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Zhan-Heng Qi et al.
The Journal of biological chemistry, 282(45), 33052-33063 (2007-09-19)
Ethanol enhances gamma-aminobutyrate (GABA) signaling in the brain, but its actions are inconsistent at GABA(A) receptors, especially at low concentrations achieved during social drinking. We postulated that the epsilon isoform of protein kinase C (PKCepsilon) regulates the ethanol sensitivity of...
A Rodríguez-Núñez et al.
Brain & development, 22(7), 427-431 (2000-12-05)
If febrile seizures cause significant compromise of neuronal metabolism (whether permanent or reversible), this should be reflected in an increase in the cerebrospinal fluid concentrations of neuron-specific enolase (NSE) and/or adenosine triphosphate (ATP) breakdown products. In the present study, AMP...
Gabapentin for the prophylaxis of episodic migraine in adults.
Corey D Fogleman
American family physician, 89(9), 714-715 (2014-05-03)
Thomas Gregory et al.
American journal of physical medicine & rehabilitation, 94(1), e1-e5 (2014-10-31)
A case of quadrilateral space syndrome is presented, where a large near-circumferential glenoid labrum tear led to a paralabral cyst that dissected into the quadrilateral space and caused a compressive neuropathy of the axillary nerve. This led to a 6-mo...
Marie Soukupová et al.
Experimental neurology, 257, 39-49 (2014-04-29)
The alterations in GABA release have not yet been systematically measured along the natural course of temporal lobe epilepsy. In this work, we analyzed GABA extracellular concentrations (using in vivo microdialysis under basal and high K(+)-evoked conditions) and loss of...
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the...
Noritaka Nakamichi et al.
Journal of pharmacological sciences, 110(2), 133-149 (2009-06-02)
In this review, we will summarize our ongoing studies on the functionality of both gamma-aminobutyric acid (GABA) and glutamate receptors expressed by undifferentiated neural progenitor cells isolated from embryonic rodent brains. Cells were cultured with growth factors for the formation...
Pregabalin versus pramipexole for restless legs syndrome.
Richard P Allen
The New England journal of medicine, 370(21), 2050-2051 (2014-05-23)
J Shilpa et al.
Journal of biomedical nanotechnology, 10(4), 622-631 (2014-04-17)
Use of nanoparticulate drug delivery system for an effective therapeutic outcome against diseases gains immense hope in the study of drug delivery to partially hepatectomised rats. In the present study, partially hepatectomised rats treated with Gamma aminobutyric acid (GABA) and...
W-Y Lu et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 39(7), 956-961 (2009-04-30)
Asthma often occurs as a result of immune-based inflammatory responses, which consequently cause pathological changes in airway structural cells. However, the underlying mechanisms of airway pathology in asthma are still not fully understood. Our recent studies revealed a critical role...
Neuroscience. Can oxytocin treat autism?
Larry J Young et al.
Science (New York, N.Y.), 347(6224), 825-826 (2015-02-24)
Richard A E Edden et al.
Magnetic resonance in medicine, 68(3), 657-661 (2012-07-11)
Edited magnetic resonance spectroscopy makes possible noninvasive studies of the role of the inhibitory neurotransmitter GABA in the healthy brain and in disease processes. A major limitation of the methodology is coediting of macromolecular signals. Although it has previously been...
V V Danilov et al.
Urologiia (Moscow, Russia : 1999), (5)(5), 55-58 (2014-01-21)
17 patients (mean age, 61 +/- 1.7 years) with an benign prostate hyperplasia (BPH) and urination disorders were under observation. After examination by ultrasound, urodynamic and laboratory studies, patients received conservative combined therapy, including alpha1-adrenoblocker silodosin, L-carnitine, B vitamins and...
Gaetano Zaccara et al.
Epilepsia, 55(7), 1048-1057 (2014-06-07)
To assess the comparative efficacy and safety of pregabalin and levetiracetam for the reduction of seizure frequency in patients with partial seizures. This was a randomized, double-blind, flexible-dose, parallel-group noninferiority study of pregabalin and levetiracetam (randomized 1:1) as adjunctive treatment...
Cortical inhibition, gamma-aminobutyric acid, and major depression: there is plenty of smoke but is there fire?
Gerard Sanacora
Biological psychiatry, 67(5), 397-398 (2010-02-18)
Richard P Allen et al.
The New England journal of medicine, 370(7), 621-631 (2014-02-14)
Dopaminergic medications relieve symptoms of the restless legs syndrome (RLS) but have the potential to cause iatrogenic worsening (augmentation) of RLS with long-term treatment. Pregabalin may be an effective alternative. In this 52-week, randomized, double-blind trial, we assessed efficacy and...
Should anaesthetists routinely use a gabapentinoid perioperatively?
G J Sanders
British journal of hospital medicine (London, England : 2005), 75(1), 58-58 (2014-01-10)
I M Mykheĭtseva
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(1), 78-83 (2013-05-30)
We explored the melatonin influence on the level of amino acid neurotransmitters of the retina in glaucoma neuropathy in rats. Glaucoma was caused by the prolong systemic introduction of adrenalin. In the study 3 groups were participated: control animals; the...
T Fujita et al.
Clinica chimica acta; international journal of clinical chemistry, 287(1-2), 99-109 (1999-10-06)
Pipecolic acid is regarded as a gamma-aminobutyric acid receptor agonist. Stereochemical studies of pipecolic acid were performed in patients with chronic liver diseases. Plasma D- and L-pipecolic acid were significantly elevated in 15 liver cirrhotic patients with no history of...
[Phenibut yielded withdrawal symptoms and psychosis. Drugs for cosmonauts--now marketed as dietary supplements online].
Lovisa Högberg et al.
Lakartidningen, 110(16), 825-827 (2013-05-31)
T Clayton et al.
Current medicinal chemistry, 14(26), 2755-2775 (2007-11-30)
A successful unified pharmacophore/receptor model which has guided the synthesis of subtype selective compounds is reviewed in light of recent developments both in ligand synthesis and structural studies of the binding site itself. The evaluation of experimental data in combination...
Bo Hjorth Bentzen et al.
Advances in pharmacological sciences, 2011, 578273-578273 (2011-12-14)
Intuitively one might expect that activation of GABAergic inhibitory neurons results in bradycardia. In conscious animals the opposite effect is however observed. GABAergic neurons in nucleus ambiguus hold the ability to control the activity of the parasympathetic vagus nerve that...
Luz M Delgado et al.
The Journal of comparative neurology, 514(5), 459-472 (2009-04-08)
In the vertebrate retina, gamma-aminobutyric acid (GABA) mediates inhibitory processes that shape the visual response and is also thought to have neurotrophic functions during retinal development. To investigate the role of GABAergic signaling at the beginning of visual experience, we...
Michael J Buys et al.
Anesthesia and analgesia, 119(2), 481-488 (2014-06-11)
The anticonvulsant drugs pregabalin and gabapentin are often used systemically to treat some forms of chronic neuropathic pain. However, many patients report side effects serious enough to cause discontinuation of the drug. Here we present evidence that pregabalin may block...
Roman Tyzio et al.
Science (New York, N.Y.), 343(6171), 675-679 (2014-02-08)
We report that the oxytocin-mediated neuroprotective γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery is abolished in the valproate and fragile X rodent models of autism. During delivery and subsequently, hippocampal neurons in these models have elevated intracellular chloride levels, increased...
Daniel M Tassone et al.
Clinical therapeutics, 29(1), 26-48 (2007-03-24)
The US Food and Drug Administration (FDA) approved pregabalin in December 2004 for the treatment of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Pregabalin is the first drug approved in the United States and in Europe for...
Mayumi Yamada et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 4786-4800 (2014-04-04)
In the cerebellum, the bHLH transcription factors Ptf1a and Atoh1 are expressed in distinct neuroepithelial regions, the ventricular zone (VZ) and the rhombic lip (RL), and are required for producing GABAergic and glutamatergic neurons, respectively. However, it is unclear whether...
Cecilia M Borghese et al.
Alcohol (Fayetteville, N.Y.), 41(3), 155-162 (2007-05-25)
The gamma-aminobutyric acid type A receptors (GABAA-Rs) display a wide variety of subunit combinations. Drugs such as benzodiazepines have shown differential effects based on GABAA-R subunit composition. Actions of alcohols and volatile anesthetics generally do not vary markedly with subunit...
J D Shoemaker et al.
Journal of chromatography, 562(1-2), 125-138 (1991-01-02)
Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio...
Megan M Eaton et al.
Molecular pharmacology, 86(6), 647-656 (2014-09-23)
Native γ-aminobutyric acid (GABA)A receptors consisting of α4, β1-3, and δ subunits mediate responses to the low, tonic concentration of GABA present in the extracellular milieu. Previous studies on heterologously expressed α4βδ receptors have shown a large degree of variability...
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