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Vinnitsa Buzoianu-Anguiano et al.
Neural plasticity, 2015, 389520-389520 (2015-12-04)
Functional recovery following spinal cord injury (SCI) is limited by poor axonal and cellular regeneration as well as the failure to replace damaged myelin. Employed separately, both the transplantation of the predegenerated peripheral nerve (PPN) and the transplantation of bone...
Marcus Buggert et al.
PLoS pathogens, 10(7), e1004251-e1004251 (2014-07-18)
CD8(+) T cell exhaustion represents a major hallmark of chronic HIV infection. Two key transcription factors governing CD8(+) T cell differentiation, T-bet and Eomesodermin (Eomes), have previously been shown in mice to differentially regulate T cell exhaustion in part through...
Subhendu Das et al.
Journal of virology, 88(16), 9086-9099 (2014-06-06)
Human cytomegalovirus (HCMV) has many effects on cells, including remodeling the cytoplasm to form the cytoplasmic virion assembly complex (cVAC), the site of final virion assembly. Viral tegument, envelope, and some nonstructural proteins localize to the cVAC, and cytoskeletal filaments...
Yun-Ching Chang et al.
Journal of the Chinese Medical Association : JCMA, 77(12), 618-625 (2014-12-03)
A recent research breakthrough has demonstrated that the ectopic expression of four genes is sufficient to reprogram human fibroblasts into inducible pluripotent stem cells (iPSCs). However, whether human dental pulp cells (DPCs) could be reprogrammed into iPSCs remains an open...
M G Sanders et al.
Cell death & disease, 6, e1813-e1813 (2015-07-15)
The human inflammatory caspases, including caspase-1, -4, -5 and -12, are considered as key regulators of innate immunity protecting from sepsis and numerous inflammatory diseases. Caspase-1 is activated by proximity-induced dimerization following recruitment to inflammasomes but the roles of the...
Andreas Noack et al.
PloS one, 9(2), e88154-e88154 (2014-02-08)
P-glycoprotein (Pgp; ABCB1/MDR1) is a major efflux transporter at the blood-brain barrier (BBB), restricting the penetration of various compounds. In other tissues, trafficking of Pgp from subcellular stores to the cell surface has been demonstrated and may constitute a rapid...
M Kaiser et al.
Scientific reports, 5, 10048-10048 (2015-05-15)
Capsaicin has known pharmacological effects including the ability to reversibly open cellular tight junctions, among others. The aim of this study was to develop a strategy to enhance the paracellular transport of a substance with low permeability (FITC-dextran) across an...
K I R Teixeira et al.
Drug delivery, 22(3), 444-453 (2014-02-05)
Although several studies have shown that chlorhexidine (Cx) has bactericidal activity and exerts toxic effects on periodontal tissues a few studies evaluated mechanisms to reduce its adverse effects maintaining the antimicrobial properties. Therefore, the aim of the present study was...
Hanan Awad et al.
Pediatric pulmonology, 49(9), 885-897 (2013-10-30)
Hypoxia and reactive oxygen species (ROS) including H(2)O(2) play major roles in triggering and progression of pulmonary vascular remodeling in persistent pulmonary hypertension. Catalase (CAT), the major endogenous enzyme scavenging H(2)O(2), is regulated in a tissue- and context-specific manner. To...
Muzamil Yaqub Want et al.
Colloids and surfaces. B, Biointerfaces, 130, 215-221 (2015-05-06)
Visceral leishmaniasis (VL) is a fatal vector-borne parasitic syndrome attributable to the protozoa of the Leishmania donovani complex. The available chemotherapeutic options are not ideal due to their potential toxicity, high cost and prolonged treatment schedule. In the present study...
Wesley P Black et al.
Scientific reports, 5, 17831-17831 (2015-12-08)
Here we attempted to identify the downstream target of the DifE histidine kinase in the regulation of exopolysaccharide (EPS) production in the Gram-negative bacterium Myxococcus xanthus. This bacterium is an important model system for the studies of Type IV pilus...
Fumitaka Kamachi et al.
Biochemical and biophysical research communications, 463(4), 739-745 (2015-06-07)
Group 2 innate lymphoid cells (ILC2s) are newly identified, potent producers of type 2 cytokines, such as IL-5 and IL-13, and contribute to the development of allergic lung inflammation induced by cysteine proteases. Although it has been shown that inducible...
Min-Yu Chung et al.
Journal of medicinal food, 18(6), 648-655 (2014-12-03)
Green tea extract (GTE) protects against nonalcoholic steatohepatitis (NASH) by decreasing hepatic steatosis and nuclear factor kappa B (NFκB) activation. We hypothesized that hypolipidemic and anti-inflammatory activities of GTE would protect against NASH by reducing cyclooxygenase-2 (COX-2), an NFκB-dependent enzyme...
Thomas Laeger et al.
The Journal of clinical investigation, 124(9), 3913-3922 (2014-08-19)
Enhanced fibroblast growth factor 21 (FGF21) production and circulation has been linked to the metabolic adaptation to starvation. Here, we demonstrated that hepatic FGF21 expression is induced by dietary protein restriction, but not energy restriction. Circulating FGF21 was increased 10-fold...
Rodrigo Carlessi et al.
Molecular and cellular endocrinology, 412, 239-250 (2015-05-16)
Islet quality loss after isolation from brain-dead donors still hinders the implementation of human islet transplantation for treatment of type 1 diabetes. In this scenario, systemic inflammation elicited by donor brain death (BD) is among the main factors influencing islet...
Katarzyna Brodowska et al.
Experimental eye research, 124, 67-73 (2014-05-20)
Verteporfin (VP), a benzoporphyrin derivative, is clinically used in photodynamic therapy for neovascular macular degeneration. Recent studies indicate that VP may inhibit growth of hepatoma cells without photoactivation through inhibition of YAP-TEAD complex. In this study, we examined the effects...
S Saveljeva et al.
Cell death & disease, 6, e1587-e1587 (2015-01-09)
Endoplasmic reticulum (ER) stress-induced cellular dysfunction and death is associated with several human diseases. It has been widely reported that ER stress kills through activation of the intrinsic mitochondrial apoptotic pathway. Here we demonstrate that ER stress can also induce...
Siyuan Ding et al.
PLoS biology, 12(1), e1001758-e1001758 (2014-01-11)
Type III interferon (IFN-λ) exhibits potent antiviral activity similar to IFN-α/β, but in contrast to the ubiquitous expression of the IFN-α/β receptor, the IFN-λ receptor is restricted to cells of epithelial origin. Despite the importance of IFN-λ in tissue-specific antiviral...
Masamichi Yano et al.
Scientific reports, 5, 15857-15857 (2015-11-03)
Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step in the salvage pathway for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, and thereby regulates the deacetylase activity of sirtuins. Here we show accommodative regulation of myocardial NAD(+) by monocyte-derived extracellular Nampt (eNampt), which is...
Ksenia Yuryeva et al.
Biochemical and biophysical research communications, 464(4), 1314-1320 (2015-08-02)
Adenosine is generated from adenosine triphosphate, which is released by stressed and damaged cells. Adenosine levels are significantly increased in patients with bronchial asthma (BA) and mediate mast cell degranulation and bronchoconstriction. Over the last decade, increasing evidence has shown...
Carmen Maria Jimenez-Moreno et al.
Current gene therapy, 15(4), 436-446 (2015-07-01)
Successful normalization of blood glucose in patients transplanted with pancreatic islets isolated from cadaveric donors established the proof-of-concept that Type 1 Diabetes Mellitus is a curable disease. Nonetheless, major caveats to the widespread use of this cell therapy approach have...
Yong Ho Kim et al.
Particle and fibre toxicology, 11, 29-29 (2014-06-18)
Emissions from a large peat fire in North Carolina in 2008 were associated with increased hospital admissions for asthma and the rate of heart failure in the exposed population. Peat fires often produce larger amounts of smoke and last longer...
P Ceschi et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 102(6), 1255-1267 (2014-01-18)
To improve the electrode-nerve interface of cochlear implants (CI), the role of poly(L-lactide) (PLLA) and poly(4-hydroxybutyrate) (P(4HB)) as potential coating matrices for CI was assessed both in vitro and in vivo in terms of degradation behavior and effects on spiral...
Lori R Bernstein et al.
Endocrinology, 155(6), 2287-2300 (2014-03-25)
Women experience a series of specific transitions in their reproductive function with age. Shortening of the menstrual cycle begins in the mid to late 30s and is regarded as the first sign of reproductive aging. Other early changes include elevation...
Ankita Agarwal et al.
Scientific reports, 5, 13838-13838 (2015-09-09)
In recent years the DNA minor groove has attracted much attention for the development of anti-malarial agents. In view of this we have attempted to discover novel DNA minor groove binders through in-silico and in-vitro workflow. A rigorously validated pharmacophore...
Yang Zhang et al.
Dalton transactions (Cambridge, England : 2003), 44(29), 13100-13111 (2015-06-25)
We have recently demonstrated that complexation with (η(6)-arene)Ru(II) fragments confers 4-anilinoquinazoline pharmacophores a higher potential for inducing cellular apoptosis while preserving the highly inhibitory activity of 4-anilinoquinazolines against EGFR and the reactivity of the ruthenium centre to 9-ethylguanine (Chem. Commun....
Xavier Michelet et al.
Journal of immunology (Baltimore, Md. : 1950), 194(5), 2079-2088 (2015-02-01)
Dendritic cells (DCs) are specialized APCs with the ability to prime naive T cells. DCs first sample Ags from the environment and then orchestrate their processing and loading onto MHC class II (MHC II) Ag-presenting molecules in lysosomes. Once MHC...
Michaela Griesser et al.
Plant science : an international journal of experimental plant biology, 234, 38-49 (2015-03-26)
Gall forming phylloxera may compete for nutrients with meristematic tissues and develop heterotrophic structures that act as carbon sinks. In this work, we studied the underlying starch metabolism, sink-source translocation of soluble sugars towards and within root galls. We demonstrated...
Shanye Yin et al.
Scientific reports, 5, 11992-11992 (2015-07-08)
Previous studies in vivo reported that processing of primary microRNA (pri-miRNA) is coupled to transcription by RNA polymerase II (RNAP II) and can occur co-transcriptionally. Here we have established a robust in vivo system in which pri-miRNA is transcribed by...
Andreia F Jorge et al.
Biochimica et biophysica acta, 1850(6), 1325-1335 (2015-02-24)
The potential use of Fe(III) ions in biomedical applications may predict the interest of its combination with pDNA-PEI polyplexes. The present work aims at assessing the impact of this metal on pDNA complex properties. Variations in the formation of complexes...