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860336

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Thiago S L Araújo et al.
Journal of ethnopharmacology, 174, 299-307 (2015-08-25)
Anacardium occidentale L. (Anacardiaceae) is commonly known as the cashew tree. It is native to tropical America and extracts of the leaves, bark, roots, chestnut net and exudate have been traditionally used in northeast Brazil for the treatment of various...
Xiaohu Xia et al.
ACS nano, 9(10), 9994-10004 (2015-09-04)
Peroxidase mimics with dimensions on the nanoscale have received great interest as emerging artificial enzymes for biomedicine and environmental protection. While a variety of peroxidase mimics have been actively developed recently, limited progress has been made toward improving their catalytic...
Elizabeth F Wallin et al.
Blood, 124(17), 2666-2674 (2014-09-17)
The monoclonal anti-CD20 antibody rituximab (RTX) depletes B cells in the treatment of lymphoma and autoimmune disease, and contributes to alloantibody reduction in transplantation across immunologic barriers. The effects of RTX on T cells are less well described. T-follicular helper...
Hao Li et al.
The Journal of clinical investigation, 125(7), 2877-2890 (2015-06-23)
Systemic lupus erythematosus (SLE) is a severe autoimmune disease that is associated with increased circulating apoptotic cell autoantigens (AC-Ags) as well as increased type I IFN signaling. Here, we describe a pathogenic mechanism in which follicular translocation of marginal zone...
Yacong Zhao et al.
International immunopharmacology, 24(2), 219-223 (2014-12-24)
BLyS antagonists have become the therapeutic reagents in the treatment of autoimmune disorders. BLyS binding peptides and their Fc fusion proteins may be alternative BLyS antagonists in such application. In this study, the activity of BLyS binding peptide 814 obtained...
Matthew J Gold et al.
The Journal of allergy and clinical immunology, 136(3), 725-736 (2015-03-10)
Inpp5d (Src homology 2 domain-containing inositol-5-phosphatase [Ship1])-deficient mice experience spontaneous airway inflammation and have enhanced sensitivity to allergen-induced airway inflammation. We hypothesized that lineage-specific deletion of Ship1 expression in cells known to be crucial for adaptive TH2 responses would uncover...
Agnès Fleury et al.
PLoS neglected tropical diseases, 9(8), e0003980-e0003980 (2015-08-08)
Human neurocysticercosis (NC) is caused by the establishment of Taenia solium larvae in the central nervous system. NC is a severe disease still affecting the population in developing countries of Latin America, Asia, and Africa. While great improvements have been...
Jari Intra et al.
Insect biochemistry and molecular biology, 63, 133-143 (2015-06-24)
Sperm-oocyte interaction during fertilization is multiphasic, with multicomponent events, taking place between egg's glycoproteins and sperm surface receptors. Protein-carbohydrate complementarities in gamete recognition have observed in cases throughout the whole evolutionary scale. Sperm-associated α-L-fucosidases have been identified in various organisms....
Carina Hillgruber et al.
The Journal of experimental medicine, 212(8), 1255-1266 (2015-07-15)
Spontaneous organ hemorrhage is the major complication in thrombocytopenia with a potential fatal outcome. However, the exact mechanisms regulating vascular integrity are still unknown. Here, we demonstrate that neutrophils recruited to inflammatory sites are the cellular culprits inducing thrombocytopenic tissue...
Shanshan Cao et al.
Immunological investigations, 44(5), 438-450 (2015-06-25)
An enzyme-linked immunosorbent assay (ELISA) and an immunochromatographic assay were constructed for the detection of lincomycin (LIN) in both milk and honey samples based on the monoclonal antibody named 5F6. The half-maximum inhibition of ELISA was 0.3 ng/mL after optimizing pH...
Sunao Imai et al.
Analytical biochemistry, 484, 91-98 (2015-06-01)
The blood concentration of intact proinsulin, but not total proinsulin, has been suggested to be a diagnostic marker for type 2 diabetes mellitus (T2DM), but a sensitive assay specific for rodent intact proinsulin is lacking. Here, a novel enzyme-linked immunosorbent...
Huey Wen Ooi et al.
Analytical biochemistry, 456, 6-13 (2014-04-12)
A novel metal-based chelating method has been used to provide an order of magnitude increase in immunoassay performance on cyclic olefin copolymer (COC) plastics compared with passive binding. COCs are hydrophobic, and without surface modification they are often unsuitable for...
Grégoire Couvrat-Desvergnes et al.
The Journal of clinical investigation, 125(12), 4655-4665 (2015-11-10)
Rabbit-generated antithymocyte globulins (ATGs), which target human T cells, are widely used as immunosuppressive agents during treatment of kidney allograft recipients. However, ATGs can induce immune complex diseases, including serum sickness disease (SSD). Rabbit and human IgGs have various antigenic...
D J Begg et al.
Veterinary immunology and immunopathology, 166(3-4), 125-131 (2015-07-07)
Many studies have examined the serum antibody response to Mycobacterium avium subspecies paratuberculosis (MAP) infection in cases of Johne's disease (JD), but there are no reports on the mucosal antibody response. Faecal immunoglobulin (Ig) G and IgA ELISA responses were...
Anushi E Rajapaksa et al.
Respiratory research, 15, 60-60 (2014-06-03)
Pulmonary-delivered gene therapy promises to mitigate vaccine safety issues and reduce the need for needles and skilled personnel to use them. While plasmid DNA (pDNA) offers a rapid route to vaccine production without side effects or reliance on cold chain...
Stefanie Meister et al.
Rheumatology international, 35(8), 1311-1318 (2015-01-30)
The inhibitory FcγRIIB plays an important role for the peripheral B cell tolerance and plasma cell homeostasis, and any malfunctioning is predicted to result in humoral autoimmunity. An association between rheumatoid arthritis (RA) and FCGR2B promoter and TM region variant...
Bella Ungar et al.
World journal of gastroenterology, 21(6), 1907-1914 (2015-02-17)
To evaluate the prevalence of double negative (DN) sera and the mechanisms responsible for DN status. Sera of inflammatory bowel disease patients treated with infliximab (IFX) were tested for drug/antibodies to infliximab (ATI) trough levels and the proportion of DN...
Anna Pennacchio et al.
Analytical biochemistry, 481, 55-59 (2015-05-07)
Patulin (PAT) is a toxic secondary metabolite (mycotoxin) of different fungal species belonging to the genera Penicillium, Aspergillus, and Byssochlamys. They can grow on a large variety of food, including fruits, grains, and cheese. The amount of PAT in apple...
Beatrice N Vetter et al.
BMC infectious diseases, 15, 468-468 (2015-10-30)
The detection of HIV-1 p24 antigen in diagnostic tests relies on antibodies binding to conserved areas of the protein to cover the full range of HIV-1 subtypes. Using a panel of 43 different virus-like particles (VLPs) expressing Gag from clinical...
L M Carrillo-Cocom et al.
Cytotechnology, 67(5), 809-820 (2014-05-07)
Most commercial media for mammalian cell culture are designed to satisfy the amino acid requirements for cell growth, but not necessarily those for recombinant protein production. In this study, we analyze the amino acid consumption pattern in naïve and recombinant...
Stewart Coleman et al.
PloS one, 10(8), e0135567-e0135567 (2015-08-13)
Development of a cytomegalovirus (CMV) vaccine is a major public health priority due to the risk of congenital infection. A key component of a vaccine is thought to be an effective neutralizing antibody response against the viral glycoproteins necessary for...
Majid Motaghinejad et al.
Fundamental & clinical pharmacology, 29(3), 299-309 (2015-04-08)
Chronic consumption of morphine induces physical dependency, anxiety, and neurodegeneration. In this study, morphine on its own has been used for the management of morphine-induced dependency, oxidative stress, and apoptosis. Forty-eight male rats were randomly divided into six groups. Rats...
Wen-Hsiang Chen et al.
Human vaccines & immunotherapeutics, 10(3), 648-658 (2013-12-21)
Development of vaccines for preventing a future pandemic of severe acute respiratory syndrome (SARS) caused by SARS coronavirus (SARS-CoV) and for biodefense preparedness is urgently needed. Our previous studies have shown that a candidate SARS vaccine antigen consisting of the...
Kiran Kumar Chereddy et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(8), 1975-1984 (2015-08-05)
Growth factor therapies to induce angiogenesis and thereby enhance the blood perfusion, hold tremendous potential to address the shortcomings of current impaired wound care modalities. Vascular endothelial growth factor stimulates (VEGF) wound healing via multiple mechanisms. Poly(lactic-co-glycolic acid) (PLGA) supplies...
Maria Grazia Clemente et al.
The Journal of pediatrics, 166(1), 79-84 (2014-12-03)
To analyze the prevalence of acute asymptomatic group A and C rotavirus (RV-A and RV-C) infection in neonates with cholestasis. Participants were infants <180 days of age with cholestasis (serum direct or conjugated bilirubin >20% of total and ≥2 mg/dL)...
Zahra Kianmehr et al.
Medical microbiology and immunology, 204(2), 205-213 (2014-09-05)
Brucella abortus lipopolysaccharide (LPS) has less toxicity and no pyrogenic properties in comparison with other bacterial LPS. It is a toll-like receptor 4 agonist and has been shown to have the potential use as a vaccine adjuvant. In this study...
Islam Amine Larabi et al.
Journal of analytical toxicology, 39(9), 720-725 (2015-09-06)
A liquid chromatography-MS-MS turbulent flow on-line extraction method was developed for the determination of trimebutine (TMB) and its main active metabolite N-mono-desmethyltrimebutine (nortrimebutine or nor-TMB) in human plasma. After protein precipitation and internal standard (IS, haloperidol-d4) addition, 50 µL of...
Hyojung Lee et al.
Basic & clinical pharmacology & toxicology, 116(3), 222-228 (2014-08-20)
Inflammation is a common feature in the pathogenesis of cigarette smoke (CS)-associated diseases. In this study, we investigated the effects of Galla Chinensis (GC) extract on pulmonary inflammatory responses in a CS-exposed mouse model. In vitro studies showed that GC...
K J Taylor et al.
Parasite immunology, 37(1), 23-31 (2014-11-08)
Translationally controlled tumour protein (TCTP) may play an important role in the establishment or maintenance of parasitemia in a malarial infection. In this study, the potential of TCTP as a malaria vaccine was investigated in two trials. In the initial...
Daniel Menezes-Souza et al.
PloS one, 9(6), e99216-e99216 (2014-06-13)
The search toward the establishment of novel serological tests for the diagnosis of leishmaniasis and proper differential diagnosis may represent one alternative to the invasive parasitological methods currently used to identify infected individuals. In the present work, we investigated the...
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