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88597

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A qualitative method for prediction of amine oxidation in methanol and water.

Carina Bäcktorp et al.

Journal of pharmaceutical sciences, 104(4), 1409-1420 (2015-02-26)

We have developed a predictive method, based on quantum chemical calculations, that qualitatively predicts N-oxidation by hydrogen peroxides in drug structures. The method uses linear correlations of two complementary approaches to estimate the activation barrier without calculating it explicitly. This

T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung.

Shoichi Iriguchi et al.

Blood, 125(2), 370-382 (2014-10-29)

Although overexpression of T-bet, a master transcription factor in type-1 helper T lymphocytes, has been reported in several hematologic and immune diseases, its role in their pathogenesis is not fully understood. In the present study, we used transgenic model mice

Prenatal alcohol exposure alters response of kisspeptin-ir neurons to estradiol and progesterone in adult female rats.

Joanna H Sliwowska et al.

Alcoholism, clinical and experimental research, 38(11), 2780-2789 (2014-11-26)

Prenatal alcohol exposure (PAE) has adverse effects on reproductive function and hypothalamic-pituitary-gonadal (HPG) activity. Kisspeptin neurons play a role in mediating feedback effects of estradiol (E2 ) and progesterone (P4 ) on the HPG axis. We hypothesized that PAE will

Development of high energy density supercapacitor through hydrothermal synthesis of RGO/nano-structured cobalt sulphide composites.

Milan Jana et al.

Nanotechnology, 26(7), 075402-075402 (2015-02-03)

Co9S8/reduced graphene oxide (RGO) composites were prepared on nickel foam substrate through hydrothermal reaction and used directly as supercapacitor electrode. The field emission scanning electron microscopy analysis of the composites showed the formation of Co9S8 nano-rods on the RGO surfaces.

Hypoxia-induced glucose-6-phosphate dehydrogenase overexpression and -activation in pulmonary artery smooth muscle cells: implication in pulmonary hypertension.

Sukrutha Chettimada et al.

American journal of physiology. Lung cellular and molecular physiology, 308(3), L287-L300 (2014-12-07)

Severe pulmonary hypertension is a debilitating disease with an alarmingly low 5-yr life expectancy. Hypoxia, one of the causes of pulmonary hypertension, elicits constriction and remodeling of the pulmonary arteries. We now know that pulmonary arterial remodeling is a consequence

Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration.

André Ferreira-da-Silva et al.

PloS one, 10(3), e0122308-e0122308 (2015-03-31)

Oncocytic cell tumors are characterized by the accumulation of morphologically abnormal mitochondria in their cells, suggesting a role for abnormal mitochondrial biogenesis in oncocytic cell transformation. Little is known about the reason for the dysmorphology of accumulated mitochondria. The proteins

Dentin hypersensitivity after teeth bleaching with in-office systems. Randomized clinical trial.

Javier Martin et al.

American journal of dentistry, 26(1), 10-14 (2013-06-04)

To comparatively and prospectively compare in a randomized clinical trial, dentin hypersensitivity after treatment with three in-office bleaching systems, based on hydrogen peroxide at different concentrations, with and without light source activation. 88 individuals were included according to inclusion and

A stability-indicating HPLC method for the quantification of aliskiren and hydrochlorothiazide in a pharmaceutical formulation.

Dimitrios Karvelis et al.

Journal of AOAC International, 97(6), 1519-1525 (2015-01-30)

A novel, fast, and sensitive stability-indicating HPLC method was developed, fully validated, and applied to the simultaneous determination of aliskiren and hydrochlorothiazide in a combined formulation. Effective chromatographic separation was achieved using a phenyl analytical column with isocratic elution using

Molecular magnetic resonance imaging of angiogenesis in vivo using polyvalent cyclic RGD-iron oxide microparticle conjugates.

Stavros Melemenidis et al.

Theranostics, 5(5), 515-529 (2015-03-15)

Angiogenesis is an essential component of tumour growth and, consequently, an important target both therapeutically and diagnostically. The cell adhesion molecule α(v)β(3) integrin is a specific marker of angiogenic vessels and the most prevalent vascular integrin that binds the amino

Increased CD4+CD25+ regulatory T cells correlate with poor short-term outcomes in hepatitis B virus-related acute-on-chronic liver failure patients.

Chuan Shen et al.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 48(2), 137-146 (2014-01-07)

The roles of CD4(+)CD25(+) regulatory T cells (Treg) in chronicity of hepatitis B virus (HBV) infection have been confirmed. We aimed to explore alteration of Treg in patients with HBV-related acute-on-chronic liver failure (ACLF). Thirty-two HBV-related ACLF patients, 44 chronic

The use of functional chemical-protein associations to identify multi-pathway renoprotectants.

Jia Xu et al.

PloS one, 9(5), e97906-e97906 (2014-05-17)

Typically, most nephropathies can be categorized as complex human diseases in which the cumulative effect of multiple minor genes, combined with environmental and lifestyle factors, determines the disease phenotype. Thus, multi-target drugs would be more likely to facilitate comprehensive renoprotection

Hesperidin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress in a mouse model of Alzheimer's disease.

Dongmei Wang et al.

Cellular and molecular neurobiology, 34(8), 1209-1221 (2014-08-20)

The role of mitochondrial dysfunction and oxidative stress has been well-documented in Alzheimer's disease (AD). Bioflavonoids are being utilised as neuroprotectants in the treatment of various neurological disorders, including AD. Therefore, we conducted this current study in order to explore

Ethyl acetate extract of germinated brown rice attenuates hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuroblastoma cells: role of anti-apoptotic, pro-survival and antioxidant genes.

Nur Hanisah Azmi et al.

BMC complementary and alternative medicine, 13, 177-177 (2013-07-20)

There are reports of improved metabolic outcomes due to consumption of germinated brown rice (GBR). Many of the functional effects of GBR can be linked to its high amounts of antioxidants. Interestingly, dietary components with high antioxidants have shown promise

Reconstituted human upper airway epithelium as 3-d in vitro model for nasal polyposis.

Francisco de Borja Callejas et al.

PloS one, 9(6), e100537-e100537 (2014-06-20)

Primary human airway epithelial cells cultured in an air-liquid interface (ALI) develop a well-differentiated epithelium. However, neither characterization of mucociliar differentiation overtime nor the inflammatory function of reconstituted nasal polyp (NP) epithelia have been described. 1st) To develop and characterize

Mineralization of wastewater from the pharmaceutical industry containing chloride ions by UV photolysis of H2O2/Fe(II) and ultrasonic irradiation.

J M Monteagudo et al.

Journal of environmental management, 141, 61-69 (2014-04-29)

The mineralization of pharmaceutical wastewater containing chloride ions using a UV/H2O2/Fe(II) process was studied. The addition of Fe(II) to the UV/H2O2 system did not improve the degradation efficiency due to inhibition of the photo-Fenton reaction, at acid pH, in the

miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18.

Seunghee Lee et al.

Age (Dordrecht, Netherlands), 36(6), 9724-9724 (2014-12-04)

Previously, AIMP3 (aminoacyl-tRNAsynthetase-interacting multifunctional protein-3) was shown to be involved in the macromolecular tRNA synthetase complex or to act as a tumor suppressor. In this study, we report a novel role of AIMP3/p18 in the cellular aging of human mesenchymal

Human fascia lata ECM scaffold augmented with immobilized hyaluronan: inflammatory response and remodeling in the canine body wall and shoulder implantation sites.

Diane R Leigh et al.

Journal of biomaterials science. Polymer edition, 26(1), 1-15 (2014-11-18)

We postulate that immobilization of tyramine-substituted hyaluronan (THA) into an extracellular matrix (ECM) scaffold may be a strategy to promote an anti-inflammatory response to the ECM. Further, we posit that the implantation site could influence the inflammatory response and remodeling

Temporo-spatial requirement of Smad4 in dentin formation.

Tak-Heun Kim et al.

Biochemical and biophysical research communications, 459(4), 706-712 (2015-03-17)

The TGF-β/BMP family plays an important role in multiple stages of tooth development. TGF-β/BMP signaling is required for odontoblast differentiation and dentin formation; however, the precise molecular mechanisms underlying dentin formation remain unclear. To address the role of TGF-β/BMP signaling

Roles of mitochondrial fragmentation and reactive oxygen species in mitochondrial dysfunction and myocardial insulin resistance.

Tomoyuki Watanabe et al.

Experimental cell research, 323(2), 314-325 (2014-03-19)

Evidence suggests an association between aberrant mitochondrial dynamics and cardiac diseases. Because myocardial metabolic deficiency caused by insulin resistance plays a crucial role in heart disease, we investigated the role of dynamin-related protein-1 (DRP1; a mitochondrial fission protein) in the

Polyethylene glycol-fused allografts produce rapid behavioral recovery after ablation of sciatic nerve segments.

D C Riley et al.

Journal of neuroscience research, 93(4), 572-583 (2014-11-27)

Restoration of neuronal functions by outgrowths regenerating at ∼1 mm/day from the proximal stumps of severed peripheral nerves takes many weeks or months, if it occurs at all, especially after ablation of nerve segments. Distal segments of severed axons typically

Monitoring of trace amounts of heavy metals in different food and water samples by flame atomic absorption spectrophotometer after preconcentration by amine-functionalized graphene nanosheet.

Mohammad Behbahani et al.

Environmental monitoring and assessment, 186(11), 7245-7257 (2014-07-16)

We are introducing graphene oxide modified with amine groups as a new solid phase for extraction of heavy metal ions including cadmium(II), copper(II), nickel(II), zinc(II), and lead(II). Effects of pH value, flow rates, type, concentration, and volume of the eluent

Specific IgE recognition of pollen allergens from subtropic grasses in patients from the subtropics.

Emmanuel Nony et al.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 114(3), 214-220 (2015-03-07)

Pollens of subtropical grasses, Bahia (Paspalum notatum), Johnson (Sorghum halepense), and Bermuda (Cynodon dactylon), are common causes of respiratory allergies in subtropical regions worldwide. To evaluate IgE cross-reactivity of grass pollen (GP) found in subtropical and temperate areas. Case and

Oxidation by neutrophils-derived HOCl increases immunogenicity of proteins by converting them into ligands of several endocytic receptors involved in antigen uptake by dendritic cells and macrophages.

Rafał Biedroń et al.

PloS one, 10(4), e0123293-e0123293 (2015-04-08)

The initiation of adaptive immune responses to protein antigens has to be preceded by their uptake by antigen presenting cells and intracellular proteolytic processing. Paradoxically, endocytic receptors involved in antigen uptake do not bind the majority of proteins, which may

Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range.

Satoko Baba et al.

Journal of pharmacological sciences, 127(3), 326-331 (2015-04-04)

Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human studies have shown that most antipsychotics do not occupy D3 receptors in vivo, despite their

Modulating the level of the Rpb7 subunit of RNA polymerase II affects cell separation in Schizosaccharomyces pombe.

Deepak Kumar et al.

Research in microbiology, 166(1), 20-27 (2014-12-23)

The rpb7(+) gene encodes the seventh largest subunit of RNA polymerase II and is essential for survival of yeast cells. To gain insight into its functions, we expressed rpb7(+) under the control of the nmt1 promoter and investigated its role

Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis.

Eiji Matsuura et al.

Journal of neuropathology and experimental neurology, 74(1), 2-14 (2014-12-04)

Activated human T-lymphotropic virus type-1 (HTLV-1)-specific CD8-positive cytotoxic T lymphocytes (CTLs) are markedly increased in the periphery of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), an HTLV-1-induced inflammatory disease of the CNS. Although virus-specific CTLs play a pivotal role to

Intracellular hydrogen peroxide and superoxide poison 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase, the first committed enzyme in the aromatic biosynthetic pathway of Escherichia coli.

Jason M Sobota et al.

Journal of bacteriology, 196(11), 1980-1991 (2014-03-25)

In Escherichia coli, aromatic compound biosynthesis is the process that has shown the greatest sensitivity to hydrogen peroxide stress. This pathway has long been recognized to be sensitive to superoxide as well, but the molecular target was unknown. Feeding experiments

Expression of peroxiredoxins I and IV in multiple myeloma: association with immunoglobulin accumulation.

Ana Paula Dias Demasi et al.

Virchows Archiv : an international journal of pathology, 463(1), 47-55 (2013-06-06)

B cell malignancies are classified according to the postulated differentiation stage of the originating cell. During differentiation, structural and molecular changes occur to support massive processing of immunoglobulin in the endoplasmic reticulum (ER) of plasma cells at the final stage.

Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis.

Elizabeth A Wellberg et al.

Breast cancer research : BCR, 16(6), 481-481 (2014-12-05)

Spot14 (S14), encoded by the THRSP gene, regulates de novo fatty acid synthesis in the liver, adipose, and lactating mammary gland. We recently showed that S14 stimulated fatty acid synthase (FASN) activity in vitro, and increased the synthesis of fatty

Spontaneously hypertensive rats have more orexin neurons in their medial hypothalamus than normotensive rats.

Liam Clifford et al.

Experimental physiology, 100(4), 388-398 (2015-02-03)

What is the central question of this study? Blockade of orexin receptors reduces blood pressure in spontaneously hypertensive rats (SHRs) but not in normotensive Wistar-Kyoto (WKY) rats, suggesting that upregulation of orexin signalling underlies the hypertensive phenotype of the SHR.

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