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85429

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Shelley N Jackson et al.
Journal of the American Society for Mass Spectrometry, 16(2), 133-138 (2005-02-08)
After water, lipids are the most common biomolecules found in the brain (12%). A brief perusal of the physiology, anatomy, and pathophysiology of the brain illustrates the importance of lipids. Recent advances in mass spectrometry have allowed the direct probing...
Danila V Zimenkov et al.
Journal of clinical microbiology, 53(4), 1103-1114 (2015-01-23)
In addition to the obligatory pathogenic species of the Mycobacterium tuberculosis complex and Mycobacterium leprae, the genus Mycobacterium also includes conditionally pathogenic species that in rare cases can lead to the development of nontuberculous mycobacterial diseases. Because tuberculosis and mycobacteriosis...
Shinyoung Lee et al.
The Plant journal : for cell and molecular biology, 72(3), 411-422 (2012-07-06)
Glucosinolates (GSLs) are nitrogen- and sulfur-containing metabolites that contribute to human health and plant defense. The biological activities of these molecules are largely dependent on modification of the GSL R-groups derived from their corresponding amino acid precursors. In Arabidopsis seeds...
Yong Jin Bae et al.
Journal of the American Society for Mass Spectrometry, 22(6), 1070-1078 (2011-09-29)
Time-of-flight (TOF) mass spectra for a peptide (Y(6)) were obtained by utilizing matrix-assisted infrared laser desorption ionization (IR-MALDI) with glycerol as the matrix and by ultraviolet MALDI with α-cyano-4-hydroxycinnamic acid (CHCA), sinapinic acid (SA), and 2,5-dihydroxybenzoic acid (DHB). Collisional activation...
Patricia V Demkura et al.
Molecular plant, 5(3), 642-652 (2012-03-27)
Light is emerging as a central regulator of plant immune responses against herbivores and pathogens. Solar UV-B radiation plays an important role as a positive modulator of plant defense. However, since UV-B photons can interact with a wide spectrum of...
Liping Chung et al.
Breast cancer research : BCR, 16(3), R63-R63 (2014-06-18)
Serum profiling using proteomic techniques has great potential to detect biomarkers that might improve diagnosis and predict outcome for breast cancer patients (BC). This study used surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry (MS) to identify differentially expressed proteins in...
Toshiyuki Takahashi et al.
Bioorganic & medicinal chemistry letters, 22(7), 2494-2496 (2012-03-06)
The inhibitory effects of the synthetic serotonin analogues (1-8) on COX (1 and 2) were evaluated. Two serotonin derivatives (4 and 8) showed inhibitory effect of COX (1 and 2). Especially, 4 exhibited excellent inhibitions on COX-2 with extremely high...
Nisha D Sherma et al.
Proteome science, 12(1), 52-52 (2014-10-21)
The cytokine MIF (Macrophage Migration Inhibitory Factor) has diverse physiological roles and is present at elevated concentrations in numerous disease states. However, its molecular heterogeneity has not been previously investigated in biological samples. Mass Spectrometric Immunoassay (MSIA) may help elucidate...
Subhro Jyoti Roy et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(11), 3984-3989 (2012-08-28)
In the pathology of myocardial infarction, lysosomal lipid peroxidation and resulting enzyme release play an important role. We evaluated the protective effects of sinapic acid on lysosomal dysfunction in isoproterenol induced myocardial infarcted rats. Male Wistar rats were treated with...
Magdalena Luczak et al.
Journal of translational medicine, 13, 20-20 (2015-01-28)
Atherosclerosis is a major cause of cardiac events and mortality in patients suffering from chronic kidney disease (CKD). Moreover, the risk of cardiovascular disease (CVD) development in patients with CKD increases as kidney function declines. Although the close connection between...
L Gallego et al.
Food science and technology international = Ciencia y tecnologia de los alimentos internacional, 17(5), 429-438 (2011-09-29)
The aim of this study is to assess the use of polymeric cartridges with diode array detection to extract the main low-molecular mass phenolic compounds from red wine samples. This method expanded and improved permitted to quantify 20 compounds in...
O Kenny et al.
Food chemistry, 161, 79-86 (2014-05-20)
Antimicrobial properties of ethanol and water extracts from eight Asteraceae species were investigated against three Gram positive (Staphylococcus aureus, MRSA and Bacillus cereus) and two Gram negative (Escherichia coli and Salmonella typhimurium) bacterial strains. Ethanol extracts from Centaurea scabiosa, Arctium...
Anne Arnold et al.
Rapid communications in mass spectrometry : RCM, 25(19), 2844-2850 (2011-09-14)
A simple, sensitive and fast method for the determination of melamine and its derivatives in milk powder using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) was developed. Neither time-consuming sample preparation, nor special target plates, or other extra equipment are...
Thangarasu Silambarasan et al.
PloS one, 9(12), e115682-e115682 (2014-12-23)
Hypertensive heart disease is a constellation of abnormalities that includes cardiac fibrosis in response to elevated blood pressure, systolic and diastolic dysfunction. The present study was undertaken to examine the effect of sinapic acid on high blood pressure and cardiovascular...
Clifton K Fagerquist et al.
Journal of the American Society for Mass Spectrometry, 23(12), 2102-2114 (2012-10-12)
We previously reported the apparent formation of matrix adducts of 3,5-dimethoxy-4-hydroxy-cinnamic acid (sinapinic acid or SA) via covalent attachment to disulfide bond-containing proteins (HdeA, Hde, and YbgS) from bacterial cell lysates ionized by matrix-assisted laser desorption/ionization (MALDI) time-of-flight-time-of-flight tandem mass...
Xiaoyun Zeng et al.
Molecular pharmacology, 83(5), 1099-1108 (2013-03-09)
Inhibition of oxidative stress and inflammation in vascular endothelial cells (ECs) may represent a new therapeutic strategy against endothelial activation. Sinapic acid (SA), a phenylpropanoid compound, is found in natural herbs and high-bran cereals and has moderate antioxidant activity. We...
Toshiyuki Takahashi et al.
Bioorganic & medicinal chemistry letters, 21(7), 1983-1986 (2011-03-08)
In this manuscript, we synthesized a series of phenylpropanoid amide of serotonin 1-9, analyzed their structural importance for two biologic activities (antioxidant activity and tyrosinase inhibitory activity). While the serotonin moiety and the amide linkage of serotonin derivatives affect antioxidant...
Jana Škerlová et al.
The FEBS journal, 281(18), 4280-4292 (2014-05-28)
Deoxyribonucleoside regulator (DeoR) from Bacillus subtilis negatively regulates expression of enzymes involved in the catabolism of deoxyribonucleosides and deoxyribose. The DeoR protein is homologous to the sorbitol operon regulator family of metabolic regulators and comprises an N-terminal DNA-binding domain and...
Kyueng-Whan Min et al.
Journal of Korean medical science, 29(7), 934-940 (2014-07-22)
Direct tissue imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization and time-of-flight (MALDI-TOF) mass spectrometry has become increasingly important in biology and medicine, because this technology can detect the relative abundance and spatial distribution of interesting proteins in tissues....
Kimberly J Nelson et al.
Analytical biochemistry, 375(2), 187-195 (2007-12-29)
Cysteine reactivity in enzymes is imparted to a large extent by the stabilization of the deprotonated form of the reduced cysteine (i.e., the thiolate) within the active site. Although this is likely to be an important chemical attribute of many...
Hussein N Yassine et al.
PloS one, 10(1), e0115320-e0115320 (2015-01-22)
Using mass spectrometric immunoassay, the abundance of SAA truncations relative to the native variants was examined in plasma of 91 participants with type 2 diabetes and chronic kidney disease and 69 participants without diabetes. The ratio of SAA 1.1 (missing...
Mattia Gasperotti et al.
Talanta, 128, 221-230 (2014-07-26)
An increasing number of studies have concerned the profiling of polyphenol microbial metabolites, especially in urine or plasma, but only a few have regarded their accurate quantification. This study reports on a new ultra-performance liquid chromatography tandem mass spectrometry method...
Anand Natrajan et al.
Organic & biomolecular chemistry, 13(9), 2622-2633 (2015-01-13)
Chemiluminescent acridinium dimethylphenyl esters are highly sensitive labels that are used in automated assays for clinical diagnosis. Light emission from these labels and their conjugates is triggered by treatment with alkaline peroxide. Conjugation of acridinium ester labels is normally done...
David M G Anderson et al.
Analytical and bioanalytical chemistry, 407(8), 2311-2320 (2015-02-11)
MALDI imaging requires careful sample preparation to obtain reliable, high-quality images of small molecules, peptides, lipids, and proteins across tissue sections. Poor crystal formation, delocalization of analytes, and inadequate tissue adherence can affect the quality, reliability, and spatial resolution of...
Najla AlMasoud et al.
Analytica chimica acta, 840, 49-57 (2014-08-05)
Over the past few decades there has been an increased interest in using various analytical techniques for detecting and identifying microorganisms. More recently there has been an explosion in the application of matrix assisted laser desorption ionization time of flight...
Jiyan Liu et al.
Journal of ethnopharmacology, 155(2), 1322-1331 (2014-07-30)
Chemotherapy is the mainstay of modern tuberculosis (TB) control. Traditional Chinese Medicine (TCM) can enhance the effect of anti-TB drug, promote the absorption of the foci in the lung and reduce drug toxicity. In TCM, the determination of treatment is...
S.N. Singh
Climate Change and Crops, 249-249 (2009)
Ana Carolina Pereira et al.
Phytochemistry, 107, 119-125 (2014-09-10)
Parasitic diseases continue to be a major worldwide health problem, and there is an urgent need for development of therapeutic drugs. This paper describes synthesis of dehydrodiferulic acid dilactone 1 and dehydrodisinapic acid dilactone 2 furofuran lignans by oxidative coupling...
L Pari et al.
Chemico-biological interactions, 194(1), 40-47 (2011-08-26)
Arsenic compounds are classified as toxicants and human carcinogens. Environmental exposure to arsenic imposes a big health issue worldwide. Sinapic acid is a phenylpropanoid compound and is found in various herbal materials and high-bran cereals. It has been reported that...
Andrew D Watt et al.
Methods in molecular biology (Clifton, N.J.), 752, 229-240 (2011-06-30)
Alzheimer's disease (AD) is a highly heterogeneous and progressive dementia which is characterised by a progressive decline in cognitive functioning, selective neuronal atrophy, and loss of cortical volume in areas involved in learning and memory. However, recent research has indicated...
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