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Davide Povero et al.
PloS one, 9(12), e113651-e113651 (2014-12-04)
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in both adult and children. Currently there are no reliable methods to determine disease severity, monitor disease progression, or efficacy of therapy, other than an invasive liver biopsy....
Malte Feja et al.
Psychopharmacology, 232(7), 1291-1302 (2014-10-14)
Deficits in impulse control are prevalent in several neuropsychiatric disorders that are based on impaired frontostriatal communication. The ventral medial prefrontal cortex (vmPFC) and the nucleus accumbens (NAc) are key substrates of impulse control in rats. The NAc core and...
Chao Zhen et al.
Journal of neuroimmunology, 280, 1-7 (2015-03-17)
Multiple sclerosis (MS) has been associated with a history of sub-optimal exposure to ultraviolet light, implicating vitamin D3 as a possible protective agent. We evaluated whether 1,25(OH)2D3 attenuates the progression of experimental autoimmune encephalomyelitis (EAE), and explored its potential mechanisms....
Minako Imamura et al.
The Biochemical journal, 464(1), 35-48 (2014-08-26)
MondoA is a basic helix-loop-helix (bHLH)/leucine zipper (ZIP) transcription factor that is expressed predominantly in skeletal muscle. Studies in vitro suggest that the Max-like protein X (MondoA:Mlx) heterodimer senses the intracellular energy status and directly targets the promoter region of...
Oluseye A Ogunbayo et al.
The FEBS journal, 281(3), 766-777 (2013-11-19)
Flavonoids are group of plant-derived hydroxylated polycyclic molecules found in fruit and vegetables. They are known to bio-accumulate within humans and are considered to have beneficial health effects, including cancer chemoprotection. One mechanism proposed to explain this is that they...
Mira Mooreville et al.
Obesity (Silver Spring, Md.), 23(4), 808-814 (2015-02-17)
Determine the association of children's susceptibility to large food portion sizes with appetite regulation and obesity. Normal-weight and obese non-Hispanic black children (n = 100) aged 5-6 years were observed in four dinner conditions of varying portion size; portions of all foods...
Elizabeth A Wellberg et al.
Breast cancer research : BCR, 16(6), 481-481 (2014-12-05)
Spot14 (S14), encoded by the THRSP gene, regulates de novo fatty acid synthesis in the liver, adipose, and lactating mammary gland. We recently showed that S14 stimulated fatty acid synthase (FASN) activity in vitro, and increased the synthesis of fatty...
Hemant Kumar Rawat et al.
Antonie van Leeuwenhoek, 107(3), 799-811 (2015-01-07)
Owing to applications in the food and nutraceutical industries, inulinases, fructosyltransferases and sucrases have gained considerable attention in recent times. Twenty-five fungal strains were screened for production of these enzymes on three different media formulated using inulin-rich plant extracts prepared...
Luiz G Maturana et al.
Brain and behavior, 3(4), 417-430 (2014-01-02)
The purpose of this study was to investigate the influence of implanting collagen with a supramolecular organization on peripheral nerve regeneration, using the sciatic nerve tubulization technique. For this purpose, adult female Sprague Dawley rats were divided into five groups:...
Chun-Nun Chao et al.
Journal of translational medicine, 13, 29-29 (2015-01-28)
Diffuse large B-cell lymphoma (DLBCL) is one of the most common types of aggressive B-cell non-Hodgkin lymphoma. About one-third of patients are either refractory to the treatment or experience relapse afterwards, pointing to the necessity of developing other effective therapies...
R Huang et al.
Applied and environmental microbiology, 80(23), 7212-7218 (2014-09-14)
Streptococcus gordonii is a commensal species of human oral flora. It initiates dental biofilm formation and provides binding sites for later colonizers to attach to and generate mature biofilm. Smoking is the second highest risk factor for periodontal disease, and...
Marina Zaitseva et al.
Journal of virology, 89(6), 3295-3307 (2015-01-16)
Protection from lethality by postchallenge administration of brincidofovir (BCV, CMX001) was studied in normal and immune-deficient (nude, nu/nu) BALB/c mice infected with vaccinia virus (VACV). Whole-body bioluminescence imaging was used to record total fluxes in the nasal cavity, lungs, spleen...
Taira Matsuo et al.
MicrobiologyOpen, 2(5), 725-742 (2013-07-31)
Resistance nodulation cell division (RND)-type efflux transporters play the main role in intrinsic resistance to various antimicrobial agents in many gram-negative bacteria. Here, we estimated 12 RND-type efflux transporter genes in Vibrio parahaemolyticus. Because VmeAB has already been characterized, we...
Anne-Cécile Boulay et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(10), 4427-4439 (2015-03-13)
In the normal brain, immune cell trafficking and immune responses are strictly controlled and limited. This unique homeostatic equilibrium, also called brain immune quiescence, is crucial to maintaining proper brain functions and is altered in various pathological processes, from chronic...
Ruixue Sun et al.
Biochimica et biophysica acta, 1847(2), 248-261 (2014-12-03)
Minor antennae of photosystem (PS) II, located between the PSII core complex and the major antenna (LHCII), are important components for the structural and functional integrity of PSII supercomplexes. In order to study the functional significance of minor antennae in...
Nayara Cristina Perez de Albuquerque et al.
Journal of pharmaceutical and biomedical analysis, 109, 192-201 (2015-03-18)
Zopiclone (ZO) is a chiral drug that undergoes extensive metabolism to N-desmethylzopiclone (N-Des-ZO) and zopiclone-N-oxide (N-Ox-ZO). Pharmacological studies have shown (S)-N-Des-ZO metabolite presents anxiolytic activity and a patent for this metabolite was requested for anxiety treatment and related disorders. In...
Freeze-dried cake structural and physical heterogeneity in relation to freeze-drying cycle parameters.
Badal Tejedor, et al.
International Journal of Pharmaceutics, 590, 119891-119891 (2020)
Brett M Morrison et al.
Experimental neurology, 263, 325-338 (2014-12-03)
Peripheral nerve regeneration following injury occurs spontaneously, but many of the processes require metabolic energy. The mechanism of energy supply to axons has not previously been determined. In the central nervous system, monocarboxylate transporter 1 (MCT1), expressed in oligodendroglia, is...
Esak Lee et al.
Scientific reports, 4, 5853-5853 (2014-07-30)
Tumor lymphatic vessels (LV) serve as a conduit of tumor cell dissemination, due to their leaky nature and secretion of tumor-recruiting factors. Though lymphatic endothelial cells (LEC) lining the LV express distinct factors (also called lymphangiocrine factors), these factors and...
Stefano Toldo et al.
Cardiovascular research, 105(2), 203-212 (2014-12-20)
The NLRP3 inflammasome is activated in the ischaemic heart promoting caspase-1 activation, inflammation, and cell death. Ischaemic injury establishes both a priming signal (transcription of inflammasome components) and a trigger (NLRP3 activation). Whether NLRP3 activation, without priming, induces cardiac dysfunction...
Rostislav Chudnovskiy et al.
PloS one, 9(10), e108408-e108408 (2014-10-09)
To determine the metabolic effects of grapefruit juice consumption we established a model in which C57Bl/6 mice drank 25-50% sweetened GFJ, clarified of larger insoluble particles by centrifugation (cGFJ), ad libitum as their sole source of liquid or isocaloric and...
Qiong Lin et al.
Gene, 554(1), 64-74 (2014-12-03)
Ponkan (Citrus reticulata Blanco cv. Ponkan) is an important mandarin citrus in China. However, the low ratio of sugars to organic acids makes it less acceptable for consumers. In this work, three stages (S120, early development stage; S195, commercial harvest...
Esther Fuente-Martín et al.
Endocrinology, 154(7), 2318-2330 (2013-05-15)
Hypothalamic inflammation and gliosis are proposed to participate in the pathogenesis of high-fat diet-induced obesity. Because other factors and nutrients also induce weight gain and adiposity, we analyzed the inflammatory and glial responses to a sucrose (S)-enriched diet. Neonatal overnutrition...
Sucrose and oxidants.
Aziz A Keshvani
The Journal of pediatrics, 164(1), 220-220 (2013-10-23)
Eric D Berglund et al.
Nature neuroscience, 17(7), 911-913 (2014-06-09)
Whether melanocortin 4 receptors (MC4Rs) in extra-hypothalamic neurons, including cholinergic autonomic pre-ganglionic neurons, are required to control energy and glucose homeostasis is unclear. We found that MC4Rs in sympathetic, but not parasympathetic, pre-ganglionic neurons were required to regulate energy expenditure...
Christopher L Lord et al.
The Journal of cell biology, 208(6), 729-744 (2015-03-18)
The eukaryotic nuclear permeability barrier and selective nucleocytoplasmic transport are maintained by nuclear pore complexes (NPCs), large structures composed of ∼ 30 proteins (nucleoporins [Nups]). NPC structure and function are disrupted in aged nondividing metazoan cells, although it is unclear...
Santiago Roura et al.
International journal of cardiology, 176(3), 805-814 (2014-08-19)
Idiopathic dilated cardiomyopathy (IDCM) is characterized by adverse ventricular remodeling attributed to altered activity of extracellular matrix metalloproteinase (MMP). MMP overactivation is linked to changes in extracellular signal-regulated kinases (ERK), reportedly modulated by the low-density lipoprotein receptor-related protein 1 (LRP1)...
Ya He et al.
Cell transplantation, 23(6), 747-760 (2013-07-03)
Although neural stem cell (NSC) transplantation is widely expected to become a therapy for nervous system degenerative diseases and injuries, the low neuronal differentiation rate of NSCs transplanted into the inner ear is a major obstacle for the successful treatment...
Jaymes Beech et al.
Bioconjugate chemistry, 26(3), 529-536 (2015-02-19)
High-throughput screening of combinatorial chemical libraries is a powerful approach for identifying targeted molecules. The display of combinatorial peptide libraries on the surface of bacteriophages offers a rapid, economical way to screen billions of peptides for specific binding properties and...
Sabine Giesbert et al.
PloS one, 9(5), e95172-e95172 (2014-05-07)
In phytopathogenic fungi the establishment and maintenance of polarity is not only essential for vegetative growth and differentiation, but also for penetration and colonization of host tissues. We investigated orthologs of members of the yeast polarity complex in the grey...
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