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Chang Ho Min et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 19(5), 473-478 (2015-09-04)
To see the inhibitory mechanism of gentamicin in response to electrical field stimulation (EFS) using the rat bladder smooth muscle, atropine or guanethidine was treated but had no effect. Methylsergide, a non-selective 5-HT1, 5-HT2 receptor antagonist was also treated but
Hong-Jun Wang et al.
European journal of pharmacology, 595(1-3), 7-12 (2008-08-16)
Calbindin-D28K is a calcium-binding protein in neuronal cytoplasm, which has the capability to protect neurons from degeneration. It was reported that glial cell line-derived neurotrophic factor (GDNF) increased calbindin-D28K expression in dopaminergic neurons in vitro. It was observed in our
Ting Gong et al.
Animals : an open access journal from MDPI, 11(2) (2021-02-12)
Testicular expression of taste receptor type 1 subunit 3 (T1R3), a sweet/umami taste receptor, has been implicated in spermatogenesis and steroidogenesis in mice. We explored the role of testicular T1R3 in porcine postnatal development using the Congjiang Xiang pig, a
D J F von Pfeil et al.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T, 28(6), 371-378 (2015-10-02)
To evaluate whether doxycycline administered to dogs with unilateral cranial cruciate ligament rupture (Uni-CCLR) would decrease the risk of contralateral-CCLR (Co-CCLR). To evaluate predictors for Co-CCLR survival. To evaluate if a predisposition of Labrador Retrievers to Co-CCLR exists when compared
Feng-Yun J Huang et al.
International journal of nanomedicine, 10, 463-473 (2015-01-28)
In this study, the (188)Re-labeled PEGylated nanoliposome ((188)Re-liposome) was prepared and evaluated as a therapeutic agent for glioma. The reporter cell line, F98(luc) was prepared via Lentivector expression kit system and used to set up the orthotopic glioma-bearing rat model
Barbara Bogner et al.
PloS one, 10(6), e0128759-e0128759 (2015-06-09)
Adeno associated virus (AAV) is well known for its ability to deliver transgenes to retina and to mediate improvements in animal models and patients with inherited retinal disease. Although the field is less advanced, there is growing interest in AAV's
Francois Malecaze et al.
Investigative ophthalmology & visual science, 55(10), 6712-6721 (2014-09-25)
To characterize the expression of the bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases (collectively called BTPs), which include BMP-1, mammalian tolloid (mTLD), and mammalian tolloid-like 1 (mTLL-1) and 2 (mTLL-2), as well as the associated proteins procollagen C-proteinase enhancers (PCPE-1 and -2)
Anniek F Lubberding et al.
Journal of cardiovascular pharmacology, 74(1), 38-43 (2019-07-06)
Adrenaline (epinephrine) is one of the prime messengers of the fight-or-flight response, favoring the activation of β-adrenergic receptors. Although general vasoconstriction to nonessential tissues is imperative, the vasodilatory effect of β-adrenergic receptor activation contends with this. We aimed to determine
Ivan Pavlović et al.
Chemistry & biodiversity, 11(9), 1417-1427 (2014-09-23)
Plants from the genus Ferula L. (Apiaceae) were used for various purposes in traditional medicine of different nations throughout the history. Ferula heuffelii Griseb. ex Heuffel is a perennial species endemic for Balkan peninsula. Ten compounds which belong to classes
Shima Changizi et al.
Naunyn-Schmiedeberg's archives of pharmacology, 388(8), 843-852 (2015-04-23)
A few studies explored the atrioventricular (AV) nodal effects of 5-hydroxytyptamine (serotonin, 5-HT) during supraventricular tachyarrhythmia. The aims of the present study are to investigate (i) 5-HT effects on the rate-dependent electrophysiological functions of AV node during atrial fibrillation (AF)
Miklós Palotai et al.
Neurochemical research, 39(8), 1477-1483 (2014-06-05)
The nociceptin/orphanin FQ peptide (NOP) receptor and its endogenous ligand plays role in several physiologic functions of the central nervous system, including pain, locomotion, anxiety and depression, reward and drug addiction, learning and memory. Previous studies demonstrated that the NOP-receptor
Richard T Addo et al.
Journal of pharmaceutical sciences, 104(5), 1677-1690 (2015-02-06)
The overall study goal was to produce a microparticle formulation containing atropine sulfate for ocular administration with improved efficacy and lower side effects, compared with that of the standard marketed atropine solution. The objective was to prepare an atropine sulfate-loaded
José-Ángel García-Pedraza et al.
Vascular pharmacology, 72, 172-180 (2015-05-25)
Although serotonin has been shown to inhibit peripheral sympathetic outflow, serotonin regulation on renal sympathetic outflow has not yet been elucidated. This study investigated which 5-HT receptor subtypes are involved. Wistar rats were anesthetized (sodium pentobarbital; 60mg/kg, i.p.), and prepared
Valery Golderman et al.
Journal of molecular neuroscience : MN, 67(2), 227-234 (2018-12-06)
Organophosphates (OP) are a major threat to the health of soldiers and civilians due to their use as chemical weapons in war and in terror attacks. Among the acute manifestations of OP poisoning, status epilepticus (SE) is bearing the highest
Bei Liu et al.
Molecular neurobiology, 50(2), 327-338 (2014-01-28)
Efflux of monocaroxylates like lactate, pyruvate, and ketone bodies from astrocytes through monocarboxylate transporter 4 (MCT4) supplies the local neuron population with metabolic intermediates to meet energy requirements under conditions of increased demand. Disruption of this astroglial-neuron metabolic coupling pathway
Steven L Miller et al.
Toxicology and applied pharmacology, 284(2), 204-216 (2015-02-18)
Inhibition of acetylcholinesterase (AChE) after nerve agent exposure induces status epilepticus (SE), which causes brain damage or death. The development of countermeasures appropriate for the pediatric population requires testing of anticonvulsant treatments in immature animals. In the present study, exposure
Derek W Hanes et al.
Journal of translational medicine, 13, 187-187 (2015-06-07)
Although the incidence of acute death related to coronary artery disease has decreased with the advent of new interventional therapies, myocardial infarction remains one of the leading causes of death in the US. Current animal models developed to replicate this
Laxmikant S Deshpande et al.
Toxicological sciences : an official journal of the Society of Toxicology, 116(2), 623-631 (2010-05-26)
Organophosphate (OP) compounds are among the most lethal chemical weapons ever developed and are irreversible inhibitors of acetylcholinesterase. Exposure to majority of OP produces status epilepticus (SE) and severe cholinergic symptoms that if left untreated are fatal. Survivors of OP
Dafne M Silberman et al.
PloS one, 9(6), e98831-e98831 (2014-06-05)
The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod and cone photoreceptors and downstream ON-bipolar neurons is a highly demanding energy consuming process. Sirtuin 6 (SIRT6), a NAD-dependent
Thanh Thao Nguyen et al.
Die Pharmazie, 70(3), 183-192 (2015-05-20)
DA-9701, a new prokinetic agent for the treatment of functional dyspepsia, is formulated with Pharbitis semen and Corydalis tuber. This study wasconducted to determine the pharmacological action of DA-9701 and to identify the receptors involved in DA-9701 -induced contractile responsesin
Richard J McMullen et al.
Veterinary ophthalmology, 18(5), 393-403 (2014-10-15)
To describe a surgical modification of deep lamellar endothelial keratoplasty (DLEK) and posterior lamellar keratoplasty (PLK) procedures, to facilitate surgery on standing horses under-sedation. Four client-owned horses, for which the owners declined surgery under general anesthesia, underwent standing corneal lamellar
Jun Xu et al.
Molecular cell, 75(1), 53-65 (2019-05-20)
The M2 muscarinic acetylcholine receptor (M2R) is a prototypical GPCR that plays important roles in regulating heart rate and CNS functions. Crystal structures provide snapshots of the M2R in inactive and active states, but the allosteric link between the ligand
Lise Román Moltzau et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 681-690 (2014-07-16)
We previously found a negative inotropic (NIR) and positive lusitropic response (LR) to C-type natriuretic peptide (CNP) in the failing heart ventricle. In this study, we investigated and compared the functional responses to the natriuretic peptides (NPs), brain (BNP) and
Ashish Dogra et al.
Xenobiotica; the fate of foreign compounds in biological systems, 50(11), 1332-1340 (2020-05-21)
Diclofenac is an extensively used nonsteroidal anti-inflammatory drug, but gastrointestinal liabilities and cardiovascular complications take the shine away from such a widely prescribed drug. On the other hand, rutin, a dietary bioflavonoid, has quite a few pharmacological attributes to improve
Laxmikant S Deshpande et al.
Neurotoxicology, 44, 17-26 (2014-05-03)
Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations. Exposure to POX produces high mortality. OP poisoning is often associated with chronic neurological disorders. In this study, we optimize
Eric M Prager et al.
Neurotoxicology, 44, 335-343 (2014-08-26)
The recent sarin attack in Syria killed 1429 people, including 426 children, and left countless more to deal with the health consequences of the exposure. Prior to the Syrian chemical assault, nerve agent attacks in Japan left many victims suffering
Bruce J Baum et al.
Methods in molecular biology (Clifton, N.J.), 666, 3-20 (2010-08-19)
For many years, our laboratory has been developing gene transfer approaches for salivary gland disorders that currently lack effective therapy. The purpose of this chapter is to describe key methods used in this developmental process. Specifically, we focus on one
Nicoletta K Memos et al.
Pharmacology, biochemistry, and behavior, 124, 380-388 (2014-07-22)
The present study investigated the role of the endocannabinoid system on sexual motivation in the female rat. In Experiment 1, gonadally intact female rats were first tested for partner preference after a vehicle injection. Approximately 2 weeks later, all rats
Xiaoguang Lei et al.
PloS one, 10(5), e0127953-e0127953 (2015-05-27)
Complete and specific ablation of a single dopaminergic (DA) pathway is a critical step to distinguish the roles of DA pathways in vivo. However, this kind of technique has not been reported in non-human primates. This study aimed to establish
Astra S Bryant et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(2), 761-775 (2015-01-16)
The modulation of gamma power (25-90 Hz) is associated with attention and has been observed across species and brain areas. However, mechanisms that control these modulations are poorly understood. The midbrain spatial attention network in birds generates high-amplitude gamma oscillations
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