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Annie Moisan et al.
Nature cell biology, 17(1), 57-67 (2014-12-10)
The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of new therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white
Chee Man Cheong et al.
Experimental cell research, 332(1), 24-38 (2015-02-01)
Increased expression of the tetraspanin TSPAN7 has been observed in a number of cancers; however, it is unclear how TSPAN7 plays a role in cancer progression. We investigated the expression of TSPAN7 in the haematological malignancy multiple myleoma (MM) and
N Sumru Bayin et al.
PloS one, 9(12), e116114-e116114 (2014-12-30)
Glioblastoma multiforme (GBM) is a deadly primary brain malignancy. Glioblastoma stem cells (GSC), which have the ability to self-renew and differentiate into tumor lineages, are believed to cause tumor recurrence due to their resistance to current therapies. A subset of
Jeroen ten Dam et al.
ChemSusChem, 4(8), 1017-1034 (2011-09-03)
The production of renewable chemicals is gaining attention over the past few years. The natural resources from which they can be derived in a sustainable way are most abundant in sugars, cellulose and hemicellulose. These highly functionalized molecules need to
Kristian Karstoft et al.
American journal of physiology. Endocrinology and metabolism, 308(5), E426-E433 (2015-01-08)
The objective of this study was to assess the insulin-independent effects of incretin hormones on glucose and glycerol metabolism and hemodynamics under euglycemic and hyperglycemic conditions. Young, healthy men (n=10) underwent three trials in a randomized, controlled, crossover study. Each
Oliver Simon et al.
Journal of proteomics, 109, 212-227 (2014-07-16)
Understanding of the molecular response of bacteria to precursors, products and environmental conditions applied in bioconversions is essential for optimizing whole-cell biocatalysis. To investigate the molecular response of the potential biocatalyst Pseudomonas putida KT2440 to the flavor compound vanillin we
The quantitative determination of glycerol in beer by gas?liquid chromatography.
Parker E W and Richardson J P.
Journal of the Institute of Brewing, 76(2), 191-198 (1970)
Jayanta K Das et al.
Microvascular research, 98, 126-138 (2015-02-11)
While significant progress has been made to advance our knowledge of microvascular lesion formation, yet the investigation of how stem-like cells may contribute to the pathogenesis of microvascular diseases is still in its infancy. We assessed whether the inhibitor of
Bella Kalderon et al.
The Journal of biological chemistry, 290(6), 3542-3551 (2014-12-20)
Hsp60, an essential oligomeric molecular mitochondrial chaperone, has been subject to rigorous basic and clinical research. With yeast as a model system, we provide evidence for the ability of cytosolic yHsp60 to inhibit the yeast proteasome. (i) Following biological turnover
Karina Zitta et al.
Journal of translational medicine, 13, 34-34 (2015-01-28)
Transient episodes of ischemia in a remote organ (remote ischemic preconditioning, RIPC) can attenuate myocardial ischemia/reperfusion injury but the underlying mechanisms of RIPC in the target organ are still poorly understood. Recent animal studies suggested that the small redox protein
M Valenzuela et al.
British journal of cancer, 111(5), 874-882 (2014-07-09)
Standard therapy for acute promyelocytic leukaemia (APL) includes retinoic acid (all-trans retinoic acid (ATRA)), which promotes differentiation of promyelocytic blasts. Although co-administration of arsenic trioxide (ATO) with ATRA has emerged as an effective option to treat APL, the molecular basis
Neil T Umbreit et al.
Nature communications, 5, 4951-4951 (2014-09-23)
Kinetochores assemble on centromeric DNA and present arrays of proteins that attach directly to the dynamic ends of microtubules. Kinetochore proteins coordinate at the microtubule interface through oligomerization, but how oligomerization contributes to kinetochore function has remained unclear. Here, using
Yaarit Simchon-Tenenbaum et al.
Behavioural brain research, 282, 125-132 (2015-01-13)
Attention deficit hyperactivity disorder (ADHD) overdiagnosis and a pharmacological attempt to increase cognitive performance, are the major causes for the frequent (ab)use of psychostimulants in non-ADHD individuals. Methylphenidate is a non-addictive psychostimulant, although its mode of action resembles that of
Chika Tateda et al.
The Plant cell, 26(10), 4171-4187 (2014-10-16)
In Arabidopsis thaliana, responses to pathogen-associated molecular patterns (PAMPs) are mediated by cell surface pattern recognition receptors (PRRs) and include the accumulation of reactive oxygen species, callose deposition in the cell wall, and the generation of the signal molecule salicylic
Maria Schindler et al.
Endocrinology, 155(4), 1498-1509 (2014-01-17)
According to the "developmental origin of health and disease" hypothesis, the metabolic set points of glucose and lipid metabolism are determined prenatally. In the case of a diabetic pregnancy, the embryo is exposed to higher glucose and lipid concentrations as
Atsushi Konishi et al.
Biochemical and biophysical research communications, 454(2), 269-274 (2014-12-03)
We have previously used site-directed mutagenesis to introduce basic residues (i.e., Arg; Lys) in the nucleic acid binding cleft of the Moloney murine leukemia virus reverse transcriptase (MMLV RT) in order to increase its template-primer (T/P) binding affinity. Three stabilizing
Tim Sobolevsky et al.
Drug testing and analysis, 7(2), 131-142 (2014-11-28)
The data are reported for an in vitro metabolism study of two novel synthetic cannabinoids, N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) and its fluorinated analog N-(1-adamantyl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide (5F-APICA, STS-135), which are active ingredients of smoking mixtures sold in Russia since 2012. The cannabinoids were isolated
Francesca Fiory et al.
PloS one, 9(12), e113655-e113655 (2014-12-10)
The small scaffold protein PED/PEA-15 is involved in several different physiologic and pathologic processes, such as cell proliferation and survival, diabetes and cancer. PED/PEA-15 exerts an anti-apoptotic function due to its ability to interfere with both extrinsic and intrinsic apoptotic
Brett Deml et al.
PLoS genetics, 11(2), e1005002-e1005002 (2015-02-27)
Ocular coloboma results from abnormal embryonic development and is often associated with additional ocular and systemic features. Coloboma is a highly heterogeneous disorder with many cases remaining unexplained. Whole exome sequencing from two cousins affected with dominant coloboma with microcornea
Rajeswara Rao Arasada et al.
Cancer research, 74(19), 5572-5584 (2014-08-16)
Mutations in the epidermal growth factor receptor (EGFR) are the most common actionable genetic abnormalities yet discovered in lung cancer. However, targeting these mutations with kinase inhibitors is not curative in advanced disease and has yet to demonstrate an impact
Willem Flameng et al.
The Journal of thoracic and cardiovascular surgery, 149(1), 340-345 (2014-12-03)
Despite improved anticalcification technology, bioprosthetic heart valves still cannot be used in younger patients because of progressive structural valve degeneration. A novel advanced tissue preservation technology was developed that uses stable functional group capping and preservation by glycerolization. Valves incorporating
Jinous Samavat et al.
Fertility and sterility, 102(5), 1274-1281 (2014-09-18)
To compare spontaneous (Sp-AR) and P-induced acrosome reaction (AR) in spermatozoa of obese and lean subjects. Bariatric unit at a university hospital. Prospective, observational study. Twenty-three obese (mean±SD body mass index [BMI], 44.3±5.9 kg/m2) and 25 age-matched lean (BMI, 24.2±3.0
Marion Cortier et al.
Oncotarget, 6(9), 6877-6886 (2015-03-13)
High doses of the organic nitrate glyceryl trinitrate (GTN), a nitric oxide (NO) donor, are known to trigger apoptosis in human cancer cells. Here, we show that such a cytotoxic effect can be obtained with subtoxic concentrations of GTN when
Shuyuan Chen et al.
Biochemical and biophysical research communications, 458(4), 823-829 (2015-02-24)
Recently GLP-1 was found to have cardioprotective effects independent of those attributable to tight glycemic control. We employed ultrasound targeted microbubble destruction (UTMD) to deliver piggybac transposon plasmids encoding the GLP-1 gene with a nuclear localizing signal to rat hearts
Margaret Essenberg et al.
Phytopathology, 104(10), 1088-1097 (2014-03-25)
Near-isogenic lines of upland cotton (Gossypium hirsutum) carrying single, race-specific genes B4, BIn, and b7 for resistance to bacterial blight were used to develop a pyramid of lines with all possible combinations of two and three genes to learn whether
Amit Kumar Srivastava et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(14), 4411-4416 (2015-04-02)
Cancer stem cells (CSCs) with enhanced tumorigenicity and chemoresistance are believed to be responsible for treatment failure and tumor relapse in ovarian cancer patients. However, it is still unclear how CSCs survive DNA-damaging agent treatment. Here, we report an elevated
Daniele Maggioni et al.
Nutrition and cancer, 66(7), 1257-1267 (2014-09-27)
In this study the potential anticancer effect of 2 flavonoids, myiricetin (MYR) and naringenin (NAR) has been evaluated on an oral squamous cell carcinoma (OSCC) cell line, SCC-25, and HaCaT cells. Both the flavonoids inhibited SCC-25 cell growth, although NAR
Shinsuke Araki et al.
PloS one, 10(1), e0116929-e0116929 (2015-01-13)
Accumulating evidence has demonstrated the importance of alternative splicing in various physiological processes, including the development of different diseases. CDC-like kinases (CLKs) and serine-arginine protein kinases (SRPKs) are components of the splicing machinery that are crucial for exon selection. The
Marta Putrinš et al.
Infection and immunity, 83(3), 1056-1067 (2015-01-07)
Uropathogenic strains of Escherichia coli (UPEC) are the major cause of bacteremic urinary tract infections. Survival in the bloodstream is associated with different mechanisms that help to resist serum complement-mediated killing. While the phenotypic heterogeneity of bacteria has been shown
Tian Qiu et al.
Nature communications, 5, 5119-5119 (2014-11-05)
Biological microorganisms swim with flagella and cilia that execute nonreciprocal motions for low Reynolds number (Re) propulsion in viscous fluids. This symmetry requirement is a consequence of Purcell's scallop theorem, which complicates the actuation scheme needed by microswimmers. However, most
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