Showing 1-30 of 131 results for "A0170"
Nikolai Siebert et al.
mAbs, 8(3), 604-616 (2016-01-21)
Ch14.18 manufactured in Chinese hamster ovary (CHO) cells is currently being evaluated in clinical trials. Short-term infusion (STI) (8-20 h/day; 4-5 days) of 100 mg/m2 ch14.18/CHO (dinutiximab β) per cycle in combination with cytokines is standard treatment of neuroblastoma (NB)...
Fabian Richter et al.
mAbs, 11(4), 653-665 (2019-04-02)
The development of alternative therapeutic strategies to tumor necrosis factor (TNF)-blocking antibodies for the treatment of inflammatory diseases has generated increasing interest. In particular, selective inhibition of TNF receptor 1 (TNFR1) promises a more precise intervention, tackling only the pro-inflammatory...
Andrew D Westmuckett et al.
PloS one, 8(8), e71822-e71822 (2013-08-21)
Protein-tyrosine sulfation is a post-translational modification of an unknown number of secreted and membrane proteins mediated by two known Golgi tyrosylprotein sulfotransferases (TPST-1 and TPST-2). We reported that Tpst2-/- mice have mild-moderate primary hypothyroidism, whereas Tpst1-/- mice are euthyroid. While...
Fredy Brice Nemg Simo et al.
Intervirology, 61(6), 265-271 (2019-05-03)
On May 2017, a case of dengue serotype 1 was detected and confirmed through routine surveillance in a traveler returning from Kribi, a seaside town of Southern Cameroon. This study aimed at confirming the circulation of dengue virus (DENV) in...
Daming Zhou et al.
Cell, 184(9), 2348-2361 (2021-03-18)
The race to produce vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began when the first sequence was published, and this forms the basis for vaccines currently deployed globally. Independent lineages of SARS-CoV-2 have recently been reported: UK, B.1.1.7;...
Luke Muir et al.
Wellcome open research, 2, 97-97 (2018-03-29)
Background: Human memory B cells play a vital role in the long-term protection of the host from pathogenic re-challenge. In recent years the importance of a number of different memory B cell subsets that can be formed in response to...
Miguel Ángel Muñoz-Alía et al.
PloS one, 13(2), e0192245-e0192245 (2018-02-22)
Subacute sclerosing panencephalitis (SSPE) is a progressive, lethal complication of measles caused by particular mutants of measles virus (MeV) that persist in the brain despite high levels of neutralizing antibodies. We addressed the hypothesis that antigenic drift is involved in...
Priyank Jaiswal et al.
Frontiers in cellular and infection microbiology, 10, 251-251 (2020-06-13)
Background: Post Kala Azar Dermal Leishmaniasis (PKDL) is a non-fatal dermal sequel of Visceral Leishmaniasis (VL), affecting individuals worldwide. Available diagnostic tools lack sensitivity and specificity toward identifying macular (MAC) PKDL patients, due to low parasite load in patients' sample....
Brian Hassett et al.
mAbs, 10(1), 159-165 (2017-10-12)
Etanercept (ETN) (Enbrel®) is a soluble protein that binds to, and specifically inhibits, tumor necrosis factor (TNF), a proinflammatory cytokine. ETN is synthesized in Chinese hamster ovary cells by recombinant DNA technology as a fusion protein, with a fully human...
Yvonne Rosenberg et al.
PloS one, 10(3), e0120451-e0120451 (2015-03-26)
The identification of highly potent broadly neutralizing antibodies (bnAbs) against HIV-1, and success in preventing SHIV infection following their passive administration, have increased the likelihood that immunotherapeutic strategies can be adopted to prevent and treat HIV-1 infection. However, while broad...
Muriel Viau et al.
Journal of immunology (Baltimore, Md. : 1950), 175(11), 7719-7727 (2005-11-23)
Protein A (SpA) of Staphylococcus aureus is endowed with the capacity to interact with the H chain variable region (V(H)) of human Abs and to target >40% of B lymphocytes. To investigate whether this property represents a virulence factor and...
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Isaak Quast et al.
The Journal of clinical investigation, 125(11), 4160-4170 (2015-10-06)
IgG molecules exert both pro- and antiinflammatory effector functions based on the composition of the fragment crystallizable (Fc) domain glycan. Sialylated IgG Fc domains have antiinflammatory properties that are attributed to their ability to increase the activation threshold of innate...
Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases.
Irani V, et al.
Molecular Immunology, 67(2)), 171-182 (2015)
Jorg C de Ruijter et al.
FEMS yeast research, 17(1) (2016-12-14)
Cost-effective manufacturing of biopharmaceuticals in non-mammalian hosts still requires tremendous efforts in strain development. In order to expedite identification of novel leads for strain engineering, we used a transposon-mutagenized yeast genomic DNA library to create a collection of Saccharomyces cerevisiae...
Daniel J Sheward et al.
Cell host & microbe, 24(4), 593-599 (2018-10-03)
Eliciting antibodies that neutralize a broad range of circulating HIV strains (broadly neutralizing antibodies [bnAbs]) represents a key priority for vaccine development. HIV superinfection (re-infection with a second strain following an established infection) has been associated with neutralization breadth, and...
Viola Fühner et al.
Frontiers in microbiology, 9, 2908-2908 (2018-12-24)
Clostridioides difficile is the causative bacterium in 15-20% of all antibiotic associated diarrheas. The symptoms associated with C. difficile infection (CDI) are primarily induced by the two large exotoxins TcdA and TcdB. Both toxins enter target cells by receptor-mediated endocytosis....
Alda Maria Soares Silveira et al.
PLoS neglected tropical diseases, 10(1), e0004357-e0004357 (2016-01-12)
The Kato-Katz (KK) stool smear is the standard test for the diagnosis of Schistosoma mansoni infection, but suffers from low sensitivity when infections intensities are moderate to low. Thus, misdiagnosed individuals remain untreated and contribute to the disease transmission, thereby...
Isolation, identification, and characterization of the human airway ligand for the eosinophil and mast cell immunoinhibitory receptor Siglec-8.
Gonzalez-Gil, et al.
The Journal of Allergy and Clinical Immunology, 147, 1442-1452 (2021)
Nouha Chahed Bel-Ochi et al.
Clinical and vaccine immunology : CVI, 20(4), 468-473 (2013-01-25)
Serologic detection of Toxoplasma gondii IgG antibodies is widely accepted as a means to determine immune status and susceptibility to Toxoplasma infection during pregnancy. However, current commercial kits present some drawbacks, such as a requirement for whole-parasite antigen preparation or...
Ryan Limbocker et al.
Nature communications, 10(1), 225-225 (2019-01-16)
Transient oligomeric species formed during the aggregation process of the 42-residue form of the amyloid-β peptide (Aβ42) are key pathogenic agents in Alzheimer's disease (AD). To investigate the relationship between Aβ42 aggregation and its cytotoxicity and the influence of a...
Manon Fuchs et al.
BMC biotechnology, 14, 68-68 (2014-07-19)
Tuberculosis is the leading cause of death due to bacterial infections worldwide, mainly caused by Mycobacterium tuberculosis. The antigen 85 complex comprises a set of major secreted proteins of M. tuberculosis, which are potential biomarkers for diagnostic. In this work...
Kristopher R Bosse et al.
Cancer cell, 32(3), 295-309 (2017-09-13)
We developed an RNA-sequencing-based pipeline to discover differentially expressed cell-surface molecules in neuroblastoma that meet criteria for optimal immunotherapeutic target safety and efficacy. Here, we show that GPC2 is a strong candidate immunotherapeutic target in this childhood cancer. We demonstrate...
Yvonne J Rosenberg et al.
Chemico-biological interactions, 187(1-3), 279-286 (2010-03-10)
Human serum and recombinant butyrylcholinesterase (rHuBChE) are the most advanced prophylactics against organophosphate (OP) toxicity due to nerve agent or insecticide exposure. For ethical reasons, such potential multi-use treatments cannot be tested in humans and will require extensive testing in...
Weiyi Qiu et al.
Journal of immunology research, 2019, 3017360-3017360 (2019-02-09)
To improve efficacy and minimize toxicity of EGFR inhibition treatment, we developed Ame55, a novel anti-EGFR IgG1 with lower affinity to EGFR than cetuximab (C225) from a human phage library. Ame55 had lower bioactivity than cetuximab in vitro but similar...
Martin Becker et al.
BMC biotechnology, 15, 43-43 (2015-05-31)
Ticks act as vectors for a large number of different pathogens, perhaps most notably Borrelia burgdorferi, the causative agent of Lyme disease. The most prominent tick vector in the United States is the blacklegged tick, Ixodes scapularis. Tick bites are...
Zhi Liu et al.
The Journal of biological chemistry, 289(6), 3571-3590 (2013-12-07)
Antibody-dependent cellular cytotoxicity (ADCC) is mediated through the engagement of the Fc segment of antibodies with Fcγ receptors (FcγRs) on immune cells upon binding of tumor or viral antigen. The co-crystal structure of FcγRIII in complex with Fc revealed that...
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Julia Herrmann et al.
The Journal of biological chemistry, 289(2), 765-777 (2013-11-28)
The natural cytotoxicity receptors, comprised of three type I membrane proteins NKp30, NKp44, and NKp46, are a unique set of activating proteins expressed mainly on the surface of natural killer (NK) cells. Among these, NKp30 is a major receptor targeting...
Margaretha Jurstrand et al.
Sexually transmitted infections, 83(4), 319-323 (2007-05-04)
Establishing a connection between the emerging urogenital tract pathogen Mycoplasma genitalium and upper genital tract infection in women would be of major importance. The aim of this study was to evaluate the association between M genitalium antibodies and pelvic inflammatory...

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