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Showing 1-30 of 32 results for "778788" within Papers
Yi Zhou et al.
Molecular pharmaceutics, 9(5), 1067-1076 (2012-04-10)
Safe and effective gene delivery is essential to the success of gene therapy. We synthesized and characterized a novel nonviral gene delivery system in which folate (FA) molecules were functioned as blockers on cationic polyrotaxanes (PR) composed of poly(ethylenimine) (PEI)(600)-grafted
Zhen-Qiang Dong et al.
Langmuir : the ACS journal of surfaces and colloids, 29(10), 3188-3194 (2013-02-05)
Photoreversible micelles were achieved by a combination of commercially available components sodium alginate (Alg), tetradecyltrimethylammonium bromide (TTAB), α-cyclodextrin (α-CD), and 4-(phenylazo)benzoic acid (PBA). Under visible light irradiation, α-CD interacted more favorably with PBA than with alkyl chains of TTAB. Therefore
M C Hamoudi et al.
Drug development and industrial pharmacy, 39(9), 1306-1314 (2012-10-12)
Freeze-dried beads made of α-cyclodextrin and soybean oil were reported previously as an efficient system for the oral delivery of lipophilic drugs. In the present study, oven-drying was evaluated as another method for drying beads. Oven-drying was optimised and the
Martha Mullally et al.
Canadian journal of physiology and pharmacology, 92(9), 758-764 (2014-08-21)
The mode of action of the anxiolytic medicinal plant Souroubea sympetala was investigated to test the hypothesis that extracts and the active principle act at the pharmacologically important GABAA-benzodiazepine (GABAA-BZD) receptor. Leaf extracts prepared by ethyl acetate extraction or supercritical
Hidetoshi Arima et al.
Molecular pharmaceutics, 9(9), 2591-2604 (2012-08-10)
We previously reported that of the various polyamidoamine (PAMAM) STARBURST dendrimer (generation 3, G3) (dendrimer) conjugates with cyclodextrins (CyDs), the dendrimer (G3) conjugate with α-CyD having an average degree of substitution of 2.4 (α-CDE (G3)) has the greatest potential for
Jing Chang et al.
Nanoscale, 5(2), 813-820 (2012-12-14)
The fabrication and drug delivery of novel polypseudorotaxane micelles with small molecule coumarin derivative as hydrophobic segment were reported. 7-Carboxymethoxy coumarin was immobilized on the terminal hydroxyl groups of poly(ethylene glycol) (PEG). The modified PEG chains were threaded in α-cyclodextrins
Yoshinori Takashima et al.
Nature communications, 3, 1270-1270 (2012-12-13)
The development of stimulus-responsive polymeric materials is of great importance, especially for the development of remotely manipulated materials not in direct contact with an actuator. Here we design a photoresponsive supramolecular actuator by integrating host-guest interactions and photoswitching ability in
Takayuki Anno et al.
International journal of pharmaceutics, 426(1-2), 239-247 (2012-02-07)
We previously reported that glucuronylglucosyl-β-cyclodextrin (GUG-β-CyD) conjugate with polyamidoamine starburst dendrimer (GUG-β-CDE conjugate) with the average degree of substitution (DS) of cyclodextrin (CyD) of 1.8 (GUG-β-CDE conjugate (DS 1.8)), showed remarkably higher gene transfer activity than α-CyD/dendrimer conjugate (α-CDE conjugate
Self-assembly of chitosan-g-PEG and α-cyclodextrin into hollow spheres in aqueous solution.
Wei Ha et al.
Journal of controlled release : official journal of the Controlled Release Society, 152 Suppl 1, e204-e205 (2011-12-27)
Hiroyasu Yamaguchi et al.
Nature communications, 3, 603-603 (2012-01-05)
The formation of effective and precise linkages in bottom-up or top-down processes is important for the development of self-assembled materials. Self-assembly through molecular recognition events is a powerful tool for producing functionalized materials. Photoresponsive molecular recognition systems can permit the
Syed Mashhood Ali et al.
Magnetic resonance in chemistry : MRC, 50(4), 299-304 (2012-03-15)
Complexation of fexofenadine with α-cyclodextrin in aqueous medium was studied. The stoichiometry of the resulting inclusion complex was determined by (1) H NMR titration data. 2D ROESY data provided the evidence of formation of the complex by entry of the
Juan Zhou et al.
Chemical communications (Cambridge, England), 48(30), 3596-3598 (2012-01-10)
Supermolecular quantum dots (QDs) nanofluids have been firstly proposed and synthesized by virtue of the strong inclusion interactions between α-cyclodextrin (α-CD) and polyethylene glycol (PEG) chains, resulting in tunable liquid-like behaviour, and controllable assembly of single QDs.
H Arima et al.
Cancer gene therapy, 19(5), 358-366 (2012-03-10)
We previously reported that polyamidoamine STARBURST dendrimer (generation 3, G3) (dendrimer) conjugate with α-cyclodextrin (α-CyD) having an average degree of substitution of 2.4 of α-CyD (α-CDE) provided remarkable aspects as novel carriers for DNA and small-interfering RNA. To develop novel
Juliana Isabel Clodt et al.
Macromolecular rapid communications, 34(2), 190-194 (2012-12-12)
Highly porous polystyrene-block-poly(4-vinylpyridine) (PS-b-P4VP) diblock copolymer membranes are prepared using carbohydrates as additives. Therefore α-cyclodextrine, α-(D)-glucose, and saccharose (cane sugar) are tested for the membrane formation of three different PS-b-P4VP polymers. The addition of the carbohydrates leads to an increasing
Tao Chen et al.
Nanotechnology, 23(50), 505705-505705 (2012-11-21)
The hollow mesoporous silica nanoparticles (HMSNs), which have been used as the nanocontainers for the corrosion inhibitor, benzotriazole, were fabricated using the hard-template method. Alkaline-responsive HMSNs based on cucurbit[6]uril (CB[6])/bisammonium supramolecular complex and acid-responsive HMSNs based on α-cyclodextrin (α-CD)/aniline supramolecular
Boris Ermolinsky et al.
Journal of medical microbiology, 62(Pt 7), 1011-1014 (2013-03-30)
Cholera toxin (CT), the principal virulence factor secreted by Vibrio cholerae, is an A-B5 type exotoxin that binds to host cell GM1-gangliosides and is responsible for cholera diarrhoea. We tested the hypothesis that the cyclic hexasaccharide α-cyclodextrin (α-CD), but not
Cyclodextrins and their uses: a review.
Del V E M M.
Process Biochemistry (Oxford, United Kingdom), 39(9), 1033-1046 (2004)
M C Hamoudi et al.
Journal of controlled release : official journal of the Controlled Release Society, 161(3), 861-867 (2012-05-29)
The purpose of this work was to investigate the potential of α-cyclodextrin combined to soybean oil-based formulations to modulate the release of a model drug, indomethacin. Dry emulsion, naked and coated beads were prepared from the same initial formulation using
Michael Kundel et al.
Analytical chemistry, 84(3), 1439-1445 (2012-01-17)
Here we present a new application of a time-of-flight aerosol mass spectrometer (TOF-AMS) for the measurement of atmospheric trace gases in real-time. Usually, TOF-AMS instruments are not sensitive to gas-phase species due to the aerodynamic particle focusing inlet system which
Lynne M Chepulis et al.
Journal of complementary & integrative medicine, 9, Article 25-Article 25 (2012-10-02)
The bioactive properties of Manuka honey are now well recognised, but the nature of honey (a sticky, viscous fluid) can make it hard to use as a health remedy. A new technology using encapsulation of Manuka honey with alpha-cyclodextrin molecules
Sergey Shityakov et al.
International journal of nanomedicine, 7, 3211-3219 (2012-07-20)
This paper attempts to predict and emphasize molecular interactions of dopamine, levodopa, and their derivatives (Dopimid compounds) containing 2-phenyl-imidazopyridine moiety with the α-cyclodextrin dimer in order to assess and improve drug delivery to the central nervous system. The molecular docking
Hidetoshi Arima
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 124(7), 451-464 (2004-07-06)
Due to the growing concerns over the toxicity and immunogenicity of viral DNA delivery systems, DNA delivery via nonviral routes has become more desirable and advantageous. In particular, polycation complexes with DNA (polyplex) are attractive nonviral vectors. To design novel
Injectable drug?delivery systems based on supramolecular hydrogels formed by poly (ethylene oxide) s and α?cyclodextrin.
Li J N X and Leong K W
Journal of Biomedical Materials Research Part A, 65(2), 196-202 (2003)
Francisco Gámez et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 14(2), 400-407 (2012-12-15)
The benchmark inclusion complexes formed by α-cyclodextrin (αCD) with alkali-metal cations are investigated under isolated conditions in the gas phase. The relative αCD-M(+) (M=Li(+), Na(+), K(+), Cs(+)) binding affinities and the structure of the complexes are determined from a combination
Ioanna Deligkiozi et al.
Physical chemistry chemical physics : PCCP, 15(10), 3497-3503 (2013-01-31)
The photoconductive properties of an azo-containing [2]rotaxane, bearing a π-conjugated axial part and its corresponding dumbbell compound are investigated. Structural effects on the observed photoconductive behavior in both cases are discussed. The photoresponsive behavior of the title [2]rotaxane was proved
Zhongshu Li et al.
Chemical communications (Cambridge, England), 48(79), 9864-9866 (2012-08-07)
A novel deconvolution method for energy-resolved reaction cross sections is applied to determine intrinsic gas-phase dissociation energies for non-covalent α-cyclodextrin host-guest complexes. M06-2X//M06-L/6-31+G(d,p) calculations reproduce the experimental results and enable us to quantify the contribution of intermolecular hydrogen bonding.
Costanza Casati et al.
Journal of the American Chemical Society, 134(46), 19108-19117 (2012-10-31)
We present here the results of a CW-ESR investigation of a double spin labeled α-cyclodextrin-based [2]rotaxane that is characterized by the presence of nitroxide labels both at the wheel and at the dumbbell. This was accomplished by synthesizing a spin
The Beneficial Effects a-Cyclodextrin on Blood Lipids and Weight Loss in Healthy Humans
Comerford KB, et al
Obesity (Silver Spring, Md.), 19(6), 1200-1204 (2011)
Yuya Hayashi et al.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 19 Suppl 1, 47-49 (2012-04-24)
RNA interference (RNAi) is a sequence-specific gene-silencing mechanism triggered by double-stranded RNA and powerful tools for a gene function study and RNAi therapy. Although siRNAs offer several advantages as potential new drugs to treat various diseases, the efficient delivery system
Bárbara Herrera et al.
Journal of colloid and interface science, 389(1), 42-45 (2012-10-16)
Gold nanorods (AuNRs) stabilized by cetyltrimethylammonium bromide (CTAB) were deposited onto crystals of α-cyclodextrin (α-CD) inclusion compounds (ICs) that contained octanethiol (OT) as guest molecules. The nanodecoration was produced specifically at the {001} crystal planes through interaction between the -SH
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