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Zhong Wang et al.
Mediators of inflammation, 2011, 848309-848309 (2011-03-16)
Our previous study concerning brain trauma has shown that progesterone could regulate toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) signaling pathway in the brain, which also has been proved to play important roles in early brain injury (EBI)...
Rachel J Smith et al.
The European journal of neuroscience, 30(3), 493-503 (2009-08-07)
The orexin/hypocretin system has recently been implicated in reward-processing and addiction. We examined the involvement of the orexin system in cue-induced reinstatement of extinguished cocaine-seeking by administering the orexin 1 receptor antagonist SB-334867 (SB) or the orexin 2 receptor antagonist...
?Back to the future?: a new look at hydroxypropyl beta-cyclodextrins.
Malanga M, et al.
Journal of Pharmaceutical Sciences, 105(9), 2921-2931 (2016)
Weijin Wang et al.
Theranostics, 11(11), 5279-5295 (2021-04-17)
Intracellular accumulation of tau is a hallmark pathology in Alzheimer disease (AD) and the related tauopathies, thus targeting tau could be promising for drug development. Proteolysis Targeting Chimera (PROTAC) is a novel drug discovery strategy for selective protein degradation from...
Dmitri R Davydov et al.
Biochemistry, 47(43), 11348-11359 (2008-10-04)
To establish a direct method for monitoring substrate binding in cytochrome P450eryF applicable at elevated hydrostatic pressures, we introduce a laser dye Fluorol-7GA (F7GA) as a novel fluorescent ligand. The high intensity of fluorescence and the reasonable resolution of the...
Jagdishbhai L Italia et al.
PloS one, 6(10), e25744-e25744 (2011-10-15)
Despite advances in the treatment, the morbidity and mortality rate associated with invasive aspergillosis remains unacceptably high (70-90%) in immunocompromised patients. Amphotericin B (AMB), a polyene antibiotic with broad spectrum antifungal activity appears to be a choice of treatment but...
Shuhua Chen et al.
PloS one, 6(8), e24293-e24293 (2011-09-16)
Previously, we demonstrated that allopregnanolone (APα) promoted proliferation of rodent and human neural progenitor cells in vitro. Further, we demonstrated that APα promoted neurogenesis in the hippocampal subgranular zone (SGZ) and reversed learning and memory deficits in the male triple...
2-Hydroxypropyl-?-cyclodextrin (HP-?-CD): a toxicology review.
Gould S & Scott RC.
Food And Chemical Toxicology, 43(10), 1451-1459 (2005)
D E Rusyniak et al.
Neuroscience, 154(4), 1619-1626 (2008-06-07)
When given in a warm environment MDMA (3,4-methylenedioxymethamphetamine, ecstasy) causes hyperthermia by increasing interscapular brown adipose tissue (iBAT) heat production and decreasing heat loss via cutaneous vasoconstriction. When given in a cold environment, however, MDMA causes hypothermia by an unknown...
2-Hydroxypropyl-?-cyclodextrin acts as a novel anticancer agent.
Yokoo M, et al.
PLoS ONE, 10(11), e0141946-e0141946 (2015)