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870817P

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Elisabeth Svensson et al.
Rapid communications in mass spectrometry : RCM, 29(23), 2263-2271 (2015-11-03)
Compound-specific isotope analysis (CSIA) of nitrogen in amino acids has proven a valuable tool in many fields (e.g. ecology). Several intact polar lipids (IPLs) also contain nitrogen, and their nitrogen isotope ratios have the potential to elucidate food-web interactions or...
Shalini Chaturvedi et al.
Prostaglandins & other lipid mediators, 81(3-4), 136-149 (2006-11-07)
Oleamide (cis-9-octadecenamide) is a member of an emerging class of lipid-signaling molecules, the primary fatty acid amides. A growing body of evidence indicates that oleamide mediates fundamental neurochemical processes including sleep, thermoregulation, and nociception. Nevertheless, the mechanism for oleamide biosynthesis...
James R Foster et al.
Pharmacology research & perspectives, 7(6), e00542-e00542 (2019-11-27)
The G-protein-coupled receptor GPR132, also known as G2A, is activated by 9-hydroxyoctadecadienoic acid (9-HODE) and other oxidized fatty acids. Other suggested GPR132 agonists including lysophosphatidylcholine (LPC) have not been readily reproduced. Here, we identify N-acylamides in particular N-acylglycines, as lipid...
Cyrine Ezzili et al.
Bioorganic & medicinal chemistry letters, 20(20), 5959-5968 (2010-09-08)
Key studies leading to the discovery and definition of the role of endogenous fatty acid amide signaling molecules are summarized.
Neta Rimmerman et al.
Molecular pharmacology, 74(1), 213-224 (2008-04-22)
N-arachidonoyl glycine is an endogenous arachidonoyl amide that activates the orphan G protein-coupled receptor (GPCR) GPR18 in a pertussis toxin (PTX)-sensitive manner and produces antinociceptive and antiinflammatory effects. It is produced by direct conjugation of arachidonic acid to glycine and...
D J Merkler et al.
Archives of biochemistry and biophysics, 330(2), 430-434 (1996-06-15)
Fatty acid primary amides have recently been recognized as mammalian hormones [Cravatt et al. (1995) Science 268, 1506-1509]. The route to their biosynthesis is unknown. Many mammalian peptide hormones also possess a C-terminal alpha-amide moiety that arises from the posttranslational...
Heather B Bradshaw et al.
Vitamins and hormones, 81, 191-205 (2009-08-04)
Discovery of the endogenous cannabinoid and N-acyl amide, anandamide (N-arachidonoyl ethanolamine), paved the way for lipidomics discoveries in the growing family of N-acyl amides. Lipidomics is a field that is broadening our view of the molecular world to include a...