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Keum-Shik Hong et al.
Neuroscience letters, 587, 87-92 (2014-12-23)
Functional near-infrared spectroscopy (fNIRS) is an optical imaging method that can be used for a brain-computer interface (BCI). In the present study, we concurrently measure and discriminate fNIRS signals evoked by three different mental activities, that is, mental arithmetic (MA)
Eleonore Durand et al.
BMC evolutionary biology, 15, 103-103 (2015-06-08)
Long term selection experiments bring unique insights on the genetic architecture of quantitative traits and their evolvability. Indeed, they are utilized to (i) monitor changes in allele frequencies and assess the effects of genomic regions involved traits determinism; (ii) evaluate
Chan Mi Kim et al.
Current Alzheimer research, 12(6), 563-571 (2015-06-02)
Alzheimer's disease (AD) is the most common neurodegenerative disorder pathologically characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. The aggregation of Aβ precedes tau pathologies in AD; however, the causal relation between the two pathologies and the mechanisms by which
Yulia B Monakhova et al.
Talanta, 141, 60-65 (2015-05-13)
Discriminant analysis (DA) methods, such as linear discriminant analysis (LDA) or factorial discriminant analysis (FDA), are well-known chemometric approaches for solving classification problems in chemistry. In most applications, principle components analysis (PCA) is used as the first step to generate
Miren Ettcheto et al.
Experimental gerontology, 65, 69-78 (2015-03-24)
Previous studies suggest that Alzheimer's disease (AD) neurobiology could not be explained solely by an increase in β-amyloid levels. Recently, it has been proposed that alterations in brain cholesterol metabolism may contribute to the pathogenesis of AD. In the present
Hadrien D'inca et al.
The American journal of pathology, 185(7), 1877-1888 (2015-05-17)
The rabbit VX2 tumor is a fast-growing carcinoma model commonly used to study new therapeutic devices, such as catheter-based therapies for patients with inoperable hepatocellular carcinoma. The evaluation of tumor viability after such locoregional therapies is essential to directing hepatocellular
Fatemeh Shahbazi et al.
Computer methods and programs in biomedicine, 122(2), 191-198 (2015-09-08)
The aims of this study are summarized in the following items: first, to investigate the class discrimination power of long-term heart rate variability (HRV) features for risk assessment in patients suffering from congestive heart failure (CHF); second, to introduce the
Zhaobin Wu et al.
Journal of agricultural and food chemistry, 63(22), 5388-5394 (2015-05-21)
The objective of this study is to test the feasibility of multi-isotopic and elemental analyses combined with chemometric techniques for differentiating the botanical origins of major honey products in China. The stable isotope and elemental compositions of 57 honey samples
Shahla Hamza Al-Saqi et al.
Cell and tissue banking, 16(2), 181-193 (2014-08-15)
Mesenchymal stem cells (MSCs) have vast potential in cell therapy, and are experimentally used in the clinic. Therefore, it is critical to find a serum- and xeno-free cryopreservation method. The aim of this study was to compare two serum- and
Mogens K Boisen et al.
PloS one, 9(10), e109430-e109430 (2014-10-21)
We tested the hypothesis that expression of microRNAs (miRNAs) in cancer tissue can predict effectiveness of bevacizumab added to capecitabine and oxaliplatin (CAPEOX) in patients with metastatic colorectal cancer (mCRC). Patients with mCRC treated with first line CAPEOX and bevacizumab
Sanjeev Ahuja et al.
Biotechnology progress, 31(5), 1370-1380 (2015-06-23)
Characterization of manufacturing processes is key to understanding the effects of process parameters on process performance and product quality. These studies are generally conducted using small-scale model systems. Because of the importance of the results derived from these studies, the
Stefano Biffani et al.
Genetics, selection, evolution : GSE, 47, 4-4 (2015-02-06)
SNP (single nucleotide polymorphisms) genotype data are increasingly available in cattle populations and, among other things, can be used to predict carriers of specific haplotypes. It is therefore convenient to have a practical statistical method for the accurate classification of
Tetrahedron Letters, 47, 6405-6405 (2006)
Roberta Fusco et al.
BioMed research international, 2015, 237863-237863 (2015-09-05)
The purpose of our study was to evaluate the diagnostic value of an imaging protocol combining dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DW-MRI) in patients with suspicious breast lesions. A total of 31 breast lesions (15 malignant and 16
Leandi Liebenberg et al.
Journal of forensic sciences, 60(5), 1277-1282 (2015-03-17)
Historically, population differences were quantified using cranial indices. Even though the application of indices is associated with numerous statistical and methodological problems, the use of cranial indices to estimate ancestry persists as demonstrated by its inclusion in several recent papers
Juan Eugenio Iglesias et al.
NeuroImage, 115, 117-137 (2015-05-06)
Automated analysis of MRI data of the subregions of the hippocampus requires computational atlases built at a higher resolution than those that are typically used in current neuroimaging studies. Here we describe the construction of a statistical atlas of the
Diane N H Kim et al.
Journal of biomedical optics, 20(11), 111211-111211 (2015-08-26)
Standard algorithms for phase unwrapping often fail for interferometric quantitative phase imaging (QPI) of biological samples due to the variable morphology of these samples and the requirement to image at low light intensities to avoid phototoxicity. We describe a new
Pieter Laurens Baljon et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(6), 2398-2406 (2015-02-13)
The "local bend response" of the medicinal leech (Hirudo verbana) is a stimulus-response pathway that enables the animal to bend away from a pressure stimulus applied anywhere along its body. The neuronal circuitry that supports this behavior has been well
Sandi Wong et al.
mBio, 6(5), e00687-e00615 (2015-10-01)
Gut microbiota influence the development and physiology of their animal hosts, and these effects are determined in part by the composition of these microbial communities. Gut microbiota composition can be affected by introduction of microbes from the environment, changes in
Bjoern Titz et al.
Journal of proteomics, 128, 306-320 (2015-08-27)
Chronic obstructive pulmonary disease (COPD) is one of the most prevalent lung diseases. Cigarette smoking is the main risk factor for COPD. In this parallel-group clinical study we investigated to what extent the transitions in a chronic-exposure-to-disease model are reflected
Nan Hu et al.
Medicine, 94(5), e375-e375 (2015-02-06)
Epidermal growth factor receptor (EGFR) activating mutations are a predictor of tyrosine kinase inhibitor effectiveness in the treatment of non-small-cell lung cancer (NSCLC). The objective of this study is to build a model for predicting the EGFR mutation status of
J Brendan Ritchie et al.
PLoS computational biology, 11(6), e1004316-e1004316 (2015-06-25)
Recognizing an object takes just a fraction of a second, less than the blink of an eye. Applying multivariate pattern analysis, or "brain decoding", methods to magnetoencephalography (MEG) data has allowed researchers to characterize, in high temporal resolution, the emerging
Aristea Sideri et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(7), G591-G604 (2015-01-17)
In inflammatory bowel disease (IBD), obesity is associated with worsening of the course of disease. Here, we examined the role of obesity in the development of colitis and studied mesenteric fat-epithelial cell interactions in patients with IBD. We combined the
Martin E Gosnell et al.
Biochimica et biophysica acta, 1863(1), 56-63 (2015-10-04)
Hyperspectral imaging uses spectral and spatial image information for target detection and classification. In this work hyperspectral autofluorescence imaging was applied to patient olfactory neurosphere-derived cells, a cell model of a human metabolic disease MELAS (mitochondrial myopathy, encephalomyopathy, lactic acidosis
Levi J Hargrove et al.
JAMA, 313(22), 2244-2252 (2015-06-10)
Some patients with lower leg amputations may be candidates for motorized prosthetic limbs. Optimal control of such devices requires accurate classification of the patient's ambulation mode (eg, on level ground or ascending stairs) and natural transitions between different ambulation modes.
Joshua D Schaefferkoetter et al.
Physics in medicine and biology, 60(14), 5543-5556 (2015-07-03)
In the context of investigating the potential of low-dose PET imaging for screening applications, we developed methods to assess small lesion detectability as a function of the number of counts in the scan. We present here our methods and preliminary
Philip D Harvey et al.
Schizophrenia research, 166(1-3), 334-338 (2015-06-29)
We previously reported that treatment with 160mg/d of lurasidone improved cognitive performance in a manner superior to placebo, quetiapine XR 600mg/d, and lurasidone 80mg/d, based on a 6-week randomized trial of patients with an acute exacerbation of schizophrenia. The objective
Niels F Andersen et al.
European journal of haematology, 95(3), 211-217 (2014-10-30)
Syndecan-1 (SDC1), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF) and interleukin-6 (IL6) are expressed by malignant plasma cells and cells in the bone marrow microenvironment and may be involved in the angiogenic process in multiple myeloma (MM). In
Baihong Guo et al.
International journal of clinical and experimental medicine, 8(3), 3619-3628 (2015-06-13)
To detect the expression profile of bladder cancer and to delineate the interaction network of these genes in invasive bladder cancer. A total of 126 differentially expressed genes were identified, and input into STRING online database to delineate interaction network.
Maxence Urbani et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(45), 16252-16265 (2015-09-12)
The detailed synthesis and characterization of four ruthenium(II) complexes [RuLL'(NCS)2 ] is reported, in which L represents a 2,2'-bipyridine ligand functionalized at the 4,4' positions with benzo[1,2-b:4,5-b']dithiophene derivatives (BDT) and L' is 2,2'-bipyridine-4,4'-dicarboxylic acid unit (dcbpy) (NCS=isothiocyanate). The reaction conditions
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