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77607

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Eef Boets et al.
Nutrients, 7(11), 8916-8929 (2015-11-01)
Short chain fatty acids (SCFA), including acetate, propionate, and butyrate, are produced during bacterial fermentation of undigested carbohydrates in the human colon. In this study, we applied a stable-isotope dilution method to quantify the in vivo colonic production of SCFA...
Subburaj Vanitha et al.
Toxicology and industrial health, 31(12), 1185-1194 (2013-05-31)
The present study was designed to investigate the antinociceptive effects of methanolic leaf extract of Swietenia mahagoni (MESM) on acrylamide-induced painful neuropathy in rats. The intraperitoneal administration of acrylamide (30 mg/kg; for 24 consecutive days) has been employed for the...
Jiaqi Shi et al.
Environmental science and pollution research international, 20(9), 6138-6149 (2013-04-03)
The lethal doses (LD50s) of fluorinated, chlorinated, brominated, and iodinated benzene, phenol, and diphenyl ether in mice were ascertained respectively under the consistent condition. The acute toxicity of four benzenes orders in fluorobenzene (FB) < iodobenzene < chlorobenzene≈bromobenzene, that of four phenols orders in...
Alessio Innocenti et al.
Bioorganic & medicinal chemistry letters, 20(17), 5050-5053 (2010-08-03)
A series of polyphenolic derivatives, including resveratrol, dobutamine, curcumin, catechin and silymarine were investigated for the inhibition of all the catalytically active mammalian isozymes of the metalloprotein carbonic anhydrase (CA, EC 4.2.1.1), that is, CA I-CA XV. These polyphenols effectively...
C W Kwok et al.
Targeted oncology, 10(3), 365-373 (2014-10-09)
Triple negative breast cancers express receptors for gonadotropin-releasing hormone (GnRH) in more than 50% of the cases, which can be targeted with peptidic analogs of GnRH, such as triptorelin. The current study investigates cytotoxic activity of triptorelin as a monotherapy...
Saori Ishizaka et al.
Journal of equine science, 25(4), 65-72 (2015-01-06)
The effects of probiotics on horses are still controversial. The present study was a randomized, double-blinded, placebo-controlled crossover study designed to evaluate the ability of probiotics to improve intestinal conditions in adult horses. Fermented probiotics were administered to 10 healthy...
Joshua J Corrigan et al.
The Journal of physiology, 592(17), 3901-3916 (2014-06-22)
We tested the hypothesis that development of hypothermia instead of fever in endotoxic shock is consequential to hypoxia. Endotoxic shock was induced by bacterial lipopolysaccharide (LPS, 500 μg kg(-1) i.v.) in rats at an ambient temperature of 22 °C. A...
Yohei Sakaguchi et al.
The Analyst, 140(6), 1965-1973 (2015-02-12)
We have developed a novel amino acid analysis method using derivatization of multiple functional groups (amino, carboxyl, and phenolic hydroxyl groups). The amino, carboxyl, and phenolic hydroxyl groups of the amino acids were derivatized with 1-bromobutane so that the hydrophobicities...
Sandeep Kumar Dash et al.
Bioorganic chemistry, 63, 85-100 (2015-10-16)
The main complication in betulinic acid (BA) based drug delivery has been observed due to its bulk structure. The present study demonstrates the potential effects of self assembled nano size betulinic acid (SA-BA) by treating human leukemic cell lines (KG-1A...
Zizwe A Chase et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(46), 16541-16546 (2015-09-26)
The state of Ni supported on HZSM-5 zeolite, silica, and sulfonated carbon was studied during aqueous-phase catalysis of phenol hydrodeoxygenation using in situ extended X-ray absorption fine structure spectroscopy. On sulfonated carbon and HZSM-5 supports, NiO and Ni(OH)2 were readily...
Enbo Xu et al.
Journal of food science, 80(7), C1476-C1489 (2015-06-20)
Enzymatic extrusion, instead of traditional steam cooking, to treat rice is an efficient and alternative pretreatment for Chinese rice wine fermentation. In order to determine the formation of volatiles in enzymatic extrusion-processed rice wine (EE), and to confirm its characteristic...
Yu-Hong Cheng et al.
The Journal of biological chemistry, 290(23), 14302-14313 (2015-04-24)
Glucagon-like peptide-1 (GLP-1) analogs are approved for treatment of type 2 diabetes and are in clinical trials for disorders including neurodegenerative diseases. GLP-1 receptor (GLP-1R) is expressed in many peripheral and neuronal tissues and is activated by circulating GLP-1. Other...
Dimitar Petrov et al.
Acta chimica Slovenica, 61(4), 759-770 (2015-01-01)
In the present study bulk NiO(x) and supported NiO(x)/ZrO(2) catalysts have been prepared. The bulk NiO(x) was synthesized using the precipitation-oxidation method with reverse order of precipitation while deposition-precipitation technique was used for the preparation of zirconia supported catalyst. The...
Paul-Andre Genest et al.
Nucleic acids research, 43(4), 2102-2115 (2015-02-11)
Base J (β-D-glucosyl-hydroxymethyluracil) replaces 1% of T in the Leishmania genome and is only found in telomeric repeats (99%) and in regions where transcription starts and stops. This highly restricted distribution must be co-determined by the thymidine hydroxylases (JBP1 and...
Seda Kayhan et al.
Artificial cells, nanomedicine, and biotechnology, 43(4), 224-229 (2013-11-22)
We report a easy approach for the immobilization of glucose oxidase enzyme (GOx) on nanoparticles. Nanoparticles-modified polystyrene-ANH2 (PSA) with some salicylaldehyde derivatives were synthesized by means of condensation and investigated the enzymatic properties of GOx immobilized on there. Modified polystyrenes...
Josh M Morganti et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(2), 748-760 (2015-01-16)
Traumatic brain injury (TBI) is a major risk factor for the development of multiple neurodegenerative diseases. With respect to the increasing prevalence of TBI, new therapeutic strategies are urgently needed that will prevent secondary damage to primarily unaffected tissue. Consistently...
Je-Hyun Yoon et al.
Genes & development, 29(15), 1599-1604 (2015-08-09)
Eukaryotic gene expression is tightly regulated post-transcriptionally by RNA-binding proteins (RBPs) and microRNAs. The RBP AU-rich-binding factor 1 (AUF1) isoform p37 was found to have high affinity for the microRNA let-7b in vitro (Kd = ∼ 6 nM) in cells....
Balananda-Dhurjati Kumar Putcha et al.
PloS one, 10(6), e0129216-e0129216 (2015-06-13)
For the rabphillin-3A-like (RPH3AL) gene, a putative tumor suppressor, the clinical significance of genetic alterations in breast cancers was evaluated. DNA and RNA were extracted from formalin-fixed, paraffin-embedded (FFPE) cancers and matching normal tissues. DNA samples were assessed for loss...
Fabrice Gritti et al.
Journal of chromatography. A, 1356, 96-104 (2014-07-08)
Computer calculations of gradient chromatograms were performed by taking into account the adsorption behavior of the strong eluent in RPLC and the true Henry constant of the analytes. This improves the accuracy of classical gradient calculations, which all assume no...
Satoshi Ninagawa et al.
The Journal of cell biology, 211(4), 775-784 (2015-11-18)
Glycoproteins and non-glycoproteins possessing unfolded/misfolded parts in their luminal regions are cleared from the endoplasmic reticulum (ER) by ER-associated degradation (ERAD)-L with distinct mechanisms. Two-step mannose trimming from Man9GlcNAc2 is crucial in the ERAD-L of glycoproteins. We recently showed that...
Tsukasa Baba et al.
Medical molecular morphology, 48(2), 76-84 (2014-06-09)
Metastin/kisspeptin is encoded by KISS1 and functions as an endogenous ligand of GPR54. Interaction of metastin with GPR54 suppresses metastasis and also regulates release of gonadotropin-releasing hormone, which promotes secretion of estradiol (E2) and progesterone (P4). We have previously demonstrated...
L Ciofi et al.
Journal of chromatography. A, 1362, 75-88 (2014-08-31)
Four different pellicular stationary phases (i.e. octadecylsilane, octasilane, Phenyl-Hexyl and pentafluorophenyl) were investigated for the chromatographic resolution of alkylphenols (APs), alkylphenols polyethoxylates (APnEOs) and alkylphenoxy carboxylates (APECs) using mixtures of water and organic solvents (i.e. methanol, acetonitrile and tetrahydrofuran) as...
Ayumi Yamamoto et al.
Pharmaceutical biology, 52(6), 782-788 (2014-01-08)
Blackcurrant (Ribes nigrum L.) is a classical fruit that has long been used to make juice, liqueur and sometimes medicines in Europe. The beneficial effects of blackcurrant, which are inhibition of lipopolysaccharide-stimulated inflammatory, anticarcinogenesis and other health effects, have been...
Tsong-Long Hwang et al.
Bioorganic & medicinal chemistry, 23(5), 1123-1134 (2015-02-05)
Proteinase 3 (Pr3), and human neutrophil elastase (HNE) are two major neutrophilic serine proteases (NsPs) expressed in neutrophil azurophil granules. Emerging data suggest that excessive release of proteases mediates tissue damage, and therefore prolonged neutrophil accumulation has an important role...
Gökhan Dalgin et al.
Developmental biology, 402(1), 81-97 (2015-03-24)
During development a network of transcription factors functions to differentiate foregut cells into pancreatic endocrine cells. Differentiation of appropriate numbers of each hormone-expressing endocrine cell type is essential for the normal development of the pancreas and ultimately for effective maintenance...
Q-M Zeng et al.
Cellular and molecular biology (Noisy-le-Grand, France), 61(2), 64-68 (2015-05-31)
The study aims to reveal the effect of estrogen deficiency on Treg cells population in bone marrow in the development of osteoclastogenis with comparing the differences about Treg cells phenotypes and cytokines related with the homeostasis and functions maintenance of...
S Cyboran et al.
Life sciences, 126, 1-9 (2015-02-24)
This study was undertaken to determine the biological activity of a green tea supplement with respect to cells and erythrocyte membranes and the molecular mechanism of that activity. The extract's activity was evaluated on the basis of its hemolytic, antioxidant...
Zheng Qiao et al.
Journal of chromatography. A, 1393, 18-25 (2015-03-31)
In this present study, magnetic Fe3O4@SiO2 nanoparticles (MNPs) functionalized with octadecyl groups (Fe3O4@SiO2-C18 NPs) were synthesized, characterized and employed, for the first time, as powerful nanosorbent to extract endogenous volatile organic metabolites (EVOMs) namely, hexanal, heptanal, decanal, benzaldehyde, 4-heptanone, 5-methyl-2-furfural...
Sudipta Dey et al.
Journal of environmental sciences (China), 25(4), 698-709 (2013-08-09)
Performance of a hybrid reactor comprising of trickling filter (TF) and aeration tank (AT) unit was studied for biological treatment of wastewater containing mixture of phenol and m-cresol, using mixed microbial culture. The reactor was operated with hydraulic loading rates...
Mohsen Parvas et al.
Environmental technology, 35(9-12), 1140-1149 (2014-04-08)
Catalytic wet air oxidation (CWAO) of phenol was carried out under atmospheric pressure of oxygen at 160 degrees C in a stirred batch reactor over copper catalysts supported by CeO2-ZrO2. The copper with different loadings were impregnated over the composite...
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