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Md Nazir Hossen et al.
ACS applied materials & interfaces, 11(29), 26060-26068 (2019-05-24)
Activated cancer-associated fibroblasts (CAFs) play a major role in the poor outcome in many diseases including pancreatic cancer. Normally quiescent with high lipid content and low proliferative capacity, CAFs receiving cues from cancer cells in the tumor microenvironment become activated
Taro Yasumoto et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(8), 9220-9234 (2019-05-16)
Amyloid β-protein (Aβ) molecules tend to aggregate and subsequently form low MW (LMW) oligomers, high MW (HMW) aggregates such as protofibrils, and ultimately fibrils. These Aβ species can generally form amyloid plaques implicated in the neurodegeneration of Alzheimer disease (AD)
M Masuda et al.
Journal of immunological methods, 96(2), 225-231 (1987-02-11)
A method was established for measuring membrane fluidity of polymorphonuclear leukocytes (PMN) by the excimer-forming lipid technique with pyrenedecanoic acid in flow cytometry. When cells were labeled, the use of 2-25 microM of pyrenedecanoic acid provided similar results. Neither the
J Radom et al.
Biochimica et biophysica acta, 920(2), 131-139 (1987-07-31)
The lipid metabolism in cultured fibroblasts from multisystemic (type 3) lipid storage myopathy and controls has been studied through pulse-chase experiments using 1-pyrenedecanoic acid as precursor. The uptake of 1-pyrenedecanoic acid was not significantly different in multisystemic lipid storage myopathy
Markus A Keller et al.
Nature communications, 5, 4439-4439 (2014-07-23)
Mutations in the gene coding for membrane-bound fatty aldehyde dehydrogenase (FALDH) lead to toxic accumulation of lipid species and development of the Sjögren-Larsson Syndrome (SLS), a rare disorder characterized by skin defects and mental retardation. Here, we present the crystallographic
Hwa-Young Lee et al.
British journal of pharmacology, 177(7), 1556-1567 (2019-11-13)
Phosphatidylinositol 3-kinase (PI3K), especially PI3K-δ, and endoplasmic reticulum (ER) stress play important roles in refractory asthma induced by the fungus Aspergillus fumigatus through mechanisms that are not well understood. Here we have investigated these mechanisms, using BEAS-2B human bronchial epithelial
Pyrenedecanoic acid and pyrene lecithin.
H J Galla et al.
Methods in enzymology, 72, 471-479 (1981-01-01)
Hyun-Kyoung Kim et al.
Redox biology, 40, 101853-101853 (2021-01-15)
Chalcone is a polyphenolic compound found abundantly in natural plant components. They have been acclaimed as potential antitumor compounds in multiple tumor cells. However, not much attention has been paid to elucidate its antitumor mechanism of action. Here, chalcone was
Amit K Saha et al.
Journal of biomechanics, 52, 83-88 (2017-01-14)
The role of cholesterol content on monocyte biomechanics remains understudied despite the well-established link between cholesterol and monocytes/macrophages in atherosclerosis, and the effect on other cell types. In this work, we have investigated the effect of cholesterol on monocyte deformability
Sung Jin Shim et al.
Bioresource technology, 303, 122944-122944 (2020-02-12)
This study aimed to improve valuable omega-3 fatty acids production in freshwater microalgae at normal temperature by inducing homeoviscous adaptation using CaCl2, which could have a role in decreasing the cellular membrane fluidity followed by increasing the rigidity of cell
Lay T Gan et al.
Journal of hepatology, 61(6), 1376-1384 (2014-07-30)
Free cholesterol (FC) accumulates in non-alcoholic steatohepatitis (NASH) but not in simple steatosis. We sought to establish how FC causes hepatocyte injury. In NASH-affected livers from diabetic mice, subcellular FC distribution (filipin fluorescence) was established by subcellular marker co-localization. We
Baran A Ersoy et al.
The Journal of clinical investigation, 128(1), 141-156 (2017-12-05)
The incorporation of excess saturated free fatty acids (SFAs) into membrane phospholipids within the ER promotes ER stress, insulin resistance, and hepatic gluconeogenesis. Thioesterase superfamily member 2 (Them2) is a mitochondria-associated long-chain fatty acyl-CoA thioesterase that is activated upon binding
Amit K Saha et al.
Biophysical journal, 112(7), 1481-1488 (2017-04-14)
Cholesterol is an important risk factor of atherosclerosis, due to its active uptake by monocytes/macrophages. Monocyte recruitment from flowing blood to atherosclerotic foci is the key first step in the development of atherosclerosis. Cholesterol content alters cell membrane stiffness, and
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