Showing 1-30 of 144 results for "81381"
Ashok A Kumar et al.
American journal of hematology, 90(1), 31-36 (2014-09-30)
This paper demonstrates the enrichment of reticulocytes by centrifuging whole blood through aqueous multiphase systems (AMPSs)-immiscible phases of solutions of polymers that form step-gradients in density. The interfaces of an AMPS concentrate cells; this concentration facilitates the extraction of blood...
Cedric S Tremblay et al.
Nature communications, 9(1), 3535-3535 (2018-09-01)
Pre-leukemic stem cells (pre-LSCs) give rise to leukemic stem cells through acquisition of additional gene mutations and are an important source of relapse following chemotherapy. We postulated that cell-cycle kinetics of pre-LSCs may be an important determinant of clonal evolution...
Dwaipayan Adhya et al.
Molecular autism, 12(1), 4-4 (2021-01-24)
The inability to observe relevant biological processes in vivo significantly restricts human neurodevelopmental research. Advances in appropriate in vitro model systems, including patient-specific human brain organoids and human cortical spheroids (hCSs), offer a pragmatic solution to this issue. In particular...
Emmanuel Dornier et al.
The Journal of cell biology, 199(3), 481-496 (2012-10-24)
The metalloprotease ADAM10/Kuzbanian catalyzes the ligand-dependent ectodomain shedding of Notch receptors and activates Notch. Here, we show that the human tetraspanins of the evolutionary conserved TspanC8 subfamily (Tspan5, Tspan10, Tspan14, Tspan15, Tspan17, and Tspan33) directly interact with ADAM10, regulate its...
Julia Kokesch-Himmelreich et al.
Analytical and bioanalytical chemistry, 407(16), 4555-4565 (2015-04-15)
The detection and localization of polymer-based nanoparticles in human bone marrow-derived stromal cells (hBMSC) by time-of-flight secondary ion mass spectrometry (ToF-SIMS) is reported as an example for the mass spectrometry imaging of organic nanoparticles in cell environments. Polyelectrolyte complex (PEC)...
Feng-yong Liu et al.
Acta radiologica (Stockholm, Sweden : 1987), 54(1), 61-66 (2013-02-05)
Preoperative embolization of tumors is a well-established procedure that has been successfully applied in various clinical situations. Preoperative embolization can reduce the vascularity of tumors resulting in a clearer operative field, less difficult dissection, decreased blood loss, and, in some...
Narayana Pineda-Ramírez et al.
Molecular neurobiology, 57(2), 1055-1069 (2019-11-02)
During cerebral ischemia, oxygen and glucose levels decrease, producing many consequences such as the generation of reactive oxygen species, tissue injury, and the general metabolism collapse. Resveratrol triggers signaling dependent on the protein kinase activated by adenosine monophosphate (AMPK), the...
Emily A Tarr et al.
Cell and tissue research, 376(1), 83-96 (2018-11-09)
FMRFamide-related proteins have been described in both vertebrate and invertebrate nervous systems and have been suggested to play important roles in a variety of physiological processes. One proposed function is the modulation of signal transduction in mechanosensory neurons and their...
Oeystein R Brekk et al.
Acta neuropathologica communications, 8(1), 127-127 (2020-08-09)
Sandhoff disease (SD) is a lysosomal storage disease, caused by loss of β-hexosaminidase (HEX) activity resulting in the accumulation of ganglioside GM2. There are shared features between SD and Parkinson's disease (PD). α-synuclein (aSYN) inclusions, the diagnostic hallmark sign of...
Thomas L Lynch et al.
Journal of molecular and cellular cardiology, 102, 83-93 (2016-12-14)
Cardiomyopathies are a leading cause of heart failure and are often caused by mutations in sarcomeric genes, resulting in contractile dysfunction and cellular damage. This may stimulate the production of a robust proinflammatory response. To determine whether myocardial inflammation is...
Sreejith Raveendran et al.
Carbohydrate polymers, 92(2), 1225-1233 (2013-02-13)
Extremophilic bacterial polysaccharide based biocompatible nanofibers were produced for the first time via electrospinning technique. Mauran (MR), an extremophilic sulfated exopolysaccharide was extracted from moderately halophilic bacterium, Halomonas maura and characterized for the application of nanofiber synthesis. Thin-uniform MR nanofibers...
Xiao Huang et al.
Nature nanotechnology, 16(2), 214-223 (2020-12-16)
Biomaterials can improve the safety and presentation of therapeutic agents for effective immunotherapy, and a high level of control over surface functionalization is essential for immune cell modulation. Here, we developed biocompatible immune cell-engaging particles (ICEp) that use synthetic short...
Wenkai Chang et al.
Materials science & engineering. C, Materials for biological applications, 33(7), 4369-4376 (2013-08-06)
Nanocomposite materials consisting of polymer matrix and inorganic salts in the form of nanocrystals of hydroxyapatite (HA) are regarded as superior candidates for bone treatment. A biomimetic nanocomposite scaffold with HA formation on the electrospun poly(vinyl alcohol) (PVA) nanofibrous structure...
Jiankang Song et al.
Nanoscale, 5(6), 2482-2490 (2013-02-16)
C6-carboxy-cellulose with a carboxylate content of 0.8 mmol g(-1) was obtained by oxidation of once-dried cellulose, using the 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)/NaClO/NaClO2 system at pH 6.8 and 60 °C for 16 h. This method, with the addition of reagents in the order...
E Fortunati et al.
Carbohydrate polymers, 97(2), 837-848 (2013-08-06)
Cellulose nanocrystals (CNC) extracted from three different sources, namely flax, phormium, and commercial microcrystalline cellulose (MCC) have been used in a polyvinyl alcohol (PVA) matrix to produce anti-bacterial films using two different amounts of silver nanoparticles (0.1 wt% and 0.5...
Bailin Zhao et al.
Nucleic acids research, 48(22), 12746-12750 (2020-12-03)
As nucleotidyl transferases, formation of a covalent enzyme-adenylate intermediate is a common first step of all DNA ligases. While it has been shown that eukaryotic DNA ligases utilize ATP as the adenylation donor, it was recently reported that human DNA...
Yuming Dong et al.
Pharmaceutical development and technology, 19(8), 960-967 (2013-12-11)
High concentration of 5-amino salicylic acid (5-ASA) in the distal ileum and colon is necessary for the treatment of inflammatory bowel disease (IBD). The control of small molecules, drugs, released from a polymeric matrix remains a great challenge. To study...
Daniela Moretti et al.
Frontiers in neuroscience, 12, 909-909 (2019-01-09)
Magnetoencephalography has been established nowadays as a crucial in vivo technique for clinical and diagnostic applications due to its unprecedented spatial and temporal resolution and its non-invasive methods. However, the innate nature of the biomagnetic signals derived from active biological...
Susmita Singh et al.
Colloids and surfaces. B, Biointerfaces, 106, 46-50 (2013-02-26)
Alpha-amylase was immobilized onto polyaniline-polyvinyl alcohol (PAni-PVA) film by cross linking with glutaraldehyde. The activity yield and immobilization efficiency was calculated as 13.58% and 30.60% respectively. The PAni-PVA-Amylase films were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and amylase activity...
Ana M Paiva et al.
International journal of pharmaceutics, 454(1), 394-402 (2013-07-17)
One possible approach to overcome solubility complications and enhance the biological activity of drugs is their incorporation into drug delivery systems. Within this scope, several nanosphere and nanocapsule formulations of a new inhibitor of p53-MDM2 interaction (xanthone 1) were developed...
Hanne Halkinrud Thoen et al.
The Journal of comparative neurology, 528(7), 1079-1094 (2019-10-18)
Mantis shrimps (Stomatopoda) possess in common with other crustaceans, and with Hexapoda, specific neuroanatomical attributes of the protocerebrum, the most anterior part of the arthropod brain. These attributes include assemblages of interconnected centers called the central body complex and in...
Dragana Vidović et al.
Human gene therapy, 27(1), 60-71 (2015-11-17)
Gene therapy holds promise to cure a wide range of genetic and acquired diseases. Recent successes in recombinant adeno-associated viral vector (rAAV)-based gene therapy in the clinic for hereditary disorders such as Leber's congenital amaurosis and hemophilia B encouraged us...
Santanu Kaity et al.
Carbohydrate polymers, 94(1), 456-467 (2013-04-03)
A novel interpenetrating polymer network (IPN) microspheres of locust bean gum (LBG) and poly (vinyl alcohol) (PVA) was developed for oral controlled release of buflomedil hydrochloride (BH) by emulsion crosslinking method using glutaraldehyde as crosslinker. The effects of gum-polymer ratio...
Claudia M Persoon et al.
Neuron, 104(6), 1065-1080 (2019-11-05)
Secretion principles are conserved from yeast to humans, and many yeast orthologs have established roles in synaptic vesicle exocytosis in the mammalian brain. Surprisingly, SEC4 orthologs and their effectors, the exocyst, are dispensable for synaptic vesicle exocytosis. Here, we identify...
Melek Kiristi et al.
Materials science & engineering. C, Materials for biological applications, 33(7), 3845-3850 (2013-08-06)
Plasma-modified chitosan and poly(3,4-ethylenedioxythiophene) were blended to obtain conducting nanofibers with polyvinyl alcohol as a supporting polymer at various volumetric ratios by electrospinning method. Chemical compositions and molecular interactions among nanofiber blend components were determined using Fourier transform infrared spectroscopy...
Raquel Damasceno et al.
Canadian journal of microbiology, 59(11), 716-719 (2013-11-12)
The electrospinning technique of rhizobia immobilization in nanofibres is an innovative and promising alternative for reducing the harmful effects of environmental stress on bacteria strains in a possible inoculant nanotechnology product for use in agriculture. The use of polyvinyl alcohol...
William H Parker et al.
American journal of physiology. Cell physiology, 311(4), C652-C662 (2016-09-09)
Vitamin C, or ascorbic acid, both tightens the endothelial permeability barrier in basal cells and also prevents barrier leak induced by inflammatory agents. Barrier tightening by ascorbate in basal endothelial cells requires nitric oxide derived from activation of nitric oxide...
Kelly E Coller et al.
PLoS pathogens, 5(12), e1000702-e1000702 (2009-12-31)
Hepatitis C virus (HCV) enters hepatocytes following a complex set of receptor interactions, culminating in internalization via clathrin-mediated endocytosis. However, aside from receptors, little is known about the cellular molecular requirements for infectious HCV entry. Therefore, we analyzed a siRNA...
Bor-Sen Chiou et al.
International journal of biological macromolecules, 55, 214-220 (2013-01-29)
Pollock gelatin/poly(vinyl alcohol) (PVA) fibers were electrospun using deionized water as the solvent and pollock gelatin/poly(lactic acid) (PLA) fibers were electrospun using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as the solvent. The chemical, thermal, and thermal stability properties were examined for the electrospun samples....
Olatz Ugarteburu et al.
Journal of clinical medicine, 9(4) (2020-04-01)
Recessive HACE1 mutations are associated with a severe neurodevelopmental disorder (OMIM: 616756). However, the physiopathologycal bases of the disease are yet to be completely clarified. Whole-exome sequencing identified homozygous HACE1 mutations (c.240C>A, p.Cys80Ter) in a patient with brain atrophy, psychomotor...

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