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Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response.

Hyun-Eui Kim et al.

Cell, 166(6), 1539-1552 (2016-09-10)

Defects in mitochondrial metabolism have been increasingly linked with age-onset protein-misfolding diseases such as Alzheimer's, Parkinson's, and Huntington's. In response to protein-folding stress, compartment-specific unfolded protein responses (UPRs) within the ER, mitochondria, and cytosol work in parallel to ensure cellular

Critical role for the protons in FRTL-5 thyroid cells: nuclear sphingomyelinase induced-damage.

Elisabetta Albi et al.

International journal of molecular sciences, 15(7), 11555-11565 (2014-07-01)

Proliferating thyroid cells are more sensitive to UV-C radiations than quiescent cells. The effect is mediated by nuclear phosphatidylcholine and sphingomyelin metabolism. It was demonstrated that proton beams arrest cell growth and stimulate apoptosis but until now there have been

Effect of ER stress on sphingolipid levels and apoptotic pathways in retinal pigment epithelial cells.

Ebru Afşar et al.

Redox biology, 30, 101430-101430 (2020-01-25)

We aimed to determine sphingolipid levels and examine apoptotic pathways in human retinal pigment epithelial cells (ARPE-19) undergoing endoplasmic reticulum (ER) stress. Cells were treated with tunicamycin (TM) to induce ER stress and tauroursodeoxycholic acid (TUDCA), an ER stress inhibitor

Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism.

Xingzhong Zhang et al.

Cell metabolism, 30(5), 937-951 (2019-11-02)

Obesity-induced adipose dysfunction is a major contributor to atherosclerosis. Cold exposure has been reported to affect atherosclerosis through regulation of adipose function, but the mechanism has not been well clarified. Here, adipocyte hypoxia-inducible factor 2α (HIF-2α) was upregulated after mild cold

Endocannabinoid and ceramide levels are altered in patients with colorectal cancer.

Ling Chen et al.

Oncology reports, 34(1), 447-454 (2015-05-16)

Endocannabinoids and ceramides have demonstrated growth inhibition, cell death induction and pro-apoptotic activity in cancer research. In the present study, we describe the profiles of two major endocannabinoids, ceramides, free fatty acids and relevant metabolic enzymes in 47 pairs of

Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress.

Mutay Aslan et al.

Nutrition and cancer, 1-13 (2020-04-15)

We aimed to investigate the impact of thymoquinone (TQ), on sphingolipid metabolites, ER stress and apoptotic pathways in MCF-7 and HepG2 cancer cells. Antiproliferative effect was exerted in cancer cells via TQ incubation at different doses and durations. Cell viability

Increased ceramide content and NFκB signaling may contribute to the attenuation of anabolic signaling after resistance exercise in aged males.

Donato A Rivas et al.

Journal of applied physiology (Bethesda, Md. : 1985), 113(11), 1727-1736 (2012-10-09)

One of the most fundamental adaptive physiological events is the response of skeletal muscle to high-intensity resistance exercise, resulting in increased protein synthesis and ultimately larger muscle mass. However, muscle growth in response to contraction is attenuated in older humans.

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