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S Stevens Negus
Pharmacological reviews, 71(2), 225-266 (2019-03-23)
All preclinical procedures for analgesic drug discovery involve two components: 1) a "pain stimulus" (the principal independent variable), which is delivered to an experimental subject with the intention of producing a pain state; and 2) a "pain behavior" (the principal...
C Cremon et al.
Alimentary pharmacology & therapeutics, 45(7), 909-922 (2017-02-07)
Intestinal immune activation is involved in irritable bowel syndrome (IBS) pathophysiology. While most dietary approaches in IBS involve food avoidance, there are fewer indications on food supplementation. Palmithoylethanolamide, structurally related to the endocannabinoid anandamide, and polydatin are dietary compounds which...
Giuseppe Talani et al.
Alcohol (Fayetteville, N.Y.), 49(8), 781-794 (2015-11-26)
The basolateral amygdala (BLA) plays crucial roles in stimulus value coding, as well as drug and alcohol dependence. Ethanol alters synaptic transmission in the BLA, while endocannabinoids (eCBs) produce presynaptic depression at BLA synapses. Recent studies suggest interactions between ethanol...
Thomas F Gamage et al.
Pharmacology, biochemistry, and behavior, 193, 172918-172918 (2020-04-06)
Synthetic cannabinoid receptor agonists (SCRAs) possess high abuse liability and complex toxicological profiles, making them serious threats to public health. EG-018 is a SCRA that has been detected in both illicit products and human samples, but it has received little...
May Poh Lai et al.
Protein science : a publication of the Protein Society, 29(7), 1606-1617 (2020-04-17)
Two different members of the fatty acid-binding protein (FABP) family are found in enterocyte cells of the gastrointestinal system, namely liver-type and intestinal fatty acid-binding proteins (LFABP and IFABP, also called FABP1 and FABP2, respectively). Striking phenotypic differences have been...
Chunyan Liu et al.
Oral diseases, 26(7), 1366-1374 (2019-12-04)
Cannabis, also known as marijuana, is one of the most commonly used substances for medical and recreational purposes globally. With the trend of global legalization of medical use of cannabis and even the recreational use, the prevalence of recreational use...
Modulation of intracellular pathways by anandamide and its evolving role in oncology.
Shailendra Kapoor
European journal of cancer (Oxford, England : 1990), 49(8), 2065-2065 (2013-02-26)
D Luque-Córdoba et al.
Talanta, 185, 602-610 (2018-05-16)
Endocannabinoids are lipids with a key role in physiological processes such as the immune response or the metabolism. This involvement explains their association to pathologies such as cancer, obesity or multiple sclerosis. The determination of endocannabinoids constitutes a challenge for...
J Maia et al.
Archives of toxicology, 93(3), 649-658 (2019-01-20)
Cannabis use has become a hot topic in several countries due to the debate about its legalization for medical purposes. However, data are limited regarding adverse events, safety and potential impact on reproductive health. Cannabis consumption during pregnancy has been...
Blood transfusion support for sickle cell patients during haematopoietic stem cell transplantation: a single-institution experience.
Gil C De Santis et al.
British journal of haematology, 190(5), e295-e297 (2020-05-19)
M A Costa et al.
Placenta, 36(1), 69-76 (2014-12-04)
A balanced proliferation, apoptosis and differentiation in trophoblast cells of the human placenta is crucial for a proper placental development. Alteration in trophoblast apoptosis and differentiation are associated with gestational-related complications, such as preeclampsia, intrauterine growth restriction or miscarriages. The...
Paula Accialini et al.
Placenta, 93, 23-25 (2020-02-25)
Oxytocin plays a pivotal role in the regulation of human parturition, however its role and modulation in the placenta is not fully understood. Non-labour cesarean section placentas were cultured with the endocannabinoid anandamide. We observed an increase in placental oxytocin...
Tamás Oláh et al.
The Journal of physiology, 594(24), 7381-7398 (2016-10-28)
Marijuana was found to cause muscle weakness, although the exact regulatory role of its receptors (CB1 cannabinoid receptor; CB1R) in the excitation-contraction coupling (ECC) of mammalian skeletal muscle remains unknown. We found that CB1R activation or its knockout did not...
Akshay Kumar et al.
Theriogenology, 128, 207-217 (2019-02-21)
In view of the limited information available on functional significance of TRPV1 in regulating sperm functions, present study was undertaken on bull spermatozoa. Sixty four ejaculates were collected from four Hariana bulls and were used for molecular and functional characterisation...
Bakri M Assas et al.
Immunology, 147(3), 292-304 (2015-12-09)
Neuro-immune interactions, particularly those driven by neuropeptides, are increasingly implicated in immune responses. For instance, triggering calcium-channel transient receptor potential vanilloid 1 (TRPV1) on sensory nerves induces the release of calcitonin-gene-related peptide (CGRP), a neuropeptide known to moderate dendritic cell...
Tinglu Ning et al.
Endocrine, 56(2), 366-378 (2017-03-01)
DGAT2 is the critical catalyzing enzyme for triglyceride biosynthesis, and excess triglyceride accumulation in fat tissues is a fundamental process for obesity. Mutations in DGAT2 or other genes interacting with DGAT2 associated with adiposity have not been reported in human...
Georgia Balsevich et al.
Frontiers in neuroendocrinology, 47, 86-108 (2017-07-26)
For decades, there has been speculation regarding the interaction of cannabinoids with glucocorticoid systems. Given the functional redundancy between many of the physiological effects of glucocorticoids and cannabinoids, it was originally speculated that the biological mechanisms of cannabinoids were mediated...
Manoela V Fogaça et al.
Psychopharmacology, 226(3), 579-587 (2012-11-28)
The endocannabinoid and endovanniloid anandamide (AEA) exerts biphasic effects when injected into the dorsolateral periaqueductal grey (dlPAG) in rats submitted to threatening situations. Whereas lower doses of AEA induce anxiolytic-like effects by activating cannabinoid CB1 receptors, no effects are observed...
Isabel Forner-Piquer et al.
Endocrinology, 158(10), 3462-3476 (2017-09-25)
Phthalates, used as plasticizers, have become a ubiquitous contaminant and have been reported for their potential to induce toxicity in living organisms. Among them, di-isononyl phthalate (DiNP) has been recently used to replace di(2-ethylhexyl) phthalate (DEHP). Nowadays, there is evidence...
C J Hillard et al.
Journal of lipid research, 38(12), 2383-2398 (1998-02-11)
This review presents and explores the hypothesis that N-arachidonylethanolamine (AEA, also called anandamide) is synthesized in the brain and functions as an endogenous ligand of the cannabinoid receptor. Support for this hypothesis comes from in vitro experiments demonstrating that AEA...
Martin A Katzman et al.
Journal of clinical psychopharmacology, 36(6), 691-703 (2016-11-05)
Prevalence of psychiatric disorders continues to rise globally, yet remission rates and patient outcome remain less than ideal. As a result, novel treatment approaches for these disorders are necessary to decrease societal economic burden, as well as increase individual functioning....
Anna Chorniy et al.
Journal of health economics, 60, 1-15 (2018-05-19)
In the U.S., nearly 11% of school-age children have been diagnosed with ADHD, and approximately 10% of children suffer from asthma. In the last decade, the number of children diagnosed with these conditions has inexplicably been on the rise. This...
Margherita Brindisi et al.
Journal of medicinal chemistry, 59(6), 2612-2632 (2016-02-19)
We report the discovery of compound 4a, a potent β-lactam-based monoacylglycerol lipase (MGL) inhibitor characterized by an irreversible and stereoselective mechanism of action, high membrane permeability, high brain penetration evaluated using a human in vitro blood-brain barrier model, high selectivity...
Setareh Sianati et al.
Frontiers in bioengineering and biotechnology, 8, 608951-608951 (2021-02-05)
Ion channels activated by mechanical inputs are important force sensing molecules in a wide array of mammalian cells and tissues. The transient receptor potential channel, TRPV4, is a polymodal, nonselective cation channel that can be activated by mechanical inputs but...
Austin R Jackson et al.
Journal of leukocyte biology, 95(4), 609-619 (2013-12-10)
Endocannabinoids are lipid-signaling molecules found in the nervous system; however, their precise role in the periphery is unclear. In the current study, we observed that a single i.p. administration of AEA caused rapid induction of MDSCs. The MDSCs contained a...
Tarvi Teder et al.
Archives of biochemistry and biophysics, 676, 108126-108126 (2019-10-08)
A catalase-related allene oxide synthase (cAOS) or a hydroperoxide lyase (cHPL) fused together with an 8R-lipoxygenase is involved in the stress signaling of corals via an arachidonic acid pathway. cAOS gives rise to α-ketol and cyclopentenone, while cHPL catalyzes the...
Malena Lis Mul Fedele et al.
Frontiers in cellular and infection microbiology, 10, 100-100 (2020-04-01)
Sepsis is caused by a dysregulated host response to infection, and characterized by uncontrolled inflammation together with immunosuppression, impaired innate immune functions of phagocytes and complement activation. Septic patients develop fever or hypothermia, being the last one characteristic of severe...
Aidan Levine et al.
Frontiers in pharmacology, 11, 615028-615028 (2021-02-16)
Recent findings suggested that Clinical Endocannabinoid Deficiency underlies the pathophysiology of pain disorders, including migraine and headache. In models of medication overuse headache induced by sustained administration of sumatriptan or morphine, 2-AG levels were selectively depleted in the periaqueductal gray...
Emmanuel Dotsey et al.
Scientific reports, 7, 42584-42584 (2017-02-18)
The hallmark of vaccines is their ability to prevent the spread of infectious pathogens and thereby serve as invaluable public health tool. Despite their medical relevance, there is a gap in our understanding of the physiological factors that mediate innate...
Andrea Martella et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(12), 4275-4288 (2016-09-15)
The developmental role of the endocannabinoid system still remains to be fully understood. Here, we report the presence of a complete endocannabinoid system during zebrafish development and show that the genes that code for enzymes that catalyze the anabolism and...
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