surgery (RGS) technique for cerebral tumors using β(-) radiation is being developed. Checking for a radiotracer that can deliver a β(-) emitter to the tumor is a fundamental step in the deployment of such a technique. This
Yung-Chih Kuo et al.
International journal of pharmaceutics, 479(1), 138-149 (2015-01-07)
Lactoferrin (Lf) and folic acid (FA) were crosslinked on poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) for transporting etoposide across the blood-brain barrier (BBB) and treating human brain malignant glioblastoma. Lf- and FA-grafted PLGA NPs (Lf/FA/PLGA NPs) were employed to permeate the monolayer
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