Showing 1-26 of 26 results for "91802"
Alyson M Browning et al.
The Journal of pharmacy and pharmacology, 57(8), 1037-1042 (2005-08-17)
Epidemiologic evidence supports the view that dietary flavonoids exert protective effects in oral diseases, including cancer. However, the dietary forms of flavonoids, the flavonoid glycosides, are thought to be inactive, thus they must first be hydrolysed to their active aglycones....
K Murota et al.
Archives of biochemistry and biophysics, 384(2), 391-397 (2001-05-23)
The efficiency of intestinal absorption and metabolic conversion of quercetin aglycone and its glucosides, quercetin-4'-O-beta-D-glucoside (Q4'G), quercetin-3-O-beta-D-glucoside (Q3G), and quercetin-3,4'-di-O-beta-D-glucoside (Q3,4'G), was estimated by using Caco-2 cell monolayers as an intestinal epithelial cell model. Aglycone was significantly lost from the...
Jeanelle Boyer et al.
Nutrition journal, 4, 1-1 (2005-01-13)
Quercetin and quercetin glycosides are widely consumed flavonoids found in many fruits and vegetables. These compounds have a wide range of potential health benefits, and understanding the bioavailability of flavonoids from foods is becoming increasingly important. This study combined an...
P Ader et al.
Cancer letters, 162(2), 175-180 (2001-01-09)
Recently it has been postulated that flavonoid glucosides may be absorbed by the small intestine via the SGLT-1. Therefore, we applied an in vitro mucosal uptake method to investigate mucosal uptake of the non-metabolisable glucose analogue methyl-alpha-D-glucopyranoside (MDG) as influenced...
Andrea J Day et al.
Biochemical pharmacology, 65(7), 1199-1206 (2003-03-29)
Two hypotheses on absorption mechanisms of flavonoid glucosides across the small intestine have been proposed: active uptake of the quercetin glucoside by the sodium-dependent glucose transporter (SGLT1) with subsequent deglycosylation within the enterocyte by cytosolic beta-glucosidase, or luminal hydrolysis of...
Kaeko Murota et al.
Journal of agricultural and food chemistry, 52(7), 1907-1912 (2004-04-01)
Quercetin is a typical antioxidative flavonoid found in vegetables, which is more commonly present as its glucosides, quercetin-3-glucoside (Q3G) and quercetin-4'-glucoside (Q4'G). The main aim of this study was to estimate the antioxidant activity of Q3G and Q4'G on iron...
Sandra Tribolo et al.
Journal of molecular biology, 370(5), 964-975 (2007-06-09)
Human cytosolic beta-glucosidase (hCBG) is a xenobiotic-metabolizing enzyme that hydrolyses certain flavonoid glucosides, with specificity depending on the aglycone moiety, the type of sugar and the linkage between them. In this study, the substrate preference of this enzyme was investigated...
Densitometric evaluation of spiraeoside after derivatization in flowers of Filipendula ulmaria (L.) Maxim
Poukens-Renwart.P, et al.
Journal of Pharmaceutical and Biomedical Analysis, 10, 1085-1088 (1992)
Brigitte A Graf et al.
Drug metabolism and disposition: the biological fate of chemicals, 33(7), 1036-1043 (2005-04-19)
Quercetin-4'-glucoside is a major flavonol in onions, and this study investigated the absorption and fate of radiolabeled quercetin-4'-glucoside in rats. Rats ingested [2-(14)C]quercetin-4'-glucoside and the distribution of radioactivity throughout the body was determined after 0.5, 1, 2, and 5 h....
A J Day et al.
FEBS letters, 468(2-3), 166-170 (2000-02-29)
Lactase phlorizin hydrolase (LPH; EC is a membrane-bound, family 1 beta-glycosidase found on the brush border of the mammalian small intestine. LPH, purified from sheep small intestine, was capable of hydrolysing a range of flavonol and isoflavone glycosides. The...
G P Hubbard et al.
Journal of thrombosis and haemostasis : JTH, 2(12), 2138-2145 (2004-12-23)
Quercetin, a flavonoid present in the human diet, which is found in high levels in onions, apples, tea and wine, has been shown previously to inhibit platelet aggregation and signaling in vitro. Consequently, it has been proposed that quercetin may...
R A Walgren et al.
The Journal of pharmacology and experimental therapeutics, 294(3), 837-843 (2000-08-17)
Although it has been suggested that the intestinal glucose transporter may actively absorb dietary flavonoid glucosides, there is a lack of direct evidence for their transport by this system. In fact, our previous studies with the human Caco-2 cell model...
G Williamson et al.
Carcinogenesis, 17(11), 2385-2387 (1996-11-01)
It has recently been shown by Hollman et al. (Am. J. Clin. Nutr., 62, 1276-1282) that flavonoid glycosides are preferentially absorbed from dietary onions compared to the flavonoid aglycone. In the light of this, we have compared the bioactivities of...
A J Day et al.
FEBS letters, 436(1), 71-75 (1998-10-15)
Flavonoid and isoflavonoid glycosides are common dietary phenolics which may be absorbed from the small intestine of humans. The ability of cell-free extracts from human small intestine and liver to deglycosylate various (iso)flavonoid glycosides was investigated. Quercetin 4'-glucoside, naringenin 7-glucoside...
Umeo Takahama et al.
Journal of agricultural and food chemistry, 50(15), 4317-4322 (2002-07-11)
Under acidic conditions, nitrite is protonated to nitrous acid (pK(a) = 3.2-3.4) that can be transformed into nitric oxide by self-decomposition and reduction. When sodium nitrite was mixed with quercetin at pH 1-2, quercetin was oxidized producing nitric oxide. In...
E U Graefe et al.
Journal of clinical pharmacology, 41(5), 492-499 (2001-05-22)
Due to its potentially beneficial impact on human health, the polyphenol quercetin has come into the focus of medicinal interest. However, data on the bioavailability of quercetin after oral intake are scarce and contradictory. Previous investigations indicate that the disposition...
T Walle et al.
The Journal of nutrition, 130(11), 2658-2661 (2000-10-29)
Flavonoids, dietary components in vegetables, fruits and beverages, may protect against coronary heart disease, stroke and cancer. However, the bioavailability of these compounds is questionable. A previous study in ileostomy patients of the most abundant flavonoid, quercetin, suggested a 52%...
William Mullen et al.
Journal of agricultural and food chemistry, 50(23), 6902-6909 (2002-10-31)
Epidemiological studies suggest that consumption of flavonol-rich diets decreases the risk of developing heart disease and certain cancers. Recent studies have detected flavonol conjugates in blood and urine following various dietary interventions. To assess to what extent flavonols also accumulate...
A A Aziz et al.
Free radical research, 29(3), 257-269 (1998-11-05)
Flavonols are polyphenols found ubiquitously in plants and plant-products. Flavonols, particularly quercetin, are potent antioxidants in vitro and their intake has been associated inversely with the incidence of coronary heart disease. The aim of this study was to investigate the...
Rainer Cermak et al.
The British journal of nutrition, 91(6), 849-855 (2004-06-09)
Recent experimental data point to an interaction of dietary flavonol monoglucosides with the intestinal Na-dependent glucose transporter 1 (SGLT1). To investigate this interaction in more detail, we performed experiments with SGLT1-containing brush-border-membrane vesicles (BBMV) from pig jejunum. The flavonol quercetin-3-O-glucoside...
Ilja C W Arts et al.
The British journal of nutrition, 91(6), 841-847 (2004-06-09)
Quercetin is an important dietary flavonoid with putative beneficial effects in the prevention of cancer and CVD. The in vivo bioactivity of quercetin depends on its bioavailability, which varies widely between foods. We used an in situ rat intestinal perfusion...
R A Walgren et al.
The Journal of pharmacology and experimental therapeutics, 294(3), 830-836 (2000-08-17)
Although there is strong evidence to suggest that flavonoid consumption is beneficial to human health, the extent to which flavonoids are absorbed and the mechanisms involved are controversial. Contrary to common dogma, we previously demonstrated that quercetin 4'-beta-glucoside, the predominant...
J M Gee et al.
The Journal of nutrition, 130(11), 2765-2771 (2000-10-29)
Flavonoids are polyphenolic plant secondary metabolites with antioxidant and other biological activities potentially beneficial to health. Food-borne flavonoids occur mainly as glycosides, some of which can be absorbed in the human small intestine; however, the mechanism of uptake is uncertain....
P C Hollman et al.
Free radical research, 31(6), 569-573 (2000-01-12)
Flavonoids are antioxidants present in plant foods. They occur mainly as glycosides, i.e. linked with various sugars. It is uncertain to what extent dietary flavonoid glycosides are absorbed from the gut. We investigated how the nature of the sugar group...
A L Sesink et al.
The Journal of nutrition, 131(7), 1938-1941 (2001-07-04)
The nature of quercetin conjugates present in blood after consumption of quercetin glucosides is still unclear. In this study, we analyzed plasma of volunteers that had consumed 325 micromol of either quercetin-3-glucoside or quercetin-4'-glucoside as an oral solution. Quercetin metabolites...
M R Olthof et al.
The Journal of nutrition, 130(5), 1200-1203 (2000-05-10)
The flavonoid quercetin is an antioxidant which occurs in foods mainly as glycosides. The sugar moiety in quercetin glycosides affects their bioavailability in humans. Quercetin-3-rutinoside is an important form of quercetin in foods, but its bioavailability in humans is only...

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