Showing 1-30 of 105 results for "93979"
Dany Spaggiari et al.
Analytical and bioanalytical chemistry, 406(20), 4875-4887 (2014-06-05)
The cocktail approach is an advantageous strategy used to monitor the activities of several cytochromes P450 (CYPs) in a single test to increase the throughput of in vitro phenotyping studies. In this study, a cocktail mixture was developed with eight...
Atsushi Kato et al.
Bioorganic & medicinal chemistry letters, 20(19), 5630-5633 (2010-09-02)
We report the structure-activity relationship of a series of coumarins as aldose reductase 2 (ALR2) inhibitors and their suppressive effect on the accumulation of galactitol in the rat lens. We evaluated their ALR2 selectivity profile against sorbitol dehydrogenase and aldehyde...
Milica M Fotirić Akšić et al.
Journal of agricultural and food chemistry, 63(34), 7476-7486 (2015-08-19)
The European pear psylla, Cacopsylla pyri L. (Hemiptera: Psyllidae), is one of the most serious arthropod pests of pear. Since proper control of this pest is essential, better understanding of the complex plant-pest relationship is mandatory. This research deals with...
S Sebastian et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 101, 370-381 (2012-11-06)
In this work, we report harmonic vibrational frequencies, molecular structure, NBO and HOMO, LUMO analysis of Umbelliferone also known as 7-hydroxycoumarin (7HC). The optimized geometric bond lengths and bond angles obtained by computation (monomer and dimmer) shows good agreement with...
Jacqueline Ramírez et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(7), 928-935 (2015-04-15)
OTS167 is a potent maternal embryonic leucine zipper kinase inhibitor undergoing clinical testing as antineoplastic agent. We aimed to identify the UDP-glucuronosyltransferases (UGTs) involved in OTS167 metabolism, study the relationship between UGT genetic polymorphisms and hepatic OTS167 glucuronidation, and investigate...
Vassiliki Panteleon et al.
Bioorganic & medicinal chemistry letters, 18(21), 5781-5784 (2008-10-07)
A series of novel spiro-substituted 4-hydroxypyranocoumarins and their corresponding dihydropyrano cis-diols has been synthesized. Among them the spiroadamantylpyranocoumarin and the diols can interact with the stable free radical 1,1-diphenyl-2-picrylhydrazyl and scavenge superoxide anions generated in the xanthine-xanthine oxidase system.
S Huber et al.
Journal of pharmaceutical and biomedical analysis, 104, 137-143 (2014-12-17)
Esters of the cytostatic bendamustine (1), previously demonstrated to be much more potent than the parent compound as antiproliferative agents in vitro, were investigated for stability in buffer and plasma, as well as against porcine liver esterase in the presence...
Ju-ying Zou et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(5), 724-725 (2012-12-12)
To study the chemical constituents of Pileostegia viburnoides var. glabrescens. The compounds were isolated and purified by various techniques. Their structures were determined by physicochemical properties and spectral analysis. Five compounds were isolated and identified as friedelin (1), beta-sitosterol (2)...
Alexander H Penn et al.
Journal of pediatric gastroenterology and nutrition, 59(3), 365-373 (2014-05-21)
Fat is digested in the intestine into free fatty acids (FFAs), which are detergents and therefore toxic to cells at micromolar concentration. The mucosal barrier protects cells in the adult intestine, but this barrier may not be fully developed in...
Hemakesh Mohapatra et al.
Angewandte Chemie (International ed. in English), 51(44), 11145-11148 (2012-10-06)
Smell of success: Reagent 1 provides the dual readouts of odor (ethanethiol) and fluorescence (derivative of 7-hydroxycoumarin) and can be used in down-selection assays based on smell and quantitative fluorescence assays of the samples that give a positive result. An...
Bonnie S Watson et al.
Plant physiology, 167(4), 1699-1716 (2015-02-11)
Integrated metabolomics and transcriptomics of Medicago truncatula seedling border cells and root tips revealed substantial metabolic differences between these distinct and spatially segregated root regions. Large differential increases in oxylipin-pathway lipoxygenases and auxin-responsive transcript levels in border cells corresponded to...
Tao Yi et al.
Journal of ethnopharmacology, 153(3), 701-713 (2014-03-26)
Saussurea laniceps Hand.-Mazz. (SL) has long been used under the herbal name Tibetan "Snow Lotus" for the treatment of rheumatoid arthritis, stomachache and dysmenorrhea in Tibetan folk medicine. Since herbal medicine (HM) is a synergistical system with multiple components, both...
Niina Tani et al.
Bioorganic & medicinal chemistry, 22(23), 6655-6664 (2014-12-03)
Inhibition of CYP2A6-mediated nicotine metabolism can reduce cigarette smoking. We sought potent and selective CYP2A6 inhibitors to be used as leads for drugs useful in smoking reduction therapy, by evaluating CYP2A6 inhibitory effect of novel formyl, alkyl amine or carbonitrile...
Behrooz M Parast et al.
Plant physiology and biochemistry : PPB, 49(10), 1138-1146 (2011-04-29)
Psoralen, an important furanocoumarin occurring abundantly in seeds of Psoralea corylifolia is used as an anticancerous compound against leukemia and other cancer cell lines. Evaluation and isolation of psoralen from the calluses derived from different plant parts, viz. cotyledons, nodes...
Juri M Timonen et al.
European journal of medicinal chemistry, 46(9), 3845-3850 (2011-06-18)
A number of 7-hydroxycoumarins have been synthesised by Pechmann cyclisation using differently substituted resorcinols employing perchloric acid as the condensing agent. All the compounds have been characterised by analytical and spectroscopic methods. The anti-inflammatory properties were tested with LPS-induced inflammation...
Jing Dai et al.
Drug development and industrial pharmacy, 39(9), 1457-1463 (2013-08-02)
Photo-responsive monoolein (MO) cubic phase was developed by incorporating coumarin-Tween 20 conjugate in the cubic phase. 7-chlorocarbonylmethoxycoumarin was obtained from 7-hydroxycoumarin through three-step reactions with the yield of 19.8% and it was conjugated to the head group of Tween 20....
C Preston Pugh et al.
Archives of biochemistry and biophysics, 564, 244-253 (2014-12-03)
The widely used anticoagulant Coumadin (R/S-warfarin) undergoes oxidation by cytochromes P450 into hydroxywarfarins that subsequently become conjugated for excretion in urine. Hydroxywarfarins may modulate warfarin metabolism transcriptionally or through direct inhibition of cytochromes P450 and thus, UGT action toward hydroxywarfarin...
Issha Nadirah Ismail et al.
Journal of fluorescence, 25(4), 777-785 (2015-06-10)
A coumarin-terminated self-assembled monolayer on silver particles (C-SAM) from the reduction of silver ions in the presence of compound 3 was successfully prepared by utilizing phase transfer method, and analyzed by FTIR, SEM-EDS, UV-Visible and a particle sizer. The fluorescence...
Tao Lin et al.
Zygote (Cambridge, England), 23(2), 297-306 (2014-01-05)
In the present study, a porcine system was supplemented with sorbitol during in vitro maturation (IVM) or in vitro culture (IVC), and the effects of sorbitol on oocyte maturation and embryonic development following parthenogenetic activation were assessed. Porcine immature oocytes...
Soo Hyeon Bae et al.
Antimicrobial agents and chemotherapy, 58(9), 5036-5046 (2014-06-04)
Macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA), polyene macrolides containing a 24-membered lactone ring, show antibiotic effects superior to those of teicoplanin against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. MA and SMA are currently being evaluated as antitumor agents...
Maria João Matos et al.
Bioorganic & medicinal chemistry letters, 21(11), 3342-3345 (2011-04-26)
With the aim to find out structural features for the tyrosinase inhibitory activity, in the present communication we report the synthesis and pharmacological evaluation of a new series of phenylcoumarin derivatives with different number of hydroxyl or ether groups and...
Stefan Starcević et al.
Journal of medicinal chemistry, 54(1), 248-261 (2010-12-09)
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is an enzyme that catalyzes NADPH-dependent reduction of the weak estrogen, estrone, into the most potent estrogen, estradiol, which exerts proliferative effects via the estrogen receptors. Overexpression of 17β-HSD1 in estrogen-responsive tissues is related to...
Yoshihiko Shimokawa et al.
Biological & pharmaceutical bulletin, 37(11), 1727-1735 (2014-11-05)
Delamanid is a new drug for the treatment of multidrug-resistant tuberculosis. Individuals who are co-infected with human immunodeficiency virus and Mycobacterium tuberculosis may require treatment with a number of medications that might interact significantly with the CYP enzyme system as...
In-Hwan Baek et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(11), 975-987 (2014-05-31)
1. JHL45, a novel immune modulator against atopic dermatitis (AD), was synthesized from decursin isolated from Angelica gigas. The goal is to evaluate the lead compound using quantitative modeling approaches to novel anti-AD drug development. 2. We tested the anti-inflammatory effect of...
Yuki Kondo et al.
PloS one, 9(8), e104010-e104010 (2014-08-02)
In this study, we aimed to elucidate the effects and mechanism of action of valproic acid on hepatic differentiation from human induced pluripotent stem cell-derived hepatic progenitor cells. Human induced pluripotent stem cells were differentiated into endodermal cells in the...
Ana C A X De-Oliveira et al.
PloS one, 10(1), e0117842-e0117842 (2015-01-31)
Mouse cytochrome P450 (CYP) 2A5 is induced by inflammatory conditions and infectious diseases that down-regulate the expression and activity of most other CYP isoforms. Enhanced oxidative stress and nuclear factor (erythroid 2-related factor) 2 (Nrf2) transcription factor activation have been...
Dany Spaggiari et al.
Journal of chromatography. A, 1371, 244-256 (2014-12-03)
The goal of this study was to evaluate the combination of powerful chromatographic methods and compact single quadrupole MS device for simple in vitro cytochrome P450 (CYP) inhibition assay, instead of more expensive triple quadrupole MS/MS detectors. For this purpose...
Ye V Liu et al.
Vaccine, 33(18), 2152-2158 (2015-03-17)
In March 2013, diagnosis of the first reported case of human infection with a novel avian-origin influenza A(H7N9) virus occurred in eastern China. Most human cases have resulted in severe respiratory illness and, in some instances, death. Currently there are...
Victor M Navarro-García et al.
Mycoses, 54(5), e569-e571 (2011-05-25)
The bis-coumarin daphnoretin and its monomeric precursors scopoletin and umbelliferone were isolated for the first time from the aerial part of Loeselia mexicana Brand (a vegetal species used in Mexican traditional medicine) using chromatographic techniques. The structures of these compounds...
Anna Maria Ferrari et al.
European journal of medicinal chemistry, 42(7), 1028-1031 (2007-02-24)
Quantum-chemical descriptors related to proton dissociation constants of a set of coumarins hydroxylated in various positions have been computed and related to the experimental pK(a) values. An excellent correlation was found between the computed deprotonation energies of hydroxycoumarins in water...

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