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Mehdi Shakibaei et al.
BMC cancer, 15, 250-250 (2015-04-18)
To overcome the limitations of animal-based experiments, 3D culture models mimicking the tumor microenvironment in vivo are gaining attention. Herein, we investigated an alginate-based 3D scaffold for screening of 5-fluorouracil (5-FU) or/and curcumin on malignancy of colorectal cancer cells (CRC)....
G Wolf et al.
Biotechnology and bioengineering, 72(3), 297-306 (2001-01-03)
The use of two-dimensional scanning fluorometry as an on-line, noninvasive, in situ bioreactor monitoring technique is extended to complex bioprocesses using mixed cultures, with particular attention to biofilm systems. Using the example of spectra subtraction, it is demonstrated that established...
N. Mishra et al.
Analyst, 112, 1131-1131 (1987)
Melissa Y Cui et al.
Endocrinology, 155(11), 4202-4214 (2014-08-26)
In mammals, leptin acts on leptin receptor (LepR) -expressing neurons in the brain to suppress food intake and stimulate whole-body metabolism. A similar action of leptin on food intake has been reported in the frog Xenopus laevis and in several...
Nenad Manevski et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(12), 2049-2057 (2014-09-25)
Human aldehyde oxidase (AO) is a molybdoflavoenzyme that commonly oxidizes azaheterocycles in therapeutic drugs. Although high metabolic clearance by AO resulted in several drug failures, existing in vitro-in vivo correlations are often poor and the extrahepatic role of AO practically...
Gabriella M Johansson et al.
Occupational and environmental medicine, 72(1), 57-63 (2014-06-11)
Carcinogenic aromatic amines derived from hair dyes have recently received new attention. One of these is ortho (o)-toluidine, which is classified as carcinogenic to humans. To clarify exposure of hairdressers to potentially carcinogenic aromatic amines, including o-toluidine. We measured eight...
D R Doerge et al.
Chemical research in toxicology, 4(5), 556-560 (1991-09-01)
The metabolism of three arylamine substrates by H2O2 in the presence of each of the peroxidative enzymes chloroperoxidase (CPX) and pea seed peroxygenase (PSM) was conducted with normal H2O2 and with 18O-labeled H2O2. The resulting C-nitroso aromatic metabolites were examined...
Hao Wu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 67(3-4), 976-979 (2007-02-03)
The molecular interactions between aniline, p-toluidines, benzidine and p-phenylenediamine as electron donors and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as acceptor have been investigated by spectrophotometric method. Different variables affecting the reaction were studies and optimized. At the optimum reaction conditions Beer's law was...
W J Brock et al.
Toxicology letters, 54(2-3), 317-325 (1990-12-01)
The in vivo covalent binding of ortho- and para-toluidine (OT and PT) to rat hepatic macromolecules was investigated to determine if a relationship exists between the degree of binding for each isomer and its carcinogenic potency. The ortho-isomer has been...
Shiping Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(40), 14460-14465 (2014-09-24)
Lineage-specific microRNAs (miRNAs) may contribute to functions specific to hematophagous mosquitoes and, as such, have potential for contributing to the development of future mosquito control approaches. Here we report that the mosquito- and gut-specific miRNA, miR-1174, is required for proper...
Jolanda Neef et al.
Applied microbiology and biotechnology, 98(24), 10131-10141 (2014-09-02)
Cell surface-exposed and secreted proteins are attractive targets for vaccination against pathogenic gram-positive bacteria. To obtain sufficient amounts of such antigens, efficient protein production platforms are needed. In this study, a pipeline for the production and purification of surface-exposed and...
Bandana Shrestha et al.
Journal of neuropathology and experimental neurology, 73(11), 1047-1061 (2014-10-08)
The choroid plexus (CP) is considered to be a point of leukocyte entry into the CNS during normal immune surveillance and in neuroinflammatory diseases. The structural and functional alterations within the CP that support this migration are not understood. We...
J C Kennelly et al.
Mutation research, 137(1), 39-45 (1984-07-01)
The conventional Ames assay metabolising system was confirmed to be deficient in its ability to N-acetylate. This may render the test less sensitive to compounds which normally have an acetylation step during their in vivo activation to carcinogens. The addition...
Jingyan Zhang et al.
Journal of colloid and interface science, 316(2), 796-802 (2007-10-02)
The kinetics and mechanism of sphere-to-rod transitions of sodium alkyl sulfate micelles induced by hydrotropic salt, p-toluidine hydrochloride (PTHC), were investigated by stopped-flow with light scattering detection. Spherical sodium dodecyl sulfate (SDS) micelles transform into short ellipsoidal shapes at low...
Xiujuan Liu et al.
Journal of separation science, 30(15), 2506-2512 (2007-09-01)
In this study, two microextraction methods, viz. continuous-flow microextraction (CFME) and static liquid-phase microextraction (s-LPME), were optimized and compared for the determination of p-toluidine in water and Chlamydomonas reinhardtii samples. The calibration curve for p-toluidine was linear in the concentration...
Nenad Manevski et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 126-139 (2014-10-24)
Although skin is the largest organ of the human body, cutaneous drug metabolism is often overlooked, and existing experimental models are insufficiently validated. This proof-of-concept study investigated phase II biotransformation of 11 test substrates in fresh full-thickness human skin explants...
Monika Bubka et al.
Biochimie, 103, 37-49 (2014-04-15)
An important role in cancer pathogenesis is attributed to N-glycans with "bisecting" N-acetylglucosamine and beta1-6 branches but the exact mechanisms still remain to be elucidated. Two structures are formed by Golgi beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC = 2.4.1.144, GnT-III) and alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase...
Svetlana N Ignatieva et al.
Inorganic chemistry, 49(12), 5407-5412 (2010-05-28)
The first representative of 1,5-diaza-3,7-diphosphacyclooctanes (1) with chiral L-menthyl substituents on the phosphorus atoms was obtained by condensation of L-menthylphosphine with formaldehyde and p-toluidine. This optically active cyclic bisphosphine readily forms a stable P,P-complex with borane (2) and P,P-chelate complexes...
K Takahashi et al.
Drug development and industrial pharmacy, 27(2), 159-164 (2001-03-27)
The influence of pH on the permeability of p-toluidine (pKa, 5.3) and aminopyrine (pKa, 5.0) through shed snake skin as a model membrane was studied. The pH was adjusted to several values, and the solubility of the drugs in each...
Julian C Lui et al.
Pediatric research, 77(3), 406-415 (2014-12-19)
In juvenile mammals, the epiphyses of long bones grow by chondrogenesis within the articular cartilage. A better understanding of the molecular mechanisms that regulate the growth of articular cartilage may give insight into the antecedents of joint disease, such as...
Karina Taciana Silva et al.
Journal of proteome research, 14(1), 385-396 (2014-11-05)
Dibenzothiophene (DBT) and its oxidized derivative dibenzothiophene sulfone (DBTO2) are important representatives of polycyclic aromatic hydrocarbons (PAHs). Due to the importance of PAHs in oncogenesis and the lack of toxicological investigations related to DBT and DBTO2, this work proposes to...
Yoshimitsu Kuwabara et al.
The Journal of endocrinology, 224(1), 49-59 (2014-10-30)
Osteopontin (OPN), a secreted glycoprotein, has multiple physiological functions. This study investigated the regulation and roles of OPN in the mouse ovary during the periovulatory stages. Immature female mice were treated with pregnant mare serum gonadotropin (PMSG) and human chorionic...
Paul G Stevenson et al.
Journal of chromatography. A, 1218(45), 8255-8263 (2011-10-11)
Several simple techniques are presented for the identification of the boundaries of chromatographic peaks. These methods provide a significant reduction in the time needed to perform the rapid, automatic calculation of the central peak moments and to evaluate the quality...
Micheline Soares Braga et al.
Molecular and biochemical parasitology, 195(1), 43-53 (2014-07-16)
The exoproteome of some Leishmania species has revealed important insights into host-parasite interaction, paving the way for the proposal of novel disease-oriented interventions. The focus of the present investigation constituted the molecular profile of the L. infantum exoproteome revealed by...
Shuuji Mawaribuchi et al.
Endocrinology, 155(10), 3996-4005 (2014-07-23)
The African clawed frog, Xenopus laevis, has a ZZ/ZW-type sex-determination system. We previously reported that a W-linked gene, Dm-W, can determine development as a female. However, the mechanisms of early sex differentiation remain unclear. We used microarrays to screen for...
Roberta Russo et al.
The FEBS journal, 281(17), 3828-3843 (2014-07-22)
Growing evidence suggests that the transcription factors belonging to the Jun family are involved in many important cellular events, such as the control of bone development in mammalians. We have characterized, for the first time, a member of the Jun...
G. Pfrepper
Fresenius Journal of Analytical Chemistry, 193, 179-179 (1963)
B Shyla et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 776-783 (2012-08-15)
The new methods are working on the principle that iron(III) is reduced to iron(II) by hydrogen sulfide, catechol and p-toluidine the system 1/hydrogen sulfide the system 2, in acidic medium followed by the reduced iron forming complex with 1,10-phenanthroline with...
Rukhsana Gul et al.
European journal of medicinal chemistry, 85, 438-449 (2014-08-12)
Some novel ferrocenyl guanidines 1-8 were synthesized and characterized by different spectroscopic methods, elemental analysis and single crystal X-rays diffraction techniques. The crystallographic studies revealed that the existence of the strong non-bonding interactions facilitate these molecules to interact with biological...
Candace S Hayes et al.
Cancer immunology research, 2(3), 274-285 (2014-04-30)
Correcting T-cell immunosuppression may unleash powerful antitumor responses; however, knowledge about the mechanisms and modifiers that may be targeted to improve therapy remains incomplete. Here, we report that polyamine elevation in cancer, a common metabolic aberration in aggressive lesions, contributes...
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