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Christopher Tipper et al.
Journal of virology, 87(7), 3628-3639 (2013-01-25)
After entering a host cell, retroviruses such as simian immunodeficiency virus (SIV) uncoat, disassembling the viral capsid. Rates of uncoating that are too high and too low can be detrimental to the efficiency of infection. Rapid uncoating typically leads to...
Conor N Gruber et al.
Cell, 183(4), 982-995 (2020-09-30)
Initially, children were thought to be spared from disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel multisystem inflammatory syndrome in children (MIS-C) emerged. Herein, we report on the immune profiles...
Yan Wang et al.
mAbs, 12(1), 1748322-1748322 (2020-04-11)
Selecting the dose for efficacy and first-in-human studies of bispecific antibodies (BsAbs) is a challenging process. Herein, positron emission tomography (PET) imaging with 89Zr-labeled IBI322, an anti-CD47/PD-L1 BsAb, was used to optimize the safety and effective therapy dose. By labeling...
S Küpcü et al.
Journal of immunological methods, 196(1), 73-84 (1996-09-13)
In the present study, cup-shaped 1-3 microns large cell wall fragments from Thermoanaerobacter thermohydrosulfuricus L111-69 covered with a hexagonal S-layer lattice composed of glycoprotein subunits were shown to act as a matrix for the immobilization of human IgG. After cross-linking...
Convalescent plasma treatment of severe COVID-19: a propensity score-matched control study.
Liu, et al.
Nature Medicine, 26, 1708-1713 (2020)
Fabian Richter et al.
mAbs, 11(4), 653-665 (2019-04-02)
The development of alternative therapeutic strategies to tumor necrosis factor (TNF)-blocking antibodies for the treatment of inflammatory diseases has generated increasing interest. In particular, selective inhibition of TNF receptor 1 (TNFR1) promises a more precise intervention, tackling only the pro-inflammatory...
Audrey Gossart et al.
Colloids and surfaces. B, Biointerfaces, 179, 114-120 (2019-04-06)
Biomaterial implants often lead to specific tissue reactions that could compromise their bio-integration and/or optimal cellular interactions. Polyurethanes (PU) are of particular interest as coatings to mask CoCr's bioactivity, since they are generally more biocompatible than metal substrates, present a...
James Duehr et al.
mSphere, 3(1) (2018-02-13)
Recent reports in the scientific literature have suggested that anti-dengue virus (DENV) and anti-West Nile virus (WNV) immunity exacerbates Zika virus (ZIKV) pathogenesis in vitro and in vivo in mouse models. Large populations of immune individuals exist for a related...
Hanieh Khalili et al.
Scientific reports, 6, 36905-36905 (2016-11-23)
Infliximab is an antibody that neutralizes TNF-α and is used principally by systemic administration to treat many inflammatory disorders. We prepared the antibody mimetic Fab-PEG-Fab (FpFinfliximab) for direct intravitreal injection to assess whether such formulations have biological activity and potential...
Daniel Stadlbauer et al.
Nature, 590(7844), 146-150 (2020-11-04)
In late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in China and has since caused a pandemic of coronavirus disease 2019 (COVID-19). The first case of COVID-19 in New York City was officially confirmed on 1 March...
Chen Li et al.
Acta pharmacologica Sinica, 32(3), 329-337 (2011-02-01)
To transform the human anti-rabies virus glycoprotein (anti-RABVG) single-chain variable fragment (scFv) into a Fab fragment and to analyze its immunological activity. The Fab gene was amplified using overlap PCR and inserted into the vector pComb3XSS. The recombinant vector was...
Fatima Amanat et al.
Cell, 184(15), 3936-3948 (2021-07-01)
In this study we profiled vaccine-induced polyclonal antibodies as well as plasmablast-derived mAbs from individuals who received SARS-CoV-2 spike mRNA vaccine. Polyclonal antibody responses in vaccinees were robust and comparable to or exceeded those seen after natural infection. However, the...
Danique Giesen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 26(15), 3999-4009 (2020-01-19)
Probody therapeutic CX-072 is a protease-activatable antibody that is cross-reactive with murine and human programmed death-ligand 1 (PD-L1). CX-072 can be activated in vivo by proteases present in the tumor microenvironment, thereby potentially reducing peripheral, anti-PD-L1-mediated toxicities. To study its...
Mehmet H Ucisik et al.
Colloids and surfaces. B, Biointerfaces, 128, 132-139 (2015-03-04)
Selective targeting of tumor cells by nanoparticle-based drug delivery systems is highly desirable because it maximizes the drug concentration at the desired target while simultaneously protecting the surrounding healthy tissues. Here, we show a design for smart nanocarriers based on...
Guangcan Cao et al.
mAbs, 12(1), 1689027-1689027 (2019-12-05)
The immunoglobulin (Ig) CH2 domain is a promising scaffold for the development of candidate therapeutics. We have previously shown that the stability of isolated CH2 could be increased by the introduction of an additional disulfide bond and removal of seven...
Felix Schiele et al.
mAbs, 7(5), 871-880 (2015-06-06)
Novel oral anticoagulants are effective and safe alternatives to vitamin-K antagonists for anticoagulation therapy. However, anticoagulation therapy in general is associated with an elevated risk of bleeding. Idarucizumab is a reversal agent for the direct thrombin inhibitor, dabigatran etexilate (Pradaxa®)...
An immuno-assay to quantify influenza virus hemagglutinin with correctly folded stalk domains in vaccine preparations
Rajendran M, et al.
PLoS ONE, 13(4), e0194830-e0194830 (2018)
Lars E Clark et al.
Nature communications, 9(1), 1884-1884 (2018-05-16)
While five arenaviruses cause human hemorrhagic fevers in the Western Hemisphere, only Junin virus (JUNV) has a vaccine. The GP1 subunit of their envelope glycoprotein binds transferrin receptor 1 (TfR1) using a surface that substantially varies in sequence among the...
Dawei Zhang et al.
Oncology letters, 5(5), 1694-1698 (2013-06-14)
In view of the previously demonstrated clinical role of the anti-latent membrane protein 1 (LMP1) immunoconjugate HLEAFab-MMC in the treatment of advanced nasopharyngeal carcinoma (NPC), reliable detection of LMP1 expression is of key importance. The aim of this study was...
Karl A Brokstad et al.
Scandinavian journal of immunology, e12679-e12679 (2018-06-09)
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by exocrine gland dysfunction, mainly causing sicca symptoms. B cells have a prominent role in SS, and the T follicular helper (TFH ) cells provide B cells with survival- and...
Renjie Chen et al.
Molecular cancer therapeutics, 11(3), 594-603 (2011-12-16)
Nasopharyngeal carcinoma (NPC) is a major cause of cancer-related death in Southeast Asia and China. Metastasis and relapse are the primary cause of morbidity and mortality in NPC. Recent evidence suggests that the Epstein-Barr virus latent membrane protein 1 (LMP1)...
Metabolic responses of CHO cells to limitation of key amino acids
Duarte TM, et al.
Biotechnology and Bioengineering, 111(10), 2095-2106 (2014)
Madhusudan Rajendran et al.
PloS one, 13(4), e0194830-e0194830 (2018-04-05)
The standard method to quantify the hemagglutinin content of influenza virus vaccines is the single radial immunodiffusion assay. This assay primarily relies on polyclonal antibodies against the head domain of the influenza virus hemagglutinin, which is the main target antigen...
Treatment of Coronavirus Disease 2019 Patients with Convalescent Plasma Reveals a Signal of Significantly Decreased Mortality.
Salazar, et al.
The American Journal of Pathology, 190, 2290-2303 (2020)
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Eduardo C Roncolato et al.
Infection and immunity, 83(2), 713-720 (2014-12-03)
Diarrhea and amebic liver abscesses due to invasive Entamoeba histolytica infections are an important cause of morbidity and mortality in the developing world. Entamoeba histolytica adherence and cell migration, two phenotypes linked to virulence, are both aberrant in trophozoites deficient...
F Cataldo et al.
Minerva pediatrica, 42(12), 509-514 (1990-12-01)
IgG are the most common isotype of Ig and include four subclasses which differ from one another in the following ways: their initial amino acid sequence, their physical and chemical properties and the different serum concentrations reached with age. Every...
Raffael Nachbagauer et al.
Nature immunology, 18(4), 464-473 (2017-02-14)
Infection with influenza virus induces antibodies to the viral surface glycoproteins hemagglutinin and neuraminidase, and these responses can be broadly protective. To assess the breadth and magnitude of antibody responses, we sequentially infected mice, guinea pigs and ferrets with divergent...
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