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Chuang Xu et al.
Monoclonal antibodies in immunodiagnosis and immunotherapy, 34(5), 341-345 (2015-10-23)
When abrin-a was combined with several polyclonal antibodies (PAb), the detection limit could be increased. In this way, a monoclonal antibody (capture) and polyclonal antibody (detection) sandwich enzyme-linked immunosorbent assay (ELISA) and a colloidal gold-PAb conjugate-based immunochromatographic assay for detection
Jianxuan Zou et al.
Cancer science, 106(5), 512-521 (2015-02-11)
Bispecific antibodies play an important role in immunotherapy. They have received intense interest from pharmaceutical enterprises. The first antibody drug, OKT3 (muromonab-CD3), showed great performance in clinical treatment. We have successfully developed a single-chain variable fragment (ScFv) combination of anti-CD3
Nobuhiko Fukuda et al.
Brain research, 1602, 62-74 (2015-01-21)
Oa1 is the casual gene for ocular albinism-1 in humans. The gene product OA1, alternatively designated as GPR143, belongs to G-protein coupled receptors. It has been reported that OA1 is a specific receptor for 3, 4-dihydroxy- L-phenylalanine (DOPA) in retinal
G M Proshkina et al.
Biochimie, 118, 116-122 (2015-09-01)
Cytotoxic effects of a new targeted phototoxin DARPin-miniSOG and mechanism of its action were investigated in vitro. It was determined that DARPin-miniSOG causes light-induced death of HER2/neu-positive cancer cells (IC50 0.8 μM). Treatment of the cells with DARPin-miniSOG in the presence of
Elizabeth F Wallin et al.
Blood, 124(17), 2666-2674 (2014-09-17)
The monoclonal anti-CD20 antibody rituximab (RTX) depletes B cells in the treatment of lymphoma and autoimmune disease, and contributes to alloantibody reduction in transplantation across immunologic barriers. The effects of RTX on T cells are less well described. T-follicular helper
Thiago S L Araújo et al.
Journal of ethnopharmacology, 174, 299-307 (2015-08-25)
Anacardium occidentale L. (Anacardiaceae) is commonly known as the cashew tree. It is native to tropical America and extracts of the leaves, bark, roots, chestnut net and exudate have been traditionally used in northeast Brazil for the treatment of various
Shih-Yeh Lin et al.
Vaccine, 33(44), 5966-5973 (2015-05-06)
Enterovirus 71 (EV71) causes the outbreaks of hand-foot-and-mouth disease and results in deaths of hundreds of young children. EV71 virus-like particles (VLPs) are empty capsids consisting of viral structural proteins and can elicit potent immune responses, thus holding promise as
Kiran Kumar Chereddy et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(8), 1975-1984 (2015-08-05)
Growth factor therapies to induce angiogenesis and thereby enhance the blood perfusion, hold tremendous potential to address the shortcomings of current impaired wound care modalities. Vascular endothelial growth factor stimulates (VEGF) wound healing via multiple mechanisms. Poly(lactic-co-glycolic acid) (PLGA) supplies
Peng Hu et al.
Chemical communications (Cambridge, England), 49(17), 1705-1707 (2013-01-24)
We have constructed a colorimetric protein assay platform based on a nanoreactor. The novel strategy presents high sensitivity and excellent performance for the detection of thrombin. The linear range is 5.58 × 10(-10) to 6.50 × 10(-9) M and the
Wen-Hsiang Chen et al.
Human vaccines & immunotherapeutics, 10(3), 648-658 (2013-12-21)
Development of vaccines for preventing a future pandemic of severe acute respiratory syndrome (SARS) caused by SARS coronavirus (SARS-CoV) and for biodefense preparedness is urgently needed. Our previous studies have shown that a candidate SARS vaccine antigen consisting of the
Sebastian P Fuchs et al.
PLoS pathogens, 11(8), e1005090-e1005090 (2015-08-08)
Long-term delivery of potent broadly-neutralizing antibodies is a promising approach for the prevention of HIV-1 infection. We used AAV vector intramuscularly to deliver anti-SIV monoclonal antibodies (mAbs) in IgG1 form to rhesus monkeys. Persisting levels of delivered mAb as high
Majid Motaghinejad et al.
Fundamental & clinical pharmacology, 29(3), 299-309 (2015-04-08)
Chronic consumption of morphine induces physical dependency, anxiety, and neurodegeneration. In this study, morphine on its own has been used for the management of morphine-induced dependency, oxidative stress, and apoptosis. Forty-eight male rats were randomly divided into six groups. Rats
Stewart Coleman et al.
PloS one, 10(8), e0135567-e0135567 (2015-08-13)
Development of a cytomegalovirus (CMV) vaccine is a major public health priority due to the risk of congenital infection. A key component of a vaccine is thought to be an effective neutralizing antibody response against the viral glycoproteins necessary for
María P Roberti et al.
European journal of immunology, 45(5), 1560-1569 (2015-03-03)
Clinical studies suggest that triple negative breast cancer (TNBC) patients with epidermal growth factor receptor (EGFR)-expressing tumors could benefit from therapy with Cetuximab, which targets EGFR. NK cells are the primary effectors of antibody (Ab)-dependent cell-mediated cytotoxicity (ADCC) and thus
Brenton R Ware et al.
Toxicological sciences : an official journal of the Society of Toxicology, 145(2), 252-262 (2015-02-27)
Primary human hepatocytes (PHHs) are a limited resource for drug screening, their quality for in vitro use can vary considerably across different lots, and a lack of available donor diversity restricts our understanding of how human genetics affect drug-induced liver
Jun He et al.
The journal of spinal cord medicine, 38(6), 717-728 (2015-01-15)
Background Establishing bladder reflex arcs only with the efferent pathway to induce micturition after spinal cord injury (SCI) has been successful. However, the absence of sensory function and micturition desires can lead to serious complications. Objectives To reconstruct a bladder
Babett Oesterreich et al.
Human vaccines & immunotherapeutics, 10(4), 926-937 (2014-02-06)
Multi-antigen immunotherapy approaches against Staphylococcus aureus are expected to have the best chance of clinical success when used in combinatorial therapy, potentially incorporating opsonic killing of bacteria and toxin neutralization. We recently reported the development of a murine monoclonal antibody
Maria Grazia Clemente et al.
The Journal of pediatrics, 166(1), 79-84 (2014-12-03)
To analyze the prevalence of acute asymptomatic group A and C rotavirus (RV-A and RV-C) infection in neonates with cholestasis. Participants were infants <180 days of age with cholestasis (serum direct or conjugated bilirubin >20% of total and ≥2 mg/dL)
Giuseppina Barutello et al.
Oncoimmunology, 4(5), e1005500-e1005500 (2015-07-15)
Maternal immunization is successfully applied against some life-threatening infectious diseases as it can protect the mother and her offspring through the passive transfer of maternal antibodies. Here, we sought to evaluate whether the concept of maternal immunization could also be
Mariana Carlomagno et al.
Analytical chemistry, 86(20), 10467-10473 (2014-09-27)
Short peptide loops selected from phage libraries can specifically recognize the formation of hapten-antibody immunocomplexes and can thus be used to develop phage anti-immunocomplex assays (PHAIA) for noncompetitive detection of small molecules. In this study, we generated recombinant chimeras by
Moitza Principe et al.
Oncotarget, 6(13), 11098-11113 (2015-04-11)
Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by rapid progression, invasiveness and resistance to treatment. We have previously demonstrated that most PDAC patients have circulating antibodies against the glycolytic enzyme alpha-enolase (ENO1), which correlates with a better
Takeshi Tomita et al.
PloS one, 10(3), e0118835-e0118835 (2015-03-05)
Serum amyloid A3 (SAA3) possesses characteristics distinct from the other serum amyloid A isoforms, SAA1, SAA2, and SAA4. High density lipoprotein contains the latter three isoforms, but not SAA3. The expression of mouse SAA3 (mSAA3) is known to be up-regulated
Cristina Bruno et al.
Journal of immunology (Baltimore, Md. : 1950), 195(1), 166-173 (2015-05-29)
The generation of CTLs is crucial in the immunological fight against cancer and many infectious diseases. To achieve this, vaccine Ags need to be targeted to the cytosol of dendritic cells, which can activate CD8 T cells via MHC class
Zhifei Wang et al.
Analytica chimica acta, 862, 53-63 (2015-02-16)
Nanomaterial-based artificial enzymes have received great attention in recent year due to their potential application in immunoassay techniques. However, such potential is usually limited by poor dispersion stability or low catalytic activity induced by the capping agent essentially required in
Arindam Maity et al.
Molecules (Basel, Switzerland), 20(6), 10253-10263 (2015-06-06)
Copper(I)-catalyzed azide-alkyne cycloaddition, or CuAAC click chemistry, is an efficient method for bioconjugation aiming at chemical and biological applications. Herein, we demonstrate how the CuAAC method can provide novel phospholipid-protein conjugates with a high potential for the diagnostics and therapy
Yu-Ju Lin et al.
Applied microbiology and biotechnology, 99(16), 6765-6774 (2015-05-10)
No commercial vaccines are currently available for enterovirus 71 (EV71) infection. Oral virus-like particle (VLP) vaccines are regarded as a better choice for prevention from food-borne diseases compared with injected whole virus vaccines. Unfortunately, the application of oral VLP vaccines
Na Li et al.
Cellular immunology, 290(2), 217-225 (2014-08-03)
Extracellular adenosine is an essential negative regulator of immune reactions that acts by signaling via 4 distinct adenosine receptors. We evaluated adenosine receptor expression in Lewis rats presenting with experimental autoimmune myasthenia gravis (EAMG) to determine whether the expression of
Susanne Bäck et al.
Brain and behavior, 3(2), 75-88 (2013-03-28)
Cerebral dopamine neurotrophic factor (CDNF) protein has been shown to protect the nigrostriatal dopaminergic pathway when given as intrastriatal infusions in rat and mouse models of Parkinson's disease (PD). In this study, we assessed the neuroprotective effect of CDNF delivered
Jing Wu et al.
Journal of agricultural and food chemistry, 62(29), 7078-7084 (2014-07-08)
The high level of acrylamide in widely consumed processed foods poses a potentially significant risk to human health, which has led to an increasing demand for rapid, simple, and selective analytical methods. In the present work, several haptens for acrylamide
Abdullah Alghasham et al.
Nucleosides, nucleotides & nucleic acids, 34(1), 56-68 (2014-12-17)
Present study probes the role of peroxynitrite (ONOO(-))-modified thymidine-5'-monophosphate (TMP) in SLE patients with different disease activity scores according to the SLE Disease Activity Index (SLEDAI). Serum analysis showed significant increased number of subjects positive for anti-ONOO(-)-TMP-protein antibodies in SLE
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