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Maria Luisa Gelmi et al.
Journal of medicinal chemistry, 49(18), 5571-5577 (2006-09-01)
A novel class of 3-demethoxy-3-glycosylaminothiocolchicines (7) was prepared and tested for muscle relaxant activity. The syntheses were performed starting from the new 3-amino-3-demethoxythiocolchicine (5) prepared in good yield from 3-O-demethylthiocolchicine (1c) using the Buchwald-Hartwig reaction. The condensation of 5 with
H K Knych et al.
Journal of veterinary pharmacology and therapeutics, 38(2), 113-122 (2014-08-19)
The anti-anxiety and calming effects following activation of the GABA receptor have been exploited in performance horses by administering products containing GABA. The primary goal of the study reported here was to describe endogenous concentrations of GABA in horses and
Benzodiazepines: revealing of the secrets of GABAA-mediated immunosuppression: GABAA subtype-specific benzodiazepines are the hope.
Gyorgy Frendl
Critical care medicine, 41(7), 1807-1808 (2013-06-19)
Martin D Haustein et al.
Neuron, 82(2), 413-429 (2014-04-20)
The spatiotemporal activities of astrocyte Ca²⁺ signaling in mature neuronal circuits remain unclear. We used genetically encoded Ca²⁺ and glutamate indicators as well as pharmacogenetic and electrical control of neurotransmitter release to explore astrocyte activity in the hippocampal mossy fiber
Charles C Lee et al.
Neuroreport, 26(12), 688-694 (2015-07-15)
The thalamocortical pathways form highly topographic connections from the primary sensory thalamic nuclei to the primary cortical areas. The synaptic properties of these thalamocortical connections are modifiable by activation from various neuromodulators, such as acetylcholine. Cholinergic activation can alter functional
Mayumi Yamada et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 4786-4800 (2014-04-04)
In the cerebellum, the bHLH transcription factors Ptf1a and Atoh1 are expressed in distinct neuroepithelial regions, the ventricular zone (VZ) and the rhombic lip (RL), and are required for producing GABAergic and glutamatergic neurons, respectively. However, it is unclear whether
Ke Li et al.
Neuroscience bulletin, 24(3), 195-200 (2008-05-27)
gamma -aminobutyric acid (GABA) is an inhibitory neurotransmitter in adult mammalian central nervous system (CNS). During CNS development, the role of GABA is switched from an excitatory transmitter to an inhibitory transmitter, which is caused by an inhibition of calcium
Melanie M Hoefer et al.
Experimental neurology, 263, 221-234 (2014-09-24)
Methamphetamine (METH) abuse is frequent in individuals infected with human immunodeficiency virus type-1 (HIV-1) and is suspected to aggravate HIV-associated neurocognitive disorders (HAND). METH is a psychostimulant that compromises several neurotransmitter systems and HIV proteins trigger neuronal injury but the
Ivan Pavlov et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(1), 504-509 (2013-12-18)
The spiking output of interneurons is key for rhythm generation in the brain. However, what controls interneuronal firing remains incompletely understood. Here we combine dynamic clamp experiments with neural network simulations to understand how tonic GABAA conductance regulates the firing
Joseph E Cillo et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72(10), 1909-1914 (2014-09-23)
The purpose of this study was to determine the efficacy of pre-emptive analgesia with pregabalin and celecoxib on narcotic consumption and perceived pain in adult patients undergoing maxillomandibular advancement surgery for obstructive sleep apnea. This was a prospective, randomized, double-blinded
Drugs for neuropathic pain.
Eija Kalso et al.
BMJ (Clinical research ed.), 347, f7339-f7339 (2013-12-21)
Sergiy V Korol et al.
Diabetes, 64(1), 79-89 (2014-08-13)
Glucagon-like peptide-1 (GLP-1) is a hormone that stimulates insulin secretion. Receptors for GLP-1 are also found in the brain, including the hippocampus, the center for memory and learning. Diabetes is a risk factor for decreased memory functions. We studied effects
D-K Zhang et al.
Clinical radiology, 69(8), 836-840 (2014-05-20)
To investigate the diagnostic performance of the acoustic radiation force impulse (ARFI) elastography for the assessment of primary biliary cirrhosis (PBC) stage. Sixty-one patients with PBC in which liver biopsy and ARFI elastography measurements were performed in the same session
Michael J Buys et al.
Anesthesia and analgesia, 119(2), 481-488 (2014-06-11)
The anticonvulsant drugs pregabalin and gabapentin are often used systemically to treat some forms of chronic neuropathic pain. However, many patients report side effects serious enough to cause discontinuation of the drug. Here we present evidence that pregabalin may block
Donald Mann et al.
Epilepsia, 55(12), 1934-1943 (2014-11-08)
To evaluate the safety, tolerability, and pharmacokinetics (PK) of pregabalin as adjunctive therapy in children with refractory partial seizures. This was a phase 1, randomized, placebo-controlled, parallel-group, escalating-dose, multiple-dose study comprising a 7-day, double-blind treatment period and a single-blind, single
Gábor Molnár et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(4), 1133-1137 (2014-01-24)
Concentrations of insulin in the brain are severalfold higher than blood plasma levels. Insulin in the brain regulates the metabolism, molecular composition, and cognitive performance of microcircuits and reduces food intake; cerebral insulin levels are altered in diabetes, aging, obesity
Catherine A Christian et al.
Neuron, 78(6), 1063-1074 (2013-06-04)
Benzodiazepines (BZs) allosterically modulate γ-aminobutyric acid type-A receptors (GABAARs) to increase inhibitory synaptic strength. Diazepam binding inhibitor (DBI) protein is a BZ site ligand expressed endogenously in the brain, but functional evidence for BZ-mimicking positive modulatory actions has been elusive.
Gabapentinoids and postsurgical pain: safe and effective?
Johan M van Schalkwyk
Anesthesiology, 121(2), 423-423 (2014-07-23)
Ann-Na Cho et al.
Nature communications, 12(1), 4730-4730 (2021-08-07)
Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro model to recapitulate human brain development and neurological diseases. However, the current systems for brain organoid culture require further improvement for the reliable production of high-quality
Adam J McShane et al.
Journal of the American Society for Mass Spectrometry, 25(10), 1694-1704 (2014-08-06)
Direct reductive methylation of peptides is a common method for quantitative proteomics. It is an active derivatization technique; with participation of the dimethylamino group, the derivatized peptides preferentially release intense a1 ions. The advantageous generation of a1 ions for quantitative
Ludmila A Kasatkina et al.
Biochemical pharmacology, 174, 113783-113783 (2019-12-28)
Neuroinflammation plays a prominent role in the onset of demyelinating diseases, major depressive disorder and delayed neurodegeneration. An open question remains whether pharmacological suppression of inflammation can effectively reduce the progression of these states. Bioactive lipid mediators such as N-acylethanolamines
Beatrice Bocca et al.
Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <
Stephen West et al.
Current opinion in organ transplantation, 19(2), 201-208 (2014-02-21)
The use of corticosteroids is increasing, and while the physical complications of their use are well known, the neuropsychiatric consequences are not. This review focuses on preventing these neuropsychiatric complications. Although there are limited data on this subject, it is
Jin Kyung Kim et al.
Nature communications, 9(1), 4184-4184 (2018-10-12)
Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain; however, the roles of GABA in antimicrobial host defenses are largely unknown. Here we demonstrate that GABAergic activation enhances antimicrobial responses against intracellular bacterial infection. Intracellular bacterial infection decreases
Marisa Roberto et al.
Cold Spring Harbor perspectives in medicine, 2(12), a012195-a012195 (2012-10-23)
Alcohol dependence is a chronically relapsing disorder characterized by compulsive drug seeking and drug taking, loss of control in limiting intake, and the emergence of a withdrawal syndrome in the absence of the drug. Accumulating evidence suggests an important role
K J Bär et al.
Neurobiology of aging, 24(2), 333-338 (2002-12-25)
Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels of pentosidine and N(epsilon)-(carboxymethyl)-lysine (CML) in serum and cerebrospinal fluid (CSF) of
Victorio Bambini-Junior et al.
Science (New York, N.Y.), 346(6206), 176-176 (2014-10-11)
Tyzio et al. (Reports, 7 February 2014, p. 675) reported that bumetanide restored the impaired oxytocin-mediated γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery in animal models of autism, ameliorating some autistic-like characteristics in the offspring. However, standard practices in the
Margarita V Glazova et al.
Journal of neurochemistry, 132(2), 218-229 (2014-10-30)
It has recently been proposed that extracellular signal-regulated kinases 1 and 2 (ERK1/2) are one of the factors mediating seizure development. We hypothesized that inhibition of ERK1/2 activity could prevent audiogenic seizures by altering GABA and glutamate release mechanisms. Krushinsky-Molodkina
May-Yun Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(8), 2503-2508 (2015-02-13)
Insulin monotherapy can neither maintain normoglycemia in type 1 diabetes (T1D) nor prevent the long-term damage indicated by elevated glycation products in blood, such as glycated hemoglobin (HbA1c). Here we find that hyperglycemia, when unaccompanied by an acute increase in
Cortical inhibition, gamma-aminobutyric acid, and major depression: there is plenty of smoke but is there fire?
Gerard Sanacora
Biological psychiatry, 67(5), 397-398 (2010-02-18)
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