Showing 1-30 of 456 results for "93350"
Qi-Bin Zhang et al.
Nature communications, 6, 8062-8062 (2015-08-22)
The South Asian Monsoon and mid-latitude Westerlies are two important controls on Tibetan Plateau (TP) fresh water resources. Understanding their interaction requires long-term information on spatial patterns in moisture variability on the TP. Here we develop a network of 23...
Raimo A Ketola et al.
Forensic science international, 249, e7-11 (2015-02-17)
Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxiolytic and sedative properties. Sales of kava extracts were...
Lisa Mathiasen et al.
PloS one, 10(4), e0125789-e0125789 (2015-04-10)
Human PREP1 and PBX1 are homeodomain transcriptional factors, whose biochemical and structural characterization has not yet been fully described. Expression of full-length recombinant PREP1 (47.6 kDa) and PBX1 (46.6 kDa) in E. coli is difficult because of poor yield, high...
Piyasi Mukhopadhyay et al.
International journal of biological macromolecules, 72, 640-648 (2014-09-23)
Chitosan-alginate (CS/ALG) nanoparticles were prepared by formation of an ionotropic pre-gelation of an alginate (ALG) core entrapping insulin, followed by chitosan (CS) polyelectrolyte complexation, for successful oral insulin administration. Mild preparation process without harsh chemicals is aimed at improving insulin...
D R Brocks et al.
Clinical pharmacokinetics, 23(6), 415-427 (1992-12-01)
Ketorolac is a new chiral nonsteroidal anti-inflammatory drug (NSAID) which is marketed for analgesia as the racemate. The drug is administered as the water soluble tromethamine salt and is available in tablets or as an intramuscular injection. The absorption of...
Heidary Shayesteh Tavakol et al.
Toxicology and industrial health, 31(9), 862-867 (2013-04-12)
Chemical materials are environmental contaminants, are extensively used in laboratories, and may cause various forms of health hazards in laboratory workers. Therefore, this toxicity most likely is a result of the oxidative metabolism of chemical to reactive products. As green...
Erica Dorigatti de Avila et al.
Biomaterials, 67, 84-92 (2015-07-27)
Bacterial biofilm infections remain prevalent reasons for implant failure. Dental implant placement occurs in the oral environment, which harbors a plethora of biofilm-forming bacteria. Due to its trans-mucosal placement, part of the implant structure is exposed to oral cavity and...
Marzia Salzillo et al.
Journal of basic microbiology, 55(7), 890-897 (2015-02-28)
Collagen is a target of pathogens for adhesion, colonization, and invasion of host tissue. Probiotic bacteria can mimic the same mechanism as used by the pathogens in the colonization process, expressing cell surface proteins that specifically interact with extracellular matrix...
Andreas Reisch et al.
ACS nano, 9(5), 5104-5116 (2015-04-22)
Ultrasmall polymer nanoparticles are rapidly gaining importance as nanocarriers for drugs and contrast agents. Here, a straightforward modular approach to efficiently loaded and stable sub-20-nm polymer particles is developed. In order to obtain ultrasmall polymer nanoparticles, we investigated the influence...
Azmat Ali Khan et al.
Journal of fluorescence, 25(3), 519-525 (2015-02-02)
Novel conjugate 2,6-Diisopropylphenol-Oleic acid (2,6P-OLA) has shown potent anticancer activity on various cancer cell lines (Khan et al. Lipids 47:973-986, 2012). In the present study, the protein-or/ and DNA-binding property of 2,6P-OLA was evaluated that could predict its potential toxic...
Sebastian Fiedler et al.
Biophysical journal, 109(10), 2079-2089 (2015-11-21)
Cyclic lipopeptides act against a variety of plant pathogens and are thus highly efficient crop-protection agents. Some pesticides contain Bacillus subtilis strains that produce lipopeptide families, such as surfactins (SF), iturins (IT), and fengycins (FE). The antimicrobial activity of these...
Maria Peiris-Pagès et al.
Aging, 7(10), 816-838 (2015-11-06)
Cancer cells grow in highly complex stromal microenvironments, which through metabolic remodelling, catabolism, autophagy and inflammation nurture them and are able to facilitate metastasis and resistance to therapy. However, these changes in the metabolic profile of stromal cancer-associated fibroblasts and...
Tzung-Yi Lin et al.
PloS one, 9(7), e101980-e101980 (2014-07-08)
The liver plays a vital role in metabolism, detoxification, digestion, and the maintenance of homeostasis. During development, the vertebrate embryonic liver undergoes a series of morphogenic processes known as hepatogenesis. Hepatogenesis can be separated into three interrelated processes: endoderm specification...
Hyo Jin Kang et al.
Biosensors & bioelectronics, 67, 413-418 (2014-09-15)
Caspase-3 is an apoptotic cysteine protease and its aberrancy is highly implicated to numerous diseases thereby rendering caspase-3 activity as an important disease marker. Most caspase-3 sensors are caspase-3 substrates of which the fluorescence signals are turned on upon catalytic...
Mi-Young Kim et al.
Vaccine, 33(15), 1830-1838 (2015-03-03)
Dengue infection is on the rise in many endemic areas of the tropics. Vaccination remains the most realistic strategy for prevention of this potentially fatal viral disease but there is currently no effective vaccine that could protect against all four...
Robin Dufour et al.
Scientific reports, 5, 12670-12670 (2015-08-04)
The triple negative basal-like (TNBL) breast carcinoma is an aggressive and unfavorable prognosis disease. Inhibitors of poly(ADP-ribose) polymerase such as Olaparib could represent a promising targeted therapy but their sensitivity against Multidrug Resistance proteins (MDR), which causes resistance, is not...
Martina Sandberg Abelius et al.
Journal of reproductive immunology, 106, 100-109 (2014-07-23)
The immunological milieu in the placenta may be crucial for priming the developing foetal immune system. Early imbalances may promote the establishment of immune-mediated diseases in later life, including allergies. The initial exposure to allergens seems to occur in utero...
Ujala Rana et al.
Journal of inorganic biochemistry, 102(3), 489-499 (2008-01-04)
Many cell types contain metal-ion unsaturated metallothionein (MT). Considering the Zn(2+) binding affinity of metallothionein, the existence of this species in the intracellular environment constitutes a substantial "thermodynamic sink". Indeed, the mM concentration of glutathione may be thought of in...
Patrícia Pereira et al.
Journal of chromatography. A, 1368, 173-182 (2014-12-03)
MicroRNA-based therapeutic applications have fostered a growing interest in the development of microRNAs purification processes in order to obtain the final product with high purity degree, good quality and biologically active. The pre-miR-29 deficiency or overexpression has been associated to...
Seung Ho Baek et al.
Immunopharmacology and immunotoxicology, 37(3), 265-273 (2015-05-20)
Cinobufagin (CBG) is a cardiotoxic bufanolide steroid secreted by the skin and parotid venom glands of the Asiatic toad Bufo bufo gargarizans (called Chan-Su). Although CBG is known to exhibit anti-cancer activities, very little is known about its potential mechanism(s)...
Smita Joel et al.
ACS chemical biology, 9(7), 1595-1602 (2014-05-21)
Advancements in biotechnology have allowed for the preparation of designer proteins with a wide spectrum of unprecedented chemical and physical properties. A variety of chemical and genetic methods can be employed to tailor the protein's properties, including its stability and...
[Ketorolac tromethamine--with special reference to postoperative pain therapy].
S S Andersen et al.
Ugeskrift for laeger, 156(8), 1160-1163 (1994-02-21)
Natalia A Stefanova et al.
Journal of pineal research, 59(2), 163-177 (2015-05-20)
Translational research on Alzheimer's disease (AD) has often focused on reducing the high cerebral levels of amyloid-β (Aβ) as a key characteristic of AD pathogenesis. There is, however, a growing body of evidence that synaptic dysfunction may be crucial for...
P A Mosier-Boss et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 153, 591-598 (2015-10-07)
SERS substrates were fabricated by filtering either Ag or Au colloidal particles onto rigid, ceramic filters - onto which suspensions of bacteria were then filtered. SERS spectra of the bacteria were obtained using a Raman spectrometer that has an 'orbital...
Irene Moraleja et al.
Analytical and bioanalytical chemistry, 407(9), 2393-2403 (2015-01-27)
A shotgun approach including peptide-based OFFGEL-isoelectric focusing (IEF) fractionation has been developed with the aim of improving the identification of platinum-binding proteins in biological samples. The method is based on a filter-aided sample preparation (FASP) tryptic digestion under denaturing and...
Olivia Larne et al.
Carcinogenesis, 36(8), 858-866 (2015-05-15)
Androgen signalling through the androgen receptor (AR) is essential for prostate cancer initiation, progression and transformation to the lethal castration-resistant state. The aim of this study was to characterize the mechanisms by which miR-145 deregulation contribute to prostate cancer progression....
Frantisek Jursky et al.
European journal of pharmacology, 765, 1-6 (2015-08-15)
We previously identified cysteine 475 as a key residue for the inhibitory action of sanguinarine on the human glycine transporter GlyT1c. To define potential benzophenanthridine binding pocket more closely, we created a structural homology model of GlyT1 and also mutated...
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated...
Lijuan Chen et al.
Journal of separation science, 38(16), 2915-2923 (2015-05-29)
In this work, a facile approach was developed to modify a fused-silica capillary inner surface based on poly(dopamine) and poly(acrylamide) mixed coatings for protein separation by capillary electrophoresis. The surface morphology, thickness, and chemical components of poly(dopamine)/poly(acrylamide) mixed coatings on...
Esra Maltas et al.
Materials science & engineering. C, Materials for biological applications, 54, 43-49 (2015-06-06)
The interaction of thiabendazole (Tbz) with hemoglobin (Hb) on epoxy-functionalized iron oxide nanoparticles was presented in this study. The binding capacity of Tbz was determined by measuring at an excitation wavelength of 299 nm using fluorescence spectroscopy. The thermodynamic parameters...

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