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Mónica Moreno et al.
Electrophoresis, 36(16), 1945-1952 (2015-06-03)
This work reports on the positive effects observed upon both the separation and analytical signals in electrophoretic separations of selected phenolic compounds when using aqueous BGE containing carbon nanotubes (CNTs) in connection to electrochemical detection (ECD). The influence of the...
Simona Codruţa Cobzac et al.
Journal of chromatographic science, 52(9), 1095-1103 (2013-10-29)
The retention behavior for a series of amine neurotransmitters, their precursors, metabolites and structurally related drugs has been investigated in reversed-phase thin-layer chromatography using RP-18, RP-8, RP-2, CN and Diol stationary phases and mixtures of phosphate buffer and methanol as...
Imola Plangár et al.
Ideggyogyaszati szemle, 66(11-12), 407-414 (2014-02-22)
The available scientific data indicate that the pathomechanism of Parkinson's disease (PD) involves the accumulation of endogenous and exogenous toxic substances. The disruption of the proper functioning of certain transporters in the blood-brain barrier and in the blood-cerebrospinal fluid barrier...
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the...
Mireia Urpi-Sarda et al.
Journal of chromatography. A, 1216(43), 7258-7267 (2009-08-13)
The biological properties of cocoa (Theobroma cacao L.) polyphenols are strictly dependent on their bioavailability. A long-term cocoa feeding trial was performed with subjects at high risk for cardiovascular disease. Subjects (n=42) received two sachets of 20 g of cocoa...
Houbo Jiang et al.
The Journal of biological chemistry, 281(13), 8591-8599 (2006-02-04)
Mutations of parkin are linked to early onset Parkinson disease. Here we show that stable transfection of parkin in the human dopaminergic neuroblastoma cell line SH-SY5Y markedly reduced the activities of both monoamine oxidase (MAO) A and B. The amount...
Zhao-fu Sheng et al.
Acta pharmacologica Sinica, 36(8), 949-956 (2015-08-05)
7-O-ethylfangchinoline (YH-200) is a bisbenzylisoquinoline derivative. The aim of this study was to investigate the antidepressant-like action and underlying mechanisms of YH-200 in mice. Mice were treated with YH-200 (15, 30, and 60 mg/kg, ig) or tetrandrine (30 and 60...
Steven Tran et al.
Behavioural brain research, 276, 161-170 (2014-03-07)
The zebrafish is emerging as a popular animal model for alcohol (ethanol or EtOH) addiction due to its simplicity and practical advantages. Two phenomena associated with ethanol addiction are the development of tolerance and withdrawal. Using a multi-level approach in...
Vânia Patrícia Martins Gomes et al.
Journal of agricultural and food chemistry, 63(43), 9565-9571 (2015-10-23)
The growing interest in the bioactivity of natural polyphenols and of their metabolites requires metabolites to be used in bioassays and as standards in research protocols. We report here on the synthesis of several hydroxytyrosol metabolite monosulfates achieved using a...
Magda Nowicki et al.
Pharmacology, biochemistry, and behavior, 138, 32-39 (2015-09-15)
Zebrafish have been successfully employed in the study of the behavioural and biological effects of ethanol. Like in mammals, low to moderate doses of ethanol induce motor hyperactivity in zebrafish, an effect that has been attributed to the activation of...
I J Chopra et al.
The Journal of clinical endocrinology and metabolism, 76(1), 145-150 (1993-01-01)
A highly sensitive, specific, and reproducible RIA has been developed to measure T4 sulfate (T4S) in ethanol extracts of serum. rT3 sulfate (rT3S) cross-reacted 7.1%, and T3S cross-reacted 0.59% in the RIA; T4, T3, rT3, and 3,3'-diiodothyronine cross-reacted 0.004% or...
Le Qu et al.
Neuropharmacology, 144, 291-300 (2018-10-22)
Rosmarinic acid (RA) is a naturally occurring polyphenolic compound. In this study, we demonstrated that RA could protect against the degeneration of the nigrostriatal dopaminergic system in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease (PD). In addition, RA could inhibit...
J Kalita et al.
Journal of the neurological sciences, 252(1), 62-66 (2006-12-01)
To evaluate cerebrospinal fluid (CSF) catecholamine (CA) and its metabolites in encephalitis patients in acute and convalescent period and correlate these with clinical and magnetic resonance imaging (MRI) features. Patients with acute encephalitis diagnosed on the basis of clinical, CSF...
Li-Qin Chen et al.
Biomedical chromatography : BMC, 29(1), 103-109 (2014-06-12)
For the first time, electrospun composite nanofibers comprising polymeric crown ether with polystyrene (PCE-PS) have been used for the selective extraction of catecholamines - dopamine (DA), norepinephrine (NE) and epinephrine (E) - prior to their analysis by high-performance liquid chromatography-electrochemical...
Electrocatalytic oxidation of 3, 4-dihydroxyphenylacetic acid at a glassy carbon electrode modified with single-wall carbon nanotubes.
Wang J, et al.
Electrochimica Acta, 47(4), 651-657 (2001)
Donna Crabtree et al.
Neuroscience letters, 538, 3-8 (2013-02-09)
Cathepsin D (CD) is a lysosomal aspartyl protease which plays an important role in α-synuclein degradation, and neuronal survival. CD knockout mice die by post-natal day 25±1 due to intestinal necrosis. We analyzed the young adult male heterozygous mice, and...
Muhammed Saif et al.
Behavioural brain research, 243, 294-299 (2013-01-30)
Zebrafish are gaining popularity in behavioural brain research as this species combines practical simplicity with system complexity. The dopaminergic system has been thoroughly investigated using mammals. Dopamine plays important roles in motor function and reward. Zebrafish have dopamine receptors homologous...
L Barros-Miñones et al.
Neuropharmacology, 93, 124-133 (2015-02-11)
Methylenedioxymethamphetamine (MDMA) causes a persistent loss of dopaminergic cell bodies in the substantia nigra of mice. Current evidence indicates that MDMA-induced neurotoxicity is mediated by oxidative stress probably due to the inhibition of mitochondrial complex I activity. In this study...
Beatrice Bocca et al.
Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <...
V R Florang et al.
Neurotoxicology, 28(1), 76-82 (2006-09-08)
Recent evidence indicates a role for oxidative stress and resulting products, e.g. 4-hydroxy-2-nonenal (4HNE) in the pathogenesis of Parkinson's disease (PD). 4HNE is a known inhibitor of mitochondrial aldehyde dehydrogenase (ALDH2), an enzyme very important to the dopamine (DA) metabolic...
Naoyuki Nakao et al.
Experimental neurology, 188(1), 65-73 (2004-06-12)
We have investigated the potential of autologous sympathetic neurons as a donor for cell therapy of Parkinson's disease (PD). Our recent study demonstrated that sympathetic neuron autografts increase the duration of levodopa-induced "on" periods with consequent reduction in the percent...
Sandy Stayte et al.
PloS one, 10(4), e0124325-e0124325 (2015-04-23)
Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by a significant loss of dopaminergic neurons within the substantia nigra pars compacta (SNpc) and a subsequent loss of dopamine (DA) within the striatum. Despite advances in the development of pharmacological...
Michael M Mbughuni et al.
Biochemistry, 51(44), 8743-8754 (2012-10-17)
Homoprotocatechuate (HPCA; 3,4-dihydroxyphenylacetate or 4-carboxymethyl catechol) and O(2) bind in adjacent ligand sites of the active site Fe(II) of homoprotocatechuate 2,3-dioxygenase (FeHPCD). We have proposed that electron transfer from the chelated aromatic substrate through the Fe(II) to O(2) gives both...
[3,4-Dihydroxyphenylacetic acid (DOPAC)].
Midori Sasaki et al.
Nihon rinsho. Japanese journal of clinical medicine, 63 Suppl 8, 384-387 (2005-09-10)
Neha Milind Chitre et al.
Neuropharmacology, 167, 107976-107976 (2020-02-01)
Parkinson's disease (PD) is a devastating neurodegenerative disease that leads to motor deficits and selective destruction of nigrostriatal dopaminergic neurons. PD is typically treated by dopamine replacement agents; however, dopamine replacement loses effectiveness in the later stages of the disease....
Steven Tran et al.
Psychopharmacology, 232(20), 3709-3718 (2015-07-27)
The zebrafish has become an increasingly popular animal model for investigating ethanol's actions in the brain and its effects on behavior. Acute exposure to ethanol in zebrafish has been shown to induce a dose-dependent increase of locomotor activity, to reduce...
T Eklundh et al.
Journal of psychiatric research, 30(3), 201-208 (1996-05-01)
In order to elucidate methodological aspects of CSF investigations, 14 healthy male subjects were lumbar-punctured at the L4-5 level following a standardised procedure. CSF concentrations of precursors, transmitters and transmitter metabolites were used as dependent variables, while age, height, body...
Jackson T Del Bonis-O'Donnell et al.
ACS chemical neuroscience, 9(4), 849-857 (2017-12-20)
Neurotransmitters are small molecules that orchestrate complex patterns of brain activity. Unfortunately, there exist few sensors capable of directly detecting individual neurotransmitters. Those sensors that do exist are either unspecific or fail to capture the temporal or spatial dynamics of...
David H Root et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(8), 3460-3469 (2015-02-27)
The lateral habenula (LHb) is involved in reward and aversion and is reciprocally connected with dopamine (DA)-containing brain regions, including the ventral tegmental area (VTA). We used a multidisciplinary approach to examine the properties of DA afferents to the LHb...
J L Izzo et al.
Life sciences, 33(5), 483-488 (1983-08-01)
An adaptation of the single-isotope radioenzymatic catecholamine assay technique allows simultaneous quantitation of free dihydroxyphenylglycol (DHPG), dihydroxymandelic acid (DOMA), and dihydroxyphenylacetic acid (DOPAC) in small volumes of plasma. Incubation of sample with catechol-O-methyltransferase and S-adenosylmethionine is followed by acidic extractions...
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