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Bert Wouters et al.
Journal of chromatography. A, 1370, 63-69 (2014-12-03)
The gradient-performance limits of capillary ion chromatography have been assessed at maximum system pressure (34.5 MPa) using capillary columns packed with 4.1 μm macroporous anion-exchange particles coated with 65 nm positively-charged nanobeads. In analogy to the van-Deemter curve, the gradient
C J L Silwood et al.
Journal of dental research, 81(6), 422-427 (2002-07-05)
We have explored the ability of high-resolution NMR techniques to (1) index salivary biomolecules and (2) provide valuable data regarding intra- and inter-subject variability in the concentrations of a series of components readily determinable by this technique (organic acids and
Giovanna Pitarresi et al.
Carbohydrate polymers, 92(2), 1054-1063 (2013-02-13)
In this work, an efficient method for the synthesis of hyaluronic acid based brush copolymers using atom transfer radical polymerization (ATRP) has been reported. At first, two different hyaluronic acid (HA) based macroinitiators have been prepared and then they have
Jessica Karlsson et al.
PloS one, 9(7), e103589-e103589 (2014-07-26)
In addition to their effects upon prostaglandin synthesis, the non-steroidal anti-inflammatory drugs ibuprofen and flurbiprofen inhibit the metabolism of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA) by cyclooxygenase-2 (COX-2) and fatty acid amide hydrolase (FAAH), respectively. Here, we investigated whether
Wooram Park et al.
Biomaterials, 35(25), 7239-7247 (2014-06-02)
Directing the controlled differentiation and tracking of stem cells is essential to achieve successful stem cell therapy. In this work, we describe a multi-modal (MR/optical) transfection agent (MTA) for efficient gene delivery and cell tracking of human mesenchymal stem cells
Anders H Honoré et al.
Analytical and bioanalytical chemistry, 405(25), 8151-8170 (2013-08-21)
Co-cultures of specific lactic and propionic acid bacteria have been shown to have an antagonistic effect against yeast and moulds in dairy systems. In studies of these co-cultures by bioassay-guided fractionation and analysis, numerous compounds have been reported to inhibit
Sumit Bhatnagar et al.
Journal of pharmaceutical sciences, 103(10), 3276-3286 (2014-07-23)
Low and heterogeneous delivery of drugs and imaging agents to tumors results in decreased efficacy and poor imaging results. Systemic delivery involves a complex interplay of drug properties and physiological factors, and heterogeneity in the tumor microenvironment makes predicting and
The many roles for fluorine in medicinal chemistry.
William K Hagmann
Journal of medicinal chemistry, 51(15), 4359-4369 (2008-06-24)
W K Coblentz et al.
Journal of dairy science, 96(4), 2521-2535 (2013-02-19)
Unstable weather, poor drying conditions, and unpredictable rainfall events often place valuable hay crops at risk. Recent research with large round bales composed of alfalfa (Medicago sativa L.) and orchardgrass (Dactylis glomerata L.) has shown that these large-bale packages are
Hossein Bayahia et al.
Chemical communications (Cambridge, England), 49(37), 3842-3844 (2013-03-19)
Amorphous silica and crystalline silicalite (MFI structure) are demonstrated to be active and environmentally benign catalysts for propionic acid ketonisation at 450-500 °C to form 3-pentanone. The silicalite is particularly efficient, and its ketonisation selectivity is increased by base modification
Nicole M Payton et al.
Journal of pharmaceutical sciences, 103(12), 3869-3878 (2014-10-14)
Because aqueous liposomal formulations containing multiply unsaturated lipids are susceptible to chemical degradation, these formulations are often lyophilized. Despite their limited chemical stability, interest in the use of multiply unsaturated lipids to promote intracellular delivery has increased considerably in recent
Seyed Assad Karimi et al.
Neurochemical research, 40(4), 811-817 (2015-02-07)
In the hippocampus, metabotropic glutamate receptors (mGluRs) are involved in various forms of synaptic plasticity. High-fat diets (HFDs) adversely influence hippocampal structure and function and induce changes in hippocampal glutamate metabolism and neurotransmission. Here, we studied the induction of hippocampal
Tamar L Greaves et al.
Physical chemistry chemical physics : PCCP, 17(4), 2357-2365 (2014-12-06)
A high-throughput approach was developed in order to prepare and dry a series of protic ionic liquids (PILs) from 48 Brønsted acid-base combinations. Many combinations comprised an alkyl carboxylic acid paired with an alkyl amine. Visual screens were developed to
Kathleen Machiels et al.
Gut, 63(8), 1275-1283 (2013-09-12)
Bacteria play an important role in the onset and perpetuation of intestinal inflammation in inflammatory bowel disease (IBD). Unlike in Crohn's disease (CD), in which dysbiosis has been better characterised, in ulcerative colitis (UC), only small cohorts have been studied
John M Chaston et al.
mBio, 5(5), e01631-e01614 (2014-10-02)
Animal-associated bacteria (microbiota) affect host behaviors and physiological traits. To identify bacterial genetic determinants of microbiota-responsive host traits, we employed a metagenome-wide association (MGWA) approach in two steps. First, we measured two microbiota-responsive host traits, development time and triglyceride (TAG)
L B Bindels et al.
British journal of cancer, 107(8), 1337-1344 (2012-09-15)
Metabolites released by the gut microbiota may influence host metabolism and immunity. We have tested the hypothesis that inulin-type fructans (ITF), by promoting microbial production of short-chain fatty acids (SCFA), influence cancer cell proliferation outside the gut. Mice transplanted with
Greta Jakobsdottir et al.
The British journal of nutrition, 110(9), 1565-1572 (2013-03-28)
SCFA are important end products formed during colonic fermentation of dietary fibre (DF). It has been suggested that propionic and butyric acids affect metabolic parameters, low-grade systemic inflammation, insulin resistance and obesity. The aim of the present study was to
Xian-Bing Xu et al.
Journal of chromatography. A, 1366, 65-72 (2014-09-24)
A novel interface that enables high-performance anion-exchange chromatography (HPAEC) to be coupled with electrospray ionization (ESI) mass spectrometry (MS) is reported. A sheath liquid consisting of 50mM NH4Ac in isopropanol with 0.05% acetic acid, infused at a flow rate of
S Somerma et al.
Acta dermato-venereologica, 64(1), 41-45 (1984-01-01)
The effect of five corticosteroid ointments on epidermal thickness was studied using occlusive chamber application. Thinning of the epidermis and telangiectasia were noted 3 weeks after application of betamethasone-17-valerate (BV), budesonide (BD), clobetasol-17-propionate (CP), and fluocinolone acetonide (FA), but not
Yang Liu et al.
Molecular pharmaceutics, 11(10), 3330-3341 (2014-06-26)
Achieving effective gene therapy for glioma depends on gene delivery systems. The gene delivery system should be able to cross the blood-brain barrier (BBB) and further target glioma at its early stage. Active brain tumor targeted delivery can be achieved
Wendy Franco et al.
Journal of food science, 77(10), M586-M592 (2012-08-29)
Calcium chloride fermentations represent an alternative to reduce chloride concentrations in the wastewaters generated from commercial cucumber fermentations, currently performed in cover brine solutions containing 6% to 12% sodium chloride. However, preliminary attempts to commercially ferment the cucumbers in the
Ienaka Takeda et al.
NMR in biomedicine, 22(6), 577-584 (2009-03-05)
Saliva is a readily accessible biofluid that is important for the overall health, aiding in the chewing, swallowing, and tasting of food as well as the regulation mouth flora. As a first step to determining and understanding the human saliva
Structural elucidation and in vitro fermentation of extracellular ?-d-glucan from Lactobacillus reuteri SK24. 003
Miao M, et al.
Bioactive Carbohydrates and Dietary Fibre, 6(2), 109-116 (2015)
Elena Herzog et al.
Biophysical journal, 103(6), 1305-1314 (2012-09-22)
The E-pathway of transmembrane proton transfer has been demonstrated previously to be essential for catalysis by the diheme-containing quinol:fumarate reductase (QFR) of Wolinella succinogenes. Two constituents of this pathway, Glu-C180 and heme b(D) ring C (b(D)-C-) propionate, have been validated
Randy J Chandler et al.
Molecular genetics and metabolism, 89(1-2), 64-73 (2006-07-18)
We have utilized Caenorhabditis elegans to study human methylmalonic acidemia. Using bioinformatics, a full complement of mammalian homologues for the conversion of propionyl-CoA to succinyl-CoA in the genome of C. elegans, including propionyl-CoA carboxylase subunits A and B (pcca-1, pccb-1)
Pengyuan Sun et al.
Pharmacological reports : PR, 66(2), 311-319 (2014-06-10)
Eprosartan is an angiotensin II receptor antagonist, used in the treatment of hypertension and heart failure in clinical patients. The objective of this study was to clarify the mechanism underlying hepatic uptake and biliary excretion of eprosartan in rats and
Shih-Chun Lin et al.
Glia, 47(3), 290-298 (2004-07-15)
Rapid signaling between vertebrate neurons occurs primarily at synapses, intercellular junctions where quantal release of neurotransmitter triggers rapid changes in membrane conductance through activation of ionotropic receptors. Glial cells express many of these same ionotropic receptors, yet little is known
Bo Tjellström et al.
Scandinavian journal of gastroenterology, 47(12), 1454-1459 (2012-09-29)
Exclusive enteral nutrition (EEN) is a first-line treatment in children with active Crohn's disease (CD) but is seldom used in adults with active disease. The mode of action of EEN in suppressing mucosal inflammation is not fully understood, but modulation
Bachir Latli et al.
Journal of labelled compounds & radiopharmaceuticals, 57(5), 350-357 (2014-04-05)
Drug candidates labeled with radioactive and stable isotopes are required for absorption, distribution, metabolism, and excretion (ADME) studies, pharmacokinetics, autoradiography, bioanalytical, and other research activities. The findings from these studies are crucial in the development of a drug candidate and
Sa'ad H Al-Lahham et al.
Biochimica et biophysica acta, 1801(11), 1175-1183 (2010-08-10)
Undigested food is fermented in the colon by the microbiota and gives rise to various microbial metabolites. Short-chain fatty acids (SCFA), including acetic, propionic and butyric acid, are the principal metabolites produced. However, most of the literature focuses on butyrate
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