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76511

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Lele Guo et al.
PloS one, 10(4), e0124002-e0124002 (2015-04-14)
Treatment of systemic lupus erythematosus (SLE), a chronic inflammatory disease, involves the long-term use of immunosuppressive agents with significant side effects. New therapeutic approaches are being explored to find better treatment possibilities. In this study, age-matched female MRL/lpr mice were...
Y J Chun et al.
Biochemical and biophysical research communications, 262(1), 20-24 (1999-08-17)
Resveratrol (trans-3,4',5-trihydroxystilbene) is a phytoalexin compound found in juice and wine produced from dark-skinned grape cultivars and reported to have anti-inflammatory and anticarcinogenic activities. To investigate the mechanism of anticarcinogenic activities of resveratrol, the effects on cytochrome P450 (P450) were...
Jamie L Barger
Annals of the New York Academy of Sciences, 1290, 122-129 (2013-07-17)
Adipose tissue is an active endocrine organ that responds to changes in energy balance and influences whole-body physiology. Adipose tissue dysfunction with obesity is associated with metabolic disease, neurodegeneration, inflammation, and cancer, whereas calorie restriction (CR) decreases both adiposity and...
Li-Xue Zhang et al.
World journal of gastroenterology, 20(41), 15335-15342 (2014-11-12)
To investigate the effects and underlying mechanisms of resveratrol and genistein on contractile responses of rat gastrointestinal smooth muscle. Isolated strips of gastrointestinal smooth muscle from Spraque-Dawley rats were suspended in organ baths containing Kreb's solution, and the contractility of...
U Schube et al.
The Journal of clinical endocrinology and metabolism, 99(1), 229-239 (2013-10-31)
Obese women suffer from anovulation and infertility, which are driven by oxidative stress caused by increased levels of lipid peroxides and circulating oxidized low-density lipoprotein (oxLDL). OxLDL binds to lectin-like oxLDL receptor 1 (LOX-1), cluster of differentiation 36 (CD36), and...
Moammir H Aziz et al.
Molecular cancer therapeutics, 5(5), 1335-1341 (2006-05-30)
Prostate cancer is a major health problem in the U.S. and the available treatment and surgical options have proven to be inadequate in controlling the mortality and morbidity associated with this disease. It is therefore necessary to intensify our efforts...
Renu Rajguru
Aviation, space, and environmental medicine, 84(12), 1268-1276 (2014-01-28)
Modern-day high performance aircraft are more powerful, more efficient, and, unfortunately, frequently produce high noise levels, resulting in noise-induced hearing loss (NIHL) in military aircrew. Military pilots are required to perform many flight duties correctly in the midst of many...
H-J Wang et al.
Andrologia, 47(1), 59-65 (2014-01-25)
The detrimental effects on Leydig cells steroidogenesis in mice on high-calorie and high-cholesterol diet (HCD) were determined, and the possible protection conferred by resveratrol supplementation was investigated. Male C57BL/6J mice were fed high-calorie and alone (HCD group) or with resveratrol...
Beobyi Lee et al.
The Journal of nutrition, 135(12), 2767-2773 (2005-12-01)
Resveratrol (RV), a polyphenolic substance found in grape skin, was suggested to play a role in preventing the development of atherosclerotic disease. Although RV has antiatherogenic effects on vascular smooth muscle cells (VSMC), the molecular mechanisms associated with tumor necrosis...
Kyuhwa Seo et al.
Toxicology and applied pharmacology, 280(2), 314-322 (2014-08-26)
Methylglyoxal is found in high levels in the blood and other tissues of diabetic patients and exerts deleterious effects on cells and tissues. Previously, we reported that resveratrol, a polyphenol in grapes, induced the expression of Sestrin2 (SESN2), a novel...
Yoon-Jin Lee et al.
Journal of Korean medical science, 29(11), 1464-1472 (2014-11-20)
Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition of Bcl-xL influences cell growth and apoptosis against simultaneous treatment...
Matthias R Meyer et al.
Scientific reports, 4, 7564-7564 (2014-12-24)
Coronary atherosclerosis and myocardial infarction in postmenopausal women have been linked to inflammation and reduced nitric oxide (NO) formation. Natural estrogen exerts protective effects on both processes, yet also displays uterotrophic activity. Here, we used genetic and pharmacologic approaches to...
Hyung-Ip Kim et al.
Bioscience, biotechnology, and biochemistry, 79(3), 475-483 (2014-12-18)
In this study, we investigated antibacterial activities of 20 plant-derived natural compounds against Gram-negative enteric pathogens. We found that both flavonoids and non-flavonoids, including honokiol and magnolol, possess specific antibacterial activities against V. cholerae, but not against other species of...
Gurinder Singh et al.
Expert opinion on drug delivery, 11(5), 647-659 (2014-03-26)
Trans-resveratrol (t-RVT) is a potent antioxidant. The drug suffers enterohepatic recirculation and extensive first-pass metabolism by CYP3A4 in liver, resulting in very low bioavailability (almost zero). The current studies entail a novel formulation approach to develop systematically optimized (OPT) nanoparticles...
Timothy M Bass et al.
Mechanisms of ageing and development, 128(10), 546-552 (2007-09-19)
It was recently reported that the plant polyphenol resveratrol, found, e.g., in grape berry skins, extended lifespan in the fruit fly Drosophila melanogaster and the nematode worm Caenorhabditis elegans. This lifespan extension was dependent on an NAD(+)-dependent histone deacetylase, Sir2...
H J Kim et al.
Bone & joint research, 3(3), 51-59 (2014-03-13)
Resveratrol is a polyphenolic compound commonly found in the skins of red grapes. Sirtuin 1 (SIRT1) is a human gene that is activated by resveratrol and has been shown to promote longevity and boost mitochondrial metabolism. We examined the effect of...
Adriana Borriello et al.
Cancer treatment and research, 159, 167-184 (2013-10-12)
Plants produce a remarkable amount of low molecular mass natural products endowed with a large array of pivotal biological activities. Among these molecules, resveratrol (3,5,4'-trihydroxystilbene) has been identified as an important modulator of cell phenotype with a complex and pleiotropic...
K Vanaja et al.
Life sciences, 93(24), 917-923 (2013-11-02)
Resveratrol (RES) is a well-known antioxidant, yet in combination with other antioxidant vitamins, it was found to be more effective than any of these antioxidants alone. Present work aims to compare the antioxidant actions of resveratrol with and without vitamin...
Chandrasekharam N Nagineni et al.
Aging and disease, 5(2), 88-100 (2014-04-15)
Age-related macular degeneration (AMD) is a sight threating retinal eye disease that affects millions of aging individuals world-wide. Choroid-retinal pigment epithelium (RPE)-neuroretina axis in the posterior compartment of the eye is the primary site of AMD pathology. There are compelling...
John T Barr et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 34-41 (2014-10-19)
The mechanistic understanding of interactions between diet-derived substances and conventional medications in humans is nascent. Most investigations have examined cytochrome P450-mediated interactions. Interactions mediated by other phase I enzymes are understudied. Aldehyde oxidase (AO) is a phase I hydroxylase that...
Amirhossein Sahebkar
Nutrition reviews, 71(12), 822-835 (2013-10-12)
A systematic review and meta-analysis of available evidence was conducted to obtain a conclusive result on the lipid-modulating effects of resveratrol. Seven randomized controlled trials with a total of 282 subjects (141 in each group) met the eligibility criteria. Overall...
Marta N Valcárcel-Ares et al.
Rheumatology (Oxford, England), 53(7), 1332-1343 (2014-03-13)
In RA, synoviocytes cause increased oxidative stress, leading to mitochondrial alterations that may participate in the pathogenesis of RA. Here we investigated whether mitochondrial dysfunction induces inflammatory responses in cultured normal human synoviocytes, a hallmark of RA. Mitochondrial dysfunction was...
Thimmappa S Anekonda
Brain research reviews, 52(2), 316-326 (2006-06-13)
Resveratrol, a red wine polyphenol, is known to protect against cardiovascular diseases and cancers, as well as to promote antiaging effects in numerous organisms. It also modulates pathomechanisms of debilitating neurological disorders, such as strokes, ischemia, and Huntington's disease. The...
Adam Khader et al.
The Journal of surgical research, 193(2), 807-815 (2014-09-13)
Renal ischemia-reperfusion (I/R) is a severe clinical complication with no specific treatment. Resveratrol has been shown as a promising experimental agent in renal I/R due to its effect on cellular energy metabolism, oxidative stress, and inflammation. Recently, we identified two...
Lin Song et al.
BioMed research international, 2014, 483501-483501 (2014-07-25)
Resveratrol has recently been used as a supplemental treatment for several neurological and nonneurological diseases. It is not known whether resveratrol has neuroprotective effect on amyotrophic lateral sclerosis (ALS). To assess the effect of resveratrol on the disease, we tested...
Chandra K Singh et al.
Annals of the New York Academy of Sciences, 1290, 113-121 (2013-07-17)
In recent years combination chemoprevention has been increasingly appreciated and investigated as a viable and effective strategy for cancer management. A plethora of evidence suggests that a combination of agents may afford synergistic (or additive) advantage for cancer management by...
John M Pezzuto et al.
Expert opinion on therapeutic patents, 23(12), 1529-1546 (2013-09-17)
There is currently a wealth of information on the effects of resveratrol and its derivatives in therapeutic, cosmetic and nutraceutical patent applications. Structure-activity studies of the resveratrol scaffold provide a foundation for the development of new analogs with potent activity...
Houhong Wang et al.
Experimental lung research, 40(6), 288-297 (2014-05-03)
Despite extensive research and clinical efforts made in the management of acute pancre-atitis during the past few decades, to date no effective cure is available and the mortality from severe acute pancre-atitis remains high. Given that lung is the primary...
Andrew Philp et al.
American journal of physiology. Cell physiology, 299(2), C240-C250 (2010-04-23)
Sodium pyruvate can increase mitochondrial biogenesis in C2C12 myoblasts in a peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC1alpha)-independent manner. The present study examined the effect of 72-h treatment with sodium pyruvate (5-50 mM) or sodium chloride (50 mM) as an osmotic control...
Xin Zhao et al.
Neuropharmacology, 85, 131-141 (2014-05-20)
Patients suffering from chronic neuropathic pain are at high risk of co-morbid depression, which burdens healthcare. This work aimed to investigate the effects of resveratrol, a phenolic monomer enriched in red wine and grapes, on pain-related and depressive-like behaviors in...
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