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Showing 1-30 of 72 results for "83-88-5" within Papers
N Kawamura et al.
The Biochemical journal, 283 ( Pt 3), 705-712 (1992-05-01)
The third component of complement (C3) is an important mediator of inflammation. Murine and human genomic cosmid clones were isolated, characterized and sequenced 5' to the complement C3 gene transcriptional initiation sites to determine cis elements that participate in constitutive
Mariko Matsumoto et al.
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, (129)(129), 68-75 (2012-01-21)
A chemical category is a group of chemicals whose toxicological properties are expected to be similar or follow a regular pattern as a result of structural similarity. The category approach is beneficial for decreasing in the resource of risk assessment
Ritsuo Imashiro et al.
The Journal of organic chemistry, 68(3), 974-979 (2003-02-01)
An efficient synthesis of methyl (2R,3S)-3-(4-methoxyphenyl)glycidate (-)-2, a key intermediate for diltiazem (1), has been developed on the basis of the highly enantioselective Mukaiyama aldol reaction of p-anisaldehyde (4a) with alpha,alpha-dichloro ketene silyl acetal 5. Thus, the reaction using a
Luis A Diaz et al.
The Journal of investigative dermatology, 123(6), 1045-1051 (2004-12-22)
Pemphigus foliaceus (PF) and the endemic form Fogo Selvagem (FS) are mediated by pathogenic antibodies to the EC1-2 domains of desmoglein-1. There is a preclinical phase with antibodies to only EC5. Based on geographic clustering of cases, FS is thought
Linda J Kay et al.
Pulmonary pharmacology & therapeutics, 23(2), 71-77 (2009-11-06)
The aim of the present study was to establish whether polymorphisms, especially those within the promoter region, of the beta(2)-adrenoceptor gene (ADRB2) influence beta(2)-adrenoceptor expression in human lung. The density of beta-adrenoceptors in human lung tissue (n=88) was determined by
H Sylvin et al.
Immunogenetics, 51(1), 59-64 (2000-02-09)
Interleukin-5 (IL-5) is thought to be a key cytokine in allergic inflammation. Pig IL-5 was cloned, sequenced, and expressed to enable us to study of the biological role of IL-5 in pigs used in a model for allergen-induced late-phase reactions.
Ayalew Tefferi et al.
Blood, 103(9), 3547-3548 (2004-01-01)
Recent studies have demonstrated neutrophil overexpression of the polycythemia rubra vera-1 (PRV-1) gene in polycythemia vera (PV) but not in secondary or spurious polycythemia (SP). To validate as well as expand upon this novel observation, we conducted a prospective study
Monica Else et al.
Leukemia & lymphoma, 52 Suppl 2, 75-78 (2011-04-21)
The purine analogs pentostatin and cladribine are effective treatments for hairy cell leukemia (HCL). However, alternative treatments are needed for patients with recurrent disease. We reviewed retrospectively data from 18 patients who were retreated with either pentostatin (n = 12) or cladribine
Muhammad T Salam et al.
Epilepsia, 56(8), 1227-1238 (2015-06-30)
To investigate the abortion of seizure generation using "minimal" intervention in hippocampi using two rat models of human temporal lobe epilepsy. The recording or stimulation electrodes were implanted into both hippocampi (CA1 area). Using the kainic acid (chronic: experiment duration
María Ibáñez et al.
Journal of chromatography. A, 1081(2), 145-155 (2005-07-26)
This paper describes a method for the sensitive and selective determination of glyphosate, glufosinate and aminomethylphosphonic acid (AMPA) residues in water and soil samples. The method involves a derivatization step with 9-fluorenylmethylchloroformate (FMOC) in borate buffer and detection based on
Masashi Mizokami et al.
The Lancet. Infectious diseases, 15(6), 645-653 (2015-04-13)
Compared with other countries, patients with chronic hepatitis C infection in Japan tend to be older, have more advanced liver disease, and are more likely to have been previously treated for hepatitis C. We aimed to assess the efficacy and
P De Vries et al.
Naunyn-Schmiedeberg's archives of pharmacology, 359(4), 331-338 (1999-05-27)
The 5-hydroxytryptamine (5-HT)-induced late depressor response in rats is mainly mediated by vascular 5-HT7 receptors. The present study was devoted to determining the systemic and regional haemodynamic changes during this response, with particular emphasis on localising vascular beds that may
Hisao Imai et al.
Histopathology, 54(7), 804-813 (2009-07-29)
To evaluate the prognostic value of L-type amino acid transporter 1 (LAT1) in patients with stage I non-small cell lung cancer (NSCLC). A total of 282 consecutive patients with completely resected pathological stage I NSCLC were retrospectively reviewed. Expression of
R C Peffer et al.
Xenobiotica; the fate of foreign compounds in biological systems, 21(9), 1139-1152 (1991-09-01)
1. The metabolism of the thiocarbamate herbicide SUTAN (butylate) was studied after administration of single oral doses of [isobutyl-1-14C]SUTAN to male and female rats. 2. The radiolabelled dose was rapidly absorbed and excreted, with 79% of the dose excreted in
A Short et al.
British journal of pharmacology, 126(3), 551-554 (1999-04-03)
A new C5a receptor antagonist, the cyclic peptide Phe-[Orn-Pro-D-cyclohexylalanine-Trp-Arg], (F-[OPdChaWR]), was tested for its ability to antagonize the neutropenic effects of both C5a and endotoxin in rats. Human recombinant C5a (2 microg kg(-1) i.v.) caused rapid neutropenia, characterized by an
Gülşah Ceçener et al.
Tumori, 93(6), 597-603 (2008-03-15)
The character, role and impact of FHIT gene alterations, for which recent studies have shown that the gene has a role in the early stage of carcinogenesis in breast cancer, are still unclear. Thus, the current study evaluated FHIT gene
Ana Mbokeleng Tsotetsi et al.
Tropical animal health and production, 45(3), 751-761 (2012-10-16)
The present study was conducted to determine the prevalence and distribution of gastrointestinal helminths, to detect the presence of anthelmintic resistance in livestock from small-scale farms and to determine the level of helminthosis awareness among small-scale farmers in Gauteng Province
Concepción Huerta et al.
International journal of pharmaceutics, 493(1-2), 152-160 (2015-07-25)
Nimesulide (NS)-loaded nanoparticles (NPNS) were prepared from polylactide-co-glycolide (PLGA) and eventually coated with chitosan (NPNSCS). Nanoparticles (NP) were spherical with sizes 379 ± 59 nm for NPNS and 393 ± 66 nm for NPNSCS and zeta potentials of -15 ±
Ji Eun Oh et al.
Brain pathology (Zurich, Switzerland), 26(4), 517-522 (2015-10-08)
The majority of glioblastomas develop rapidly with a short clinical history (primary glioblastoma IDH wild-type), whereas secondary glioblastomas progress from diffuse astrocytoma or anaplastic astrocytoma. IDH mutations are the genetic hallmark of secondary glioblastomas. Gliosarcomas and giant cell glioblastomas are
Rong-Zong Liu et al.
The FEBS journal, 274(6), 1621-1633 (2007-05-08)
Teleost fishes differ from mammals in their fat deposition and distribution. The gene for adipocyte-type fatty acid-binding protein (A-FABP or FABP4) has not been identified thus far in fishes. We have determined the cDNA sequence and defined the structure of
Igor I Pottosin et al.
Pflugers Archiv : European journal of physiology, 456(6), 1037-1048 (2008-05-29)
In this study, we present patch-clamp characterization of the background potassium current in human lymphoma (Jurkat cells), generated by voltage-independent 16 pS channels with a high ( approximately 100-fold) K+/Na+ selectivity. Depending on the background K+ channels density, from few
Lu-Yun Lian et al.
PloS one, 6(5), e20574-e20574 (2011-06-10)
NADPH-cytochrome P450 oxidoreductase (CPR) plays a central role in chemical detoxification and insecticide resistance in Anopheles gambiae, the major vector for malaria. Anopheles gambiae CPR (AgCPR) was initially expressed in Eschericia coli but failed to bind 2',5'-ADP Sepharose. To investigate
G Ambrosini et al.
The Journal of biological chemistry, 272(13), 8340-8345 (1997-03-28)
Binding of factor Xa to human umbilical vein endothelial cells (HUVEC) is contributed by effector cell protease receptor-1 (EPR-1). The structural requirements of this recognition were investigated. Factor Xa or catalytically inactive 5-dimethylaminonaphthalene-1sulfonyl (dansyl) Glu-Gly-Arg-(DEGR)-chloromethylketone-factor Xa bound indistinguishably to HUVEC
P J Thornalley et al.
Kidney international, 58(5), 2228-2234 (2000-10-24)
Advanced glycation end products (AGEs) are a novel class of uremic toxins. In plasma, they are present in proteins and also in low molecular mass peptides. AGE-modified peptides are thought to bind and modify plasma proteins. Monitoring of the consequent
A J Ouellette et al.
Infection and immunity, 62(11), 5040-5047 (1994-11-01)
Cryptdins are antimicrobial peptides of the defensin family that are produced by intestinal Paneth cells. mRNAs encoding 17 cryptdin isoforms have been characterized from a cDNA library generated from a single jejunal crypt. Six cryptdin cDNAs correspond to known peptides
S J Garcés-Eisele et al.
Journal of clinical pharmacy and therapeutics, 39(4), 368-375 (2014-04-08)
Hydralazine is an inhibitor of DNA methyltransferases, whereas valproate interferes with histone deacetylation. In combination, they show a marked synergism in reducing tumour growth as well as development of metastasis and inducing cell differentiation. Hydralazine is metabolized by the highly
Sabrina Gioria et al.
Toxicology letters, 228(2), 111-126 (2014-05-02)
Although gold nanoparticles (AuNPs) are currently used in several industrial products and biomedical applications, information about their biological effects is very limited. Thus, it is becoming crucial to assess their safety and adequately investigate the complexity of cell-nanoparticles interactions. In
Yun Zhang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 10(11), 3667-3677 (2004-06-03)
The human epidermal growth factor receptor (EGFR) plays an oncogenic role in solid cancer, including brain cancer. The present study was designed to prolong survival in mice with intracranial human brain cancer with the weekly i.v. injection of nonviral gene
T J Mariani et al.
Matrix (Stuttgart, Germany), 12(3), 242-248 (1992-06-01)
Lysyl oxidase catalyzes the oxidation of lysine residues to alpha-aminoadipic-delta-semialdehyde. This is the first step in the covalent cross-linking of collagen and tropoelastin and results in the formation of insoluble collagen and elastic fibers in the extracellular matrix. We have
Nizar Naji et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(5), 359-363 (2013-04-30)
The effect of particle size on methacholine provocation concentration causing a decrease in forced expiratory volume of 1 second (FEV1) of 20% (PC20) is debatable. To evaluate the functional effects of 3 different particle size nebulizers on methacholine PC20. Participants
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