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Showing 1-30 of 107 results for "93-17-4" within Papers
P Nokelainen et al.
European journal of biochemistry, 236(2), 482-490 (1996-03-01)
The biological activity of certain estrogens and androgens is modulated by enzymes called 17 beta-hydroxysteroid dehydrogenases (17 beta-HSDs), which catalyze the interconversion between less active 17-oxosteroid and more active 17 beta-hydroxysteroid forms. In the present report, we describe cloning of
Yoshitaka Narita et al.
Neuro-oncology, 21(3), 348-359 (2018-12-01)
We conducted a phase III trial of personalized peptide vaccination (PPV) for human leukocyte antigen (HLA)-A24+ recurrent glioblastoma to develop a new treatment modality. We randomly assigned 88 recurrent glioblastoma patients to receive PPV (n = 58) or the placebo
L H Hove et al.
Caries research, 45(1), 64-68 (2011-02-22)
To evaluate how concentration and pH of TiF(4) influence the erosion-protective effect. Specimens were treated with a TiF(4) solution: (1) 0.5 M F, pH 1.2, (2) 0.05 M F, pH 2.1, (3) 0.5 M F, pH 2.1, or (4) 0.05
Purushottam M Dewang et al.
Bioorganic & medicinal chemistry letters, 20(14), 4228-4232 (2010-07-14)
A series of 2-pyridyl-substituted pyrazoles (16a-d, 17, 18, and 28a-e) and imidazoles (22 and 23) has been synthesized and evaluated for their ALK5 inhibitory activity in cell-based luciferase reporter assays. Among them, 3-(3-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)-1H-pyrazole-1-carbothioamido)benzamide (28c) showed 96% and 93% inhibition at
C H Paik et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 24(12), 1158-1163 (1983-12-01)
Diethylenetriaminepentaacetic acid (DTPA) was conjugated with a practical concentration (300 micrograms/ml) of antibody to human albumin (Ab) and 1083 17-1A monoclonal colorectal antibody (MAb-17-1A) via an acylation reaction using cyclic DTPA anhydride (cDTPAA). The conjugation reaction was favored as pH
Changqing Ma et al.
Cancer biology & therapy, 8(10), 907-916 (2009-03-12)
The Cub and Sushi Multiple Domains-1 (CSMD1) is a tumor suppressor gene on 8p23.2, where allelic loss is both frequent and associated with poor prognosis in head and neck squamous cell carcinoma (HNSCC). To understand the extent of CSMD1 aberrations
Maike Büttner-Herold et al.
Histopathology, 78(5), 738-748 (2020-10-21)
Renal changes in patients with myeloproliferative neoplasms (MPNs) or myelodysplastic syndrome (MDS)/MPNs have been addressed by few, respectively no, reports. The aim of this study was to focus on a systematic evaluation of renal biopsies in patients with MPNs or
S R Lehrman et al.
International journal of peptide and protein research, 31(6), 544-554 (1988-06-01)
Equine prolactin was determined to be a single chain protein of 199 amino acid containing two tryptophan and six cysteine residues, as found in other mammalian prolactins. The primary sequence of equine prolactin was obtained by automated Edman analyses of
K Kim et al.
Oncogene, 31(8), 1034-1044 (2011-07-19)
The human POK family members are transcription factors with a POZ domain and zinc-fingers that act primarily as transcriptional repressors. Several members of this family are involved in oncogenesis and this prompted us to assess whether expression levels of individual
Maria Ester Bernardo et al.
Blood, 120(2), 473-476 (2012-05-31)
Sixty thalassemia patients (median age, 7 years; range, 1-37) underwent allogeneic hematopoietic stem cell transplantation (HSCT) after a preparation combining thiotepa, treosulfan, and fludarabine. Before HSCT, 27 children were assigned to risk class 1 of the Pesaro classification, 17 to
P Kedar et al.
Clinical genetics, 75(2), 157-162 (2008-09-02)
Eighteen unrelated pyruvate kinase (PK)-deficient Indian patients were identified in the past 4 years with varied clinical phenotypes ranging from a mild chronic haemolytic anaemia to a severe transfusion-dependent disorder. We identified 17 different mutations in the PKLR gene among
Ruta Gupta et al.
The American journal of surgical pathology, 33(2), 241-247 (2008-10-23)
Pax 2, expressed by metanephric mesenchyme is vital for renal tubule formation and development. Carbonic anhydrase IX (CA IX) is implicated in cell proliferation, adhesion, and invasion. Data regarding expression in renal epithelial tumors other than clear cell renal cell
Kenneth A Iczkowski et al.
Human pathology, 39(2), 275-281 (2007-11-30)
Organic cation transporter 3/4 (OCT3/4) is a transcription factor of embryonic stem cells; c-kit (CD117) is a tyrosine kinase receptor implicated in seminoma carcinogenesis. Their reactivity is well characterized in testicular, but not extragonadal and metastatic, germ cell tumors. A
Zhen Lou et al.
The Journal of steroid biochemistry and molecular biology, 82(4-5), 413-424 (2003-02-19)
Intestinal or hepatic microsomes from channel catfish converted [4-14C]-testosterone to three major metabolites: 6 beta-hydroxytestosterone, androstenedione and a third metabolite. Formation of the unknown metabolite required NADPH as cofactor. When incubated with 200 microM testosterone, the rate of formation of
Martin Reck et al.
The Lancet. Respiratory medicine, 7(5), 387-401 (2019-03-30)
The IMpower150 trial showed significant improvements in progression-free and overall survival with atezolizumab plus bevacizumab plus carboplatin plus paclitaxel (ABCP) versus the standard-of-care bevacizumab plus carboplatin plus paclitaxel (BCP) in chemotherapy-naive patients with non-squamous non-small-cell lung cancer. Here, we report
Izumi Takeyoshi et al.
Anticancer research, 31(1), 287-291 (2011-01-29)
Paclitaxel and doxifluridine (5'-DFUR) have distinct mechanisms of action and toxicity profiles. This study evaluated the antitumor activity and toxicities of combination chemotherapy with these drugs in patients with advanced/recurrent gastric cancer (AGC). Patients with histologically confirmed AGC, which was
Leonardo D Santos et al.
Pathology, 35(3), 217-223 (2003-09-26)
Using archival material, we studied the immunoreactivity and utility of monoclonal anti-human inhibin alpha subunit in the identification of chorionic villi (CV) and trophoblastic subpopulations in endometrial curettings (EC) from patients who had intra-uterine, ectopic, molar and, particularly, probable intra-uterine
K E Kronquist et al.
Journal of neuroscience research, 18(3), 395-401 (1987-01-01)
A full-length clone for the human proteolipid protein (PLP) was isolated from a cDNA library constructed from poly(A)+ RNA isolated from fetal spinal cords obtained at 15-24 weeks of conceptional age. The sequence of the human PLP cDNA was determined
Karen J Fritchie et al.
American journal of clinical pathology, 137(2), 229-239 (2012-01-21)
The variety of histologic patterns in myxoid liposarcoma is underappreciated. The diversity of these patterns can lead to diagnostic difficulty. We examined the morphologic spectrum of myxoid liposarcoma by cataloguing and describing different patterns identified in biopsy and resection specimens
Hélène Dollfus et al.
American journal of medical genetics, 109(3), 218-225 (2002-04-27)
Saethre-Chotzen syndrome is an autosomal dominant disease characterized by craniosynostosis, ptosis, and limb and external ear abnormalities. Variable expressivity is a well-known phenomenon in this disorder. A large Indian family has been recently identified as carrying a nonsense TWIST mutation
Ruth N Moro et al.
Annals of the American Thoracic Society, 15(5), 570-580 (2018-02-03)
Data are limited regarding the safety of 12-dose once-weekly isoniazid (H, 900 mg) plus rifapentine (P, 900 mg) (3HP) for latent infection treatment during pregnancy. To assess safety and pregnancy outcomes among pregnant women who were inadvertently exposed to study
E Galea et al.
Journal of neuroscience research, 37(3), 406-414 (1994-02-15)
In primary cultures of rat astroglial cells exposure to bacterial endotoxin lipopolysaccharide (LPS) causes induction of a Ca(2+)-independent form of the nitric oxide synthase (iNOS) enzyme. We have now cloned the mRNA encoding astroglial iNOS using a combination of cDNA
Maytal Raz et al.
Gene, 519(1), 67-70 (2013-02-19)
Primary lactase deficiency (PLD), the physiological decline of lactase, is associated with the LCT-13910C/T and LCT-22018G/A polymorphisms. PLD is the most common phenotype in humans and varies widely as a function of ethnicity. Israel is a multiethnic country. We analyzed
Tayfun Güngör et al.
Lancet (London, England), 383(9915), 436-448 (2013-10-29)
In chronic granulomatous disease allogeneic haemopoietic stem-cell transplantation (HSCT) in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease (GVHD), and transplant-related mortality. We examined the effect of a reduced-intensity conditioning regimen designed to
Melissa Voigt Hansen et al.
Anesthesia and analgesia, 115(2), 379-385 (2012-05-01)
The specific clock-gene PERIOD3 is important with regard to circadian rhythmicity, sleep homeostasis, and cognitive function. The allele PER3(5/5) has been associated with worse cognitive performance in response to sleep deprivation. We hypothesized that patients with the PER3(5/5) genotype would
Edwin K Jackson et al.
The Journal of pharmacology and experimental therapeutics, 314(3), 1109-1116 (2005-05-20)
alpha(2)-Adrenoceptors potentiate vascular responses to angiotensin II. The goal of this study was to test the hypothesis that the phospholipase C (PLC)/protein kinase C (PKC)/c-src/phosphatidylinositol 3-kinase (PI3K) pathway contributes to the vascular angiotensin II/alpha(2)-adrenoceptor interaction. In rats in vivo, intrarenal
M Morishima et al.
Teratology, 57(6), 302-309 (1998-07-17)
The inv mouse was reported as a novel strain with situs inversus Yokoyama et al., '93), and a few cases with heterotaxy were found in homozygotes. The original report by Yokoyama et al. described the location of the heart and
Wan-Ting Li et al.
The American journal of surgical pathology, 44(12), 1643-1648 (2020-09-15)
Identification of the primary site of cancer is essential for the treatment of patients with cancer. Numerous immunohistochemical markers have been developed to determine the differentiation of tumor cells and suggest possible primary sites, but markers of gastric and pancreatic
Circulating adipokines and the protective effects of hyperinsulinemia in inflammatory bowel disease.
Luzia Valentini et al.
Nutrition (Burbank, Los Angeles County, Calif.), 25(2), 172-181 (2008-10-14)
Adipokines are fat-derived hormones and cytokines with immune-modulating and metabolic properties. Most of them are associated with insulin resistance. The aim of the present investigation was to evaluate circulating levels of adipokines and glucose homeostasis in patients with inflammatory bowel
Takao Watanabe et al.
Neurologia medico-chirurgica, 50(12), 1062-1069 (2011-01-06)
Zygote arrest 1 (ZAR1) is a novel maternal-effect gene which is extremely important during the oocyte-to-embryo transition. Comprehensive methylation analysis of tumor-specific differentially methylated regions in human malignant melanoma has recently led to the identification of non-promoter hypermethylation of the
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