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860492p

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OPN binds alpha V integrin to promote endothelial progenitor cell incorporation into vasculature.

Theodore T Wing et al.

Reproduction (Cambridge, England), 159(4), 465-478 (2020-01-29)

Angiogenesis is fundamental to the expansion of the placental vasculature during pregnancy. Integrins are associated with vascular formation; and osteopontin is a candidate ligand for integrins to promote angiogenesis. Endothelial progenitor cells (EPCs) are released from bone marrow into the

Inhibition of sphingosine 1-phosphate lyase activates human keratinocyte differentiation and attenuates psoriasis in mice.

Suwon Jeon et al.

Journal of lipid research, 61(1), 20-32 (2019-11-07)

Sphingosine 1-phosphate (S1P) lyase is an intracellular enzyme that catalyzes the irreversible degradation of S1P and has been suggested as a therapeutic target for the treatment of psoriasis vulgaris. Because S1P induces differentiation of keratinocytes, we examined whether modulation of

Sorafenib Treatment and Modulation of the Sphingolipid Pathway Affect Proliferation and Viability of Hepatocellular Carcinoma In Vitro.

Katja Jakobi et al.

International journal of molecular sciences, 21(7) (2020-04-05)

Hepatocellular carcinoma (HCC) shows a remarkable heterogeneity and is recognized as a chemoresistant tumor with dismal prognosis. In previous studies, we observed significant alterations in the serum sphingolipids of patients with HCC. This study aimed to investigate the in vitro

Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

Jie Liang et al.

Cancer cell, 23(1), 107-120 (2013-01-01)

Inflammatory bowel disease is an important risk factor for colorectal cancer. We show that sphingosine-1-phosphate (S1P) produced by upregulation of sphingosine kinase 1 (SphK1) links chronic intestinal inflammation to colitis-associated cancer (CAC) and both are exacerbated by deletion of Sphk2.

Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons

Sheng R, et al.

The Journal of Biological Chemistry, 289(30), 20845-20857 (2014)

Effects of apolipoprotein M in uremic atherosclerosis

Bosteen MH, et al.

Atherosclerosis, 265(3), 93-101 (2017)

High-throughput assays to measure intracellular Ca²⁺ mobilization in cells that express recombinant S1P receptor subtypes.

William J Valentine et al.

Methods in molecular biology (Clifton, N.J.), 874, 77-87 (2012-04-25)

Intracellular Ca(2+) mobilization is a useful readout to screen for agonists or antagonists of G-protein -coupled receptors (GPCRs). Here, we describe methods to conduct high-throughput screening of stably or transiently transfected HTC4 cells expressing the individual S1P1-5 receptor subtypes. The

Human glycolipid transfer protein gene (GLTP) expression is regulated by Sp1 and Sp3: involvement of the bioactive sphingolipid ceramide.

Xianqiong Zou et al.

The Journal of biological chemistry, 286(2), 1301-1311 (2010-10-27)

Glycolipid transfer protein (GLTP) accelerates glycolipid intermembrane transfer via a unique lipid transfer/binding fold (GLTP fold) that defines the GLTP superfamily and is the prototype for functional GLTP-like domains in larger proteins, i.e. FAPP2. Human GLTP is encoded by the

Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis.

Maria L Allende et al.

The Journal of biological chemistry, 288(25), 18381-18391 (2013-05-03)

Sphingosine 1-phosphate (S1P) is a bioactive lipid whose levels are tightly regulated by its synthesis and degradation. Intracellularly, S1P is dephosphorylated by the actions of two S1P-specific phosphatases, sphingosine-1-phosphate phosphatases 1 and 2. To identify the physiological functions of S1P

Sphingosine-1-phosphate: an enigmatic signalling lipid

Spiegel S and Milstien S

Nature Reviews in Molecular and Cell Biology, 4(5), 397-397 (2003)

Sphingosine-1-phosphate as signaling molecule in the skin

Japtok L, et al.

Allergo journal international, 23(2), 54-59 (2014)

Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons.

Rui Sheng et al.

The Journal of biological chemistry, 289(30), 20845-20857 (2014-06-15)

Sphingosine kinase 2 (SPK2) and autophagy are both involved in brain preconditioning, but whether preconditioning-induced SPK2 up-regulation and autophagy activation are linked mechanistically remains to be elucidated. In this study, we used in vitro and in vivo models to explore

Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes.

Collin Tran et al.

Journal of neurochemistry, e14917-e14917 (2019-11-20)

Sphingosine 1-phosphate (S1P) is an essential lipid metabolite that signals through a family of five G protein-coupled receptors, S1PR1-S1PR5, to regulate cell physiology. The multiple sclerosis drug Fingolimod (FTY720) is a potent S1P receptor agonist that causes peripheral lymphopenia. Recent

CCN2 Mediates S1P-Induced Upregulation of COX2 Expression in Human Granulosa-Lutein Cells.

Liao-Liao Hu et al.

Cells, 8(11) (2019-11-17)

CCN1 and CCN2 are members of the CCN family and play essential roles in the regulation of multiple female reproductive functions, including ovulation. Cyclooxygenase-2 (COX2) is a critical mediator of ovulation and can be induced by sphingosine-1-phosphate (S1P) through the

Sphingosine 1-phosphate regulates proliferation, cell cycle and apoptosis of hepatocellular carcinoma cells via syndecan-1.

Ye Zeng et al.

Progress in biophysics and molecular biology, 148, 32-38 (2017-11-29)

Sphingosine 1-phosphate (S1P) plays an important role in hepatocarcinogenesis. We previously demonstrated that S1P induced epithelial-mesenchymal transition of hepatocellular carcinoma (HCC) cells via an MMP-7/Syndecan-1/TGF-β autocrine loop. In the present study, we investigated the regulative role of S1P in cell

S1P d20:1, an endogenous modulator of S1P d18:1/S1P2 -dependent signaling.

Rajkumar Vutukuri et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(3), 3932-3942 (2020-01-17)

Sphingosine 1-phosphate (S1P) signaling influences numerous cell biological mechanisms such as differentiation, proliferation, survival, migration, and angiogenesis. Intriguingly, our current knowledge is based solely on the role of S1P with an 18-carbon long-chain base length, S1P d18:1. Depending on the

Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3.

Chao Li et al.

Journal of neuroinflammation, 12, 70-70 (2015-04-17)

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts through a family of five G-protein-coupled receptors (S1PR1-5) and plays a key role in regulating the inflammatory response. Our previous studies demonstrated that rat sensory neurons express the mRNAs for all five

S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development.

Erin E Donovan et al.

European journal of immunology, 40(3), 688-698 (2009-12-30)

During B-cell development, immature B-cell fate is determined by whether the BCR is engaged in the bone marrow. Immature B cells that are non-autoreactive continue maturation and emigrate from the marrow, whereas autoreactive immature B cells remain and are tolerized.

Diminished anabolic signaling response to insulin induced by intramuscular lipid accumulation is associated with inflammation in aging but not obesity.

Donato A Rivas et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 310(7), R561-R569 (2016-01-15)

The loss of skeletal muscle mass is observed in many pathophysiological conditions, including aging and obesity. The loss of muscle mass and function with aging is defined as sarcopenia and is characterized by a mismatch between skeletal muscle protein synthesis

Sphingosine-1-phosphate signaling and its role in disease

Maceyka M, et al.

Trends in Cell Biology, 22(1), 50-60 (2012)

Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice.

Xiaoyun Tang et al.

Journal of lipid research, 55(11), 2389-2400 (2014-09-12)

Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling. LPP1 expression is low in many cancer cells and tumors compared with normal tissues. It was hypothesized from studies with cultured cells that increasing LPP1 activity would decrease tumor

S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development

Donovan EE, et al.

European Journal of Immunology, 40(3), 688-698 (2010)

High-Throughput Assays to Measure Intracellular Ca 2+ Mobilization in Cells that Express Recombinant S1P Receptor Subtypes

Valentine WJ and Tigyi G

Methods in Molecular Biology, 77-87 (2012)

Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism.

Ratna Karuna et al.

Atherosclerosis, 219(2), 855-863 (2011-09-29)

Apolipoprotein M (apoM) has been identified as a specific sphingosine-1-phosphate (S1P) binding protein of HDL. To investigate the in vivo effects of disturbed apoM or HDL metabolism we quantified S1P and apoM in plasmas of wild-type, apoM-knock-out, and apoM transgenic

Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4+CD45RBhigh T cells.

Kyoko Shimano et al.

PloS one, 14(12), e0226154-e0226154 (2019-12-06)

Amiselimod (MT-1303) is a novel sphingosine 1-phosphate receptor-1 (S1P1 receptor) modulator with a more favorable cardiac safety profile than other S1P1 receptor modulators. MT-1303 phosphate (MT-1303-P), an active metabolite of MT-1303, exhibits S1P1 receptor agonism at a lower EC50 value

A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.

Hazem J Abuhusain et al.

The Journal of biological chemistry, 288(52), 37355-37364 (2013-11-23)

Studies in cell culture and mouse models of cancer have indicated that the soluble sphingolipid metabolite sphingosine 1-phosphate (S1P) promotes cancer cell proliferation, survival, invasiveness, and tumor angiogenesis. In contrast, its metabolic precursor ceramide is prodifferentiative and proapoptotic. To determine

Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis.

Liheng Shi et al.

Journal of the American Heart Association, 8(22), e013673-e013673 (2019-11-09)

Background We recently discovered a small endogenous peptide, peptide Lv, with the ability to activate vascular endothelial growth factor receptor 2 and its downstream signaling. As vascular endothelial growth factor through vascular endothelial growth factor receptor 2 contributes to normal

S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells.

Christina Dillmann et al.

Journal of immunology (Baltimore, Md. : 1950), 196(4), 1579-1590 (2016-01-20)

Plasmacytoid dendritic cells (pDCs) produce large amounts of type I IFN in response to TLR7/9 ligands. This conveys antiviral effects, activates other immune cells (NK cells, conventional DCs, B, and T cells), and causes the induction and expansion of a

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